Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ATF2_ATF1_ATF3
Z-value: 12.82
Motif logo
Transcription factors associated with ATF2_ATF1_ATF3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ATF2
|
ENSG00000115966.17 | ATF2 |
|
ATF1
|
ENSG00000123268.9 | ATF1 |
|
ATF3
|
ENSG00000162772.17 | ATF3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF1 | hg38_v1_chr12_+_50764054_50764115 | 0.78 | 1.1e-46 | Click! |
| ATF2 | hg38_v1_chr2_-_175168159_175168213 | 0.35 | 1.5e-07 | Click! |
| ATF3 | hg38_v1_chr1_+_212608628_212608915, hg38_v1_chr1_+_212565334_212565414 | -0.02 | 7.3e-01 | Click! |
Activity profile of ATF2_ATF1_ATF3 motif
Sorted Z-values of ATF2_ATF1_ATF3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 25.5 | 76.6 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
| 21.0 | 41.9 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 20.1 | 60.2 | GO:2000687 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 18.5 | 55.5 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
| 18.4 | 55.1 | GO:1902269 | positive regulation of polyamine transmembrane transport(GO:1902269) |
| 18.2 | 54.7 | GO:1903778 | positive regulation of histamine secretion by mast cell(GO:1903595) protein localization to vacuolar membrane(GO:1903778) |
| 18.2 | 54.7 | GO:0072334 | UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334) |
| 16.7 | 50.0 | GO:1903722 | regulation of centriole elongation(GO:1903722) |
| 16.3 | 49.0 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 14.6 | 87.8 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 14.1 | 42.2 | GO:0071373 | cellular response to luteinizing hormone stimulus(GO:0071373) |
| 14.1 | 42.2 | GO:1902568 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 13.7 | 41.0 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 13.0 | 52.1 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
| 12.9 | 90.2 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 12.0 | 47.9 | GO:0006288 | base-excision repair, DNA ligation(GO:0006288) |
| 11.3 | 33.8 | GO:1990519 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 11.1 | 33.3 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 11.0 | 120.7 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 10.2 | 30.6 | GO:0051177 | meiotic sister chromatid cohesion(GO:0051177) |
| 9.9 | 59.2 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 9.7 | 29.1 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
| 9.6 | 28.7 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 9.4 | 37.7 | GO:2000653 | regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) regulation of genetic imprinting(GO:2000653) |
| 9.3 | 28.0 | GO:0044034 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) |
| 8.9 | 26.7 | GO:0060382 | regulation of DNA strand elongation(GO:0060382) |
| 8.5 | 25.4 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 8.3 | 66.1 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 8.0 | 56.2 | GO:0045653 | histone H4-R3 methylation(GO:0043985) negative regulation of megakaryocyte differentiation(GO:0045653) |
| 7.5 | 52.7 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 7.5 | 52.4 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 7.3 | 21.9 | GO:0009183 | purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183) |
| 7.2 | 21.7 | GO:0002188 | translation reinitiation(GO:0002188) |
| 7.2 | 21.6 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 6.9 | 27.7 | GO:0046833 | snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833) |
| 6.9 | 6.9 | GO:0009838 | abscission(GO:0009838) |
| 6.7 | 26.8 | GO:0044837 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 6.6 | 33.0 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 6.6 | 26.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 6.5 | 19.5 | GO:1902990 | mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
| 6.5 | 19.4 | GO:0036245 | cellular response to menadione(GO:0036245) |
| 6.4 | 38.2 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 6.3 | 25.2 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 6.2 | 43.7 | GO:0060702 | negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) |
| 6.1 | 79.6 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 6.0 | 24.2 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 6.0 | 18.0 | GO:0022007 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 5.9 | 29.6 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 5.9 | 17.7 | GO:0070512 | regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512) |
| 5.9 | 17.7 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 5.7 | 17.0 | GO:0034148 | negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) |
| 5.7 | 22.6 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 5.6 | 122.4 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 5.5 | 21.9 | GO:0000451 | rRNA 2'-O-methylation(GO:0000451) |
| 5.3 | 21.2 | GO:0002905 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 5.3 | 15.8 | GO:1901389 | regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389) |
| 5.2 | 41.8 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 5.1 | 35.9 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 5.1 | 30.4 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 5.0 | 35.3 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
| 5.0 | 60.1 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 5.0 | 14.9 | GO:0000472 | endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471) |
| 4.9 | 34.0 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 4.8 | 85.6 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 4.5 | 13.4 | GO:0060903 | regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of meiosis I(GO:0060903) |
| 4.5 | 8.9 | GO:0034136 | negative regulation of toll-like receptor 2 signaling pathway(GO:0034136) negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) |
| 4.4 | 57.8 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 4.4 | 13.3 | GO:0009386 | translational attenuation(GO:0009386) |
| 4.2 | 12.5 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 4.2 | 12.5 | GO:1901491 | axial mesoderm morphogenesis(GO:0048319) negative regulation of lymphangiogenesis(GO:1901491) |
| 4.1 | 28.8 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 4.1 | 12.2 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 4.1 | 12.2 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 4.0 | 60.3 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 3.9 | 38.8 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 3.9 | 11.6 | GO:0018160 | peptidyl-pyrromethane cofactor linkage(GO:0018160) |
| 3.8 | 23.0 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 3.8 | 26.5 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 3.8 | 15.1 | GO:0097501 | stress response to metal ion(GO:0097501) regulation of ATF6-mediated unfolded protein response(GO:1903891) |
| 3.7 | 22.4 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 3.7 | 63.1 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 3.7 | 11.1 | GO:1902728 | negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 3.7 | 11.1 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 3.7 | 36.8 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 3.7 | 14.6 | GO:0003290 | atrial septum secundum morphogenesis(GO:0003290) |
| 3.6 | 36.4 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 3.6 | 28.9 | GO:0006561 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 3.6 | 10.8 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 3.6 | 14.4 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 3.6 | 25.2 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 3.6 | 21.4 | GO:0046100 | hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) |
| 3.6 | 32.1 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 3.5 | 3.5 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 3.5 | 17.5 | GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) |
| 3.5 | 34.9 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 3.5 | 24.2 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 3.4 | 13.6 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 3.4 | 13.5 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 3.3 | 40.2 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 3.3 | 49.5 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 3.2 | 25.9 | GO:0010835 | regulation of protein ADP-ribosylation(GO:0010835) |
| 3.2 | 12.9 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 3.2 | 38.0 | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237) |
| 3.2 | 15.8 | GO:1900264 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 3.1 | 28.0 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 3.1 | 9.2 | GO:0006781 | succinyl-CoA pathway(GO:0006781) |
| 3.0 | 12.1 | GO:2000254 | regulation of male germ cell proliferation(GO:2000254) negative regulation of male germ cell proliferation(GO:2000255) |
| 3.0 | 12.1 | GO:1904925 | positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925) |
| 3.0 | 24.1 | GO:0014916 | regulation of lung blood pressure(GO:0014916) |
| 3.0 | 21.0 | GO:0097680 | cellular hyperosmotic salinity response(GO:0071475) double-strand break repair via classical nonhomologous end joining(GO:0097680) |
| 3.0 | 9.0 | GO:0038043 | interleukin-5-mediated signaling pathway(GO:0038043) interleukin-3-mediated signaling pathway(GO:0038156) |
| 3.0 | 17.8 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 3.0 | 14.8 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 2.9 | 29.4 | GO:2000252 | negative regulation of feeding behavior(GO:2000252) |
| 2.8 | 51.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 2.8 | 8.4 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 2.8 | 16.7 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 2.7 | 83.9 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
| 2.7 | 13.5 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 2.7 | 59.0 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 2.7 | 5.3 | GO:0018963 | phthalate metabolic process(GO:0018963) |
| 2.7 | 15.9 | GO:0033489 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 2.6 | 10.5 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 2.6 | 21.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 2.6 | 10.4 | GO:0006983 | ER overload response(GO:0006983) |
| 2.6 | 7.8 | GO:0034473 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 2.6 | 10.3 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 2.6 | 28.3 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 2.5 | 10.0 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 2.5 | 54.5 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 2.5 | 12.4 | GO:0006850 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 2.5 | 7.4 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 2.5 | 14.7 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 2.4 | 29.4 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 2.4 | 17.1 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 2.4 | 7.3 | GO:1902299 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 2.4 | 43.3 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway(GO:2000052) |
| 2.4 | 4.8 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) |
| 2.4 | 9.5 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) |
| 2.3 | 9.3 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 2.3 | 37.1 | GO:0045116 | protein neddylation(GO:0045116) |
| 2.3 | 15.9 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 2.2 | 9.0 | GO:1903121 | regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 2.2 | 6.7 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 2.2 | 22.2 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 2.2 | 19.8 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 2.2 | 74.7 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 2.2 | 6.5 | GO:0030035 | microspike assembly(GO:0030035) |
| 2.2 | 6.5 | GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity(GO:0090176) |
| 2.2 | 6.5 | GO:0042822 | pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) |
| 2.2 | 15.1 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 2.2 | 28.0 | GO:0006265 | DNA topological change(GO:0006265) |
| 2.1 | 27.6 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
| 2.1 | 17.0 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 2.1 | 6.3 | GO:0098905 | regulation of bundle of His cell action potential(GO:0098905) |
| 2.1 | 27.2 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 2.1 | 6.2 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 2.0 | 12.3 | GO:0060356 | leucine import(GO:0060356) |
| 2.0 | 44.9 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 2.0 | 10.2 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 2.0 | 24.4 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
| 2.0 | 6.1 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 2.0 | 16.0 | GO:0070900 | mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 2.0 | 19.9 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 2.0 | 17.9 | GO:0046070 | dGTP metabolic process(GO:0046070) |
| 2.0 | 25.7 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 2.0 | 5.9 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) |
| 1.9 | 27.0 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 1.9 | 9.6 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 1.9 | 5.7 | GO:0043328 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) |
| 1.9 | 3.8 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 1.9 | 9.5 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 1.9 | 11.4 | GO:0000012 | single strand break repair(GO:0000012) |
| 1.9 | 5.7 | GO:1902905 | positive regulation of fibril organization(GO:1902905) |
| 1.9 | 143.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.9 | 9.4 | GO:0072719 | cellular response to cisplatin(GO:0072719) |
| 1.9 | 5.6 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 1.9 | 5.6 | GO:0006117 | acetaldehyde metabolic process(GO:0006117) |
| 1.9 | 5.6 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
| 1.8 | 14.7 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 1.8 | 16.1 | GO:2000580 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 1.8 | 154.0 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.7 | 33.2 | GO:0006743 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 1.7 | 10.3 | GO:0060154 | cellular process regulating host cell cycle in response to virus(GO:0060154) |
| 1.7 | 1.7 | GO:0036510 | trimming of terminal mannose on C branch(GO:0036510) |
| 1.7 | 5.1 | GO:1903381 | neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0036483) regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903381) negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903382) |
| 1.7 | 8.4 | GO:0061083 | regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084) |
| 1.7 | 73.7 | GO:0031648 | protein destabilization(GO:0031648) |
| 1.7 | 1.7 | GO:1903970 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
| 1.7 | 48.4 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 1.7 | 5.0 | GO:0060279 | negative regulation of B cell differentiation(GO:0045578) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 1.7 | 5.0 | GO:2000174 | pro-T cell differentiation(GO:0002572) regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 1.7 | 6.7 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 1.7 | 81.1 | GO:0006301 | postreplication repair(GO:0006301) |
| 1.6 | 6.6 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 1.6 | 1.6 | GO:0033152 | immunoglobulin V(D)J recombination(GO:0033152) |
| 1.6 | 4.8 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 1.6 | 102.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.6 | 27.0 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 1.6 | 42.9 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 1.5 | 17.0 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 1.5 | 30.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 1.5 | 50.0 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 1.5 | 7.5 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 1.5 | 25.5 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 1.5 | 4.5 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031) |
| 1.5 | 19.4 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.5 | 10.4 | GO:0080009 | mRNA methylation(GO:0080009) |
| 1.5 | 5.9 | GO:0043335 | protein unfolding(GO:0043335) |
| 1.5 | 19.1 | GO:1900378 | regulation of melanin biosynthetic process(GO:0048021) positive regulation of melanin biosynthetic process(GO:0048023) regulation of secondary metabolite biosynthetic process(GO:1900376) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
| 1.5 | 7.3 | GO:0003164 | His-Purkinje system development(GO:0003164) |
| 1.4 | 11.5 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 1.4 | 7.2 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 1.4 | 7.1 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 1.4 | 12.7 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 1.4 | 18.2 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 1.4 | 12.6 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 1.4 | 7.0 | GO:0030242 | pexophagy(GO:0030242) |
| 1.4 | 8.4 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 1.4 | 9.7 | GO:0033123 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 1.4 | 2.8 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 1.4 | 9.7 | GO:0008215 | spermine metabolic process(GO:0008215) |
| 1.4 | 74.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 1.4 | 37.2 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 1.4 | 8.2 | GO:0090116 | C-5 methylation of cytosine(GO:0090116) |
| 1.4 | 13.6 | GO:0097647 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 1.3 | 6.7 | GO:2001107 | negative regulation of establishment of T cell polarity(GO:1903904) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107) |
| 1.3 | 1.3 | GO:0000965 | mitochondrial RNA 3'-end processing(GO:0000965) |
| 1.3 | 10.6 | GO:0051026 | chiasma assembly(GO:0051026) |
| 1.3 | 41.1 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 1.3 | 35.7 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 1.3 | 22.4 | GO:0070365 | hepatocyte differentiation(GO:0070365) |
| 1.3 | 9.2 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 1.3 | 28.9 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 1.3 | 6.5 | GO:0061004 | pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) nephrogenic mesenchyme development(GO:0072076) |
| 1.3 | 7.8 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 1.3 | 17.8 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 1.3 | 8.9 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 1.3 | 3.8 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
| 1.2 | 11.1 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 1.2 | 38.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 1.2 | 10.9 | GO:0031053 | primary miRNA processing(GO:0031053) |
| 1.2 | 23.8 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 1.2 | 10.7 | GO:0044827 | modulation by host of viral genome replication(GO:0044827) positive regulation by host of viral genome replication(GO:0044829) |
| 1.2 | 15.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 1.2 | 15.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 1.2 | 27.9 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 1.2 | 38.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 1.1 | 1.1 | GO:1901859 | regulation of mitochondrial DNA replication(GO:0090296) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) |
| 1.1 | 30.7 | GO:0043928 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 1.1 | 8.9 | GO:0007068 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 1.1 | 3.3 | GO:0060298 | sarcomerogenesis(GO:0048769) positive regulation of sarcomere organization(GO:0060298) |
| 1.1 | 27.9 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 1.0 | 10.5 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 1.0 | 2.0 | GO:0036480 | neuron intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0036480) regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903376) positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 1.0 | 3.0 | GO:0009085 | lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) |
| 1.0 | 8.0 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 1.0 | 42.5 | GO:0061462 | protein localization to lysosome(GO:0061462) |
| 1.0 | 3.0 | GO:0045875 | negative regulation of sister chromatid cohesion(GO:0045875) |
| 1.0 | 3.9 | GO:1903541 | regulation of exosomal secretion(GO:1903541) |
| 1.0 | 2.0 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 1.0 | 13.6 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 1.0 | 1.0 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 1.0 | 3.8 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.9 | 4.7 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.9 | 6.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.9 | 7.4 | GO:0090261 | positive regulation of inclusion body assembly(GO:0090261) |
| 0.9 | 0.9 | GO:0042137 | sequestering of neurotransmitter(GO:0042137) |
| 0.9 | 142.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.9 | 5.4 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.9 | 12.3 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.9 | 1.7 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
| 0.9 | 4.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.9 | 3.5 | GO:0036114 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.9 | 34.6 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.9 | 14.7 | GO:0060148 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.9 | 5.2 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.9 | 1.7 | GO:0097252 | oligodendrocyte apoptotic process(GO:0097252) |
| 0.9 | 10.3 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.9 | 6.0 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.8 | 30.2 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.8 | 15.0 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.8 | 1.7 | GO:1902410 | mitotic cytokinetic process(GO:1902410) |
| 0.8 | 4.1 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.8 | 13.2 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.8 | 7.3 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.8 | 13.0 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.8 | 5.7 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.8 | 8.0 | GO:0036109 | alpha-linolenic acid metabolic process(GO:0036109) |
| 0.8 | 2.4 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.8 | 1.6 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity(GO:2000481) |
| 0.8 | 2.3 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.8 | 4.6 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.8 | 3.1 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.8 | 6.8 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.8 | 6.8 | GO:0009125 | nucleoside monophosphate catabolic process(GO:0009125) |
| 0.8 | 7.6 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.7 | 3.0 | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport(GO:0090481) |
| 0.7 | 16.5 | GO:0060972 | left/right pattern formation(GO:0060972) |
| 0.7 | 1.5 | GO:0018312 | peptidyl-serine ADP-ribosylation(GO:0018312) |
| 0.7 | 7.4 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.7 | 1.5 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.7 | 8.0 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.7 | 2.9 | GO:1904923 | regulation of mitophagy in response to mitochondrial depolarization(GO:1904923) |
| 0.7 | 8.5 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.7 | 17.7 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.7 | 0.7 | GO:1901860 | negative regulation of mitochondrial fission(GO:0090258) positive regulation of mitochondrial DNA metabolic process(GO:1901860) |
| 0.7 | 4.2 | GO:0006050 | mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051) |
| 0.7 | 6.3 | GO:0010225 | response to UV-C(GO:0010225) |
| 0.7 | 4.1 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.7 | 27.2 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.7 | 14.2 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.7 | 2.7 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.7 | 2.7 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.6 | 3.9 | GO:1901727 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) protein kinase D signaling(GO:0089700) positive regulation of histone deacetylase activity(GO:1901727) |
| 0.6 | 3.2 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 0.6 | 3.8 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.6 | 9.4 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.6 | 20.6 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.6 | 24.9 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 0.6 | 5.9 | GO:1902235 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902235) |
| 0.6 | 1.8 | GO:0032730 | positive regulation of interleukin-1 alpha production(GO:0032730) |
| 0.6 | 1.8 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 0.6 | 4.7 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.6 | 48.0 | GO:0006413 | translational initiation(GO:0006413) |
| 0.6 | 5.7 | GO:0046040 | IMP metabolic process(GO:0046040) |
| 0.6 | 6.3 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.6 | 0.6 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.6 | 6.3 | GO:0010815 | bradykinin catabolic process(GO:0010815) |
| 0.6 | 1.7 | GO:1904245 | regulation of polynucleotide adenylyltransferase activity(GO:1904245) positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 0.6 | 4.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.6 | 8.4 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.6 | 15.5 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.6 | 2.8 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.5 | 3.3 | GO:0097460 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.5 | 17.2 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.5 | 1.6 | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of antigen processing and presentation of peptide antigen(GO:0002584) |
| 0.5 | 3.2 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) |
| 0.5 | 4.8 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.5 | 12.7 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.5 | 9.0 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.5 | 5.6 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.5 | 5.1 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.5 | 7.1 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.5 | 3.0 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.5 | 3.5 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.5 | 1.0 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.5 | 5.5 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.5 | 7.4 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.5 | 0.5 | GO:0072367 | regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) |
| 0.5 | 9.1 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.5 | 3.3 | GO:0045955 | negative regulation of calcium ion-dependent exocytosis(GO:0045955) |
| 0.5 | 55.0 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 0.5 | 5.7 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.5 | 127.3 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.5 | 25.5 | GO:0034644 | cellular response to UV(GO:0034644) |
| 0.5 | 3.2 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.5 | 1.4 | GO:0032621 | interleukin-18 production(GO:0032621) |
| 0.4 | 24.4 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.4 | 5.3 | GO:0061684 | chaperone-mediated autophagy(GO:0061684) regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.4 | 1.3 | GO:0021593 | rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658) |
| 0.4 | 11.0 | GO:0007567 | parturition(GO:0007567) |
| 0.4 | 6.4 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.4 | 1.3 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.4 | 18.1 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.4 | 75.4 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 0.4 | 5.4 | GO:0060122 | inner ear receptor stereocilium organization(GO:0060122) |
| 0.4 | 1.2 | GO:0031456 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.4 | 13.2 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 0.4 | 8.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.4 | 2.6 | GO:0003096 | renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294) |
| 0.4 | 10.0 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.4 | 2.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.4 | 24.2 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.4 | 3.2 | GO:0098779 | mitophagy in response to mitochondrial depolarization(GO:0098779) |
| 0.4 | 2.8 | GO:0001878 | response to yeast(GO:0001878) |
| 0.3 | 15.2 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation(GO:0033137) |
| 0.3 | 16.2 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.3 | 0.3 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.3 | 4.6 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.3 | 5.2 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.3 | 2.3 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.3 | 25.9 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.3 | 9.6 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.3 | 8.3 | GO:0042026 | protein refolding(GO:0042026) |
| 0.3 | 7.2 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.3 | 6.6 | GO:0030728 | ovulation(GO:0030728) |
| 0.3 | 14.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.3 | 3.0 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.3 | 1.5 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.3 | 4.4 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.3 | 2.9 | GO:0032026 | response to magnesium ion(GO:0032026) |
| 0.3 | 1.5 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.3 | 4.4 | GO:0009595 | detection of biotic stimulus(GO:0009595) |
| 0.3 | 2.9 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.3 | 0.3 | GO:0061366 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.3 | 3.1 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.3 | 2.3 | GO:0086028 | bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) |
| 0.3 | 2.3 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
| 0.3 | 1.7 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.3 | 1.7 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.3 | 1.1 | GO:0046502 | uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502) |
| 0.3 | 9.0 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.3 | 27.2 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.3 | 1.9 | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.3 | 3.0 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.3 | 2.9 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.3 | 0.5 | GO:0034371 | chylomicron remodeling(GO:0034371) |
| 0.3 | 4.8 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.3 | 4.5 | GO:0051000 | positive regulation of nitric-oxide synthase activity(GO:0051000) |
| 0.3 | 1.8 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.3 | 10.7 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.3 | 1.3 | GO:0061743 | motor learning(GO:0061743) |
| 0.2 | 9.7 | GO:0006110 | regulation of glycolytic process(GO:0006110) |
| 0.2 | 10.6 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.2 | 1.0 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
| 0.2 | 2.4 | GO:0001782 | B cell homeostasis(GO:0001782) |
| 0.2 | 2.9 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.2 | 1.4 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.2 | 0.7 | GO:1990834 | response to odorant(GO:1990834) |
| 0.2 | 4.7 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.2 | 6.2 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.2 | 7.7 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.2 | 0.4 | GO:1902369 | negative regulation of RNA catabolic process(GO:1902369) negative regulation of mRNA catabolic process(GO:1902373) |
| 0.2 | 0.6 | GO:0071934 | thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934) |
| 0.2 | 0.6 | GO:0060770 | epithelial cell proliferation involved in prostate gland development(GO:0060767) regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.2 | 1.4 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.2 | 4.1 | GO:0002407 | dendritic cell chemotaxis(GO:0002407) |
| 0.2 | 3.1 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.2 | 24.3 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161) |
| 0.2 | 8.1 | GO:0048008 | platelet-derived growth factor receptor signaling pathway(GO:0048008) |
| 0.2 | 4.5 | GO:0042953 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.2 | 8.4 | GO:0006735 | NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.2 | 6.8 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.2 | 1.1 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.2 | 2.8 | GO:0035588 | G-protein coupled purinergic receptor signaling pathway(GO:0035588) |
| 0.2 | 1.1 | GO:0060039 | pericardium development(GO:0060039) |
| 0.2 | 3.0 | GO:0034383 | low-density lipoprotein particle clearance(GO:0034383) |
| 0.2 | 0.3 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.2 | 7.9 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.2 | 1.5 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.2 | 6.3 | GO:0072337 | modified amino acid transport(GO:0072337) |
| 0.2 | 0.8 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.2 | 2.8 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.2 | 5.4 | GO:0046949 | fatty-acyl-CoA biosynthetic process(GO:0046949) |
| 0.1 | 1.8 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 4.6 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.1 | 4.8 | GO:0006414 | translational elongation(GO:0006414) |
| 0.1 | 0.4 | GO:0043313 | regulation of neutrophil degranulation(GO:0043313) negative regulation of neutrophil degranulation(GO:0043314) |
| 0.1 | 1.4 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.1 | 18.7 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.1 | 5.8 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.1 | 2.0 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
| 0.1 | 0.4 | GO:0090656 | t-circle formation(GO:0090656) |
| 0.1 | 12.7 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.1 | 3.5 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.1 | 4.8 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 9.2 | GO:0006275 | regulation of DNA replication(GO:0006275) |
| 0.1 | 7.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 0.5 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.1 | 4.3 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 0.1 | 0.7 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.1 | 2.0 | GO:0032462 | regulation of protein homooligomerization(GO:0032462) negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 3.4 | GO:0003382 | epithelial cell morphogenesis(GO:0003382) |
| 0.1 | 2.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.1 | 4.6 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.1 | 6.3 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 2.6 | GO:0009081 | branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083) |
| 0.1 | 8.5 | GO:0051262 | protein tetramerization(GO:0051262) |
| 0.1 | 0.1 | GO:1903347 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.1 | 6.8 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.1 | 0.2 | GO:0002266 | follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268) |
| 0.1 | 0.8 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
| 0.1 | 2.0 | GO:0046686 | response to cadmium ion(GO:0046686) |
| 0.1 | 1.6 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.1 | 0.9 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.1 | 3.7 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.1 | 1.0 | GO:0043117 | positive regulation of vascular permeability(GO:0043117) |
| 0.1 | 1.1 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 2.3 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.1 | 1.7 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 2.9 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.1 | 4.0 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.1 | 0.2 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 0.1 | 0.6 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 0.3 | GO:0001783 | B cell apoptotic process(GO:0001783) |
| 0.0 | 0.9 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.3 | GO:0035459 | cargo loading into vesicle(GO:0035459) |
| 0.0 | 0.5 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 0.6 | GO:1903313 | positive regulation of mRNA metabolic process(GO:1903313) |
| 0.0 | 0.5 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.0 | 0.6 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 0.1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration(GO:0043536) |
| 0.0 | 0.6 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 1.1 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.3 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.0 | 2.6 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.0 | 1.2 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.0 | 0.7 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.0 | 1.7 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.1 | GO:0061042 | vascular wound healing(GO:0061042) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.0 | 53.9 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 16.2 | 64.7 | GO:1990423 | RZZ complex(GO:1990423) |
| 13.1 | 130.6 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 13.0 | 64.8 | GO:0044094 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 12.5 | 87.8 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
| 11.4 | 80.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 11.4 | 34.3 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 11.3 | 45.3 | GO:0071986 | Ragulator complex(GO:0071986) |
| 10.7 | 42.9 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 10.0 | 120.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 9.9 | 19.8 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 9.7 | 29.2 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 8.5 | 59.3 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 7.7 | 23.0 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 7.6 | 30.4 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 7.2 | 79.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 7.0 | 42.2 | GO:0001940 | male pronucleus(GO:0001940) |
| 6.9 | 90.2 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 6.9 | 27.7 | GO:0005846 | nuclear cap binding complex(GO:0005846) |
| 6.4 | 25.6 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 6.2 | 55.5 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 5.6 | 28.0 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 5.6 | 16.7 | GO:0034657 | GID complex(GO:0034657) |
| 5.4 | 38.1 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 5.4 | 86.7 | GO:0034709 | methylosome(GO:0034709) |
| 5.4 | 26.8 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 5.4 | 5.4 | GO:0089701 | U2AF(GO:0089701) |
| 5.3 | 15.8 | GO:1990917 | sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917) |
| 5.0 | 50.3 | GO:0070552 | BRISC complex(GO:0070552) |
| 4.5 | 36.3 | GO:0070187 | telosome(GO:0070187) |
| 4.5 | 18.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 4.4 | 30.7 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 4.2 | 21.0 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 4.2 | 16.8 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 4.2 | 33.5 | GO:0000322 | storage vacuole(GO:0000322) |
| 4.0 | 24.2 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 4.0 | 12.0 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 4.0 | 20.0 | GO:0045281 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 4.0 | 36.0 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 4.0 | 160.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 3.9 | 31.2 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 3.8 | 7.6 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 3.8 | 34.3 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 3.7 | 33.3 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 3.7 | 11.0 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 3.6 | 32.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 3.5 | 17.7 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 3.4 | 54.7 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 3.4 | 60.9 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 3.3 | 43.3 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 3.3 | 6.6 | GO:0030689 | Noc complex(GO:0030689) |
| 3.3 | 39.4 | GO:0071203 | WASH complex(GO:0071203) |
| 3.3 | 35.9 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 3.2 | 16.2 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 3.1 | 36.7 | GO:0044292 | dendrite terminus(GO:0044292) |
| 3.0 | 39.6 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 3.0 | 54.1 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 2.9 | 11.4 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 2.8 | 36.8 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 2.8 | 28.0 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 2.7 | 54.8 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 2.7 | 8.2 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
| 2.7 | 13.4 | GO:0033503 | HULC complex(GO:0033503) |
| 2.7 | 34.6 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 2.6 | 28.7 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 2.6 | 20.7 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 2.6 | 31.0 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 2.6 | 72.0 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 2.6 | 33.4 | GO:0090543 | Flemming body(GO:0090543) |
| 2.5 | 22.4 | GO:0000125 | PCAF complex(GO:0000125) |
| 2.4 | 17.1 | GO:0031415 | NatA complex(GO:0031415) |
| 2.4 | 7.3 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 2.4 | 9.6 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 2.4 | 9.6 | GO:0035363 | histone locus body(GO:0035363) |
| 2.3 | 51.6 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 2.3 | 76.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 2.2 | 30.8 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 2.2 | 59.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 2.2 | 6.5 | GO:0044393 | microspike(GO:0044393) |
| 2.1 | 8.2 | GO:0036452 | ESCRT complex(GO:0036452) |
| 2.0 | 6.0 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 2.0 | 11.9 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 2.0 | 45.4 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 2.0 | 41.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 2.0 | 7.8 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 2.0 | 5.9 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 1.9 | 21.2 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 1.9 | 15.0 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 1.9 | 1.9 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 1.9 | 5.6 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 1.8 | 11.0 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 1.8 | 16.3 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 1.8 | 18.1 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 1.8 | 66.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 1.8 | 12.5 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 1.8 | 8.9 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 1.8 | 19.5 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 1.7 | 11.9 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 1.7 | 27.0 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 1.7 | 5.0 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 1.7 | 15.0 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 1.7 | 98.0 | GO:0005876 | spindle microtubule(GO:0005876) |
| 1.7 | 29.8 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 1.6 | 103.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 1.6 | 11.2 | GO:0034719 | SMN-Sm protein complex(GO:0034719) |
| 1.6 | 17.3 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 1.6 | 4.7 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 1.5 | 4.6 | GO:0000805 | X chromosome(GO:0000805) cyclin E2-CDK2 complex(GO:0097135) |
| 1.5 | 54.7 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 1.5 | 20.9 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 1.5 | 93.9 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 1.5 | 7.4 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825) |
| 1.5 | 5.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 1.4 | 272.8 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 1.4 | 197.0 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 1.4 | 19.1 | GO:0005869 | dynactin complex(GO:0005869) |
| 1.4 | 8.2 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 1.4 | 1.4 | GO:0005682 | U5 snRNP(GO:0005682) |
| 1.3 | 14.2 | GO:0000124 | SAGA complex(GO:0000124) |
| 1.3 | 8.9 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 1.3 | 10.0 | GO:0035976 | AP1 complex(GO:0035976) |
| 1.2 | 2.4 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 1.2 | 3.5 | GO:0071754 | IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756) |
| 1.1 | 88.4 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 1.1 | 9.7 | GO:1990630 | IRE1-RACK1-PP2A complex(GO:1990630) |
| 1.1 | 31.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 1.1 | 27.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.1 | 18.0 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 1.0 | 6.3 | GO:1990357 | terminal web(GO:1990357) |
| 1.0 | 5.9 | GO:0030681 | multimeric ribonuclease P complex(GO:0030681) |
| 1.0 | 46.8 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 1.0 | 11.6 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 1.0 | 3.8 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.9 | 11.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.9 | 18.7 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.9 | 42.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.9 | 12.7 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.9 | 5.4 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.8 | 10.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.8 | 5.7 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.8 | 4.0 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.8 | 5.6 | GO:0044754 | autolysosome(GO:0044754) |
| 0.8 | 69.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.8 | 4.8 | GO:0033061 | DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.8 | 3.1 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.7 | 14.9 | GO:0022624 | proteasome regulatory particle(GO:0005838) proteasome accessory complex(GO:0022624) |
| 0.7 | 20.3 | GO:0071437 | invadopodium(GO:0071437) |
| 0.7 | 7.5 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.7 | 17.6 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.7 | 6.0 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.7 | 10.4 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.7 | 2.6 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.6 | 3.2 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.6 | 3.8 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.6 | 6.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.6 | 15.2 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.6 | 5.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.6 | 2.3 | GO:0043541 | UDP-N-acetylglucosamine transferase complex(GO:0043541) |
| 0.6 | 15.0 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.6 | 64.5 | GO:0005840 | ribosome(GO:0005840) |
| 0.6 | 14.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.6 | 7.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.6 | 7.9 | GO:0033202 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.6 | 14.9 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.5 | 9.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.5 | 193.8 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 0.5 | 2.0 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.5 | 1.0 | GO:0033150 | perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) |
| 0.5 | 5.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.5 | 59.3 | GO:0030496 | midbody(GO:0030496) |
| 0.5 | 1.4 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.5 | 2.3 | GO:0016589 | NURF complex(GO:0016589) |
| 0.4 | 12.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.4 | 3.1 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.4 | 3.9 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.4 | 0.4 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.4 | 4.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.4 | 61.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.4 | 2.0 | GO:0043196 | varicosity(GO:0043196) |
| 0.4 | 106.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 42.3 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.3 | 39.2 | GO:0016605 | PML body(GO:0016605) |
| 0.3 | 13.9 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.3 | 3.7 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.3 | 6.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 3.0 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.3 | 22.6 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.3 | 7.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 3.3 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.3 | 26.2 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.3 | 22.3 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.3 | 4.0 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.3 | 2.3 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.3 | 7.0 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.3 | 8.9 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.3 | 3.0 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.3 | 4.1 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.3 | 3.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.2 | 2.7 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.2 | 1.4 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
| 0.2 | 16.5 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.2 | 2.7 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.2 | 15.9 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.2 | 7.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.2 | 1.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.2 | 2.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 0.6 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.2 | 2.1 | GO:0097413 | Lewy body(GO:0097413) |
| 0.2 | 2.0 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.2 | 6.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 55.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 10.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 5.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 2.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 4.6 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 8.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 0.7 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 0.7 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.1 | 0.2 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 3.0 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 3.7 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 9.2 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 3.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 2.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 17.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 1.0 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 1.5 | GO:0005798 | Golgi-associated vesicle(GO:0005798) |
| 0.0 | 0.7 | GO:0031306 | intrinsic component of mitochondrial outer membrane(GO:0031306) |
| 0.0 | 2.3 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 0.1 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.8 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 0.5 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 50.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 1.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 25.5 | 76.6 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 20.2 | 60.6 | GO:0000035 | acyl binding(GO:0000035) |
| 18.2 | 54.7 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 17.6 | 52.7 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 14.8 | 59.2 | GO:0043515 | kinetochore binding(GO:0043515) |
| 12.6 | 63.1 | GO:0047280 | nicotinamide phosphoribosyltransferase activity(GO:0047280) |
| 12.2 | 49.0 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 11.3 | 33.8 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 11.2 | 134.0 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 10.6 | 42.2 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 9.7 | 38.8 | GO:0042282 | hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282) |
| 9.7 | 29.1 | GO:0070362 | mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364) |
| 9.4 | 56.2 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 9.2 | 36.8 | GO:0047676 | arachidonate-CoA ligase activity(GO:0047676) |
| 8.9 | 26.7 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 8.9 | 8.9 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 8.3 | 33.0 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 7.9 | 55.3 | GO:0004459 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 7.6 | 30.4 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 7.5 | 52.6 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 7.4 | 37.2 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 7.4 | 59.3 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 7.3 | 21.9 | GO:0070039 | rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039) |
| 7.2 | 28.9 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 7.2 | 21.6 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 7.0 | 28.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 6.6 | 118.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 6.5 | 19.5 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
| 6.4 | 38.2 | GO:0008732 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 6.2 | 43.7 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 6.2 | 55.5 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 6.0 | 24.2 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 5.7 | 34.3 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 5.6 | 28.0 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 5.4 | 16.3 | GO:0001132 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 5.3 | 47.8 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 5.3 | 15.8 | GO:0002135 | CTP binding(GO:0002135) |
| 5.2 | 47.1 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 5.1 | 30.6 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 5.1 | 15.2 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 5.0 | 15.1 | GO:0050146 | nucleoside phosphotransferase activity(GO:0050146) |
| 4.6 | 18.3 | GO:0050211 | procollagen galactosyltransferase activity(GO:0050211) |
| 4.5 | 35.9 | GO:0034603 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 4.4 | 132.8 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 4.4 | 13.1 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 4.3 | 34.8 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 4.2 | 21.2 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 4.2 | 8.4 | GO:0032564 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 4.0 | 20.0 | GO:0000104 | succinate dehydrogenase activity(GO:0000104) |
| 3.9 | 11.6 | GO:0004418 | hydroxymethylbilane synthase activity(GO:0004418) |
| 3.9 | 108.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 3.8 | 68.9 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 3.8 | 11.4 | GO:0033699 | DNA 5'-adenosine monophosphate hydrolase activity(GO:0033699) |
| 3.7 | 14.9 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 3.6 | 14.4 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 3.4 | 20.2 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 3.3 | 65.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 3.1 | 9.4 | GO:0031403 | lithium ion binding(GO:0031403) |
| 3.1 | 24.5 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 3.0 | 21.0 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 3.0 | 47.9 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 3.0 | 9.0 | GO:0004912 | interleukin-3 receptor activity(GO:0004912) interleukin-5 receptor activity(GO:0004914) |
| 3.0 | 79.9 | GO:0048156 | tau protein binding(GO:0048156) |
| 2.8 | 28.5 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 2.8 | 8.4 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 2.8 | 16.7 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 2.7 | 54.8 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 2.7 | 38.0 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 2.7 | 24.2 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 2.7 | 18.6 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 2.7 | 8.0 | GO:0000248 | C-5 sterol desaturase activity(GO:0000248) sterol desaturase activity(GO:0070704) |
| 2.6 | 31.6 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 2.6 | 44.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 2.6 | 59.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 2.6 | 7.8 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 2.6 | 18.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 2.5 | 40.7 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 2.5 | 27.4 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 2.5 | 7.5 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
| 2.5 | 47.1 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 2.4 | 24.4 | GO:0035173 | histone kinase activity(GO:0035173) |
| 2.4 | 12.1 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
| 2.4 | 29.0 | GO:0000339 | RNA cap binding(GO:0000339) |
| 2.4 | 113.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 2.4 | 42.6 | GO:0070513 | death domain binding(GO:0070513) |
| 2.4 | 4.7 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 2.3 | 83.2 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 2.3 | 9.2 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 2.2 | 22.0 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 2.2 | 6.6 | GO:0051717 | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) |
| 2.2 | 21.8 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 2.2 | 36.6 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 2.1 | 79.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 2.1 | 25.4 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 2.1 | 14.6 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 2.0 | 8.2 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
| 2.0 | 18.1 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 2.0 | 26.0 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 2.0 | 6.0 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 2.0 | 17.9 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
| 1.9 | 102.9 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.9 | 3.8 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 1.9 | 5.6 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 1.8 | 5.5 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 1.8 | 5.5 | GO:0034512 | box C/D snoRNA binding(GO:0034512) |
| 1.8 | 7.2 | GO:0002046 | opsin binding(GO:0002046) |
| 1.8 | 12.5 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 1.8 | 8.9 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 1.8 | 7.0 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 1.8 | 21.0 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 1.7 | 34.9 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 1.7 | 108.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.7 | 25.4 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 1.7 | 6.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 1.6 | 3.3 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 1.6 | 8.2 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 1.6 | 27.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 1.6 | 24.0 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 1.6 | 3.2 | GO:0034046 | poly(G) binding(GO:0034046) |
| 1.6 | 4.8 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 1.6 | 9.4 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 1.6 | 71.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 1.6 | 40.3 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 1.5 | 12.4 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 1.5 | 12.4 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.5 | 12.1 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 1.5 | 9.1 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 1.5 | 12.1 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 1.5 | 19.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 1.5 | 23.8 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 1.5 | 56.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 1.5 | 17.8 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 1.5 | 7.4 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 1.4 | 11.5 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 1.4 | 19.9 | GO:0031386 | protein tag(GO:0031386) |
| 1.4 | 26.8 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 1.4 | 30.8 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 1.4 | 57.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 1.4 | 12.5 | GO:0004812 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 1.4 | 21.8 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 1.4 | 9.5 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 1.3 | 27.0 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 1.3 | 12.1 | GO:0004396 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 1.3 | 284.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.3 | 14.7 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 1.3 | 48.9 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 1.3 | 7.8 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 1.3 | 24.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 1.3 | 6.3 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 1.2 | 12.3 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 1.2 | 45.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.2 | 7.4 | GO:0046979 | peptide-transporting ATPase activity(GO:0015440) TAP2 binding(GO:0046979) |
| 1.2 | 17.1 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 1.2 | 9.7 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 1.2 | 13.1 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 1.2 | 7.1 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 1.1 | 13.7 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 1.1 | 37.6 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 1.1 | 89.2 | GO:0019003 | GDP binding(GO:0019003) |
| 1.1 | 4.3 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 1.1 | 17.3 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 1.1 | 6.5 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 1.1 | 17.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.1 | 77.1 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 1.1 | 14.7 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 1.0 | 2.1 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 1.0 | 4.2 | GO:0045127 | N-acetylglucosamine kinase activity(GO:0045127) |
| 1.0 | 3.1 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
| 1.0 | 10.3 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 1.0 | 3.0 | GO:0052794 | exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796) |
| 1.0 | 13.1 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 1.0 | 15.1 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 1.0 | 3.9 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 1.0 | 9.6 | GO:0034594 | phosphatidylinositol trisphosphate phosphatase activity(GO:0034594) |
| 0.9 | 21.8 | GO:0101005 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.9 | 8.5 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.9 | 5.6 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.9 | 7.3 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.9 | 36.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.9 | 16.3 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.9 | 7.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.9 | 24.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.9 | 3.5 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.9 | 50.4 | GO:0008186 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.9 | 31.8 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.9 | 6.1 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.9 | 6.9 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.9 | 9.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.9 | 23.2 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.8 | 23.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.8 | 37.4 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.8 | 4.2 | GO:0034597 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.8 | 7.3 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.8 | 28.9 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.8 | 19.2 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.8 | 56.4 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.8 | 3.1 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.8 | 7.8 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.8 | 14.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.7 | 3.7 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.7 | 36.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.7 | 2.9 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.7 | 5.1 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.7 | 4.3 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
| 0.7 | 5.7 | GO:0089720 | caspase binding(GO:0089720) |
| 0.7 | 30.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.7 | 11.7 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.7 | 5.5 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.7 | 5.4 | GO:0018812 | 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) |
| 0.7 | 5.4 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.7 | 7.3 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.7 | 7.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.7 | 8.5 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.7 | 4.6 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.6 | 4.5 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.6 | 12.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.6 | 5.8 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.6 | 43.2 | GO:0008235 | metalloexopeptidase activity(GO:0008235) |
| 0.6 | 40.1 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.6 | 3.0 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.6 | 7.2 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.6 | 3.0 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.6 | 5.3 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.6 | 42.9 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.6 | 1.8 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.6 | 1.8 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.6 | 36.0 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.6 | 9.7 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.6 | 3.4 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.6 | 4.5 | GO:0019863 | IgE binding(GO:0019863) |
| 0.6 | 6.1 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 0.6 | 1.7 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.5 | 2.2 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.5 | 1.6 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.5 | 3.7 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.5 | 1.6 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.5 | 1.6 | GO:0051380 | beta-adrenergic receptor activity(GO:0004939) norepinephrine binding(GO:0051380) |
| 0.5 | 18.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.5 | 26.3 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.5 | 94.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.5 | 8.2 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.5 | 10.1 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 11.8 | GO:0004659 | prenyltransferase activity(GO:0004659) |
| 0.5 | 2.0 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.5 | 14.5 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.5 | 4.3 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.4 | 10.5 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.4 | 14.2 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.4 | 7.4 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.4 | 3.3 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.4 | 4.9 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.4 | 2.0 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.4 | 4.5 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.4 | 1.2 | GO:0008900 | hydrogen:potassium-exchanging ATPase activity(GO:0008900) |
| 0.4 | 8.0 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.4 | 3.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.4 | 39.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.4 | 14.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.4 | 5.7 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.4 | 2.3 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.4 | 6.7 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
| 0.4 | 1.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.4 | 7.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.3 | 4.1 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.3 | 1.7 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.3 | 3.0 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.3 | 1.7 | GO:0008410 | CoA-transferase activity(GO:0008410) |
| 0.3 | 25.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.3 | 5.9 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.3 | 3.3 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.3 | 13.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.3 | 13.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.3 | 30.2 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.3 | 12.5 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.3 | 16.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.3 | 1.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.3 | 9.0 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.3 | 3.8 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.3 | 9.4 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.3 | 5.8 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.3 | 1.9 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.3 | 1.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.3 | 1.1 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.3 | 5.9 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.3 | 4.0 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.3 | 2.8 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.3 | 13.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.2 | 1.0 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.2 | 1.0 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.2 | 1.7 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.2 | 3.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.2 | 3.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 4.5 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 2.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 1.2 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 0.2 | 9.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.2 | 1.1 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.2 | 4.7 | GO:0072349 | modified amino acid transmembrane transporter activity(GO:0072349) |
| 0.2 | 5.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 266.7 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 3.0 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.2 | 4.0 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.2 | 10.1 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.2 | 0.6 | GO:0015403 | thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403) |
| 0.2 | 13.2 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.2 | 1.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 0.8 | GO:0005497 | androgen binding(GO:0005497) |
| 0.2 | 1.2 | GO:0039552 | RIG-I binding(GO:0039552) |
| 0.2 | 0.4 | GO:0008309 | double-stranded DNA exodeoxyribonuclease activity(GO:0008309) |
| 0.2 | 1.1 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.2 | 3.6 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.2 | 5.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.2 | 6.9 | GO:0032451 | demethylase activity(GO:0032451) |
| 0.2 | 1.8 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 2.7 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.2 | 1.4 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.2 | 2.8 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.2 | 0.8 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.2 | 0.5 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.2 | 1.1 | GO:0016790 | thiolester hydrolase activity(GO:0016790) |
| 0.1 | 12.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 1.6 | GO:0023023 | MHC protein complex binding(GO:0023023) |
| 0.1 | 1.0 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.1 | 5.7 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 0.6 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 6.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 4.6 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 0.3 | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) |
| 0.1 | 1.6 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 2.6 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 2.9 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.1 | 0.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 1.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 2.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 3.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 1.7 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.1 | 2.5 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.1 | 0.3 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 0.8 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 2.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 1.2 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 0.0 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.0 | 2.6 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.2 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.0 | 0.4 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 0.4 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 0.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.2 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.0 | 7.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.3 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.8 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.1 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.0 | 1.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.1 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.6 | GO:0008375 | acetylglucosaminyltransferase activity(GO:0008375) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 30.8 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 2.7 | 54.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 2.6 | 158.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.6 | 84.2 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 2.2 | 31.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 2.2 | 79.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.6 | 29.5 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 1.6 | 54.2 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 1.6 | 116.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 1.5 | 169.7 | PID E2F PATHWAY | E2F transcription factor network |
| 1.5 | 130.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 1.3 | 37.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 1.2 | 33.8 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 1.1 | 10.3 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 1.1 | 16.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 1.1 | 43.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 1.1 | 51.7 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 1.1 | 42.0 | PID IFNG PATHWAY | IFN-gamma pathway |
| 1.0 | 28.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 1.0 | 28.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.8 | 23.7 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.8 | 39.9 | PID FOXO PATHWAY | FoxO family signaling |
| 0.8 | 11.4 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.8 | 42.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.8 | 55.0 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.7 | 10.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.7 | 75.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 22.4 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.7 | 7.5 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.7 | 11.4 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.7 | 88.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 15.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.6 | 36.2 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.6 | 35.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.5 | 23.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.5 | 7.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.5 | 11.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.5 | 16.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.5 | 9.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.5 | 24.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.5 | 12.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.4 | 12.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.4 | 3.6 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.4 | 4.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.3 | 22.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 26.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 13.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.3 | 13.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 11.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 7.2 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.2 | 5.1 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 5.0 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.2 | 9.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 6.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 0.8 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 5.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 3.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 5.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 6.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 1.0 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 1.4 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 0.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 6.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 0.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 0.2 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 1.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 1.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.1 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.7 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 0.4 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 36.3 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 4.2 | 104.0 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 3.9 | 58.2 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 3.3 | 79.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 3.2 | 89.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 3.1 | 106.3 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 2.9 | 94.0 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 2.9 | 14.4 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 2.9 | 209.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 2.7 | 97.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 2.7 | 45.1 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 2.6 | 85.6 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 2.6 | 80.2 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 2.6 | 38.8 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 2.5 | 105.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 2.4 | 79.9 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 2.4 | 47.9 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 2.4 | 71.1 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 2.3 | 18.2 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 2.3 | 27.2 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 2.1 | 156.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.1 | 31.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 2.0 | 170.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.0 | 175.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.9 | 68.3 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 1.9 | 83.7 | REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | Genes involved in Cleavage of Growing Transcript in the Termination Region |
| 1.8 | 38.2 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 1.8 | 46.0 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 1.7 | 39.8 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 1.6 | 30.7 | REACTOME DEADENYLATION DEPENDENT MRNA DECAY | Genes involved in Deadenylation-dependent mRNA decay |
| 1.6 | 38.7 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 1.6 | 77.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.6 | 48.3 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 1.5 | 20.6 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 1.5 | 58.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 1.4 | 12.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 1.4 | 35.3 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 1.3 | 12.7 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 1.3 | 25.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 1.3 | 40.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 1.2 | 49.2 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 1.2 | 36.2 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 1.2 | 60.3 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 1.2 | 116.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.1 | 43.7 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 1.1 | 15.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 1.1 | 48.4 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 1.1 | 102.1 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 1.1 | 49.8 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 1.0 | 28.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 1.0 | 28.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 1.0 | 4.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 1.0 | 30.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.0 | 14.9 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 1.0 | 24.7 | REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| 1.0 | 4.8 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.9 | 8.4 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.9 | 31.4 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.9 | 19.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.9 | 8.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.9 | 16.8 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.9 | 133.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.8 | 13.9 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.8 | 4.6 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.7 | 42.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.7 | 7.0 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.7 | 17.4 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.7 | 7.5 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.7 | 5.4 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.7 | 10.8 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.7 | 16.3 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.7 | 2.0 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.6 | 16.8 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.6 | 31.0 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.6 | 10.9 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.6 | 17.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.6 | 10.6 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.6 | 8.0 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.6 | 9.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.6 | 4.5 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.6 | 8.4 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |
| 0.6 | 16.6 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.5 | 16.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.5 | 5.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.5 | 5.7 | REACTOME PURINE METABOLISM | Genes involved in Purine metabolism |
| 0.5 | 11.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.5 | 12.5 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.5 | 8.3 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.5 | 32.0 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.5 | 9.5 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.4 | 13.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.4 | 7.8 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.4 | 13.5 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.4 | 5.7 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.4 | 6.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.4 | 6.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.4 | 12.5 | REACTOME METABOLISM OF NUCLEOTIDES | Genes involved in Metabolism of nucleotides |
| 0.4 | 3.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 5.6 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.4 | 27.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 35.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 9.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 19.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 4.8 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.3 | 1.8 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.3 | 2.0 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.3 | 24.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 36.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.9 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.2 | 4.0 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.2 | 2.2 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 11.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 7.4 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 0.9 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.1 | 3.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 2.3 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.1 | 4.7 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 2.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 1.0 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 2.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 1.4 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |
| 0.1 | 0.8 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 4.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.9 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 1.4 | REACTOME HOST INTERACTIONS OF HIV FACTORS | Genes involved in Host Interactions of HIV factors |
| 0.1 | 0.6 | REACTOME DAG AND IP3 SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.0 | 1.0 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.5 | REACTOME METABOLISM OF RNA | Genes involved in Metabolism of RNA |
| 0.0 | 1.0 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.2 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 0.1 | REACTOME BASE EXCISION REPAIR | Genes involved in Base Excision Repair |
| 0.0 | 0.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.2 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.0 | 1.2 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |