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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZSCAN4
Z-value: 0.61
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Transcription factors associated with ZSCAN4
Network of associatons between targets according to the STRING database.
First level regulatory network of ZSCAN4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_10368645 Show fit | 9.32 |
ENST00000613496.4
|
hippocalcin like 1 |
|
| chr6_-_41941795 Show fit | 9.05 |
ENST00000372991.9
|
cyclin D3 |
|
| chr6_-_41941728 Show fit | 8.86 |
ENST00000414200.6
|
cyclin D3 |
|
| chr6_-_41941507 Show fit | 8.78 |
ENST00000372987.8
|
cyclin D3 |
|
| chr14_+_52707192 Show fit | 6.01 |
ENST00000445930.7
ENST00000555339.5 ENST00000556813.1 |
proteasome 26S subunit, ATPase 6 |
|
| chr3_-_53255990 Show fit | 5.88 |
ENST00000423525.6
|
transketolase |
|
| chr14_+_52707178 Show fit | 5.82 |
ENST00000612399.4
|
proteasome 26S subunit, ATPase 6 |
|
| chr1_-_154608140 Show fit | 5.78 |
ENST00000529168.2
ENST00000368474.9 ENST00000680305.1 ENST00000648231.2 |
adenosine deaminase RNA specific |
|
| chr7_-_10940123 Show fit | 5.71 |
ENST00000339600.6
|
NDUFA4 mitochondrial complex associated |
|
| chr3_-_53256009 Show fit | 5.68 |
ENST00000296289.10
ENST00000462138.6 ENST00000423516.5 |
transketolase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 26.7 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.7 | 13.4 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 3.9 | 11.6 | GO:0005999 | xylulose biosynthetic process(GO:0005999) |
| 0.1 | 9.1 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 1.0 | 8.6 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.9 | 8.2 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.0 | 6.4 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.1 | 5.9 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 1.0 | 5.8 | GO:1900368 | regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) |
| 0.3 | 5.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 15.6 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.3 | 13.4 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 11.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 9.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 8.3 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 7.4 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.0 | 6.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.8 | 5.8 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.4 | 5.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 27.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.8 | 14.2 | GO:0019864 | IgG binding(GO:0019864) |
| 1.5 | 13.4 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 2.9 | 11.6 | GO:0004802 | transketolase activity(GO:0004802) |
| 0.3 | 9.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 9.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.3 | 7.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.7 | 5.8 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.2 | 5.7 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.5 | 5.5 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 11.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 8.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 6.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 6.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 5.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 5.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 4.8 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 3.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 3.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 13.4 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 11.6 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.2 | 9.7 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.3 | 7.5 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 6.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 6.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 5.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 5.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 4.7 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |