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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AACCUGG

Z-value: 1.06

Motif logo

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miRNA associated with seed AACCUGG

NamemiRBASE accession
hsa-miR-490-3p
MIMAT0002806

Activity profile of AACCUGG motif

Sorted Z-values of AACCUGG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AACCUGG

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_123961304 1.63 ENST00000371160.5
ENST00000435103.5
STAG2
stromal antigen 2
chr1_+_93345893 1.07 ENST00000370272.9
ENST00000370267.1
DR1
down-regulator of transcription 1
chr19_+_34428353 1.03 ENST00000590048.6
ENST00000246548.9
UBA2
ubiquitin like modifier activating enzyme 2
chr1_+_193121950 0.91 ENST00000367435.5
CDC73
cell division cycle 73
chr11_+_125592826 0.70 ENST00000529196.5
ENST00000392708.9
ENST00000649491.1
ENST00000531491.5
STT3A
STT3 oligosaccharyltransferase complex catalytic subunit A
chr8_-_102864155 0.69 ENST00000682725.1
ENST00000337198.10
ENST00000681985.1
ENST00000684566.1
ENST00000683787.1
ENST00000682014.1
ENST00000682969.1
ENST00000684721.1
ENST00000347770.8
AZIN1
antizyme inhibitor 1
chr3_-_190120881 0.67 ENST00000319332.10
P3H2
prolyl 3-hydroxylase 2
chr7_-_26200734 0.66 ENST00000354667.8
ENST00000618183.5
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr8_-_17246846 0.65 ENST00000628418.1
ENST00000361272.9
ENST00000523917.5
CNOT7
CCR4-NOT transcription complex subunit 7
chr12_-_122526929 0.55 ENST00000331738.12
ENST00000528279.1
ENST00000344591.8
ENST00000526560.6
RSRC2
arginine and serine rich coiled-coil 2
chr7_+_77537258 0.54 ENST00000248594.11
PTPN12
protein tyrosine phosphatase non-receptor type 12
chr14_+_57268963 0.53 ENST00000261558.8
AP5M1
adaptor related protein complex 5 subunit mu 1
chr1_-_246931326 0.50 ENST00000366508.5
ENST00000326225.3
AHCTF1
AT-hook containing transcription factor 1
chr12_+_67269328 0.49 ENST00000545606.6
CAND1
cullin associated and neddylation dissociated 1
chr11_+_63938971 0.48 ENST00000539656.5
ENST00000377793.9
NAA40
N-alpha-acetyltransferase 40, NatD catalytic subunit
chr7_+_101154445 0.48 ENST00000337619.11
ENST00000429457.1
AP1S1
adaptor related protein complex 1 subunit sigma 1
chr16_+_1153202 0.48 ENST00000358590.8
ENST00000638323.1
CACNA1H
calcium voltage-gated channel subunit alpha1 H
chr2_+_177212724 0.47 ENST00000677043.1
ENST00000677863.1
ENST00000676681.1
ENST00000678111.1
ENST00000676874.1
ENST00000676736.1
ENST00000411529.6
ENST00000435711.5
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3
chr17_+_32350132 0.40 ENST00000321233.10
ENST00000394673.6
ENST00000394670.9
ENST00000579634.5
ENST00000580759.5
ENST00000342555.10
ENST00000577908.5
ENST00000394679.9
ENST00000582165.1
ZNF207
zinc finger protein 207
chr4_-_112516176 0.28 ENST00000313341.4
NEUROG2
neurogenin 2
chr17_-_50707855 0.28 ENST00000285243.7
ANKRD40
ankyrin repeat domain 40
chr7_-_140176970 0.20 ENST00000397560.7
KDM7A
lysine demethylase 7A
chrX_+_10015226 0.19 ENST00000380861.9
WWC3
WWC family member 3
chr15_+_51829644 0.17 ENST00000308580.12
TMOD3
tropomodulin 3
chr6_-_90296824 0.17 ENST00000257749.9
BACH2
BTB domain and CNC homolog 2
chr8_-_67343768 0.15 ENST00000262215.8
ARFGEF1
ADP ribosylation factor guanine nucleotide exchange factor 1
chr5_+_109689915 0.08 ENST00000261483.5
MAN2A1
mannosidase alpha class 2A member 1
chr4_+_183099244 0.08 ENST00000403733.8
WWC2
WW and C2 domain containing 2
chr18_+_57435366 0.07 ENST00000491143.3
ONECUT2
one cut homeobox 2
chr9_-_38069220 0.06 ENST00000377707.4
SHB
SH2 domain containing adaptor protein B
chr17_-_1400168 0.04 ENST00000573026.1
ENST00000575977.1
ENST00000571732.5
ENST00000264335.13
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
chr9_-_121201836 0.03 ENST00000373840.9
RAB14
RAB14, member RAS oncogene family
chr18_-_36067524 0.02 ENST00000590898.5
ENST00000357384.8
ENST00000399022.9
ENST00000588737.5
RPRD1A
regulation of nuclear pre-mRNA domain containing 1A
chr14_-_25049889 0.00 ENST00000419632.6
ENST00000396700.5
STXBP6
syntaxin binding protein 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.2 0.7 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 1.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.7 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.1 0.6 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.2 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.1 0.5 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.5 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.5 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.1 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.0 0.7 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.5 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.5 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.0 GO:0003064 regulation of heart rate by hormone(GO:0003064) negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.1 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.4 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.6 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.1 0.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1 0.5 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1 1.0 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.1 0.7 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 0.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.5 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.7 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.2 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.7 GO:0097157 pre-mRNA intronic binding(GO:0097157) N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.5 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 1.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA