Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGCAGCA
Z-value: 4.70
Motif logo
miRNA associated with seed AGCAGCA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-15a-5p
|
MIMAT0000068 |
|
hsa-miR-15b-5p
|
MIMAT0000417 |
|
hsa-miR-16-5p
|
MIMAT0000069 |
|
hsa-miR-195-5p
|
MIMAT0000461 |
|
hsa-miR-424-5p
|
MIMAT0001341 |
|
hsa-miR-497-5p
|
MIMAT0002820 |
|
hsa-miR-6838-5p
|
MIMAT0027578 |
Activity profile of AGCAGCA motif
Sorted Z-values of AGCAGCA motif
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCAGCA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 11.1 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 3.5 | 17.5 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 2.6 | 7.8 | GO:0021722 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 2.3 | 9.2 | GO:0097676 | histone H3-K36 dimethylation(GO:0097676) |
| 2.2 | 6.6 | GO:0048073 | regulation of eye pigmentation(GO:0048073) |
| 2.2 | 6.5 | GO:1990168 | protein K33-linked deubiquitination(GO:1990168) |
| 2.1 | 8.4 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 1.8 | 10.9 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 1.8 | 7.0 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 1.7 | 12.0 | GO:0051013 | microtubule severing(GO:0051013) |
| 1.6 | 12.7 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 1.6 | 4.8 | GO:0098935 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 1.5 | 16.7 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 1.3 | 2.7 | GO:0021586 | pons maturation(GO:0021586) |
| 1.3 | 5.3 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 1.3 | 3.9 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 1.3 | 3.9 | GO:0018282 | metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) |
| 1.3 | 15.6 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 1.3 | 6.3 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 1.3 | 3.8 | GO:0014813 | skeletal muscle satellite cell commitment(GO:0014813) |
| 1.2 | 9.9 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 1.2 | 3.7 | GO:0036245 | cellular response to menadione(GO:0036245) |
| 1.2 | 3.5 | GO:2000053 | regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) |
| 1.2 | 5.8 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 1.1 | 3.4 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 1.1 | 4.4 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.1 | 7.7 | GO:0072502 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 1.1 | 4.4 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 1.1 | 6.4 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 1.1 | 5.3 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 1.0 | 3.9 | GO:0019086 | late viral transcription(GO:0019086) |
| 1.0 | 8.7 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 1.0 | 9.6 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 0.9 | 2.8 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 0.9 | 2.8 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.9 | 2.7 | GO:0034653 | diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809) |
| 0.9 | 10.8 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.9 | 3.6 | GO:0035054 | atrial septum secundum morphogenesis(GO:0003290) embryonic heart tube anterior/posterior pattern specification(GO:0035054) |
| 0.9 | 5.2 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.9 | 3.4 | GO:0019470 | 4-hydroxyproline catabolic process(GO:0019470) |
| 0.9 | 5.1 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.9 | 6.0 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.9 | 7.7 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.8 | 2.5 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.8 | 2.3 | GO:1903537 | meiotic spindle elongation(GO:0051232) meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 0.8 | 1.5 | GO:0098917 | retrograde trans-synaptic signaling(GO:0098917) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) |
| 0.8 | 6.9 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.8 | 2.3 | GO:1901674 | histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674) positive regulation of response to drug(GO:2001025) |
| 0.7 | 2.9 | GO:0042488 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.7 | 5.8 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.7 | 2.1 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.7 | 16.7 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.7 | 6.9 | GO:0043045 | DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538) |
| 0.7 | 1.4 | GO:0051040 | regulation of calcium-independent cell-cell adhesion(GO:0051040) |
| 0.7 | 2.0 | GO:0071284 | cellular response to lead ion(GO:0071284) |
| 0.7 | 4.1 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.7 | 3.3 | GO:0001555 | oocyte growth(GO:0001555) |
| 0.7 | 3.3 | GO:0001957 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.6 | 8.4 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.6 | 7.0 | GO:0060068 | vagina development(GO:0060068) |
| 0.6 | 10.5 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.6 | 4.3 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.6 | 2.4 | GO:0002644 | negative regulation of tolerance induction(GO:0002644) |
| 0.6 | 9.7 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.6 | 5.4 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
| 0.6 | 1.2 | GO:0097491 | sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) |
| 0.6 | 5.8 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.6 | 1.7 | GO:0097535 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 0.5 | 3.8 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.5 | 4.2 | GO:1905049 | negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049) |
| 0.5 | 3.1 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.5 | 5.4 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.5 | 1.5 | GO:2001302 | lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303) |
| 0.5 | 9.2 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 0.5 | 18.5 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.5 | 3.7 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.5 | 2.3 | GO:1901093 | regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094) |
| 0.5 | 1.8 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.5 | 5.4 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.4 | 1.3 | GO:1903519 | lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747) |
| 0.4 | 7.2 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.4 | 2.1 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.4 | 5.0 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.4 | 5.0 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.4 | 3.6 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.4 | 66.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.4 | 6.0 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.4 | 1.2 | GO:0007037 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 0.4 | 0.8 | GO:0061535 | negative regulation of neuroblast proliferation(GO:0007406) glutamate secretion, neurotransmission(GO:0061535) |
| 0.4 | 1.5 | GO:0033591 | response to L-ascorbic acid(GO:0033591) |
| 0.4 | 2.5 | GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) |
| 0.4 | 1.8 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.4 | 2.8 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.4 | 4.3 | GO:0015074 | DNA integration(GO:0015074) |
| 0.4 | 3.2 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.3 | 1.0 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.3 | 3.1 | GO:2000582 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.3 | 5.1 | GO:0060605 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.3 | 5.4 | GO:0098780 | response to mitochondrial depolarisation(GO:0098780) |
| 0.3 | 1.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548) |
| 0.3 | 10.8 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.3 | 3.3 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.3 | 4.3 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.3 | 3.6 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 0.3 | 6.6 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.3 | 5.9 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.3 | 1.0 | GO:0048840 | otolith development(GO:0048840) |
| 0.3 | 6.6 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.3 | 0.9 | GO:0044805 | late nucleophagy(GO:0044805) |
| 0.3 | 2.1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.3 | 2.7 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
| 0.3 | 1.1 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.3 | 3.1 | GO:0046813 | receptor-mediated virion attachment to host cell(GO:0046813) |
| 0.3 | 0.8 | GO:1900275 | minus-end-directed organelle transport along microtubule(GO:0072385) negative regulation of phospholipase C activity(GO:1900275) |
| 0.3 | 0.8 | GO:1903352 | ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352) |
| 0.3 | 4.9 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.3 | 7.8 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.2 | 2.7 | GO:0070444 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.2 | 5.4 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.2 | 3.9 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.2 | 5.9 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.2 | 3.1 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.2 | 0.9 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.2 | 4.9 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.2 | 3.7 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.2 | 1.6 | GO:0006662 | glycerol ether metabolic process(GO:0006662) |
| 0.2 | 1.6 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.2 | 0.9 | GO:0003264 | cardioblast proliferation(GO:0003263) regulation of cardioblast proliferation(GO:0003264) |
| 0.2 | 3.3 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.2 | 0.8 | GO:0071503 | response to heparin(GO:0071503) cellular response to heparin(GO:0071504) |
| 0.2 | 4.2 | GO:0060211 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.2 | 1.8 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.2 | 3.9 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.2 | 0.6 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.2 | 2.0 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.2 | 1.4 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 0.2 | 6.5 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.2 | 2.6 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.2 | 6.1 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process(GO:0015012) |
| 0.2 | 7.4 | GO:0035066 | positive regulation of histone acetylation(GO:0035066) |
| 0.2 | 2.5 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804) |
| 0.2 | 2.1 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.2 | 2.3 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.2 | 3.9 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.2 | 2.4 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.2 | 1.3 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.2 | 0.9 | GO:0035992 | tendon cell differentiation(GO:0035990) tendon formation(GO:0035992) |
| 0.2 | 1.6 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.2 | 1.6 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.2 | 3.0 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.2 | 2.0 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.2 | 1.7 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.2 | 3.0 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.2 | 9.9 | GO:0033619 | membrane protein proteolysis(GO:0033619) |
| 0.2 | 0.7 | GO:0044407 | biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) |
| 0.2 | 1.0 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.2 | 0.6 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.2 | 1.2 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.2 | 2.6 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.2 | 3.5 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.2 | 0.8 | GO:0031585 | regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585) endoplasmic reticulum localization(GO:0051643) |
| 0.1 | 2.9 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 1.0 | GO:0014050 | negative regulation of glutamate secretion(GO:0014050) |
| 0.1 | 1.1 | GO:0072719 | cellular response to cisplatin(GO:0072719) |
| 0.1 | 2.0 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.1 | 1.4 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
| 0.1 | 0.7 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
| 0.1 | 8.1 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 4.7 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.1 | 3.0 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.1 | 0.9 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.1 | 1.5 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.1 | 4.5 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.1 | 3.2 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.1 | 0.6 | GO:1904075 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.1 | 0.6 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
| 0.1 | 0.5 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.1 | 1.9 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.1 | 2.0 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 0.1 | 0.8 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 0.7 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 0.1 | 1.3 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.1 | 0.6 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.1 | 1.1 | GO:0048671 | negative regulation of collateral sprouting(GO:0048671) negative regulation of synapse assembly(GO:0051964) |
| 0.1 | 2.6 | GO:0036035 | osteoclast development(GO:0036035) |
| 0.1 | 1.8 | GO:0060766 | negative regulation of androgen receptor signaling pathway(GO:0060766) |
| 0.1 | 6.7 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.1 | 5.7 | GO:0090102 | cochlea development(GO:0090102) |
| 0.1 | 1.7 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817) |
| 0.1 | 3.5 | GO:0045879 | negative regulation of smoothened signaling pathway(GO:0045879) |
| 0.1 | 1.9 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
| 0.1 | 2.3 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 0.8 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.1 | 0.3 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.1 | 0.9 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.1 | 2.6 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.1 | 2.0 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.1 | 0.7 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.1 | 0.7 | GO:0070236 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 1.5 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.1 | 2.6 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 6.8 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.1 | 0.5 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.1 | 3.9 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.1 | 2.1 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.1 | 1.1 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.1 | 1.0 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.1 | 1.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 3.7 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.1 | 1.5 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.1 | 1.7 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.1 | 1.7 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.1 | 1.1 | GO:0048243 | norepinephrine secretion(GO:0048243) |
| 0.1 | 4.4 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.1 | 5.5 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.1 | 3.1 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.1 | 2.7 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 3.8 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 1.5 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.1 | 0.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 1.5 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 10.2 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.1 | 0.2 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.2 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.1 | 0.1 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.1 | 3.1 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.1 | 0.3 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.1 | 2.0 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.1 | 2.0 | GO:0051898 | negative regulation of protein kinase B signaling(GO:0051898) |
| 0.1 | 4.7 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.1 | 1.8 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.1 | 0.6 | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642) |
| 0.1 | 0.6 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.1 | 0.7 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.1 | 4.2 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
| 0.1 | 2.2 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.1 | 2.0 | GO:0016239 | positive regulation of macroautophagy(GO:0016239) |
| 0.1 | 0.2 | GO:0000466 | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466) |
| 0.1 | 0.5 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.1 | 2.2 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 1.0 | GO:0016048 | detection of temperature stimulus(GO:0016048) |
| 0.0 | 2.6 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.0 | 7.1 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 1.8 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.3 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.5 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 0.4 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.0 | 0.6 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.0 | 1.1 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.0 | 2.9 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.0 | 5.1 | GO:0045637 | regulation of myeloid cell differentiation(GO:0045637) |
| 0.0 | 1.7 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 2.6 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 1.5 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 1.1 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.0 | 2.5 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 1.4 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.0 | 0.7 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 0.9 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.4 | GO:0032354 | response to follicle-stimulating hormone(GO:0032354) |
| 0.0 | 3.1 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 0.9 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 3.0 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 1.2 | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle(GO:0007091) |
| 0.0 | 0.1 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.0 | 0.4 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.0 | 0.9 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 1.6 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 0.7 | GO:0071364 | response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364) |
| 0.0 | 5.2 | GO:0006813 | potassium ion transport(GO:0006813) |
| 0.0 | 0.1 | GO:0016093 | polyprenol metabolic process(GO:0016093) |
| 0.0 | 0.5 | GO:0003281 | ventricular septum development(GO:0003281) |
| 0.0 | 0.1 | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241) |
| 0.0 | 5.2 | GO:0090305 | nucleic acid phosphodiester bond hydrolysis(GO:0090305) |
| 0.0 | 0.3 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.0 | 0.4 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.0 | 0.8 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 1.1 | GO:0042552 | myelination(GO:0042552) |
| 0.0 | 0.4 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 0.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.2 | GO:0046033 | AMP metabolic process(GO:0046033) |
| 0.0 | 1.1 | GO:0048705 | skeletal system morphogenesis(GO:0048705) |
| 0.0 | 0.1 | GO:0009642 | response to light intensity(GO:0009642) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 17.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 2.2 | 6.5 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 1.9 | 9.3 | GO:0044305 | calyx of Held(GO:0044305) |
| 1.6 | 6.3 | GO:0035363 | histone locus body(GO:0035363) |
| 1.6 | 7.8 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 1.4 | 19.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 1.3 | 7.6 | GO:0001940 | male pronucleus(GO:0001940) |
| 1.3 | 3.8 | GO:0034657 | GID complex(GO:0034657) |
| 1.2 | 3.6 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 1.2 | 8.4 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 1.1 | 6.4 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.9 | 6.4 | GO:0005683 | U7 snRNP(GO:0005683) |
| 0.9 | 3.5 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.8 | 2.4 | GO:0002079 | inner acrosomal membrane(GO:0002079) outer acrosomal membrane(GO:0002081) |
| 0.8 | 3.1 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.7 | 4.2 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.7 | 3.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.6 | 11.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.6 | 3.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.5 | 11.5 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.5 | 3.1 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.5 | 2.9 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.5 | 1.9 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.5 | 7.4 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.4 | 4.4 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.4 | 3.9 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.4 | 9.5 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.3 | 3.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.3 | 5.8 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.3 | 3.6 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.3 | 1.5 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.3 | 2.5 | GO:0097425 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.3 | 14.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.3 | 1.5 | GO:0032449 | CBM complex(GO:0032449) |
| 0.3 | 5.9 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.3 | 1.3 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.3 | 5.4 | GO:0031045 | dense core granule(GO:0031045) |
| 0.2 | 1.7 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.2 | 2.1 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.2 | 1.4 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.2 | 16.1 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.2 | 3.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 3.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.2 | 2.5 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.2 | 2.0 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.2 | 5.3 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.2 | 21.8 | GO:0042641 | actomyosin(GO:0042641) |
| 0.2 | 0.7 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.2 | 3.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.2 | 5.2 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.2 | 1.1 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.2 | 2.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 27.7 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.1 | 4.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 1.7 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 5.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 4.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 2.4 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 3.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 3.6 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 2.5 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 3.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 17.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 2.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 2.2 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 1.1 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 0.4 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.1 | 2.4 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 2.3 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.1 | 3.1 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 13.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 0.6 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.1 | 2.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 0.6 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 1.2 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 1.3 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 146.9 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.1 | 1.7 | GO:0030120 | vesicle coat(GO:0030120) |
| 0.1 | 1.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 8.3 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.9 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 7.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 3.3 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 3.0 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 8.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 0.6 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 3.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 2.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.1 | GO:0005953 | CAAX-protein geranylgeranyltransferase complex(GO:0005953) |
| 0.0 | 2.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 6.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.5 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 5.4 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 0.5 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 10.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.7 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 3.3 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.7 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 0.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.1 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 6.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 10.6 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 2.6 | 7.8 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 2.3 | 9.3 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 2.0 | 5.9 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 1.9 | 7.7 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 1.8 | 10.8 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 1.7 | 5.2 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 1.7 | 12.0 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 1.6 | 6.5 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 1.5 | 7.7 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 1.4 | 4.1 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 1.3 | 5.3 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 1.3 | 5.3 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 1.3 | 3.9 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 1.2 | 4.9 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 1.2 | 8.6 | GO:0000182 | rDNA binding(GO:0000182) |
| 1.2 | 6.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 1.2 | 3.5 | GO:1904928 | coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928) |
| 1.1 | 3.4 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 1.1 | 10.1 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 1.1 | 4.4 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 1.0 | 8.4 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 1.0 | 12.1 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 1.0 | 2.9 | GO:0030305 | heparanase activity(GO:0030305) |
| 0.9 | 25.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.9 | 5.3 | GO:0070728 | leucine binding(GO:0070728) |
| 0.9 | 30.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.9 | 5.1 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.8 | 4.1 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 0.8 | 2.5 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.8 | 4.5 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.8 | 2.3 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.7 | 4.4 | GO:0070004 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.7 | 0.7 | GO:0001034 | RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034) |
| 0.7 | 2.0 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.6 | 7.8 | GO:0005113 | patched binding(GO:0005113) |
| 0.6 | 2.9 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.6 | 5.2 | GO:0003958 | NADPH-hemoprotein reductase activity(GO:0003958) |
| 0.6 | 4.1 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.6 | 9.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.6 | 3.9 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 0.5 | 10.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.5 | 5.0 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.5 | 5.4 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.5 | 2.0 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.5 | 1.5 | GO:0047977 | hepoxilin-epoxide hydrolase activity(GO:0047977) |
| 0.5 | 5.6 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.5 | 2.3 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.5 | 2.8 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.4 | 7.0 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.4 | 2.1 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.4 | 2.5 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.4 | 2.0 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.4 | 5.6 | GO:0046790 | virion binding(GO:0046790) |
| 0.4 | 2.0 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.4 | 4.5 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.4 | 5.5 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.4 | 2.5 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.4 | 1.8 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) |
| 0.3 | 2.0 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.3 | 1.3 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.3 | 3.6 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.3 | 1.3 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.3 | 1.6 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.3 | 16.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.3 | 3.0 | GO:0003997 | acyl-CoA oxidase activity(GO:0003997) |
| 0.3 | 2.7 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.3 | 3.9 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.3 | 5.3 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.3 | 5.0 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.3 | 0.8 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.3 | 3.6 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.3 | 2.3 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.3 | 1.0 | GO:0070905 | serine binding(GO:0070905) |
| 0.3 | 5.3 | GO:0048185 | activin binding(GO:0048185) |
| 0.2 | 0.7 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.2 | 1.7 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.2 | 3.7 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.2 | 1.8 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.2 | 1.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.2 | 4.3 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.2 | 1.6 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 0.2 | 4.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.2 | 3.0 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.2 | 5.3 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.2 | 1.0 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.2 | 1.2 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.2 | 1.5 | GO:0038064 | collagen receptor activity(GO:0038064) |
| 0.2 | 3.6 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.2 | 3.0 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.2 | 3.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.2 | 4.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 5.7 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 1.9 | GO:0003720 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.2 | 1.5 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.2 | 2.8 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.2 | 2.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.2 | 3.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 1.0 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.2 | 4.3 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.2 | 1.5 | GO:0022821 | sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821) |
| 0.2 | 8.2 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 0.7 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 0.8 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 1.8 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 8.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 3.9 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.1 | 1.8 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 2.7 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 10.1 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.1 | 0.6 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 5.5 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.1 | 4.6 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 3.2 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 2.5 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.1 | 5.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 4.2 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 11.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 1.3 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 1.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 2.0 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.9 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 9.1 | GO:0002039 | p53 binding(GO:0002039) |
| 0.1 | 0.6 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.1 | 1.2 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 3.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 0.7 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.1 | 0.4 | GO:0001602 | pancreatic polypeptide receptor activity(GO:0001602) |
| 0.1 | 1.6 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 0.8 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.1 | 2.1 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 0.8 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 3.1 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.1 | 3.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 1.3 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 5.0 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.1 | 2.0 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 2.0 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 0.1 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.1 | 1.4 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 0.4 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 2.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 12.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 2.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 3.0 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.1 | 1.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 1.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 8.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 2.7 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.1 | 3.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 9.7 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 4.1 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.1 | 0.2 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.1 | 5.3 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 0.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 3.7 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.1 | 42.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 1.2 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.1 | 3.7 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.1 | 0.4 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.1 | 5.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 1.5 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.1 | 0.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 1.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 3.0 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 0.8 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.9 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 2.5 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.2 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.0 | 21.0 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 0.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 2.3 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 1.4 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 2.2 | GO:0016279 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.0 | 0.2 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 1.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 3.7 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.0 | 0.6 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 2.4 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 4.6 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.0 | 4.4 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.0 | 2.8 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 1.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 1.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 4.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 2.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 2.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.5 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.0 | 1.7 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.4 | GO:0008514 | organic anion transmembrane transporter activity(GO:0008514) |
| 0.0 | 0.7 | GO:0008375 | acetylglucosaminyltransferase activity(GO:0008375) |
| 0.0 | 0.5 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 5.1 | GO:0015075 | ion transmembrane transporter activity(GO:0015075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.4 | 19.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 11.6 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.3 | 2.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.3 | 7.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 6.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 4.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 3.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 9.7 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 1.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 2.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 6.1 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 3.9 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 3.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 2.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 0.9 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 4.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 2.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 2.3 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 2.9 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 14.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 1.5 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 2.3 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 3.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 1.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 0.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 2.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.2 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 2.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.0 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 2.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 6.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 16.7 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 1.0 | 21.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.5 | 2.4 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.5 | 11.7 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.4 | 6.4 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.4 | 14.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.3 | 6.7 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.3 | 8.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 4.9 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.3 | 4.8 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.2 | 4.9 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 2.5 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.2 | 2.8 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.2 | 7.0 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.2 | 27.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 4.4 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.2 | 3.0 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.2 | 5.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 1.6 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.2 | 2.1 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 5.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.4 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 2.4 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 3.0 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.1 | 2.4 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 2.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.0 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 5.7 | REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION | Genes involved in Incretin Synthesis, Secretion, and Inactivation |
| 0.1 | 2.9 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 1.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 3.2 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 7.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.7 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.1 | 3.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 5.7 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 2.7 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 4.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 3.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 2.8 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 3.8 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 4.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 0.5 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 1.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 1.0 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 2.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 2.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 4.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.3 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 0.8 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.1 | 4.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.0 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 0.9 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 5.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.7 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 3.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.8 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 1.8 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.1 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 2.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.7 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 1.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 2.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.8 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 2.6 | REACTOME PI 3K CASCADE | Genes involved in PI-3K cascade |
| 0.0 | 2.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 1.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.2 | REACTOME PI METABOLISM | Genes involved in PI Metabolism |
| 0.0 | 0.8 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.0 | 0.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |