Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGUGCUU
Z-value: 1.12
Motif logo
miRNA associated with seed AGUGCUU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-302c-3p.2
|
|
|
hsa-miR-520f-3p
|
MIMAT0002830 |
Activity profile of AGUGCUU motif
Sorted Z-values of AGUGCUU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of AGUGCUU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.3 | GO:1903294 | regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296) |
| 1.5 | 4.6 | GO:0060018 | astrocyte fate commitment(GO:0060018) retinal rod cell differentiation(GO:0060221) |
| 1.2 | 3.7 | GO:0042137 | sequestering of neurotransmitter(GO:0042137) |
| 1.1 | 10.3 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 1.1 | 7.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.0 | 6.3 | GO:0071874 | microglia differentiation(GO:0014004) microglia development(GO:0014005) collateral sprouting in absence of injury(GO:0048669) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874) |
| 0.8 | 3.1 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.7 | 6.9 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.6 | 2.6 | GO:0097676 | histone H3-K36 dimethylation(GO:0097676) |
| 0.6 | 3.1 | GO:0030242 | pexophagy(GO:0030242) |
| 0.6 | 5.3 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.6 | 2.3 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 0.6 | 1.7 | GO:1903892 | negative regulation of ATF6-mediated unfolded protein response(GO:1903892) |
| 0.6 | 3.4 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.5 | 1.6 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.5 | 2.1 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
| 0.5 | 7.9 | GO:0060137 | maternal process involved in parturition(GO:0060137) |
| 0.5 | 2.0 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.5 | 1.5 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 0.5 | 1.4 | GO:0007343 | egg activation(GO:0007343) |
| 0.4 | 3.0 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.4 | 4.6 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.4 | 5.1 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.4 | 3.9 | GO:0060013 | righting reflex(GO:0060013) |
| 0.4 | 1.1 | GO:0002101 | tRNA wobble cytosine modification(GO:0002101) |
| 0.4 | 1.4 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.4 | 1.1 | GO:1990168 | protein K33-linked deubiquitination(GO:1990168) |
| 0.4 | 1.4 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.4 | 1.4 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.3 | 3.2 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.3 | 1.9 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.3 | 0.9 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
| 0.3 | 1.5 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) |
| 0.3 | 1.7 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.3 | 1.7 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.3 | 1.9 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.3 | 2.7 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.3 | 1.3 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.3 | 1.1 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.3 | 1.0 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 0.3 | 1.0 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.2 | 1.0 | GO:0002215 | defense response to nematode(GO:0002215) |
| 0.2 | 4.1 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.2 | 1.1 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.2 | 1.0 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.2 | 4.0 | GO:0048490 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.2 | 3.0 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.2 | 2.4 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.2 | 1.8 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.2 | 2.9 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.2 | 2.9 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.2 | 1.9 | GO:0045915 | positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964) |
| 0.2 | 0.5 | GO:0090273 | regulation of somatostatin secretion(GO:0090273) positive regulation of somatostatin secretion(GO:0090274) |
| 0.2 | 6.3 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.2 | 1.4 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.2 | 1.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.2 | 2.1 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.2 | 1.8 | GO:0043129 | surfactant homeostasis(GO:0043129) |
| 0.2 | 0.8 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.2 | 0.5 | GO:0060031 | cardiac right atrium morphogenesis(GO:0003213) mediolateral intercalation(GO:0060031) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) regulation of cell proliferation in midbrain(GO:1904933) |
| 0.2 | 0.5 | GO:1900239 | phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239) |
| 0.2 | 2.1 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.2 | 1.6 | GO:0043045 | DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538) |
| 0.2 | 0.5 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.1 | 0.3 | GO:0061502 | early endosome to recycling endosome transport(GO:0061502) |
| 0.1 | 1.2 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
| 0.1 | 2.0 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 7.9 | GO:1900449 | regulation of glutamate receptor signaling pathway(GO:1900449) |
| 0.1 | 3.8 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.1 | 1.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.1 | 0.6 | GO:0048050 | sequestering of BMP in extracellular matrix(GO:0035582) post-embryonic eye morphogenesis(GO:0048050) |
| 0.1 | 0.3 | GO:0061289 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.1 | 1.0 | GO:0010694 | positive regulation of alkaline phosphatase activity(GO:0010694) |
| 0.1 | 1.3 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 0.8 | GO:0006561 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 0.1 | 1.6 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 2.1 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.1 | 0.3 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.1 | 2.1 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.1 | 0.7 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.2 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.1 | 0.7 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.1 | 0.5 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 3.2 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.1 | 0.7 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 0.3 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.1 | 1.8 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
| 0.1 | 0.3 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.1 | 1.9 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.1 | 1.2 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.1 | 0.7 | GO:0051791 | medium-chain fatty acid metabolic process(GO:0051791) |
| 0.1 | 1.8 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.1 | 2.9 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.1 | 0.4 | GO:1904849 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.1 | 2.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 2.6 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.1 | 0.3 | GO:0061091 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.1 | 1.0 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.1 | 3.0 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.1 | 3.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 0.3 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.1 | 0.4 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.1 | 0.4 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 2.1 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 0.5 | GO:0033182 | regulation of histone ubiquitination(GO:0033182) |
| 0.0 | 0.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 2.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 1.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 1.8 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 0.0 | 1.8 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.0 | 2.8 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.0 | 0.2 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 0.0 | 11.0 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.0 | 1.3 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.0 | 0.3 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
| 0.0 | 0.9 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 0.9 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 0.0 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.0 | 1.0 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.1 | GO:0060369 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) |
| 0.0 | 1.5 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
| 0.0 | 0.9 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
| 0.0 | 0.5 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.0 | 0.5 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.0 | 0.8 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.1 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 0.0 | 1.9 | GO:0030593 | neutrophil chemotaxis(GO:0030593) |
| 0.0 | 2.3 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.7 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 1.1 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 0.0 | 1.2 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.0 | 0.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.0 | 0.7 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 0.0 | 0.9 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 0.8 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 1.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 1.0 | 6.3 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.9 | 2.7 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.8 | 3.4 | GO:0070695 | FHF complex(GO:0070695) |
| 0.7 | 2.9 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.7 | 6.3 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.6 | 8.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.5 | 3.1 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.5 | 2.4 | GO:0031673 | H zone(GO:0031673) |
| 0.5 | 3.7 | GO:0060203 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.4 | 1.7 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.3 | 1.4 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.3 | 3.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.3 | 5.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.3 | 1.6 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.3 | 0.8 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
| 0.2 | 1.0 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.2 | 2.8 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.2 | 1.8 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 6.9 | GO:0043218 | compact myelin(GO:0043218) |
| 0.2 | 1.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 0.5 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 0.2 | 0.7 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.2 | 1.6 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 0.9 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 2.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 2.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 1.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 1.3 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 0.1 | 2.6 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 1.2 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 3.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 1.1 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 3.0 | GO:1990752 | microtubule end(GO:1990752) |
| 0.1 | 4.0 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 1.0 | GO:0071203 | WASH complex(GO:0071203) |
| 0.1 | 1.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 0.7 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 0.7 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 2.3 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 0.2 | GO:0097679 | other organism cytoplasm(GO:0097679) |
| 0.1 | 1.1 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 2.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 1.1 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.1 | 1.2 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 0.5 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 0.1 | 4.1 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 2.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.3 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.0 | 1.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 2.1 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 2.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.3 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 1.6 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 0.0 | 1.9 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 1.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 3.3 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 0.2 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.0 | 3.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 9.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.1 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 1.1 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 3.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.3 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 1.5 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.5 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 2.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.7 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 3.7 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 0.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 1.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.7 | GO:0005798 | Golgi-associated vesicle(GO:0005798) |
| 0.0 | 0.7 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
| 0.0 | 2.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 4.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.5 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.1 | GO:0043296 | apical junction complex(GO:0043296) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 14.4 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.9 | 2.8 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.8 | 4.6 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.7 | 3.7 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.7 | 4.3 | GO:0042285 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 0.6 | 1.9 | GO:0036505 | prosaposin receptor activity(GO:0036505) |
| 0.6 | 6.3 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.6 | 6.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.5 | 2.1 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.4 | 1.9 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.4 | 7.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.4 | 1.1 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.4 | 1.4 | GO:0004356 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.3 | 3.1 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.3 | 3.8 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.3 | 3.0 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.3 | 1.1 | GO:0004911 | interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976) |
| 0.3 | 0.8 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.3 | 1.9 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.3 | 2.4 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.2 | 6.3 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.2 | 1.1 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.2 | 1.1 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.2 | 1.2 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.2 | 6.8 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.2 | 2.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 0.7 | GO:0004513 | neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291) |
| 0.2 | 1.8 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.2 | 2.9 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 0.7 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 3.4 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 0.8 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 2.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 0.4 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.1 | 0.2 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) |
| 0.1 | 9.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 2.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 0.7 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 1.8 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 1.0 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.1 | 0.7 | GO:0016406 | carnitine O-acyltransferase activity(GO:0016406) |
| 0.1 | 1.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 2.2 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.1 | 0.7 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.7 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 1.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 0.8 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.1 | 2.3 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 0.6 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.1 | 1.2 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.1 | 3.2 | GO:0043394 | proteoglycan binding(GO:0043394) |
| 0.1 | 1.0 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.1 | 1.6 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 0.7 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.1 | 0.8 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 0.7 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 2.6 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 0.8 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.1 | 0.9 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 2.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 0.3 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 0.9 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 0.9 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 1.7 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 4.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 1.0 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.6 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 1.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.0 | 1.4 | GO:0005521 | phosphatidylinositol phospholipase C activity(GO:0004435) lamin binding(GO:0005521) |
| 0.0 | 0.3 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 3.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.4 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.0 | 2.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 2.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 2.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 4.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.9 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.8 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 1.4 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 1.3 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.6 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.0 | 4.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 3.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.0 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 1.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.5 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.0 | 1.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.7 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.0 | 1.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.4 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 4.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 1.0 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 3.3 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 3.7 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 0.8 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 8.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 5.4 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 4.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 2.1 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 7.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 3.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 1.5 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.1 | 3.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 2.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 1.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 3.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 3.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 4.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.8 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.8 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 6.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 2.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 2.4 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 5.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 1.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 1.4 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 3.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 4.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 1.5 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.1 | 2.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 4.2 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 1.8 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 2.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 5.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 1.1 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.1 | 0.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 1.2 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 0.7 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 0.5 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 1.4 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.1 | 3.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.8 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 3.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 2.6 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.9 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 2.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.1 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 1.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.3 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.5 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.8 | REACTOME G PROTEIN BETA GAMMA SIGNALLING | Genes involved in G-protein beta:gamma signalling |
| 0.0 | 2.4 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 0.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.1 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 1.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.5 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |