Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for AGUGCAA
Z-value: 5.98
Motif logo
miRNA associated with seed AGUGCAA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-130a-3p
|
MIMAT0000425 |
|
hsa-miR-130b-3p
|
MIMAT0000691 |
|
hsa-miR-301a-3p
|
MIMAT0000688 |
|
hsa-miR-301b-3p
|
MIMAT0004958 |
|
hsa-miR-3666
|
MIMAT0018088 |
|
hsa-miR-4295
|
MIMAT0016844 |
|
hsa-miR-454-3p
|
MIMAT0003885 |
Activity profile of AGUGCAA motif
Sorted Z-values of AGUGCAA motif
Network of associatons between targets according to the STRING database.
First level regulatory network of AGUGCAA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 34.1 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 3.6 | 10.8 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 3.1 | 9.2 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 3.1 | 9.2 | GO:0038162 | erythropoietin-mediated signaling pathway(GO:0038162) mast cell proliferation(GO:0070662) |
| 2.8 | 25.4 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 2.6 | 10.4 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 2.2 | 6.7 | GO:2000616 | negative regulation of histone H3-K9 acetylation(GO:2000616) |
| 2.1 | 10.5 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 2.0 | 9.8 | GO:0035973 | aggrephagy(GO:0035973) |
| 1.8 | 5.5 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 1.8 | 11.0 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 1.8 | 12.4 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 1.7 | 1.7 | GO:0007356 | thorax and anterior abdomen determination(GO:0007356) |
| 1.7 | 3.3 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
| 1.6 | 6.3 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 1.6 | 21.9 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 1.6 | 10.9 | GO:0098728 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 1.6 | 4.7 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 1.5 | 5.9 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 1.4 | 5.7 | GO:0021886 | hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) |
| 1.4 | 9.8 | GO:0033029 | regulation of neutrophil apoptotic process(GO:0033029) |
| 1.4 | 12.3 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 1.3 | 3.9 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 1.3 | 5.1 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 1.3 | 5.1 | GO:0006408 | snRNA export from nucleus(GO:0006408) |
| 1.3 | 3.8 | GO:0075071 | autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071) |
| 1.3 | 12.6 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 1.2 | 1.2 | GO:0060599 | lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) |
| 1.2 | 8.5 | GO:0052203 | modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) |
| 1.2 | 7.2 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 1.1 | 3.4 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
| 1.1 | 4.6 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 1.1 | 3.4 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 1.1 | 6.8 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 1.1 | 2.2 | GO:1900114 | positive regulation of histone H3-K9 trimethylation(GO:1900114) |
| 1.1 | 3.3 | GO:0048840 | otolith development(GO:0048840) |
| 1.1 | 4.2 | GO:1904141 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 1.0 | 3.9 | GO:1990535 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535) |
| 1.0 | 2.9 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
| 0.9 | 16.1 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.9 | 18.7 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.9 | 9.1 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.9 | 3.5 | GO:0060535 | trachea cartilage morphogenesis(GO:0060535) |
| 0.8 | 10.0 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.8 | 5.0 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.8 | 2.5 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.8 | 4.1 | GO:0051029 | rRNA transport(GO:0051029) |
| 0.8 | 3.2 | GO:0060029 | convergent extension involved in organogenesis(GO:0060029) |
| 0.8 | 4.7 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 0.8 | 4.7 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.8 | 5.3 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.8 | 2.3 | GO:1904430 | negative regulation of t-circle formation(GO:1904430) |
| 0.8 | 3.0 | GO:0072708 | response to sorbitol(GO:0072708) |
| 0.7 | 2.2 | GO:1904017 | cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.7 | 5.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.7 | 2.2 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.7 | 5.0 | GO:0035502 | metanephric part of ureteric bud development(GO:0035502) |
| 0.7 | 12.2 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.7 | 4.9 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.7 | 0.7 | GO:0061152 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.7 | 2.0 | GO:0007343 | egg activation(GO:0007343) |
| 0.7 | 0.7 | GO:1904016 | response to Thyroglobulin triiodothyronine(GO:1904016) |
| 0.7 | 6.6 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.6 | 0.6 | GO:0021571 | rhombomere 5 development(GO:0021571) |
| 0.6 | 10.8 | GO:0038065 | collagen-activated signaling pathway(GO:0038065) |
| 0.6 | 1.2 | GO:0060978 | angiogenesis involved in coronary vascular morphogenesis(GO:0060978) |
| 0.6 | 1.8 | GO:0061386 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.6 | 11.2 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.6 | 8.2 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.6 | 1.7 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 0.6 | 6.3 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.6 | 1.7 | GO:0090273 | regulation of somatostatin secretion(GO:0090273) positive regulation of somatostatin secretion(GO:0090274) |
| 0.5 | 3.8 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.5 | 4.3 | GO:0043615 | astrocyte cell migration(GO:0043615) |
| 0.5 | 4.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.5 | 6.8 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.5 | 2.1 | GO:1990167 | protein K27-linked deubiquitination(GO:1990167) |
| 0.5 | 2.6 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.5 | 9.8 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.5 | 1.5 | GO:1902263 | apoptotic process involved in embryonic digit morphogenesis(GO:1902263) |
| 0.5 | 2.9 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.5 | 16.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.5 | 1.4 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.5 | 16.2 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.4 | 4.0 | GO:0045023 | G0 to G1 transition(GO:0045023) |
| 0.4 | 9.2 | GO:0060004 | reflex(GO:0060004) |
| 0.4 | 10.3 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.4 | 4.4 | GO:0097012 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 0.4 | 3.1 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.4 | 5.0 | GO:0042355 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.4 | 6.0 | GO:0070102 | interleukin-6-mediated signaling pathway(GO:0070102) |
| 0.4 | 1.5 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
| 0.4 | 9.6 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.4 | 7.4 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.4 | 11.7 | GO:0007183 | SMAD protein complex assembly(GO:0007183) |
| 0.4 | 2.2 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 0.4 | 1.1 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.4 | 2.8 | GO:0042426 | choline catabolic process(GO:0042426) |
| 0.4 | 6.7 | GO:0071168 | protein localization to chromatin(GO:0071168) |
| 0.3 | 12.4 | GO:0034080 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.3 | 1.0 | GO:1903033 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.3 | 2.9 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.3 | 2.8 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.3 | 2.8 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.3 | 1.5 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.3 | 21.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.3 | 0.9 | GO:0036166 | phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239) |
| 0.3 | 3.5 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.3 | 3.7 | GO:0001767 | establishment of lymphocyte polarity(GO:0001767) |
| 0.3 | 2.8 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.3 | 1.6 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.3 | 6.3 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.2 | 1.5 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.2 | 9.1 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.2 | 2.5 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.2 | 0.7 | GO:2001274 | negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) negative regulation of glucose import in response to insulin stimulus(GO:2001274) |
| 0.2 | 6.6 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.2 | 1.5 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.2 | 1.0 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.2 | 5.2 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.2 | 1.4 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.2 | 0.7 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.2 | 2.1 | GO:0042090 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.2 | 3.5 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.2 | 4.9 | GO:0060742 | epithelial cell differentiation involved in prostate gland development(GO:0060742) |
| 0.2 | 2.9 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.2 | 0.6 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.2 | 7.0 | GO:0046473 | phosphatidic acid metabolic process(GO:0046473) |
| 0.2 | 1.6 | GO:0060686 | negative regulation of prostatic bud formation(GO:0060686) |
| 0.2 | 5.3 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 0.2 | 6.7 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.2 | 5.3 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.2 | 7.8 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.2 | 3.0 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.2 | 4.7 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.2 | 6.8 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.2 | 7.2 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.2 | 3.4 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.2 | 1.5 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.2 | 0.5 | GO:1902473 | regulation of protein localization to synapse(GO:1902473) positive regulation of protein localization to synapse(GO:1902474) |
| 0.2 | 1.4 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.2 | 0.5 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.2 | 12.6 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.1 | 0.9 | GO:0075509 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.1 | 7.9 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.1 | 3.7 | GO:0010832 | negative regulation of myotube differentiation(GO:0010832) |
| 0.1 | 3.3 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 15.1 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.1 | 8.2 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.1 | 4.0 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.1 | 5.0 | GO:0002931 | response to ischemia(GO:0002931) |
| 0.1 | 2.8 | GO:0097503 | sialylation(GO:0097503) |
| 0.1 | 0.4 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 0.1 | 13.3 | GO:0030516 | regulation of axon extension(GO:0030516) |
| 0.1 | 3.5 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
| 0.1 | 2.8 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 2.5 | GO:0060384 | innervation(GO:0060384) |
| 0.1 | 4.9 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 0.8 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.1 | 0.7 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.1 | 3.3 | GO:0050691 | regulation of defense response to virus by host(GO:0050691) |
| 0.1 | 3.0 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.1 | 4.1 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 3.8 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 1.0 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 1.9 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.1 | 2.0 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.1 | 0.7 | GO:0048671 | negative regulation of collateral sprouting(GO:0048671) |
| 0.1 | 0.6 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 6.4 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 5.2 | GO:0051057 | positive regulation of small GTPase mediated signal transduction(GO:0051057) |
| 0.1 | 5.0 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
| 0.1 | 3.9 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.1 | 4.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.7 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.1 | 2.1 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.1 | 3.8 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 0.6 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 1.2 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.1 | 4.1 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 0.1 | 0.9 | GO:0032957 | inositol trisphosphate metabolic process(GO:0032957) |
| 0.1 | 8.3 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.1 | 2.4 | GO:1900048 | positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048) |
| 0.1 | 2.0 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.1 | 0.7 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.1 | 4.3 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.0 | 5.6 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 2.0 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.0 | 2.9 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.0 | 3.4 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 1.4 | GO:0016577 | histone demethylation(GO:0016577) |
| 0.0 | 2.8 | GO:0021549 | cerebellum development(GO:0021549) |
| 0.0 | 2.0 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 0.0 | 1.1 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
| 0.0 | 0.2 | GO:0021796 | cerebral cortex regionalization(GO:0021796) telencephalon regionalization(GO:0021978) |
| 0.0 | 0.7 | GO:0071218 | cellular response to misfolded protein(GO:0071218) |
| 0.0 | 0.7 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 0.2 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.0 | 0.7 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.0 | 1.5 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 0.1 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.0 | 0.9 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.0 | 0.7 | GO:0090003 | regulation of establishment of protein localization to plasma membrane(GO:0090003) |
| 0.0 | 0.1 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.0 | 1.0 | GO:0030593 | neutrophil chemotaxis(GO:0030593) |
| 0.0 | 0.1 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.9 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.0 | 0.3 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 1.0 | GO:0001764 | neuron migration(GO:0001764) |
| 0.0 | 1.2 | GO:0019233 | sensory perception of pain(GO:0019233) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 34.1 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 2.8 | 11.0 | GO:0070695 | FHF complex(GO:0070695) |
| 2.7 | 10.8 | GO:0034681 | integrin alpha11-beta1 complex(GO:0034681) |
| 2.4 | 14.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 2.3 | 13.8 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 2.3 | 11.4 | GO:0044305 | calyx of Held(GO:0044305) |
| 1.8 | 7.2 | GO:0019034 | viral replication complex(GO:0019034) |
| 1.6 | 12.6 | GO:0043218 | compact myelin(GO:0043218) |
| 1.5 | 25.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 1.3 | 3.8 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 1.2 | 8.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 1.0 | 4.1 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.9 | 5.3 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.9 | 6.1 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.8 | 6.4 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.7 | 4.2 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.7 | 10.8 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.7 | 8.8 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.6 | 1.9 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.6 | 9.4 | GO:0097433 | dense body(GO:0097433) |
| 0.6 | 16.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568) |
| 0.6 | 5.0 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.5 | 1.6 | GO:0034657 | GID complex(GO:0034657) |
| 0.5 | 7.4 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.5 | 2.8 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.5 | 11.5 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.4 | 6.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.4 | 4.1 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.4 | 8.1 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.4 | 1.5 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.4 | 1.5 | GO:0035363 | histone locus body(GO:0035363) |
| 0.4 | 2.2 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.3 | 0.7 | GO:0001939 | female pronucleus(GO:0001939) |
| 0.3 | 5.9 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 4.7 | GO:0030478 | actin cap(GO:0030478) |
| 0.3 | 3.7 | GO:0071203 | WASH complex(GO:0071203) |
| 0.3 | 4.6 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.3 | 4.2 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.3 | 2.3 | GO:0070187 | telosome(GO:0070187) |
| 0.3 | 3.9 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.3 | 2.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.2 | 9.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 5.4 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.2 | 5.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 6.7 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.2 | 8.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 2.9 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.2 | 10.0 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.2 | 1.0 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.2 | 3.6 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.2 | 4.4 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.2 | 4.7 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.2 | 18.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.2 | 0.5 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.2 | 3.6 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.2 | 6.8 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.2 | 20.9 | GO:0000776 | kinetochore(GO:0000776) |
| 0.1 | 11.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 3.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 9.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 0.8 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.1 | 2.2 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 2.8 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 5.9 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.1 | 2.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 1.0 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.1 | 6.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 4.0 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 1.3 | GO:1990752 | microtubule end(GO:1990752) |
| 0.1 | 5.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 0.8 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 15.6 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 16.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 0.5 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.1 | 2.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 12.2 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 1.7 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 2.1 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 1.7 | GO:0071437 | invadopodium(GO:0071437) |
| 0.1 | 1.3 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.1 | 7.3 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.1 | GO:0030120 | vesicle coat(GO:0030120) |
| 0.0 | 2.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 2.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 8.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 2.0 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 6.7 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 2.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.5 | GO:0008328 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.0 | 2.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 6.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 4.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 6.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.7 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 1.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 4.3 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 1.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.6 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 4.8 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 0.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 2.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.7 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 2.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 1.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 1.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 14.2 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 3.8 | 11.5 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 3.4 | 10.3 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 2.9 | 8.6 | GO:0004577 | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity(GO:0004577) |
| 2.6 | 10.5 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 2.0 | 68.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 1.8 | 12.8 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 1.6 | 9.8 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 1.6 | 14.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 1.5 | 10.8 | GO:0000182 | rDNA binding(GO:0000182) |
| 1.5 | 8.8 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 1.4 | 10.0 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 1.4 | 10.8 | GO:0038064 | collagen receptor activity(GO:0038064) collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 1.3 | 4.0 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 1.2 | 3.5 | GO:0015275 | stretch-activated, cation-selective, calcium channel activity(GO:0015275) |
| 1.1 | 6.7 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 1.1 | 12.8 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 1.1 | 4.3 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 1.1 | 12.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.0 | 3.1 | GO:0047493 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 1.0 | 7.1 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 1.0 | 5.9 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 1.0 | 5.9 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.9 | 2.8 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.9 | 12.0 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.9 | 9.2 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.9 | 6.3 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.8 | 4.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.8 | 9.5 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.8 | 3.9 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.7 | 2.2 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.7 | 10.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.7 | 5.0 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.7 | 2.8 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.7 | 6.1 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.7 | 9.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.6 | 1.9 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.6 | 1.9 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.6 | 13.0 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.6 | 9.8 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.6 | 2.9 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.6 | 9.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.6 | 5.0 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.5 | 3.8 | GO:0002114 | interleukin-33 receptor activity(GO:0002114) |
| 0.5 | 1.6 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.5 | 2.6 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.5 | 12.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.5 | 3.0 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.5 | 5.9 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.5 | 1.9 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.5 | 8.0 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.5 | 5.7 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.4 | 1.3 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.4 | 6.3 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.4 | 7.9 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.4 | 2.8 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.4 | 1.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.4 | 4.3 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.4 | 3.9 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.4 | 9.3 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.4 | 7.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.4 | 5.1 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.4 | 3.9 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.4 | 5.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.4 | 1.4 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.3 | 7.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.3 | 6.6 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 3.5 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.3 | 4.7 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.3 | 6.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.3 | 0.9 | GO:0051766 | inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol tetrakisphosphate kinase activity(GO:0051765) inositol trisphosphate kinase activity(GO:0051766) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) |
| 0.3 | 10.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.3 | 1.4 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.3 | 2.5 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.3 | 2.7 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.3 | 3.7 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.3 | 14.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.3 | 4.0 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.3 | 6.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 25.2 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.2 | 2.2 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.2 | 2.2 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.2 | 3.9 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.2 | 0.7 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.2 | 0.8 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.2 | 1.2 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.2 | 6.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 4.8 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.2 | 10.6 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.2 | 7.8 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.2 | 3.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 0.7 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.2 | 7.1 | GO:0008235 | metalloexopeptidase activity(GO:0008235) |
| 0.2 | 0.5 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.2 | 4.1 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.2 | 2.4 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.1 | 0.7 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 2.1 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.1 | 10.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 1.2 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.1 | 0.5 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.1 | 2.3 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
| 0.1 | 7.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 0.4 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 0.1 | 1.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 3.5 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 1.5 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.1 | 6.4 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 7.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 17.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 3.0 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 5.3 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.1 | 3.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.6 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 2.1 | GO:0042171 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617) |
| 0.1 | 3.6 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 10.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 2.3 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 1.4 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 1.6 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.1 | 2.1 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 2.6 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.1 | 2.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 8.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 0.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 1.5 | GO:0005234 | ionotropic glutamate receptor activity(GO:0004970) extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.1 | 1.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 0.7 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 0.7 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 2.0 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.1 | 1.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 6.2 | GO:0002039 | p53 binding(GO:0002039) |
| 0.1 | 9.5 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.1 | 0.7 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 0.7 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 0.7 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 1.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 2.4 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 1.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) peptide hormone receptor binding(GO:0051428) |
| 0.0 | 2.7 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.2 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.0 | 0.2 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 1.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.5 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 5.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 4.5 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.8 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 2.5 | GO:0061659 | ubiquitin-like protein ligase activity(GO:0061659) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.4 | 20.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 21.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.3 | 14.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.3 | 2.9 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.2 | 8.5 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.2 | 12.7 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 3.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 10.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 10.4 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.2 | 4.3 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.2 | 0.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 1.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 4.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.2 | 6.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 3.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 1.2 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 5.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 4.7 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 4.2 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 3.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 1.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 3.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 2.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 2.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 1.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 1.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 5.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 3.0 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 1.6 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 1.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.9 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 8.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.9 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.1 | 1.5 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 1.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.8 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 4.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 34.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.6 | 3.6 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.5 | 12.4 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.5 | 6.3 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.4 | 8.3 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.4 | 9.2 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.4 | 10.0 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.3 | 12.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 5.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 8.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 8.6 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.3 | 2.3 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.3 | 9.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 1.9 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.2 | 8.3 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.2 | 2.8 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.2 | 5.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.2 | 3.5 | REACTOME SHC MEDIATED SIGNALLING | Genes involved in SHC-mediated signalling |
| 0.2 | 2.0 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.2 | 2.5 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 8.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 3.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 10.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 2.7 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 13.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 5.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 6.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 2.8 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 6.4 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 1.5 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.1 | 4.4 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 6.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.6 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 1.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 6.1 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 2.9 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.1 | 1.0 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 6.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 11.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 5.1 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.1 | 5.8 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 3.9 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 1.1 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 1.6 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.5 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 4.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.1 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 1.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 3.3 | REACTOME ION CHANNEL TRANSPORT | Genes involved in Ion channel transport |
| 0.1 | 3.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 2.3 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 5.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 0.7 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.7 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.2 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 4.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.0 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 1.7 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 2.0 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 0.9 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 0.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |