Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGCUUAU
Z-value: 2.17
Motif logo
miRNA associated with seed AGCUUAU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-21-5p
|
MIMAT0000076 |
|
hsa-miR-590-5p
|
MIMAT0003258 |
Activity profile of AGCUUAU motif
Sorted Z-values of AGCUUAU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCUUAU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.3 | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 2.3 | 7.0 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 1.5 | 5.8 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 1.1 | 3.2 | GO:0060434 | bronchus morphogenesis(GO:0060434) |
| 0.9 | 4.6 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.8 | 6.0 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.7 | 2.9 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.7 | 2.1 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.7 | 2.1 | GO:1990168 | protein K33-linked deubiquitination(GO:1990168) |
| 0.6 | 1.9 | GO:0060596 | mammary placode formation(GO:0060596) |
| 0.6 | 1.8 | GO:0097535 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 0.6 | 2.9 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.5 | 7.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.5 | 4.0 | GO:1904684 | negative regulation of metalloendopeptidase activity(GO:1904684) |
| 0.5 | 1.8 | GO:0061443 | ciliary body morphogenesis(GO:0061073) endocardial cushion cell differentiation(GO:0061443) |
| 0.4 | 2.9 | GO:0008050 | negative regulation of female receptivity(GO:0007621) female courtship behavior(GO:0008050) |
| 0.4 | 1.2 | GO:0021763 | subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578) |
| 0.4 | 3.1 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.3 | 2.0 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.3 | 0.9 | GO:2000053 | regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) |
| 0.3 | 0.9 | GO:2000584 | regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584) |
| 0.3 | 0.9 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.3 | 0.9 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.3 | 1.3 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.2 | 3.2 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.2 | 2.0 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.2 | 1.3 | GO:0032252 | secretory granule localization(GO:0032252) |
| 0.2 | 4.3 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.2 | 1.1 | GO:0030242 | pexophagy(GO:0030242) |
| 0.2 | 1.3 | GO:2000980 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.2 | 3.7 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.2 | 0.8 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.2 | 3.7 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.2 | 3.1 | GO:0060252 | positive regulation of glial cell proliferation(GO:0060252) |
| 0.2 | 0.7 | GO:0031064 | negative regulation of histone deacetylation(GO:0031064) |
| 0.2 | 0.5 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.2 | 2.2 | GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103) |
| 0.1 | 1.4 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.1 | 0.4 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 0.1 | 2.2 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.1 | 0.3 | GO:0046666 | retinal cell programmed cell death(GO:0046666) |
| 0.1 | 1.1 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.1 | 2.1 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 3.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 0.3 | GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 0.1 | 1.0 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.9 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 1.9 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.1 | 0.5 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.1 | 0.9 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 2.6 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.1 | 0.9 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 1.9 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.1 | 0.4 | GO:0014004 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
| 0.1 | 1.7 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.1 | 1.3 | GO:0048490 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.1 | 0.5 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 3.3 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.0 | 1.2 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.0 | 0.7 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.0 | 2.7 | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway(GO:0002755) |
| 0.0 | 1.4 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.2 | GO:0090625 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.0 | 0.5 | GO:1904896 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 0.0 | 0.3 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.0 | 0.9 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.0 | 0.4 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.0 | 0.7 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.3 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.0 | 4.6 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
| 0.0 | 0.1 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.0 | 0.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 2.4 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 1.2 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 1.5 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.7 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) |
| 0.0 | 0.5 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 3.1 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 0.7 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 0.6 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 0.4 | GO:0001946 | lymphangiogenesis(GO:0001946) |
| 0.0 | 0.6 | GO:0003416 | endochondral bone growth(GO:0003416) |
| 0.0 | 1.1 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 0.2 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 2.0 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.0 | 0.4 | GO:0097503 | sialylation(GO:0097503) |
| 0.0 | 0.6 | GO:0021772 | olfactory bulb development(GO:0021772) |
| 0.0 | 0.4 | GO:0014002 | astrocyte development(GO:0014002) |
| 0.0 | 0.4 | GO:0008228 | opsonization(GO:0008228) |
| 0.0 | 0.3 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.0 | 3.8 | GO:0045637 | regulation of myeloid cell differentiation(GO:0045637) |
| 0.0 | 0.0 | GO:0099403 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) protein auto-ADP-ribosylation(GO:0070213) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of telomeric DNA binding(GO:1904742) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.0 | 4.2 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 1.3 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 0.0 | 0.8 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.0 | 0.2 | GO:0061154 | endothelial tube morphogenesis(GO:0061154) |
| 0.0 | 0.5 | GO:0071594 | T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594) |
| 0.0 | 0.7 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 0.5 | GO:0090398 | cellular senescence(GO:0090398) |
| 0.0 | 0.1 | GO:0003360 | brainstem development(GO:0003360) |
| 0.0 | 0.3 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0034657 | GID complex(GO:0034657) |
| 0.5 | 2.2 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.5 | 3.2 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.5 | 2.9 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.4 | 1.4 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.3 | 5.8 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.3 | 2.8 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.3 | 1.4 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.2 | 3.4 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.2 | 0.8 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 6.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 0.9 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 2.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 1.1 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.1 | 2.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.3 | GO:1990075 | periciliary membrane compartment(GO:1990075) |
| 0.1 | 3.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 0.7 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 1.2 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 1.1 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.1 | 0.4 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 3.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 6.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 1.1 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 7.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 2.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 1.3 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 2.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.8 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 3.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.3 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 3.2 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.1 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 2.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.2 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.0 | 2.1 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 8.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 3.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.5 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.1 | GO:0030891 | VCB complex(GO:0030891) |
| 0.0 | 0.1 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 7.0 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 1.1 | 3.2 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.7 | 2.1 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.7 | 2.0 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.7 | 2.0 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.4 | 9.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.4 | 2.1 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.4 | 8.0 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.3 | 5.6 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.3 | 3.2 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.3 | 0.9 | GO:1904928 | coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928) |
| 0.3 | 4.6 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.3 | 0.8 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.2 | 2.9 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.2 | 1.4 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.2 | 2.9 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.2 | 0.5 | GO:0047493 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.2 | 0.7 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.2 | 0.9 | GO:0070728 | leucine binding(GO:0070728) |
| 0.2 | 0.5 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 2.8 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 0.4 | GO:0052798 | beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798) |
| 0.1 | 0.6 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.1 | 0.7 | GO:0070004 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.1 | 0.5 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.1 | 2.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.4 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.1 | 2.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 1.1 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 0.3 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.1 | 0.9 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
| 0.1 | 2.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.2 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.1 | 1.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 0.4 | GO:0071936 | coreceptor activity involved in Wnt signaling pathway(GO:0071936) |
| 0.1 | 0.4 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.1 | 1.0 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 15.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.2 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.0 | 0.2 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.0 | 0.3 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.0 | 0.2 | GO:0035252 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 0.0 | 0.3 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.0 | 0.7 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 1.1 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 15.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 2.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.4 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.0 | 0.4 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 1.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.3 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 4.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 8.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 0.1 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.0 | 0.3 | GO:0098847 | sequence-specific single stranded DNA binding(GO:0098847) |
| 0.0 | 2.0 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 2.1 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.0 | 0.2 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 1.0 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.5 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 2.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 6.8 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 4.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 2.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 4.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 4.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 1.1 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.1 | 0.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 6.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.1 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 1.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 2.2 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 3.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.7 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 5.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.4 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.7 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.7 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.6 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.2 | 3.2 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 1.8 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 2.7 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 4.2 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 2.0 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 2.6 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 2.1 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.0 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 2.7 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 3.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 1.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.1 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 6.3 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.7 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 1.1 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.6 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 1.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 2.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 2.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 3.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.5 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.5 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 0.9 | REACTOME SIGNALING BY FGFR MUTANTS | Genes involved in Signaling by FGFR mutants |
| 0.0 | 1.0 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 2.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.3 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.3 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |