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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ALX1_ARX

Z-value: 0.33

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Transcription factors associated with ALX1_ARX

Gene Symbol Gene ID Gene Info
ALX1
ENSG00000180318.4 ALX1
ARX
ENSG00000004848.8 ARX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ALX1hg38_v1_chr12_+_85280199_852802370.171.3e-02Click!

Activity profile of ALX1_ARX motif

Sorted Z-values of ALX1_ARX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX1_ARX

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_121437378 8.92 ENST00000650427.1
ENST00000647564.1
GJA1
gap junction protein alpha 1
chr3_-_195583931 7.47 ENST00000343267.8
ENST00000421243.5
ENST00000453131.1
APOD
apolipoprotein D
chr12_-_91153149 4.97 ENST00000550758.1
DCN
decorin
chr6_-_134318097 4.30 ENST00000367858.10
ENST00000533224.1
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_218010202 3.11 ENST00000646520.1
TNS1
tensin 1
chr1_-_91906280 2.91 ENST00000370399.6
TGFBR3
transforming growth factor beta receptor 3
chr1_+_207325629 2.80 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr2_-_55269038 2.29 ENST00000417363.5
ENST00000412530.1
ENST00000366137.6
ENST00000420637.5
MTIF2
mitochondrial translational initiation factor 2
chr6_-_169250825 2.03 ENST00000676869.1
ENST00000676760.1
THBS2
thrombospondin 2
chrX_+_108044967 1.90 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chrX_+_108045050 1.88 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr12_+_12725897 1.74 ENST00000326765.10
APOLD1
apolipoprotein L domain containing 1
chr18_-_24311495 1.70 ENST00000357041.8
OSBPL1A
oxysterol binding protein like 1A
chr5_+_141364153 1.57 ENST00000518069.2
PCDHGA5
protocadherin gamma subfamily A, 5
chr12_+_14419136 1.40 ENST00000545769.1
ENST00000428217.6
ENST00000396279.2
ENST00000542514.5
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr3_-_12545499 1.33 ENST00000564146.4
MKRN2OS
MKRN2 opposite strand
chr20_+_33235987 1.29 ENST00000375422.6
ENST00000375413.8
ENST00000354297.9
BPIFA1
BPI fold containing family A member 1
chr14_+_94612383 1.16 ENST00000393080.8
ENST00000555820.1
ENST00000393078.5
ENST00000467132.5
SERPINA3
serpin family A member 3
chr1_-_93681829 1.14 ENST00000260502.11
BCAR3
BCAR3 adaptor protein, NSP family member
chr9_-_92536031 1.09 ENST00000344604.9
ENST00000375540.5
ECM2
extracellular matrix protein 2
chr16_-_3372666 1.07 ENST00000399974.5
MTRNR2L4
MT-RNR2 like 4
chr4_-_175812746 1.00 ENST00000393658.6
GPM6A
glycoprotein M6A
chr3_-_125055987 1.00 ENST00000311127.9
HEG1
heart development protein with EGF like domains 1
chr10_-_29634964 0.97 ENST00000375398.6
ENST00000355867.8
SVIL
supervillin
chr12_-_89352395 0.87 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr1_+_183805105 0.86 ENST00000360851.4
RGL1
ral guanine nucleotide dissociation stimulator like 1
chr22_-_30246739 0.85 ENST00000403987.3
ENST00000249075.4
LIF
LIF interleukin 6 family cytokine
chrX_-_11265975 0.83 ENST00000303025.10
ENST00000657361.1
ARHGAP6
Rho GTPase activating protein 6
chr12_-_89352487 0.80 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr12_-_118359105 0.77 ENST00000541186.5
ENST00000539872.5
TAOK3
TAO kinase 3
chr1_+_15236509 0.76 ENST00000683790.1
FHAD1
forkhead associated phosphopeptide binding domain 1
chr21_-_41926680 0.76 ENST00000329623.11
C2CD2
C2 calcium dependent domain containing 2
chr7_+_20615653 0.75 ENST00000404938.7
ABCB5
ATP binding cassette subfamily B member 5
chr17_+_70075215 0.74 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr3_+_69936583 0.70 ENST00000314557.10
ENST00000394351.9
MITF
melanocyte inducing transcription factor
chr5_+_40909490 0.69 ENST00000313164.10
C7
complement C7
chr17_+_70075317 0.68 ENST00000589377.1
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr3_-_98523013 0.67 ENST00000394181.6
ENST00000508902.5
ENST00000394180.6
CLDND1
claudin domain containing 1
chr1_-_248277976 0.64 ENST00000641220.1
OR2T33
olfactory receptor family 2 subfamily T member 33
chr1_+_24556087 0.62 ENST00000374392.3
NCMAP
non-compact myelin associated protein
chr11_-_13496018 0.62 ENST00000529816.1
PTH
parathyroid hormone
chr1_+_180632001 0.58 ENST00000367590.9
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr5_+_141338753 0.58 ENST00000528330.2
ENST00000394576.3
PCDHGA2
protocadherin gamma subfamily A, 2
chr1_-_110391041 0.56 ENST00000369781.8
ENST00000437429.6
ENST00000541986.5
SLC16A4
solute carrier family 16 member 4
chr5_+_137867868 0.55 ENST00000515645.1
MYOT
myotilin
chr3_+_69936629 0.55 ENST00000394348.2
ENST00000531774.1
MITF
melanocyte inducing transcription factor
chr2_-_182427014 0.49 ENST00000409365.5
ENST00000351439.9
PDE1A
phosphodiesterase 1A
chr2_+_43774033 0.49 ENST00000260605.12
ENST00000406852.7
ENST00000398823.6
ENST00000605786.5
DYNC2LI1
dynein cytoplasmic 2 light intermediate chain 1
chrX_-_32412220 0.48 ENST00000619831.5
DMD
dystrophin
chr12_+_133181409 0.47 ENST00000416488.5
ENST00000228289.9
ENST00000541211.6
ENST00000536435.7
ENST00000500625.7
ENST00000539248.6
ENST00000542711.6
ENST00000536899.6
ENST00000542986.6
ENST00000611984.4
ENST00000541975.2
ZNF268
zinc finger protein 268
chr13_+_48256214 0.46 ENST00000650237.1
ITM2B
integral membrane protein 2B
chr2_+_54456311 0.42 ENST00000615901.4
ENST00000356805.9
SPTBN1
spectrin beta, non-erythrocytic 1
chr18_-_5396265 0.42 ENST00000579951.2
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr4_-_99435134 0.41 ENST00000476959.5
ENST00000482593.5
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr8_+_38820332 0.40 ENST00000518809.5
ENST00000520611.1
TACC1
transforming acidic coiled-coil containing protein 1
chr4_+_94455245 0.40 ENST00000508216.5
ENST00000514743.5
PDLIM5
PDZ and LIM domain 5
chr1_+_12857086 0.39 ENST00000240189.2
PRAMEF2
PRAME family member 2
chr10_-_20897288 0.37 ENST00000377122.9
NEBL
nebulette
chrX_+_11293411 0.36 ENST00000348912.4
ENST00000380714.7
ENST00000380712.7
AMELX
amelogenin X-linked
chr6_+_26087417 0.36 ENST00000357618.10
ENST00000309234.10
HFE
homeostatic iron regulator
chr12_+_133181529 0.35 ENST00000541009.6
ENST00000592241.5
ZNF268
zinc finger protein 268
chr1_+_186828941 0.35 ENST00000367466.4
PLA2G4A
phospholipase A2 group IVA
chr12_-_21775581 0.35 ENST00000537950.1
ENST00000665145.1
KCNJ8
potassium inwardly rectifying channel subfamily J member 8
chr5_+_141343818 0.34 ENST00000619750.1
ENST00000253812.8
PCDHGA3
protocadherin gamma subfamily A, 3
chr5_+_36606355 0.33 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
SLC1A3
solute carrier family 1 member 3
chr11_+_55262152 0.33 ENST00000417545.5
TRIM48
tripartite motif containing 48
chr11_+_95789965 0.31 ENST00000537677.5
CEP57
centrosomal protein 57
chr10_+_35175586 0.31 ENST00000494479.5
ENST00000463314.5
ENST00000342105.7
ENST00000495301.1
CREM
cAMP responsive element modulator
chr11_+_89924064 0.28 ENST00000623787.3
TRIM49D2
tripartite motif containing 49D2
chr5_-_56116946 0.28 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr5_-_116536458 0.28 ENST00000510263.5
SEMA6A
semaphorin 6A
chr12_+_71686473 0.27 ENST00000549735.5
TMEM19
transmembrane protein 19
chr19_-_43465596 0.27 ENST00000244333.4
LYPD3
LY6/PLAUR domain containing 3
chr4_-_82848843 0.24 ENST00000511338.1
SEC31A
SEC31 homolog A, COPII coat complex component
chr22_-_28306645 0.24 ENST00000612946.4
TTC28
tetratricopeptide repeat domain 28
chr4_-_99435336 0.24 ENST00000437033.7
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr8_-_101790934 0.23 ENST00000523645.5
ENST00000520346.1
ENST00000220931.11
ENST00000522448.5
ENST00000522951.5
ENST00000522252.5
ENST00000519098.5
NCALD
neurocalcin delta
chr7_+_107583919 0.23 ENST00000491150.5
BCAP29
B cell receptor associated protein 29
chr5_-_160852200 0.23 ENST00000327245.10
ATP10B
ATPase phospholipid transporting 10B (putative)
chr11_+_18412292 0.22 ENST00000541669.6
ENST00000280704.8
LDHC
lactate dehydrogenase C
chr15_+_41774459 0.22 ENST00000457542.7
ENST00000456763.6
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr4_-_99435396 0.22 ENST00000209665.8
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr8_-_90082871 0.21 ENST00000265431.7
CALB1
calbindin 1
chr11_+_66011994 0.21 ENST00000312134.3
CST6
cystatin E/M
chr15_-_26629083 0.20 ENST00000400188.7
GABRB3
gamma-aminobutyric acid type A receptor subunit beta3
chr2_+_67397297 0.20 ENST00000644028.1
ENST00000272342.6
ETAA1
ETAA1 activator of ATR kinase
chr4_+_94974984 0.20 ENST00000672698.1
BMPR1B
bone morphogenetic protein receptor type 1B
chr1_-_13285154 0.20 ENST00000357367.6
ENST00000614831.1
PRAMEF8
PRAME family member 8
chr6_-_136550407 0.19 ENST00000354570.8
MAP7
microtubule associated protein 7
chr6_-_27867581 0.19 ENST00000331442.5
H1-5
H1.5 linker histone, cluster member
chr3_-_33718207 0.19 ENST00000359576.9
ENST00000682230.1
ENST00000399362.8
CLASP2
cytoplasmic linker associated protein 2
chr4_+_70195719 0.18 ENST00000683306.1
ODAM
odontogenic, ameloblast associated
chr2_-_144520315 0.18 ENST00000465070.5
ENST00000465308.5
ENST00000636471.1
ENST00000629520.2
ENST00000675069.1
ENST00000636026.2
ENST00000444559.5
ZEB2
zinc finger E-box binding homeobox 2
chr22_+_41092869 0.18 ENST00000674155.1
EP300
E1A binding protein p300
chrY_-_6874027 0.17 ENST00000215479.10
AMELY
amelogenin Y-linked
chr5_+_69234795 0.16 ENST00000626796.2
ENST00000629350.2
ENST00000506563.5
ENST00000256443.8
ENST00000514676.5
CDK7
cyclin dependent kinase 7
chr8_-_85341659 0.14 ENST00000522389.5
CA1
carbonic anhydrase 1
chr18_-_63644250 0.13 ENST00000341074.10
ENST00000436264.1
SERPINB4
serpin family B member 4
chr9_-_27005659 0.12 ENST00000380055.6
LRRC19
leucine rich repeat containing 19
chr7_+_142384328 0.12 ENST00000390361.3
TRBV7-3
T cell receptor beta variable 7-3
chr2_+_118942188 0.12 ENST00000327097.5
MARCO
macrophage receptor with collagenous structure
chr4_+_168092530 0.11 ENST00000359299.8
ANXA10
annexin A10
chr3_+_12287899 0.11 ENST00000643888.2
PPARG
peroxisome proliferator activated receptor gamma
chr12_-_7503744 0.10 ENST00000396620.7
ENST00000432237.3
CD163
CD163 molecule
chr14_-_21098848 0.10 ENST00000556174.5
ENST00000554478.5
ENST00000553980.1
ENST00000421093.6
ZNF219
zinc finger protein 219
chr2_+_75646775 0.09 ENST00000393909.7
ENST00000358788.10
ENST00000409374.5
MRPL19
mitochondrial ribosomal protein L19
chr3_+_12287859 0.08 ENST00000309576.11
ENST00000397015.7
PPARG
peroxisome proliferator activated receptor gamma
chr3_+_154121366 0.07 ENST00000465093.6
ENST00000496710.5
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor 26
chr4_+_87832917 0.07 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr11_-_58731968 0.07 ENST00000278400.3
GLYAT
glycine-N-acyltransferase
chr12_-_111685720 0.07 ENST00000327551.6
BRAP
BRCA1 associated protein
chr2_-_229921316 0.07 ENST00000428959.5
ENST00000675423.1
TRIP12
thyroid hormone receptor interactor 12
chr5_+_141364231 0.06 ENST00000611914.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr17_+_73232637 0.06 ENST00000268942.12
ENST00000426147.6
C17orf80
chromosome 17 open reading frame 80
chr12_-_81598332 0.06 ENST00000443686.7
PPFIA2
PTPRF interacting protein alpha 2
chr7_-_14841267 0.06 ENST00000406247.7
ENST00000399322.7
DGKB
diacylglycerol kinase beta
chr15_+_45252228 0.05 ENST00000560438.5
ENST00000347644.8
SLC28A2
solute carrier family 28 member 2
chr6_-_111483700 0.05 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr7_-_83162899 0.04 ENST00000423517.6
PCLO
piccolo presynaptic cytomatrix protein
chr9_+_128566741 0.04 ENST00000630866.1
SPTAN1
spectrin alpha, non-erythrocytic 1
chr3_+_138621225 0.04 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr12_+_18261511 0.04 ENST00000538779.6
ENST00000433979.6
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr15_+_57219411 0.04 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
TCF12
transcription factor 12
chr2_+_151357583 0.03 ENST00000243347.5
TNFAIP6
TNF alpha induced protein 6
chr2_+_233691607 0.03 ENST00000373424.5
ENST00000441351.1
UGT1A6
UDP glucuronosyltransferase family 1 member A6
chr12_-_81598360 0.03 ENST00000333447.11
ENST00000407050.8
PPFIA2
PTPRF interacting protein alpha 2
chr12_-_23584600 0.03 ENST00000396007.6
SOX5
SRY-box transcription factor 5
chr13_-_46897021 0.03 ENST00000542664.4
ENST00000543956.5
HTR2A
5-hydroxytryptamine receptor 2A
chr3_+_130850585 0.03 ENST00000505330.5
ENST00000504381.5
ENST00000507488.6
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr17_-_41467386 0.02 ENST00000225899.4
KRT32
keratin 32
chr17_+_73232601 0.02 ENST00000359042.6
C17orf80
chromosome 17 open reading frame 80
chr5_-_39270623 0.01 ENST00000512138.1
ENST00000646045.2
FYB1
FYN binding protein 1
chr3_-_142029108 0.01 ENST00000497579.5
TFDP2
transcription factor Dp-2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
2.2 8.9 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
1.0 2.9 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.6 4.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.5 2.8 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.4 1.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.4 5.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3 1.3 GO:1900229 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.3 0.9 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.3 0.8 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.2 4.9 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 0.9 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.2 1.7 GO:0042118 endothelial cell activation(GO:0042118)
0.2 0.6 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.2 0.6 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 1.0 GO:0090269 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.1 0.4 GO:1990641 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.1 0.4 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.3 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.4 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.8 GO:0042908 xenobiotic transport(GO:0042908)
0.1 0.2 GO:0019249 lactate biosynthetic process(GO:0019249)
0.1 1.0 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 1.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 3.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.5 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.2 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0 0.5 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 1.3 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 1.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.7 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.3 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 1.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.2 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 1.0 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 2.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.1 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.9 GO:0005922 connexon complex(GO:0005922)
0.5 2.9 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.4 5.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.0 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.7 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.4 GO:0032437 cuticular plate(GO:0032437)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.1 1.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 1.0 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.0 2.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 4.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 2.5 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 8.9 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.4 1.1 GO:0070052 collagen V binding(GO:0070052)
0.3 0.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.3 1.3 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.3 2.9 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.2 0.9 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.2 4.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 2.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 1.7 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.4 GO:0046848 hydroxyapatite binding(GO:0046848)
0.1 7.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.5 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 5.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.3 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.4 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.2 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.6 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 2.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 2.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.9 GO:0042805 actinin binding(GO:0042805)
0.0 0.4 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 2.0 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.8 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 4.3 PID INSULIN PATHWAY Insulin Pathway
0.0 1.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 3.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.4 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 5.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 2.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 0.9 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.7 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.8 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 2.0 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects