Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ACAGUAU
Z-value: 2.04
Motif logo
miRNA associated with seed ACAGUAU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-144-3p
|
MIMAT0000436 |
Activity profile of ACAGUAU motif
Sorted Z-values of ACAGUAU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of ACAGUAU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0010752 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752) |
| 2.2 | 9.0 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 1.8 | 8.8 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 1.7 | 6.7 | GO:0003175 | tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) |
| 1.5 | 4.4 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 1.3 | 4.0 | GO:0061290 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 1.2 | 3.6 | GO:2000053 | regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) |
| 1.1 | 7.6 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.9 | 3.7 | GO:1903984 | rhythmic synaptic transmission(GO:0060024) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.9 | 3.5 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.8 | 3.2 | GO:0046223 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
| 0.8 | 4.7 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.8 | 0.8 | GO:0048370 | lateral mesoderm morphogenesis(GO:0048369) lateral mesoderm formation(GO:0048370) lateral mesodermal cell differentiation(GO:0048371) |
| 0.8 | 3.8 | GO:1904398 | positive regulation of neuromuscular junction development(GO:1904398) |
| 0.7 | 2.2 | GO:0044007 | negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010768) transmission of virus(GO:0019089) dissemination or transmission of symbiont from host(GO:0044007) dissemination or transmission of organism from other organism involved in symbiotic interaction(GO:0051821) |
| 0.7 | 2.9 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.7 | 7.9 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.7 | 4.7 | GO:0090270 | fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270) |
| 0.6 | 3.0 | GO:0048861 | oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.6 | 2.4 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.6 | 2.4 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.6 | 1.8 | GO:0006113 | fermentation(GO:0006113) regulation of fermentation(GO:0043465) |
| 0.6 | 1.7 | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.5 | 3.2 | GO:0051563 | microglia differentiation(GO:0014004) microglia development(GO:0014005) collateral sprouting in absence of injury(GO:0048669) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874) |
| 0.5 | 1.5 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.5 | 3.7 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.5 | 2.3 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.4 | 0.9 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.4 | 4.4 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.4 | 2.6 | GO:1904721 | negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.4 | 4.8 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.4 | 2.7 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 0.4 | 8.5 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.4 | 1.5 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.4 | 2.3 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.4 | 2.7 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.4 | 1.9 | GO:0035801 | adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.4 | 3.3 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.4 | 3.3 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.3 | 4.3 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.3 | 2.9 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.3 | 1.3 | GO:0046116 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.3 | 3.3 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.3 | 1.3 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) activation of meiosis(GO:0090427) |
| 0.3 | 0.9 | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) |
| 0.3 | 2.1 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.3 | 0.9 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.3 | 1.7 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.3 | 2.0 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.3 | 1.1 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 0.3 | 1.7 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.3 | 0.8 | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells(GO:1903691) |
| 0.3 | 1.4 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 0.3 | 1.4 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.3 | 4.0 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.3 | 3.8 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.3 | 1.1 | GO:0033590 | response to cobalamin(GO:0033590) response to hydroxyisoflavone(GO:0033594) |
| 0.3 | 2.4 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.3 | 3.8 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.2 | 2.4 | GO:2000576 | positive regulation of microtubule motor activity(GO:2000576) |
| 0.2 | 2.2 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.2 | 0.7 | GO:0075732 | viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594) |
| 0.2 | 0.9 | GO:0034670 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.2 | 0.7 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.2 | 2.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.2 | 0.6 | GO:0015888 | thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934) |
| 0.2 | 0.8 | GO:0070460 | thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612) |
| 0.2 | 1.6 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.2 | 1.2 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.2 | 3.1 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.2 | 0.5 | GO:0090155 | glucosylceramide biosynthetic process(GO:0006679) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) |
| 0.2 | 0.5 | GO:0014707 | branchiomeric skeletal muscle development(GO:0014707) bronchiole development(GO:0060435) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 0.2 | 2.2 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.2 | 2.9 | GO:0021957 | corticospinal tract morphogenesis(GO:0021957) |
| 0.2 | 3.0 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.2 | 1.6 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.2 | 1.6 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.2 | 1.5 | GO:0060613 | fat pad development(GO:0060613) |
| 0.2 | 1.8 | GO:0021740 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 3.5 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.2 | 0.8 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.2 | 0.2 | GO:0032472 | Golgi calcium ion transport(GO:0032472) |
| 0.2 | 1.7 | GO:0090394 | negative regulation of excitatory postsynaptic potential(GO:0090394) negative regulation of receptor catabolic process(GO:2000645) |
| 0.2 | 2.4 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.1 | 2.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 0.7 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.1 | 1.2 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 4.1 | GO:0060065 | uterus development(GO:0060065) |
| 0.1 | 1.0 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 2.1 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.1 | 0.4 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.1 | 0.4 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.1 | 0.4 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.1 | 1.2 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.1 | 0.4 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 0.1 | 1.3 | GO:1902914 | regulation of protein polyubiquitination(GO:1902914) positive regulation of protein polyubiquitination(GO:1902916) |
| 0.1 | 0.9 | GO:0035989 | tendon development(GO:0035989) |
| 0.1 | 0.8 | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport(GO:0090481) |
| 0.1 | 2.2 | GO:0033522 | histone H2A ubiquitination(GO:0033522) |
| 0.1 | 0.7 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.1 | 0.4 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) sarcomerogenesis(GO:0048769) |
| 0.1 | 3.5 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 0.3 | GO:0045643 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.1 | 1.0 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.1 | 0.8 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.1 | 2.4 | GO:0048846 | axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284) |
| 0.1 | 0.9 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.1 | 0.3 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.1 | 4.5 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.1 | 2.6 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 0.4 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 0.1 | 0.7 | GO:0060836 | lymphatic endothelial cell differentiation(GO:0060836) |
| 0.1 | 0.5 | GO:0033504 | floor plate development(GO:0033504) |
| 0.1 | 1.1 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 0.1 | 0.5 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.1 | 1.4 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.1 | 0.6 | GO:1903551 | regulation of extracellular exosome assembly(GO:1903551) |
| 0.1 | 1.9 | GO:0032354 | response to follicle-stimulating hormone(GO:0032354) |
| 0.1 | 2.3 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 1.7 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.1 | 0.8 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 1.3 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.1 | 0.3 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.1 | 1.8 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 0.8 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 0.1 | 1.8 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 0.6 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.1 | 2.4 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 1.5 | GO:0003416 | endochondral bone growth(GO:0003416) |
| 0.1 | 0.3 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.1 | 4.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 0.4 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 0.1 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.1 | 1.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 1.3 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.1 | 0.4 | GO:0001705 | ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712) |
| 0.1 | 0.4 | GO:0003344 | pericardium morphogenesis(GO:0003344) |
| 0.1 | 0.5 | GO:0060573 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.1 | 3.7 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.1 | 0.9 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 3.5 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.1 | 0.2 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
| 0.1 | 0.5 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 1.6 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.1 | 1.0 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.1 | 1.9 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.1 | 0.2 | GO:0007538 | primary sex determination(GO:0007538) |
| 0.1 | 0.3 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 0.3 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 1.2 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.1 | 0.9 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.1 | 0.1 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.4 | GO:0045617 | negative regulation of keratinocyte differentiation(GO:0045617) |
| 0.1 | 0.4 | GO:0015705 | iodide transport(GO:0015705) |
| 0.0 | 1.5 | GO:0071711 | basement membrane organization(GO:0071711) |
| 0.0 | 0.3 | GO:0060039 | pericardium development(GO:0060039) |
| 0.0 | 1.1 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.0 | 1.2 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 0.3 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.0 | 1.8 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
| 0.0 | 1.3 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 0.3 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 5.0 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 0.0 | 0.5 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.0 | 1.9 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.0 | 1.3 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.0 | 0.4 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.0 | 0.2 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.0 | 0.5 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.0 | 0.6 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 0.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.0 | 0.2 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 2.6 | GO:0045638 | negative regulation of myeloid cell differentiation(GO:0045638) |
| 0.0 | 1.3 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 2.0 | GO:0060999 | positive regulation of dendritic spine development(GO:0060999) |
| 0.0 | 0.5 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.0 | 1.5 | GO:0046039 | GTP metabolic process(GO:0046039) |
| 0.0 | 1.3 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.0 | 0.1 | GO:1901674 | histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674) |
| 0.0 | 0.9 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 0.0 | 0.7 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.0 | 0.4 | GO:0022417 | protein maturation by protein folding(GO:0022417) |
| 0.0 | 0.6 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 1.3 | GO:0009250 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 1.6 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.0 | 0.4 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
| 0.0 | 0.2 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.0 | 0.3 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.0 | 0.3 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 0.2 | GO:0032232 | negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497) |
| 0.0 | 0.5 | GO:2000272 | negative regulation of receptor activity(GO:2000272) |
| 0.0 | 0.2 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 0.0 | 3.5 | GO:0090090 | negative regulation of canonical Wnt signaling pathway(GO:0090090) |
| 0.0 | 0.5 | GO:2000279 | negative regulation of DNA biosynthetic process(GO:2000279) |
| 0.0 | 2.5 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.2 | GO:1901187 | regulation of ephrin receptor signaling pathway(GO:1901187) |
| 0.0 | 1.1 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 0.3 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 0.1 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 0.0 | 3.3 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.0 | 0.6 | GO:0007129 | synapsis(GO:0007129) |
| 0.0 | 0.1 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.0 | 0.1 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.0 | 0.9 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.0 | 0.4 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 0.0 | 1.7 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.0 | 0.1 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 2.1 | GO:0016573 | histone acetylation(GO:0016573) |
| 0.0 | 0.5 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.0 | 0.3 | GO:0007020 | microtubule nucleation(GO:0007020) |
| 0.0 | 1.9 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 0.6 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.1 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.5 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.0 | 0.9 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.1 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 7.9 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 1.5 | 4.4 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.8 | 4.8 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.6 | 9.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.6 | 7.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 1.4 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 0.4 | 3.7 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.4 | 7.6 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.4 | 3.7 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 0.4 | 1.1 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 0.3 | 3.0 | GO:0090543 | Flemming body(GO:0090543) |
| 0.3 | 0.9 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 0.3 | 3.5 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.3 | 3.7 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.3 | 4.4 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.3 | 5.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.3 | 1.1 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.3 | 3.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 1.2 | GO:0033503 | HULC complex(GO:0033503) |
| 0.2 | 5.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.2 | 0.6 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.2 | 2.4 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.2 | 0.8 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.2 | 0.6 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 0.2 | 0.9 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.2 | 1.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.2 | 2.0 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.2 | 1.4 | GO:0098642 | network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.1 | 2.2 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 1.0 | GO:0016589 | NURF complex(GO:0016589) |
| 0.1 | 16.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 2.1 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 2.7 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.1 | 0.3 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.1 | 4.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 2.2 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.1 | 1.9 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 1.4 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.1 | 3.8 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 1.2 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.1 | 2.3 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 1.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 1.0 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 1.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 0.9 | GO:0070449 | elongin complex(GO:0070449) |
| 0.1 | 2.4 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 1.4 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.1 | 2.9 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 3.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 2.7 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.1 | 1.5 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 0.4 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 2.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 2.2 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 2.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 11.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.3 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 4.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 5.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 5.8 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 0.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 3.1 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 3.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 0.3 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.1 | 0.5 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.1 | 0.4 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.1 | 1.4 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 1.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 1.7 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 3.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 4.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 3.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 1.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.5 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.4 | GO:1990752 | microtubule end(GO:1990752) |
| 0.0 | 0.2 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 1.4 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.2 | GO:0031414 | N-terminal protein acetyltransferase complex(GO:0031414) |
| 0.0 | 5.7 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 1.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.4 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 5.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 6.5 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 2.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 5.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.4 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 1.2 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 2.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 0.2 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 6.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 5.7 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 0.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 1.8 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 0.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.7 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 3.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.1 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 1.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0070052 | collagen V binding(GO:0070052) |
| 1.8 | 1.8 | GO:0034416 | bisphosphoglycerate phosphatase activity(GO:0034416) |
| 1.6 | 4.8 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 1.5 | 8.8 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 1.2 | 3.7 | GO:0051717 | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) |
| 1.1 | 4.6 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 1.1 | 4.4 | GO:0047676 | arachidonate-CoA ligase activity(GO:0047676) |
| 1.1 | 7.6 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 1.0 | 3.0 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 1.0 | 2.9 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.9 | 2.7 | GO:0034189 | very-low-density lipoprotein particle binding(GO:0034189) |
| 0.7 | 2.2 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.6 | 4.4 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.6 | 2.9 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.5 | 3.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.5 | 1.4 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
| 0.4 | 1.3 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 0.4 | 2.4 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.4 | 6.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.4 | 3.8 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.4 | 1.1 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.4 | 2.6 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.3 | 8.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.3 | 2.2 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 0.3 | 3.2 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.3 | 5.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.3 | 2.1 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.3 | 0.9 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.3 | 0.9 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 0.3 | 0.9 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.3 | 8.7 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.3 | 3.2 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.3 | 1.1 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.2 | 1.0 | GO:0050473 | arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.2 | 1.9 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.2 | 3.7 | GO:0048185 | activin binding(GO:0048185) |
| 0.2 | 0.7 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) |
| 0.2 | 2.8 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.2 | 0.9 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.2 | 5.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 1.3 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.2 | 0.6 | GO:0015403 | thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403) |
| 0.2 | 8.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 0.5 | GO:0050405 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405) |
| 0.2 | 3.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 2.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 1.2 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.2 | 7.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.2 | 0.9 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 0.2 | 0.5 | GO:0004772 | sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736) |
| 0.1 | 0.7 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 0.4 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.1 | 1.5 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.1 | 1.3 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.1 | 10.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 0.6 | GO:0038051 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.1 | 0.5 | GO:0004420 | hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282) |
| 0.1 | 0.9 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 0.3 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.1 | 0.5 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 0.8 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.1 | 1.1 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 0.8 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
| 0.1 | 4.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 1.5 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 2.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.3 | GO:0031403 | lithium ion binding(GO:0031403) |
| 0.1 | 3.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.4 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.1 | 5.2 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 1.7 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 2.9 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 2.9 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 2.3 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 2.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.8 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.1 | 4.0 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 0.3 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.1 | 2.5 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 0.3 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 0.8 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.1 | 1.1 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 3.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 0.5 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.1 | 0.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.8 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 2.4 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 1.3 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.6 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 3.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 2.2 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 2.9 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 1.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 1.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.4 | GO:0070878 | primary miRNA binding(GO:0070878) |
| 0.0 | 1.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 17.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.4 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.8 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.9 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 1.7 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.4 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.0 | 0.4 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.0 | 0.4 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 7.6 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.0 | 3.5 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.0 | 0.9 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 2.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.3 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.0 | 0.4 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.0 | 2.6 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.6 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.3 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 1.6 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.8 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.3 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
| 0.0 | 1.7 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.0 | 0.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 5.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.2 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.0 | 2.5 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.5 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.2 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.2 | GO:0050998 | vinculin binding(GO:0017166) nitric-oxide synthase binding(GO:0050998) |
| 0.0 | 1.5 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.0 | 0.1 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.0 | 0.1 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.0 | 0.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.0 | GO:0003916 | DNA topoisomerase activity(GO:0003916) |
| 0.0 | 0.2 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 7.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 8.3 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.2 | 6.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 5.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 5.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 2.7 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 3.7 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 1.0 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 9.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 3.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 3.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 7.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 1.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 3.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 3.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 0.9 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 4.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 0.5 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.1 | 3.2 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 3.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 5.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 3.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 10.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 1.8 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 1.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 1.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.2 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 4.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.2 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.8 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 1.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.4 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.6 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.8 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.2 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 1.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.3 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.3 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.3 | 3.7 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.3 | 8.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 5.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 4.8 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 8.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 4.0 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.2 | 8.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.2 | 5.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 1.8 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 4.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 3.8 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 2.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 4.8 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.1 | 12.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 4.2 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.1 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 2.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.8 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 6.2 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 1.2 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 1.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 2.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.1 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 1.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 0.8 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 2.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.0 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.9 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.4 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 2.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.5 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 2.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.8 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 1.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 1.8 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.0 | 1.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 3.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.2 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 0.3 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.3 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 1.5 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 0.5 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.0 | 0.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 1.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.4 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |