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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF8
Z-value: 0.56
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Transcription factors associated with ZNF8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF8 | hg38_v1_chr19_+_58278948_58278992 | -0.56 | 1.9e-19 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 26.1 | GO:0001504 | neurotransmitter uptake(GO:0001504) |
| 2.4 | 23.8 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.2 | 15.1 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.8 | 10.9 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.6 | 8.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 2.0 | 8.2 | GO:0035927 | RNA import into mitochondrion(GO:0035927) |
| 0.4 | 8.0 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.9 | 7.8 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.6 | 7.2 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.2 | 6.9 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 23.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 1.8 | 10.9 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.8 | 10.0 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 9.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 8.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.6 | 8.3 | GO:0042555 | MCM complex(GO:0042555) |
| 1.0 | 8.2 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.2 | 8.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.3 | 7.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.4 | 7.2 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 26.1 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
| 4.0 | 23.8 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.9 | 10.9 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.2 | 8.3 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 8.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 1.0 | 8.2 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.4 | 8.0 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.3 | 8.0 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 7.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 7.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 8.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 7.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 5.5 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 26.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 2.2 | 23.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.3 | 22.3 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.2 | 12.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.6 | 8.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 8.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 7.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 6.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 5.6 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.3 | 5.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |