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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AIRE

Z-value: 3.61

Motif logo

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Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
AIRE
ENSG00000160224.17 AIRE

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg38_v1_chr21_+_44285869_442858840.391.7e-09Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_87529460 18.17 ENST00000418378.5
SPARCL1
SPARC like 1
chr8_-_24956604 10.65 ENST00000610854.2
NEFL
neurofilament light
chr6_-_31546552 10.40 ENST00000303892.10
ENST00000376151.4
ATP6V1G2
ATPase H+ transporting V1 subunit G2
chr3_-_49429304 8.44 ENST00000636166.1
ENST00000273598.8
ENST00000436744.2
ENSG00000283189.2
NICN1
novel protein
nicolin 1
chr12_+_75481204 8.31 ENST00000550491.1
GLIPR1
GLI pathogenesis related 1
chrM_+_12329 8.00 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr17_+_43780425 6.81 ENST00000449302.8
CFAP97D1
CFAP97 domain containing 1
chr14_-_24442662 6.69 ENST00000554698.5
SDR39U1
short chain dehydrogenase/reductase family 39U member 1
chr14_-_24442765 6.63 ENST00000555365.5
ENST00000399395.8
ENST00000553930.5
SDR39U1
short chain dehydrogenase/reductase family 39U member 1
chr12_+_75480800 6.50 ENST00000456650.7
GLIPR1
GLI pathogenesis related 1
chr2_-_222656067 6.49 ENST00000281828.8
FARSB
phenylalanyl-tRNA synthetase subunit beta
chr12_-_6470667 6.20 ENST00000361716.8
ENST00000396308.4
VAMP1
vesicle associated membrane protein 1
chr11_-_85665077 6.08 ENST00000527447.2
CREBZF
CREB/ATF bZIP transcription factor
chr19_+_44914702 5.85 ENST00000592885.5
ENST00000589781.1
APOC1
apolipoprotein C1
chr7_+_150801695 5.82 ENST00000475536.5
ENST00000468689.2
TMEM176A
transmembrane protein 176A
chr7_-_36724543 5.61 ENST00000612871.4
AOAH
acyloxyacyl hydrolase
chr12_-_6470643 5.54 ENST00000535180.5
ENST00000400911.7
VAMP1
vesicle associated membrane protein 1
chr7_-_36724380 5.43 ENST00000617267.4
AOAH
acyloxyacyl hydrolase
chr2_-_240820945 5.04 ENST00000428768.2
ENST00000650053.1
ENST00000650130.1
KIF1A
kinesin family member 1A
chr20_+_45408276 4.90 ENST00000372710.5
ENST00000443296.1
DBNDD2
dysbindin domain containing 2
chr2_+_165294031 4.85 ENST00000283256.10
SCN2A
sodium voltage-gated channel alpha subunit 2
chr19_+_44914588 4.84 ENST00000592535.6
APOC1
apolipoprotein C1
chr3_+_46370854 4.82 ENST00000292303.4
CCR5
C-C motif chemokine receptor 5
chr7_-_36724457 4.80 ENST00000617537.5
ENST00000435386.1
AOAH
acyloxyacyl hydrolase
chr6_+_46129930 4.67 ENST00000321037.5
ENPP4
ectonucleotide pyrophosphatase/phosphodiesterase 4
chr6_+_28267044 4.63 ENST00000316606.10
ZSCAN26
zinc finger and SCAN domain containing 26
chr14_-_100569780 4.62 ENST00000355173.7
BEGAIN
brain enriched guanylate kinase associated
chr5_+_140786136 4.60 ENST00000378133.4
ENST00000504120.4
PCDHA1
protocadherin alpha 1
chr11_-_117098415 4.49 ENST00000445177.6
ENST00000375300.6
ENST00000446921.6
SIK3
SIK family kinase 3
chr3_+_189789672 4.49 ENST00000434928.5
TP63
tumor protein p63
chr7_+_149872955 4.41 ENST00000421974.7
ENST00000456496.7
ATP6V0E2
ATPase H+ transporting V0 subunit e2
chr19_-_23687163 4.13 ENST00000601010.5
ENST00000601935.5
ENST00000600313.5
ENST00000596211.5
ENST00000359788.9
ENST00000599168.1
ZNF675
zinc finger protein 675
chr19_+_44914833 4.10 ENST00000589078.1
ENST00000586638.5
APOC1
apolipoprotein C1
chr6_-_149484965 4.02 ENST00000409806.8
ZC3H12D
zinc finger CCCH-type containing 12D
chr9_-_110999458 3.98 ENST00000374430.6
LPAR1
lysophosphatidic acid receptor 1
chr1_-_35031905 3.90 ENST00000317538.9
ENST00000357182.9
ZMYM6
zinc finger MYM-type containing 6
chr12_-_11269696 3.90 ENST00000381842.7
PRB3
proline rich protein BstNI subfamily 3
chr9_-_65285209 3.89 ENST00000377420.1
FOXD4L5
forkhead box D4 like 5
chr18_-_55321640 3.88 ENST00000637169.2
TCF4
transcription factor 4
chr1_-_16431371 3.78 ENST00000612240.1
SPATA21
spermatogenesis associated 21
chr21_+_38272291 3.76 ENST00000438657.5
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chr2_-_165953750 3.75 ENST00000243344.8
ENST00000679799.1
ENST00000679840.1
ENST00000681606.1
ENST00000680448.1
TTC21B
tetratricopeptide repeat domain 21B
chr19_-_3600581 3.71 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr5_+_141392616 3.62 ENST00000398604.3
PCDHGA8
protocadherin gamma subfamily A, 8
chr19_-_10380558 3.53 ENST00000524462.5
ENST00000525621.6
ENST00000531836.5
TYK2
tyrosine kinase 2
chr4_+_70721953 3.53 ENST00000381006.8
ENST00000226328.8
RUFY3
RUN and FYVE domain containing 3
chr2_-_165204042 3.49 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr2_-_224947030 3.43 ENST00000409592.7
DOCK10
dedicator of cytokinesis 10
chr21_+_38272410 3.42 ENST00000398934.5
ENST00000398930.5
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chr1_-_149861210 3.33 ENST00000579512.2
H4C15
H4 clustered histone 15
chr21_+_38272250 3.21 ENST00000398932.5
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chr17_-_40565459 3.21 ENST00000578085.1
ENST00000246657.2
CCR7
C-C motif chemokine receptor 7
chr22_+_24806265 3.16 ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr13_-_48413105 3.09 ENST00000620633.5
LPAR6
lysophosphatidic acid receptor 6
chr16_+_3204247 2.93 ENST00000304646.2
OR1F1
olfactory receptor family 1 subfamily F member 1
chr10_+_89283685 2.91 ENST00000638108.1
IFIT2
interferon induced protein with tetratricopeptide repeats 2
chr4_-_119322128 2.72 ENST00000274024.4
FABP2
fatty acid binding protein 2
chr18_+_74534594 2.54 ENST00000582365.1
CNDP1
carnosine dipeptidase 1
chr9_-_101435760 2.48 ENST00000647789.2
ENST00000616752.1
ALDOB
aldolase, fructose-bisphosphate B
chr11_+_6926417 2.40 ENST00000610573.4
ENST00000278319.10
ZNF215
zinc finger protein 215
chr1_+_47137435 2.32 ENST00000371891.8
ENST00000371890.7
ENST00000619754.4
ENST00000294337.7
ENST00000620131.1
CYP4A22
cytochrome P450 family 4 subfamily A member 22
chr1_+_207496147 2.32 ENST00000400960.7
ENST00000367049.9
CR1
complement C3b/C4b receptor 1 (Knops blood group)
chr19_-_58573555 2.31 ENST00000599369.5
MZF1
myeloid zinc finger 1
chrX_-_153926220 2.31 ENST00000370016.5
ARHGAP4
Rho GTPase activating protein 4
chrM_+_4467 2.21 ENST00000361453.3
MT-ND2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
chr3_-_48089203 2.16 ENST00000468075.2
ENST00000360240.10
MAP4
microtubule associated protein 4
chr11_-_66907891 2.14 ENST00000393955.6
PC
pyruvate carboxylase
chr12_+_75480745 2.12 ENST00000266659.8
GLIPR1
GLI pathogenesis related 1
chr3_-_88149815 2.11 ENST00000467332.1
ENST00000462901.5
CGGBP1
CGG triplet repeat binding protein 1
chr13_-_26221703 2.08 ENST00000381570.7
ENST00000346166.7
RNF6
ring finger protein 6
chrX_-_49080066 2.02 ENST00000634944.1
ENST00000423215.3
ENST00000465382.6
WDR45
WD repeat domain 45
chrX_-_153926254 1.98 ENST00000393721.5
ENST00000370028.7
ENST00000350060.10
ARHGAP4
Rho GTPase activating protein 4
chr13_-_46182136 1.98 ENST00000323076.7
LCP1
lymphocyte cytosolic protein 1
chr1_+_207496229 1.94 ENST00000367051.6
ENST00000367053.6
ENST00000367052.6
CR1
complement C3b/C4b receptor 1 (Knops blood group)
chr14_-_106511856 1.80 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr12_-_11310420 1.79 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
PRB4
proline rich protein BstNI subfamily 4
chr6_+_167111789 1.79 ENST00000400926.5
CCR6
C-C motif chemokine receptor 6
chr12_+_12070932 1.78 ENST00000308721.9
BCL2L14
BCL2 like 14
chr11_-_8932944 1.77 ENST00000326053.10
ENST00000525780.5
C11orf16
chromosome 11 open reading frame 16
chr6_-_33298909 1.59 ENST00000497454.6
RGL2
ral guanine nucleotide dissociation stimulator like 2
chr11_+_65027402 1.58 ENST00000377244.8
ENST00000534637.5
ENST00000524831.5
SNX15
sorting nexin 15
chr19_-_51028015 1.57 ENST00000319720.11
KLK11
kallikrein related peptidase 11
chr2_-_208129824 1.56 ENST00000282141.4
CRYGC
crystallin gamma C
chr12_+_20695553 1.54 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family member 1C1
chr7_-_15561986 1.52 ENST00000342526.8
AGMO
alkylglycerol monooxygenase
chr21_-_6467509 1.50 ENST00000624406.3
ENST00000398168.5
ENST00000624934.3
CBSL
cystathionine beta-synthase like
chrY_-_23694579 1.49 ENST00000343584.10
PRYP3
PTPN13 like Y-linked pseudogene 3
chr20_+_8789517 1.49 ENST00000437439.2
PLCB1
phospholipase C beta 1
chr1_+_207496268 1.48 ENST00000529814.1
CR1
complement C3b/C4b receptor 1 (Knops blood group)
chr6_+_27810041 1.42 ENST00000369163.3
H3C10
H3 clustered histone 10
chr11_+_7088991 1.36 ENST00000306904.7
RBMXL2
RBMX like 2
chr16_-_89418292 1.34 ENST00000683497.1
ENST00000642443.1
ENST00000644784.1
ENST00000647238.1
ENSG00000288715.1
ANKRD11
novel protein
ankyrin repeat domain 11
chr19_-_52048803 1.33 ENST00000221315.10
ZNF432
zinc finger protein 432
chr1_-_11796536 1.31 ENST00000641820.1
MTHFR
methylenetetrahydrofolate reductase
chrX_-_101052087 1.30 ENST00000372936.4
ENST00000545398.5
TRMT2B
tRNA methyltransferase 2 homolog B
chrX_-_140784366 1.28 ENST00000674533.1
CDR1
cerebellar degeneration related protein 1
chr10_+_94089034 1.26 ENST00000676102.1
ENST00000371385.8
PLCE1
phospholipase C epsilon 1
chr8_-_16186270 1.25 ENST00000445506.6
MSR1
macrophage scavenger receptor 1
chr9_-_92536031 1.25 ENST00000344604.9
ENST00000375540.5
ECM2
extracellular matrix protein 2
chr18_+_63775395 1.25 ENST00000398019.7
SERPINB7
serpin family B member 7
chr1_-_158330957 1.23 ENST00000451207.5
CD1B
CD1b molecule
chr16_+_14708944 1.20 ENST00000526520.5
ENST00000531598.6
NPIPA3
nuclear pore complex interacting protein family member A3
chr7_-_88306880 1.20 ENST00000414498.1
ENST00000301959.9
ENST00000380079.9
STEAP4
STEAP4 metalloreductase
chr20_+_46008900 1.12 ENST00000372330.3
MMP9
matrix metallopeptidase 9
chr1_-_161238223 1.10 ENST00000515452.1
NR1I3
nuclear receptor subfamily 1 group I member 3
chr15_-_99249523 1.10 ENST00000560235.1
ENST00000394132.7
ENST00000560860.5
ENST00000558078.5
ENST00000560772.5
TTC23
tetratricopeptide repeat domain 23
chr19_+_13151975 1.07 ENST00000588173.1
IER2
immediate early response 2
chr12_+_12049840 1.05 ENST00000589718.5
BCL2L14
BCL2 like 14
chr18_+_63775369 1.05 ENST00000540675.5
SERPINB7
serpin family B member 7
chr2_+_29113989 1.00 ENST00000404424.5
CLIP4
CAP-Gly domain containing linker protein family member 4
chr12_+_12049855 0.97 ENST00000586576.5
ENST00000464885.6
BCL2L14
BCL2 like 14
chr2_+_1413456 0.93 ENST00000539820.5
ENST00000382269.7
ENST00000345913.8
ENST00000329066.9
ENST00000382201.7
TPO
thyroid peroxidase
chr10_-_100081854 0.90 ENST00000370418.8
CPN1
carboxypeptidase N subunit 1
chr9_+_133459965 0.86 ENST00000540581.5
ENST00000542192.5
ENST00000291722.11
ENST00000316948.9
CACFD1
calcium channel flower domain containing 1
chr6_-_11044275 0.81 ENST00000354666.4
ELOVL2
ELOVL fatty acid elongase 2
chr4_-_174829212 0.72 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr4_-_16084002 0.71 ENST00000447510.7
PROM1
prominin 1
chr15_+_51751587 0.70 ENST00000539962.6
ENST00000249700.9
TMOD2
tropomodulin 2
chr19_-_51027954 0.70 ENST00000391804.7
KLK11
kallikrein related peptidase 11
chr16_-_20697680 0.68 ENST00000520010.6
ACSM1
acyl-CoA synthetase medium chain family member 1
chr8_+_104339796 0.67 ENST00000622554.1
ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr14_+_20768393 0.64 ENST00000326783.4
EDDM3B
epididymal protein 3B
chr4_-_185775271 0.63 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr17_+_63484840 0.63 ENST00000290863.10
ENST00000413513.7
ACE
angiotensin I converting enzyme
chr12_-_101830926 0.62 ENST00000299314.12
GNPTAB
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
chr1_-_161238196 0.61 ENST00000367983.9
ENST00000506209.5
ENST00000367980.6
ENST00000628566.2
NR1I3
nuclear receptor subfamily 1 group I member 3
chr7_-_99735093 0.57 ENST00000611620.4
ENST00000620220.6
ENST00000336374.4
CYP3A7-CYP3A51P
CYP3A7
CYP3A7-CYP3A51P readthrough
cytochrome P450 family 3 subfamily A member 7
chr19_+_15615211 0.55 ENST00000617645.4
ENST00000612078.5
CYP4F8
cytochrome P450 family 4 subfamily F member 8
chr17_-_3398410 0.50 ENST00000322608.2
OR1E1
olfactory receptor family 1 subfamily E member 1
chr6_-_137044269 0.47 ENST00000635289.1
ENST00000541547.5
IL20RA
interleukin 20 receptor subunit alpha
chr12_+_12071396 0.45 ENST00000396367.5
ENST00000266434.8
BCL2L14
BCL2 like 14
chr6_-_131628165 0.42 ENST00000368053.8
ENST00000354577.8
ENST00000368060.7
ENST00000368068.8
MED23
mediator complex subunit 23
chrX_-_101052054 0.42 ENST00000372939.5
ENST00000372935.5
TRMT2B
tRNA methyltransferase 2 homolog B
chr10_+_112374110 0.41 ENST00000354655.9
ACSL5
acyl-CoA synthetase long chain family member 5
chr1_-_169734064 0.39 ENST00000333360.12
SELE
selectin E
chr5_+_119354771 0.35 ENST00000503646.1
TNFAIP8
TNF alpha induced protein 8
chr3_-_121749704 0.33 ENST00000393667.7
ENST00000340645.9
ENST00000614479.4
GOLGB1
golgin B1
chr1_-_51878799 0.30 ENST00000354831.11
ENST00000544028.5
NRDC
nardilysin convertase
chr17_+_3420568 0.27 ENST00000574571.4
OR3A3
olfactory receptor family 3 subfamily A member 3
chr9_+_87497222 0.15 ENST00000358077.9
DAPK1
death associated protein kinase 1
chr5_-_64768619 0.14 ENST00000513458.9
SREK1IP1
SREK1 interacting protein 1
chr6_+_42173358 0.12 ENST00000372958.2
GUCA1A
guanylate cyclase activator 1A
chr20_+_56248732 0.11 ENST00000243911.2
MC3R
melanocortin 3 receptor

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.8 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
3.5 10.6 GO:1903937 response to acrylamide(GO:1903937)
1.9 5.7 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
1.3 6.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.2 3.7 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
1.1 4.5 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
1.1 3.2 GO:2000525 dendritic cell dendrite assembly(GO:0097026) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.8 4.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.6 1.8 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.6 11.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.5 3.8 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.5 2.1 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.5 4.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.5 1.5 GO:0007343 egg activation(GO:0007343)
0.5 4.8 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.5 2.3 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.4 5.8 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.4 14.8 GO:0090383 phagosome acidification(GO:0090383)
0.4 4.3 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.4 2.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.4 2.9 GO:0002933 lipid hydroxylation(GO:0002933)
0.4 2.5 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.4 4.9 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.4 1.5 GO:0046485 ether lipid metabolic process(GO:0046485)
0.4 2.2 GO:0051012 microtubule sliding(GO:0051012)
0.3 1.5 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.3 3.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.3 4.0 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2 1.2 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 0.7 GO:0018874 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.2 0.7 GO:0034238 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 2.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 1.3 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.2 1.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.2 0.6 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.2 4.7 GO:0006152 purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.2 0.9 GO:0030070 insulin processing(GO:0030070)
0.2 10.4 GO:0010107 potassium ion import(GO:0010107)
0.2 1.1 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.2 0.6 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.1 1.2 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 9.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 5.0 GO:0008089 anterograde axonal transport(GO:0008089)
0.1 2.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 1.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.7 GO:2000768 positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 0.8 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 2.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 3.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 0.7 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 3.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 1.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 2.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 3.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 3.5 GO:0019228 neuronal action potential(GO:0019228)
0.0 1.6 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.9 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 3.5 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 7.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.5 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
0.0 3.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 14.2 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 1.7 GO:0001510 RNA methylation(GO:0001510)
0.0 6.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 11.8 GO:0043687 post-translational protein modification(GO:0043687)
0.0 18.0 GO:0006954 inflammatory response(GO:0006954)
0.0 0.1 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.6 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.5 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 1.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.6 GO:0033596 TSC1-TSC2 complex(GO:0033596)
2.2 6.5 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.6 14.8 GO:0042627 chylomicron(GO:0042627)
0.5 3.8 GO:0030991 intraciliary transport particle A(GO:0030991)
0.5 14.8 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.4 28.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 8.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.8 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 9.2 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 10.4 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 3.5 GO:0071437 invadopodium(GO:0071437)
0.1 1.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 5.0 GO:1904115 axon cytoplasm(GO:1904115)
0.1 2.0 GO:0001891 phagocytic cup(GO:0001891)
0.1 4.0 GO:0043198 dendritic shaft(GO:0043198)
0.1 2.5 GO:0034451 centriolar satellite(GO:0034451)
0.1 4.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 14.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 3.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 4.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.2 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 5.0 GO:0030426 growth cone(GO:0030426)
0.0 7.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.0 5.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.6 GO:0043197 dendritic spine(GO:0043197)
0.0 0.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.8 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
1.9 5.7 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
1.6 14.8 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.3 6.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.2 3.7 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.8 2.5 GO:0061609 fructose-1-phosphate aldolase activity(GO:0061609)
0.7 9.8 GO:0019957 C-C chemokine binding(GO:0019957)
0.6 7.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.5 10.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 1.3 GO:0070052 collagen V binding(GO:0070052)
0.4 11.0 GO:0043274 phospholipase binding(GO:0043274)
0.3 4.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.3 1.5 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.3 1.2 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 4.7 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.3 1.7 GO:0004882 androgen receptor activity(GO:0004882)
0.3 3.5 GO:0005131 growth hormone receptor binding(GO:0005131)
0.3 11.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 8.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 2.9 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.2 1.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 1.5 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 18.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 0.9 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 3.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 2.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.2 9.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 4.4 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 0.6 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 3.2 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.7 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.2 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 2.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 10.4 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.1 2.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.7 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 0.7 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 5.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.7 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 4.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 3.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.6 GO:0070330 aromatase activity(GO:0070330)
0.0 2.1 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 4.0 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 12.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 18.3 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 10.4 GO:0016491 oxidoreductase activity(GO:0016491)
0.0 3.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 10.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.5 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 4.5 PID LKB1 PATHWAY LKB1 signaling events
0.1 19.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.3 SIG CHEMOTAXIS Genes related to chemotaxis
0.1 3.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 4.8 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 8.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.3 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 1.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.8 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.7 6.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.5 11.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.4 10.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.3 10.6 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.3 3.7 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.3 10.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 5.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 3.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 1.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 3.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 4.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 17.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.5 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 4.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 4.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 3.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 3.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 3.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 4.0 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis