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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ATF2_ATF1_ATF3
Z-value: 12.82
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Transcription factors associated with ATF2_ATF1_ATF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF1 | hg38_v1_chr12_+_50764054_50764115 | 0.78 | 1.1e-46 | Click! |
| ATF2 | hg38_v1_chr2_-_175168159_175168213 | 0.35 | 1.5e-07 | Click! |
| ATF3 | hg38_v1_chr1_+_212608628_212608915, hg38_v1_chr1_+_212565334_212565414 | -0.02 | 7.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 154.0 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.9 | 143.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.9 | 142.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.5 | 127.3 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 5.6 | 122.4 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 11.0 | 120.7 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 1.6 | 102.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 12.9 | 90.2 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 14.6 | 87.8 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 4.8 | 85.6 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 272.8 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 1.4 | 197.0 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.5 | 193.8 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 4.0 | 160.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 13.1 | 130.6 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 10.0 | 120.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.4 | 106.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.6 | 103.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 1.7 | 98.0 | GO:0005876 | spindle microtubule(GO:0005876) |
| 1.5 | 93.9 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 284.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 266.7 | GO:0003723 | RNA binding(GO:0003723) |
| 11.2 | 134.0 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 4.4 | 132.8 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 6.6 | 118.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 2.4 | 113.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.7 | 108.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 3.9 | 108.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.9 | 102.9 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.5 | 94.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 169.7 | PID E2F PATHWAY | E2F transcription factor network |
| 2.6 | 158.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.5 | 130.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 1.6 | 116.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.7 | 88.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 2.6 | 84.2 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 2.2 | 79.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.7 | 75.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.8 | 55.0 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 2.7 | 54.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 209.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 2.0 | 175.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.0 | 170.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.1 | 156.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.9 | 133.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.2 | 116.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 3.1 | 106.3 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 2.5 | 105.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 4.2 | 104.0 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 1.1 | 102.1 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |