ISMARA results: ALX3

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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ALX3

Z-value: 3.04

Motif logo

Transcription factors associated with ALX3

Gene Symbol	Gene ID	Gene Info
ALX3 Ensembl NCBI GeneCards UniProt	ENSG00000156150.9	ALX3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ALX3	hg38_v1_chr1_-_110070654_110070677	-0.32	1.2e-06	Click!

Activity profile of ALX3 motif

Sorted Z-values of ALX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX3

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View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr14_+_34993240 Show fit	20.85	ENST00000677647.1	SRP54 Ensembl NCBI GeneCards UniProt Show fit	signal recognition particle 54
chr13_+_30422487 Show fit	14.86	ENST00000638137.1 ENST00000635918.2	UBE2L5 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 L5
chr3_-_64019334 Show fit	14.58	ENST00000480205.5	PSMD6 Ensembl NCBI GeneCards UniProt Show fit	proteasome 26S subunit, non-ATPase 6
chr4_+_112647059 Show fit	12.50	ENST00000511529.1	LARP7 Ensembl NCBI GeneCards UniProt Show fit	La ribonucleoprotein 7, transcriptional regulator
chr2_+_186506713 Show fit	10.78	ENST00000445547.1	ZC3H15 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing 15
chr7_-_88226965 Show fit	10.50	ENST00000490437.5 ENST00000431660.5	SRI Ensembl NCBI GeneCards UniProt Show fit	sorcin
chr7_-_88226987 Show fit	10.34	ENST00000394641.7	SRI Ensembl NCBI GeneCards UniProt Show fit	sorcin
chr3_-_142029108 Show fit	9.58	ENST00000497579.5	TFDP2 Ensembl NCBI GeneCards UniProt Show fit	transcription factor Dp-2
chr15_+_41286011 Show fit	9.50	ENST00000661438.1	ENSG00000285920.2 Ensembl NCBI GeneCards UniProt Show fit	novel protein
chr4_-_25863537 Show fit	9.41	ENST00000502949.5 ENST00000264868.9 ENST00000513691.1 ENST00000514872.1	SEL1L3 Ensembl NCBI GeneCards UniProt Show fit	SEL1L family member 3
chr4_-_102828022 Show fit	9.04	ENST00000502690.5	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr5_+_154941063 Show fit	8.81	ENST00000523037.6 ENST00000265229.12 ENST00000439747.7 ENST00000522038.5	MRPL22 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L22
chr2_-_88861258 Show fit	8.78	ENST00000390240.2	IGKJ3 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa joining 3
chr17_+_37491464 Show fit	8.76	ENST00000613659.1	DUSP14 Ensembl NCBI GeneCards UniProt Show fit	dual specificity phosphatase 14
chr4_-_102828048 Show fit	8.35	ENST00000508249.1	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr3_+_158801926 Show fit	7.48	ENST00000622669.4 ENST00000392813.8 ENST00000415822.8 ENST00000651862.1 ENST00000264266.12	MFSD1 Ensembl NCBI GeneCards UniProt Show fit	major facilitator superfamily domain containing 1
chr1_-_23799533 Show fit	7.43	ENST00000429356.5	GALE Ensembl NCBI GeneCards UniProt Show fit	UDP-galactose-4-epimerase
chr9_+_69145463 Show fit	7.40	ENST00000636438.1	TJP2 Ensembl NCBI GeneCards UniProt Show fit	tight junction protein 2
chr3_+_139344530 Show fit	7.33	ENST00000478464.5	MRPS22 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein S22
chr3_-_146528750 Show fit	7.23	ENST00000483300.5	PLSCR1 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 1
chrX_+_77899440 Show fit	6.77	ENST00000373335.4 ENST00000475465.1 ENST00000650309.2 ENST00000647835.1	COX7B Ensembl NCBI GeneCards UniProt Show fit	cytochrome c oxidase subunit 7B
chr1_-_53945661 Show fit	6.74	ENST00000194214.10	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 11
chr11_-_107858777 Show fit	6.38	ENST00000525815.6	SLC35F2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 35 member F2
chr11_-_72112750 Show fit	6.37	ENST00000545680.5 ENST00000543587.5 ENST00000538393.5 ENST00000535234.5 ENST00000227618.8 ENST00000535503.5	ANAPC15 Ensembl NCBI GeneCards UniProt Show fit	anaphase promoting complex subunit 15
chr2_-_89085787 Show fit	6.25	ENST00000390252.2	IGKV3-15 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3-15
chr11_-_72112068 Show fit	5.82	ENST00000537644.5 ENST00000538919.5 ENST00000539395.1 ENST00000542531.5	ANAPC15 Ensembl NCBI GeneCards UniProt Show fit	anaphase promoting complex subunit 15
chr16_+_11965234 Show fit	5.74	ENST00000562385.1	TNFRSF17 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 17
chr4_+_109815503 Show fit	5.59	ENST00000394631.7	GAR1 Ensembl NCBI GeneCards UniProt Show fit	GAR1 ribonucleoprotein
chr11_-_72112669 Show fit	5.53	ENST00000545944.5 ENST00000502597.2	ANAPC15 Ensembl NCBI GeneCards UniProt Show fit	anaphase promoting complex subunit 15
chr20_-_44504850 Show fit	5.43	ENST00000411544.5	SERINC3 Ensembl NCBI GeneCards UniProt Show fit	serine incorporator 3
chr12_+_56041893 Show fit	5.30	ENST00000552361.1 ENST00000646449.2	RPS26 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S26
chr1_-_150697128 Show fit	5.27	ENST00000427665.1 ENST00000271732.8	GOLPH3L Ensembl NCBI GeneCards UniProt Show fit	golgi phosphoprotein 3 like
chr2_-_219399981 Show fit	5.09	ENST00000519905.1 ENST00000523282.5 ENST00000434339.5 ENST00000457935.5	DNPEP Ensembl NCBI GeneCards UniProt Show fit	aspartyl aminopeptidase
chr1_-_23980345 Show fit	5.08	ENST00000484146.6	SRSF10 Ensembl NCBI GeneCards UniProt Show fit	serine and arginine rich splicing factor 10
chr16_+_15395745 Show fit	4.90	ENST00000287594.7 ENST00000396385.4 ENST00000568766.1	MPV17L Ensembl NCBI GeneCards UniProt Show fit ENSG00000261130.5 Ensembl NCBI GeneCards UniProt Show fit	MPV17 mitochondrial inner membrane protein like novel protein
chr12_+_28257195 Show fit	4.78	ENST00000381259.5	CCDC91 Ensembl NCBI GeneCards UniProt Show fit	coiled-coil domain containing 91
chr16_+_11965193 Show fit	4.60	ENST00000053243.6 ENST00000396495.3	TNFRSF17 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 17
chr15_-_19988117 Show fit	4.59	ENST00000558565.2	IGHV3OR15-7 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr6_-_36547400 Show fit	4.53	ENST00000229812.8	STK38 Ensembl NCBI GeneCards UniProt Show fit	serine/threonine kinase 38
chr1_-_53945567 Show fit	4.46	ENST00000371378.6	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 11
chr11_+_112025968 Show fit	4.41	ENST00000680411.1	DLAT Ensembl NCBI GeneCards UniProt Show fit	dihydrolipoamide S-acetyltransferase
chr15_+_64387828 Show fit	4.41	ENST00000261884.8	TRIP4 Ensembl NCBI GeneCards UniProt Show fit	thyroid hormone receptor interactor 4
chr1_-_53945584 Show fit	4.31	ENST00000371377.3	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 11
chr10_-_93482326 Show fit	4.27	ENST00000359263.9	MYOF Ensembl NCBI GeneCards UniProt Show fit	myoferlin
chr20_+_1118590 Show fit	4.23	ENST00000246015.8 ENST00000335877.11	PSMF1 Ensembl NCBI GeneCards UniProt Show fit	proteasome inhibitor subunit 1
chr10_-_93482194 Show fit	4.18	ENST00000358334.9 ENST00000371488.3	MYOF Ensembl NCBI GeneCards UniProt Show fit	myoferlin
chr7_+_55365317 Show fit	4.17	ENST00000254770.3	LANCL2 Ensembl NCBI GeneCards UniProt Show fit	LanC like 2
chr6_-_53510445 Show fit	4.15	ENST00000509541.5	GCLC Ensembl NCBI GeneCards UniProt Show fit	glutamate-cysteine ligase catalytic subunit
chr12_+_64404338 Show fit	4.10	ENST00000332707.10	XPOT Ensembl NCBI GeneCards UniProt Show fit	exportin for tRNA
chr4_-_102827723 Show fit	4.05	ENST00000349311.12	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr2_+_90172802 Show fit	4.00	ENST00000390277.3	IGKV3D-11 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3D-11
chr20_+_58907981 Show fit	3.92	ENST00000656419.1	GNAS Ensembl NCBI GeneCards UniProt Show fit	GNAS complex locus
chr2_+_90234809 Show fit	3.89	ENST00000443397.5	IGKV3D-7 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3D-7
chr2_-_206159509 Show fit	3.84	ENST00000423725.5	NDUFS1 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase core subunit S1
chr19_+_35648286 Show fit	3.81	ENST00000649813.2	COX6B1 Ensembl NCBI GeneCards UniProt Show fit	cytochrome c oxidase subunit 6B1
chr2_-_206159194 Show fit	3.76	ENST00000455934.6 ENST00000449699.5 ENST00000454195.1	NDUFS1 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase core subunit S1
chr4_+_70993542 Show fit	3.67	ENST00000504730.5 ENST00000504952.1 ENST00000286648.10	DCK Ensembl NCBI GeneCards UniProt Show fit	deoxycytidine kinase
chr3_+_138621225 Show fit	3.59	ENST00000479848.1	FAIM Ensembl NCBI GeneCards UniProt Show fit	Fas apoptotic inhibitory molecule
chr14_-_106470788 Show fit	3.52	ENST00000434710.1	IGHV3-43 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 3-43
chr14_-_106593319 Show fit	3.46	ENST00000390627.3	IGHV3-53 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 3-53
chr19_-_17405554 Show fit	3.42	ENST00000252593.7	BST2 Ensembl NCBI GeneCards UniProt Show fit	bone marrow stromal cell antigen 2
chr11_+_35180279 Show fit	3.30	ENST00000531873.5	CD44 Ensembl NCBI GeneCards UniProt Show fit	CD44 molecule (Indian blood group)
chr11_+_57712574 Show fit	3.24	ENST00000278422.9 ENST00000378312.8	TMX2 Ensembl NCBI GeneCards UniProt Show fit	thioredoxin related transmembrane protein 2
chr11_-_63608542 Show fit	3.13	ENST00000540943.1	PLAAT3 Ensembl NCBI GeneCards UniProt Show fit	phospholipase A and acyltransferase 3
chr2_-_206159410 Show fit	3.08	ENST00000457011.5 ENST00000440274.5 ENST00000432169.5 ENST00000233190.11	NDUFS1 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase core subunit S1
chr6_-_7313146 Show fit	2.91	ENST00000489567.5 ENST00000479365.5 ENST00000462112.1 ENST00000397511.6 ENST00000244763.9 ENST00000474597.5 ENST00000650389.1	SSR1 Ensembl NCBI GeneCards UniProt Show fit	signal sequence receptor subunit 1
chr3_-_142000353 Show fit	2.87	ENST00000499676.5	TFDP2 Ensembl NCBI GeneCards UniProt Show fit	transcription factor Dp-2
chr17_-_7263959 Show fit	2.80	ENST00000571932.2	CLDN7 Ensembl NCBI GeneCards UniProt Show fit	claudin 7
chr20_-_35147285 Show fit	2.78	ENST00000374491.3 ENST00000374492.8	EDEM2 Ensembl NCBI GeneCards UniProt Show fit	ER degradation enhancing alpha-mannosidase like protein 2
chr2_+_87338511 Show fit	2.78	ENST00000421835.2	IGKV3OR2-268 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr3_+_138621207 Show fit	2.74	ENST00000464668.5	FAIM Ensembl NCBI GeneCards UniProt Show fit	Fas apoptotic inhibitory molecule
chr10_+_69269984 Show fit	2.67	ENST00000436817.6 ENST00000450646.6 ENST00000360289.6 ENST00000448642.6 ENST00000464803.6	HK1 Ensembl NCBI GeneCards UniProt Show fit	hexokinase 1
chr1_+_81306096 Show fit	2.67	ENST00000370721.5 ENST00000370727.5 ENST00000370725.5 ENST00000370723.5 ENST00000370728.5 ENST00000370730.5	ADGRL2 Ensembl NCBI GeneCards UniProt Show fit	adhesion G protein-coupled receptor L2
chr4_-_102827948 Show fit	2.57	ENST00000394804.6 ENST00000394801.8	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr4_-_102828159 Show fit	2.54	ENST00000394803.9	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr1_+_38012706 Show fit	2.54	ENST00000373014.5	UTP11 Ensembl NCBI GeneCards UniProt Show fit	UTP11 small subunit processome component
chr1_+_207325629 Show fit	2.44	ENST00000618707.2	CD55 Ensembl NCBI GeneCards UniProt Show fit	CD55 molecule (Cromer blood group)
chr2_+_90038848 Show fit	2.36	ENST00000390270.2	IGKV3D-20 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3D-20
chr11_-_95910824 Show fit	2.28	ENST00000674528.1 ENST00000675477.1 ENST00000675636.1	MTMR2 Ensembl NCBI GeneCards UniProt Show fit	myotubularin related protein 2
chr16_-_28623560 Show fit	2.27	ENST00000350842.8	SULT1A1 Ensembl NCBI GeneCards UniProt Show fit	sulfotransferase family 1A member 1
chr11_-_95910665 Show fit	2.26	ENST00000674610.1 ENST00000675660.1	MTMR2 Ensembl NCBI GeneCards UniProt Show fit	myotubularin related protein 2
chr14_-_67412112 Show fit	2.25	ENST00000216446.9	PLEK2 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin 2
chr7_+_107583919 Show fit	2.24	ENST00000491150.5	BCAP29 Ensembl NCBI GeneCards UniProt Show fit	B cell receptor associated protein 29
chr11_-_95910748 Show fit	2.20	ENST00000675933.1	MTMR2 Ensembl NCBI GeneCards UniProt Show fit	myotubularin related protein 2
chr13_+_48037692 Show fit	2.18	ENST00000258662.3	NUDT15 Ensembl NCBI GeneCards UniProt Show fit	nudix hydrolase 15
chr10_-_104085847 Show fit	2.17	ENST00000648076.2	COL17A1 Ensembl NCBI GeneCards UniProt Show fit	collagen type XVII alpha 1 chain
chr12_-_122500520 Show fit	2.15	ENST00000540586.1 ENST00000543897.5	ZCCHC8 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCHC-type containing 8
chr10_+_68901258 Show fit	2.13	ENST00000373585.8	DDX50 Ensembl NCBI GeneCards UniProt Show fit	DExD-box helicase 50
chr6_+_158312459 Show fit	2.10	ENST00000367097.8	TULP4 Ensembl NCBI GeneCards UniProt Show fit	TUB like protein 4
chr2_-_88979016 Show fit	2.03	ENST00000390247.2	IGKV3-7 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3-7 (non-functional)
chr11_-_62556230 Show fit	2.00	ENST00000530285.5	AHNAK Ensembl NCBI GeneCards UniProt Show fit	AHNAK nucleoprotein
chr6_+_26183750 Show fit	1.97	ENST00000614097.3	H2BC6 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 6
chr3_+_148991408 Show fit	1.85	ENST00000627418.2 ENST00000296048.10 ENST00000483267.5 ENST00000345003.9 ENST00000484197.5	GYG1 Ensembl NCBI GeneCards UniProt Show fit	glycogenin 1
chr8_+_106726012 Show fit	1.82	ENST00000449762.6 ENST00000297447.10	OXR1 Ensembl NCBI GeneCards UniProt Show fit	oxidation resistance 1
chr12_-_86256299 Show fit	1.71	ENST00000552808.6 ENST00000547225.5	MGAT4C Ensembl NCBI GeneCards UniProt Show fit	MGAT4 family member C
chr3_+_184135343 Show fit	1.61	ENST00000648915.2 ENST00000432569.2 ENST00000647909.1	EIF2B5 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 2B subunit epsilon
chr12_+_26195647 Show fit	1.59	ENST00000535504.1	SSPN Ensembl NCBI GeneCards UniProt Show fit	sarcospan
chr12_-_118359639 Show fit	1.57	ENST00000541786.5 ENST00000419821.6 ENST00000541878.5	TAOK3 Ensembl NCBI GeneCards UniProt Show fit	TAO kinase 3
chrX_+_109535775 Show fit	1.55	ENST00000218004.5	NXT2 Ensembl NCBI GeneCards UniProt Show fit	nuclear transport factor 2 like export factor 2
chr5_+_177384430 Show fit	1.55	ENST00000512593.5 ENST00000324417.6	SLC34A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 34 member 1
chr22_-_32255344 Show fit	1.53	ENST00000266086.6	SLC5A4 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 5 member 4
chr8_+_23288081 Show fit	1.50	ENST00000265806.12 ENST00000519952.6 ENST00000518840.6	R3HCC1 Ensembl NCBI GeneCards UniProt Show fit	R3H domain and coiled-coil containing 1
chr16_-_28597042 Show fit	1.49	ENST00000533150.5 ENST00000335715.9	SULT1A2 Ensembl NCBI GeneCards UniProt Show fit	sulfotransferase family 1A member 2
chr15_+_78873723 Show fit	1.47	ENST00000559690.5 ENST00000559158.5	MORF4L1 Ensembl NCBI GeneCards UniProt Show fit	mortality factor 4 like 1
chr2_-_55296361 Show fit	1.46	ENST00000647547.1	CCDC88A Ensembl NCBI GeneCards UniProt Show fit	coiled-coil domain containing 88A
chr6_+_110180116 Show fit	1.40	ENST00000368932.5	CDC40 Ensembl NCBI GeneCards UniProt Show fit	cell division cycle 40
chr7_+_120988683 Show fit	1.39	ENST00000340646.9 ENST00000310396.10	CPED1 Ensembl NCBI GeneCards UniProt Show fit	cadherin like and PC-esterase domain containing 1
chrX_+_115593570 Show fit	1.38	ENST00000539310.5	PLS3 Ensembl NCBI GeneCards UniProt Show fit	plastin 3
chr1_+_186296267 Show fit	1.36	ENST00000533951.5 ENST00000367482.8 ENST00000635041.1 ENST00000367483.8 ENST00000367485.4 ENST00000445192.7	PRG4 Ensembl NCBI GeneCards UniProt Show fit	proteoglycan 4
chr7_+_138460238 Show fit	1.34	ENST00000343526.9	TRIM24 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 24
chr1_+_27935110 Show fit	1.33	ENST00000549094.1	SMPDL3B Ensembl NCBI GeneCards UniProt Show fit	sphingomyelin phosphodiesterase acid like 3B
chr6_-_31862809 Show fit	1.32	ENST00000375631.5	NEU1 Ensembl NCBI GeneCards UniProt Show fit	neuraminidase 1
chr4_-_65670478 Show fit	1.26	ENST00000613740.5 ENST00000622150.4 ENST00000511294.1	EPHA5 Ensembl NCBI GeneCards UniProt Show fit	EPH receptor A5
chr2_+_206159580 Show fit	1.24	ENST00000236957.9 ENST00000392221.5 ENST00000445505.5	EEF1B2 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation elongation factor 1 beta 2
chr2_+_11542662 Show fit	1.18	ENST00000389825.7 ENST00000381483.6	GREB1 Ensembl NCBI GeneCards UniProt Show fit	growth regulating estrogen receptor binding 1
chr7_-_22822829 Show fit	1.17	ENST00000358435.9 ENST00000621567.1	TOMM7 Ensembl NCBI GeneCards UniProt Show fit	translocase of outer mitochondrial membrane 7
chr1_-_23980278 Show fit	1.14	ENST00000374453.7 ENST00000453840.7	SRSF10 Ensembl NCBI GeneCards UniProt Show fit	serine and arginine rich splicing factor 10
chr3_-_165078480 Show fit	1.13	ENST00000264382.8	SI Ensembl NCBI GeneCards UniProt Show fit	sucrase-isomaltase
chr2_+_68734773 Show fit	1.11	ENST00000409202.8	ARHGAP25 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 25
chr4_-_65670339 Show fit	1.11	ENST00000273854.7	EPHA5 Ensembl NCBI GeneCards UniProt Show fit	EPH receptor A5
chr1_-_113871665 Show fit	1.11	ENST00000528414.5 ENST00000460620.5 ENST00000359785.10 ENST00000420377.6 ENST00000525799.1 ENST00000538253.5	PTPN22 Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase non-receptor type 22
chr9_-_112332962 Show fit	1.10	ENST00000458258.5 ENST00000210227.4	PTBP3 Ensembl NCBI GeneCards UniProt Show fit	polypyrimidine tract binding protein 3
chr7_-_22822779 Show fit	1.10	ENST00000372879.8	TOMM7 Ensembl NCBI GeneCards UniProt Show fit	translocase of outer mitochondrial membrane 7
chr11_+_72189659 Show fit	1.04	ENST00000393681.6	FOLR1 Ensembl NCBI GeneCards UniProt Show fit	folate receptor alpha
chr17_-_66229380 Show fit	1.04	ENST00000205948.11	APOH Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein H
chr2_+_206159884 Show fit	1.03	ENST00000392222.7	EEF1B2 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation elongation factor 1 beta 2
chr12_+_15546344 Show fit	1.01	ENST00000674388.1 ENST00000542557.5 ENST00000445537.6 ENST00000544244.5 ENST00000442921.7	PTPRO Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase receptor type O
chr15_+_58431985 Show fit	1.00	ENST00000433326.2 ENST00000299022.10	LIPC Ensembl NCBI GeneCards UniProt Show fit	lipase C, hepatic type
chr1_+_28438104 Show fit	0.99	ENST00000633167.1 ENST00000373836.4	PHACTR4 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 4
chr1_+_27934980 Show fit	0.99	ENST00000373894.8	SMPDL3B Ensembl NCBI GeneCards UniProt Show fit	sphingomyelin phosphodiesterase acid like 3B
chr1_-_23980308 Show fit	0.98	ENST00000374452.9 ENST00000492112.3 ENST00000343255.9 ENST00000344989.10	SRSF10 Ensembl NCBI GeneCards UniProt Show fit	serine and arginine rich splicing factor 10
chr16_-_28623330 Show fit	0.97	ENST00000677940.1	ENSG00000288656.1 Ensembl NCBI GeneCards UniProt Show fit	novel protein
chr11_+_72189528 Show fit	0.95	ENST00000312293.9	FOLR1 Ensembl NCBI GeneCards UniProt Show fit	folate receptor alpha
chr4_+_26343156 Show fit	0.94	ENST00000680928.1 ENST00000681260.1	RBPJ Ensembl NCBI GeneCards UniProt Show fit	recombination signal binding protein for immunoglobulin kappa J region
chr11_-_102843597 Show fit	0.88	ENST00000299855.10	MMP3 Ensembl NCBI GeneCards UniProt Show fit	matrix metallopeptidase 3
chrX_+_136536099 Show fit	0.85	ENST00000440515.5 ENST00000456412.1	VGLL1 Ensembl NCBI GeneCards UniProt Show fit	vestigial like family member 1
chr1_-_248277976 Show fit	0.84	ENST00000641220.1	OR2T33 Ensembl NCBI GeneCards UniProt Show fit	olfactory receptor family 2 subfamily T member 33
chr20_+_45416551 Show fit	0.80	ENST00000639292.1	PIGT Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis class T
chr14_-_50561119 Show fit	0.80	ENST00000555216.5	MAP4K5 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase kinase 5
chr6_-_127459364 Show fit	0.74	ENST00000487331.2 ENST00000483725.8	KIAA0408 Ensembl NCBI GeneCards UniProt Show fit	KIAA0408
chr12_-_86256267 Show fit	0.74	ENST00000620241.4	MGAT4C Ensembl NCBI GeneCards UniProt Show fit	MGAT4 family member C
chr5_+_141199555 Show fit	0.74	ENST00000624887.1 ENST00000354757.5	PCDHB11 Ensembl NCBI GeneCards UniProt Show fit	protocadherin beta 11
chr16_+_72054477 Show fit	0.69	ENST00000355906.10 ENST00000570083.5 ENST00000228226.12 ENST00000398131.6 ENST00000569639.5 ENST00000564499.5 ENST00000357763.8 ENST00000613898.1 ENST00000562526.5 ENST00000565574.5 ENST00000568417.6	HP Ensembl NCBI GeneCards UniProt Show fit	haptoglobin
chr3_-_151316795 Show fit	0.68	ENST00000260843.5	GPR87 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 87
chr5_-_140346596 Show fit	0.66	ENST00000230990.7	HBEGF Ensembl NCBI GeneCards UniProt Show fit	heparin binding EGF like growth factor
chr17_-_74776323 Show fit	0.63	ENST00000582870.5 ENST00000581136.5 ENST00000579218.5 ENST00000583476.5 ENST00000580301.5 ENST00000583757.5 ENST00000357814.8 ENST00000582524.5	NAT9 Ensembl NCBI GeneCards UniProt Show fit	N-acetyltransferase 9 (putative)
chr3_+_122055355 Show fit	0.56	ENST00000330540.7 ENST00000469710.5 ENST00000493101.5	CD86 Ensembl NCBI GeneCards UniProt Show fit	CD86 molecule
chr12_-_21910853 Show fit	0.55	ENST00000544039.5	ABCC9 Ensembl NCBI GeneCards UniProt Show fit	ATP binding cassette subfamily C member 9
chrX_+_85003863 Show fit	0.54	ENST00000373173.7	APOOL Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein O like
chr4_-_163613505 Show fit	0.50	ENST00000339875.9	MARCHF1 Ensembl NCBI GeneCards UniProt Show fit	membrane associated ring-CH-type finger 1
chr1_+_224183197 Show fit	0.50	ENST00000323699.9	DEGS1 Ensembl NCBI GeneCards UniProt Show fit	delta 4-desaturase, sphingolipid 1
chrX_-_152709260 Show fit	0.48	ENST00000535353.3 ENST00000638741.1 ENST00000640702.1	CSAG2 Ensembl NCBI GeneCards UniProt Show fit	CSAG family member 2
chr9_+_34652167 Show fit	0.42	ENST00000441545.7 ENST00000553620.5	IL11RA Ensembl NCBI GeneCards UniProt Show fit	interleukin 11 receptor subunit alpha
chr2_+_216659600 Show fit	0.41	ENST00000456764.1	IGFBP2 Ensembl NCBI GeneCards UniProt Show fit	insulin like growth factor binding protein 2
chr9_+_87497222 Show fit	0.39	ENST00000358077.9	DAPK1 Ensembl NCBI GeneCards UniProt Show fit	death associated protein kinase 1
chr15_+_77420880 Show fit	0.38	ENST00000336216.9 ENST00000558176.1	HMG20A Ensembl NCBI GeneCards UniProt Show fit	high mobility group 20A
chr7_-_123199960 Show fit	0.37	ENST00000194130.7	SLC13A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 13 member 1
chrX_-_18672101 Show fit	0.35	ENST00000379984.4	RS1 Ensembl NCBI GeneCards UniProt Show fit	retinoschisin 1
chr1_-_205121964 Show fit	0.32	ENST00000264515.11	RBBP5 Ensembl NCBI GeneCards UniProt Show fit	RB binding protein 5, histone lysine methyltransferase complex subunit
chr16_+_31873772 Show fit	0.30	ENST00000394846.7 ENST00000300870.15	ZNF267 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 267
chr6_-_87095059 Show fit	0.21	ENST00000369582.6 ENST00000610310.3 ENST00000630630.2 ENST00000627148.3 ENST00000625577.1	CGA Ensembl NCBI GeneCards UniProt Show fit	glycoprotein hormones, alpha polypeptide
chrX_+_77910656 Show fit	0.17	ENST00000343533.9 ENST00000341514.11 ENST00000645454.1 ENST00000642651.1 ENST00000644362.1	ATP7A Ensembl NCBI GeneCards UniProt Show fit PGK1 Ensembl NCBI GeneCards UniProt Show fit	ATPase copper transporting alpha phosphoglycerate kinase 1
chr5_+_140821598 Show fit	0.16	ENST00000614258.1 ENST00000529859.2 ENST00000529619.5	PCDHA5 Ensembl NCBI GeneCards UniProt Show fit	protocadherin alpha 5
chr1_+_151762899 Show fit	0.14	ENST00000635322.1 ENST00000321531.10	OAZ3 Ensembl NCBI GeneCards UniProt Show fit	ornithine decarboxylase antizyme 3
chr6_+_154039102 Show fit	0.14	ENST00000360422.8 ENST00000330432.12	OPRM1 Ensembl NCBI GeneCards UniProt Show fit	opioid receptor mu 1
chr8_-_90082871 Show fit	0.09	ENST00000265431.7	CALB1 Ensembl NCBI GeneCards UniProt Show fit	calbindin 1
chr1_-_151459169 Show fit	0.07	ENST00000368863.6 ENST00000409503.5 ENST00000491586.5 ENST00000533351.5	POGZ Ensembl NCBI GeneCards UniProt Show fit	pogo transposable element derived with ZNF domain
chr11_-_27700447 Show fit	0.07	ENST00000356660.9	BDNF Ensembl NCBI GeneCards UniProt Show fit	brain derived neurotrophic factor
chr2_-_74392025 Show fit	0.05	ENST00000440727.1 ENST00000409240.5	DCTN1 Ensembl NCBI GeneCards UniProt Show fit	dynactin subunit 1
chr1_-_205121986 Show fit	0.03	ENST00000367164.1	RBBP5 Ensembl NCBI GeneCards UniProt Show fit	RB binding protein 5, histone lysine methyltransferase complex subunit
chr20_-_52105644 Show fit	0.03	ENST00000371523.8	ZFP64 Ensembl NCBI GeneCards UniProt Show fit	ZFP64 zinc finger protein
chr20_+_9514562 Show fit	0.02	ENST00000246070.3	LAMP5 Ensembl NCBI GeneCards UniProt Show fit	lysosomal associated membrane protein family member 5
chr8_+_49911604 Show fit	0.02	ENST00000642164.1 ENST00000644093.1 ENST00000643999.1 ENST00000647073.1 ENST00000646880.1	SNTG1 Ensembl NCBI GeneCards UniProt Show fit	syntrophin gamma 1
chr1_+_27935022 Show fit	0.02	ENST00000411604.5 ENST00000373888.8	SMPDL3B Ensembl NCBI GeneCards UniProt Show fit	sphingomyelin phosphodiesterase acid like 3B
chr12_+_26011713 Show fit	0.02	ENST00000542004.5	RASSF8 Ensembl NCBI GeneCards UniProt Show fit	Ras association domain family member 8
chr8_-_85341705 Show fit	0.01	ENST00000517618.5	CA1 Ensembl NCBI GeneCards UniProt Show fit	carbonic anhydrase 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.2	20.8	GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
3.0	20.8	GO:0097577	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
1.9	5.6	GO:0000454	snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
1.6	4.9	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
1.4	4.2	GO:1901421	positive regulation of response to alcohol(GO:1901421)
1.4	4.1	GO:1904387	response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
1.1	3.4	GO:1901253	negative regulation of intracellular transport of viral material(GO:1901253)
1.0	15.5	GO:0070986	left/right axis specification(GO:0070986)
1.0	17.7	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.9	2.8	GO:0036510	trimming of terminal mannose on C branch(GO:0036510)
0.9	7.4	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)
0.9	7.2	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.7	5.4	GO:0009597	detection of virus(GO:0009597)
0.7	2.0	GO:0061713	neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
0.6	6.7	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.6	7.4	GO:0019388	galactose catabolic process(GO:0019388)
0.6	8.4	GO:0001778	plasma membrane repair(GO:0001778)
0.6	7.2	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5	10.6	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5	24.8	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.5	1.5	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.5	5.3	GO:0048194	Golgi vesicle budding(GO:0048194)
0.4	2.2	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.4	2.4	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.4	4.8	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.3	1.0	GO:0061386	closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3	2.2	GO:0006203	dGTP catabolic process(GO:0006203)
0.3	1.3	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.3	2.7	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
0.3	3.3	GO:1900625	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3	1.0	GO:0036058	filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.3	2.3	GO:0045040	protein import into mitochondrial outer membrane(GO:0045040)
0.2	4.4	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2	3.9	GO:0040032	post-embryonic body morphogenesis(GO:0040032)
0.2	1.5	GO:1903566	positive regulation of protein localization to cilium(GO:1903566)
0.2	0.7	GO:2000296	negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.2	12.5	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2	1.1	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.2	0.9	GO:0010727	negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.2	16.1	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.2	2.3	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.2	0.8	GO:0051541	elastin metabolic process(GO:0051541)
0.2	18.8	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.2	8.8	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.2	3.7	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process(GO:0009157)
0.2	0.6	GO:0032681	negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.2	1.6	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.2	3.8	GO:0006068	ethanol catabolic process(GO:0006068)
0.2	1.1	GO:0044245	polysaccharide digestion(GO:0044245)
0.2	10.7	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1	1.2	GO:0006689	ganglioside catabolic process(GO:0006689)
0.1	6.4	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.1	19.8	GO:0006958	complement activation, classical pathway(GO:0006958)
0.1	0.9	GO:1901297	arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1	9.6	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.1	2.8	GO:0032463	negative regulation of protein homooligomerization(GO:0032463)
0.1	1.0	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.1	0.8	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.1	2.4	GO:0032793	positive regulation of CREB transcription factor activity(GO:0032793)
0.1	1.8	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1	4.1	GO:0006409	tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1	12.7	GO:0002377	immunoglobulin production(GO:0002377)
0.1	2.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	4.5	GO:0043407	negative regulation of MAP kinase activity(GO:0043407)
0.1	4.4	GO:0045661	regulation of myoblast differentiation(GO:0045661)
0.1	1.4	GO:0051639	actin filament network formation(GO:0051639)
0.1	1.5	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	1.5	GO:1904659	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0	0.5	GO:0042407	cristae formation(GO:0042407)
0.0	1.9	GO:0000272	polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0	2.1	GO:0061512	protein localization to cilium(GO:0061512)
0.0	0.1	GO:0015847	putrescine transport(GO:0015847)
0.0	0.4	GO:1902358	sulfate transmembrane transport(GO:1902358)
0.0	0.6	GO:0034372	very-low-density lipoprotein particle remodeling(GO:0034372)
0.0	0.7	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	3.2	GO:0045454	cell redox homeostasis(GO:0045454)
0.0	2.1	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.0	2.5	GO:0042274	ribosomal small subunit biogenesis(GO:0042274)
0.0	2.3	GO:0006414	translational elongation(GO:0006414)
0.0	0.8	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	2.6	GO:0036498	IRE1-mediated unfolded protein response(GO:0036498)
0.0	0.1	GO:0031550	positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.0	0.4	GO:0009642	response to light intensity(GO:0009642)
0.0	0.4	GO:0033234	negative regulation of protein sumoylation(GO:0033234)
0.0	0.4	GO:0010226	response to lithium ion(GO:0010226)
0.0	0.7	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	2.3	GO:0051028	mRNA transport(GO:0051028)
0.0	0.1	GO:0035502	metanephric part of ureteric bud development(GO:0035502)
0.0	9.4	GO:0006396	RNA processing(GO:0006396)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.0	20.8	GO:0044326	dendritic spine neck(GO:0044326)
2.3	20.8	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
2.1	10.7	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
1.4	4.1	GO:0017109	glutamate-cysteine ligase complex(GO:0017109)
0.8	5.6	GO:0072589	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.7	4.4	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.7	15.5	GO:0030992	intraciliary transport particle B(GO:0030992)
0.6	17.7	GO:0005680	anaphase-promoting complex(GO:0005680)
0.5	14.6	GO:0005838	proteasome regulatory particle(GO:0005838)
0.4	6.8	GO:0045277	respiratory chain complex IV(GO:0045277)
0.3	3.3	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.3	2.3	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.3	1.3	GO:0005726	perichromatin fibrils(GO:0005726)
0.3	7.3	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2	8.8	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2	2.3	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2	1.6	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2	0.8	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.2	0.7	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	7.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	4.2	GO:0005839	proteasome core complex(GO:0005839)
0.1	0.9	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	2.2	GO:0030056	hemidesmosome(GO:0030056)
0.1	2.8	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	0.5	GO:0061617	MICOS complex(GO:0061617)
0.1	2.7	GO:0097228	sperm principal piece(GO:0097228)
0.1	2.8	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	2.0	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	0.5	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	5.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	2.5	GO:0032040	small-subunit processome(GO:0032040)
0.1	1.5	GO:0016580	Sin3 complex(GO:0016580)
0.1	12.3	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.1	2.2	GO:0031258	lamellipodium membrane(GO:0031258)
0.1	8.2	GO:0031225	anchored component of membrane(GO:0031225)
0.1	3.9	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	6.4	GO:0005901	caveola(GO:0005901)
0.1	5.3	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.1	4.9	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1	1.0	GO:0031089	platelet dense granule lumen(GO:0031089)
0.1	1.5	GO:0035145	exon-exon junction complex(GO:0035145)
0.1	8.5	GO:0072562	blood microparticle(GO:0072562)
0.0	4.4	GO:0031594	neuromuscular junction(GO:0031594)
0.0	21.6	GO:0010008	endosome membrane(GO:0010008)
0.0	5.0	GO:0005802	trans-Golgi network(GO:0005802)
0.0	3.8	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	4.1	GO:0005643	nuclear pore(GO:0005643)
0.0	0.3	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.7	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0	3.8	GO:0005923	bicellular tight junction(GO:0005923)
0.0	2.4	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	2.9	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.6	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	1.0	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	6.1	GO:0016607	nuclear speck(GO:0016607)
0.0	1.5	GO:0036064	ciliary basal body(GO:0036064)
0.0	12.7	GO:0005730	nucleolus(GO:0005730)
0.0	0.5	GO:0043034	costamere(GO:0043034)
0.0	1.4	GO:0032432	actin filament bundle(GO:0032432)
0.0	8.2	GO:0030529	intracellular ribonucleoprotein complex(GO:0030529)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.5	20.8	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
2.5	7.4	GO:0003978	UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
1.4	4.1	GO:0004357	glutamate-cysteine ligase activity(GO:0004357)
1.1	4.4	GO:0016418	S-acetyltransferase activity(GO:0016418)
0.9	7.2	GO:0050733	RS domain binding(GO:0050733)
0.8	5.6	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.7	2.2	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.7	2.7	GO:0016524	latrotoxin receptor activity(GO:0016524)
0.6	3.8	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.6	1.9	GO:0008466	glycogenin glucosyltransferase activity(GO:0008466)
0.6	8.8	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5	24.8	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.5	3.7	GO:0004137	deoxycytidine kinase activity(GO:0004137)
0.5	20.8	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5	10.7	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.5	2.0	GO:0061714	folic acid receptor activity(GO:0061714)
0.5	5.4	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.5	7.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.4	9.8	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.4	1.3	GO:0052794	exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.4	1.5	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.4	10.6	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3	2.4	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.3	2.8	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3	2.7	GO:0008865	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3	1.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.3	2.3	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.3	5.6	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2	4.5	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2	1.1	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.2	5.1	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.2	0.8	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.2	2.4	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.2	2.3	GO:0015266	protein channel activity(GO:0015266)
0.2	1.5	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.2	5.7	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.2	3.9	GO:0051429	corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2	4.2	GO:0070628	proteasome binding(GO:0070628)
0.2	3.4	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.1	7.4	GO:0004385	guanylate kinase activity(GO:0004385)
0.1	0.5	GO:0008281	sulfonylurea receptor activity(GO:0008281)
0.1	7.8	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	2.3	GO:0003746	translation elongation factor activity(GO:0003746)
0.1	2.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1	1.4	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1	4.1	GO:0000049	tRNA binding(GO:0000049)
0.1	2.0	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.1	1.0	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.1	18.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	13.4	GO:0003823	antigen binding(GO:0003823)
0.1	1.5	GO:0043422	protein kinase B binding(GO:0043422)
0.1	0.9	GO:0000150	recombinase activity(GO:0000150)
0.1	0.2	GO:0043682	copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.0	0.1	GO:0015489	polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
0.0	0.4	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0	0.8	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.4	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.7	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	1.6	GO:0031369	translation initiation factor binding(GO:0031369)
0.0	1.0	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	2.1	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	3.2	GO:0005518	collagen binding(GO:0005518)
0.0	0.6	GO:0004806	triglyceride lipase activity(GO:0004806) low-density lipoprotein particle binding(GO:0030169) apolipoprotein binding(GO:0034185)
0.0	0.3	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
0.0	12.7	GO:0003712	transcription cofactor activity(GO:0003712)
0.0	7.2	GO:0045296	cadherin binding(GO:0045296)
0.0	0.7	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	1.1	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	5.2	GO:0016887	ATPase activity(GO:0016887)
0.0	0.6	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.0	0.6	GO:0015026	coreceptor activity(GO:0015026)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	26.6	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	3.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	8.9	PID E2F PATHWAY	E2F transcription factor network
0.1	2.4	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	8.4	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	2.2	NABA COLLAGENS	Genes encoding collagen proteins
0.0	2.4	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	2.7	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	3.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.0	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	1.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.9	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	0.8	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.2	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	26.6	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.4	6.7	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.3	6.9	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	18.8	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.3	4.4	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	21.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.2	2.8	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.2	3.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.2	3.7	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	26.4	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1	3.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.1	4.1	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	3.9	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1	2.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	2.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	1.1	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.1	2.8	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	1.9	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	3.9	REACTOME TRANSLATION	Genes involved in Translation
0.1	2.7	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.1	0.9	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	2.3	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	1.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	2.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.6	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.8	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0	1.2	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.4	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.9	REACTOME EXTRACELLULAR MATRIX ORGANIZATION	Genes involved in Extracellular matrix organization
0.0	0.8	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.0	0.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.7	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.5	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.5	REACTOME SPHINGOLIPID METABOLISM	Genes involved in Sphingolipid metabolism
0.0	0.2	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)

Results for ALX3

Z-value: 3.04

Motif logo

Transcription factors associated with ALX3

Activity-expression correlation:

Activity profile of ALX3 motif

Sorted Z-values of ALX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX3

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: