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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AUGUGCC

Z-value: 1.83

Motif logo

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miRNA associated with seed AUGUGCC

NamemiRBASE accession
hsa-miR-455-5p
MIMAT0003150

Activity profile of AUGUGCC motif

Sorted Z-values of AUGUGCC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AUGUGCC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_63504583 7.74 ENST00000380324.8
ENST00000561442.5
ENST00000560070.5
USP3
ubiquitin specific peptidase 3
chr2_-_38751350 7.56 ENST00000409276.5
ENST00000313117.11
ENST00000446327.6
SRSF7
serine and arginine rich splicing factor 7
chr9_-_72364504 6.62 ENST00000237937.7
ENST00000343431.6
ENST00000376956.3
ZFAND5
zinc finger AN1-type containing 5
chr1_-_70205531 6.10 ENST00000370952.4
LRRC40
leucine rich repeat containing 40
chr13_-_98577131 5.67 ENST00000397517.6
STK24
serine/threonine kinase 24
chr14_-_21269451 5.21 ENST00000336053.10
HNRNPC
heterogeneous nuclear ribonucleoprotein C
chr17_-_64662290 4.53 ENST00000262435.14
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr12_+_12717359 4.34 ENST00000614874.2
ENST00000228872.9
CDKN1B
cyclin dependent kinase inhibitor 1B
chr2_+_84971093 4.26 ENST00000456682.1
ENST00000409785.9
KCMF1
potassium channel modulatory factor 1
chr12_+_123584523 4.19 ENST00000438031.2
ENST00000262225.8
TMED2
transmembrane p24 trafficking protein 2
chrX_+_41334154 4.03 ENST00000441189.4
ENST00000644513.1
ENST00000644109.1
ENST00000646122.1
ENST00000644074.1
ENST00000644876.2
ENST00000399959.7
ENST00000646319.1
DDX3X
DEAD-box helicase 3 X-linked
chr3_-_12664101 3.97 ENST00000251849.9
ENST00000442415.7
RAF1
Raf-1 proto-oncogene, serine/threonine kinase
chr4_-_184474518 3.92 ENST00000393593.8
IRF2
interferon regulatory factor 2
chr4_+_39698109 3.78 ENST00000510934.5
ENST00000261427.10
UBE2K
ubiquitin conjugating enzyme E2 K
chr6_+_89080739 3.76 ENST00000369472.1
ENST00000336032.4
PNRC1
proline rich nuclear receptor coactivator 1
chr12_+_62260338 3.08 ENST00000353364.7
ENST00000549523.5
USP15
ubiquitin specific peptidase 15
chr17_+_31936993 3.05 ENST00000322652.10
SUZ12
SUZ12 polycomb repressive complex 2 subunit
chr10_+_110919595 2.99 ENST00000369452.9
SHOC2
SHOC2 leucine rich repeat scaffold protein
chr5_-_176537361 2.93 ENST00000274811.9
RNF44
ring finger protein 44
chr22_+_38681941 2.82 ENST00000216034.6
TOMM22
translocase of outer mitochondrial membrane 22
chr20_-_50113139 2.45 ENST00000371657.9
ENST00000371674.8
ENST00000625172.3
ENST00000557021.5
ENST00000617119.4
UBE2V1
ubiquitin conjugating enzyme E2 V1
chr3_-_177196451 2.30 ENST00000430069.5
ENST00000630796.2
ENST00000428970.5
TBL1XR1
TBL1X receptor 1
chr1_+_101237009 2.28 ENST00000305352.7
S1PR1
sphingosine-1-phosphate receptor 1
chr5_+_83471736 2.24 ENST00000265077.8
VCAN
versican
chr19_-_32675139 2.22 ENST00000586693.7
ENST00000587352.5
ENST00000306065.9
ENST00000586463.5
ANKRD27
ankyrin repeat domain 27
chr22_+_40177917 2.16 ENST00000454349.7
ENST00000335727.13
TNRC6B
trinucleotide repeat containing adaptor 6B
chr1_+_193121950 2.10 ENST00000367435.5
CDC73
cell division cycle 73
chr4_+_41935423 2.01 ENST00000504986.6
TMEM33
transmembrane protein 33
chr13_-_49792675 1.85 ENST00000261667.8
KPNA3
karyopherin subunit alpha 3
chr17_+_59565598 1.73 ENST00000251241.9
ENST00000425628.7
ENST00000584385.5
ENST00000580030.1
DHX40
DEAH-box helicase 40
chr17_+_50719565 1.63 ENST00000625349.2
ENST00000393227.6
ENST00000240304.5
ENST00000505658.6
ENST00000505619.5
ENST00000510984.5
LUC7L3
LUC7 like 3 pre-mRNA splicing factor
chr2_+_105744876 1.53 ENST00000233154.9
ENST00000451463.6
NCK2
NCK adaptor protein 2
chr1_+_26695993 1.50 ENST00000324856.13
ENST00000637465.1
ARID1A
AT-rich interaction domain 1A
chr8_-_8893548 1.45 ENST00000276282.7
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr20_-_50153637 1.45 ENST00000341698.2
ENST00000371652.9
ENST00000371650.9
PEDS1-UBE2V1
PEDS1
PEDS1-UBE2V1 readthrough
plasmanylethanolamine desaturase 1
chr10_-_15168667 1.34 ENST00000378165.9
NMT2
N-myristoyltransferase 2
chr11_+_9384621 1.28 ENST00000379719.8
ENST00000527431.1
ENST00000630083.1
IPO7
importin 7
chr20_-_62065834 1.27 ENST00000252996.9
TAF4
TATA-box binding protein associated factor 4
chr5_-_77492309 1.04 ENST00000296679.9
ENST00000507029.5
WDR41
WD repeat domain 41
chr7_+_39950187 1.04 ENST00000181839.10
CDK13
cyclin dependent kinase 13
chr14_-_89619118 0.95 ENST00000345097.8
ENST00000555855.5
ENST00000555353.5
FOXN3
forkhead box N3
chrX_+_41085436 0.77 ENST00000324545.9
ENST00000378308.7
USP9X
ubiquitin specific peptidase 9 X-linked
chrX_+_46573757 0.75 ENST00000276055.4
CHST7
carbohydrate sulfotransferase 7
chr13_-_51453015 0.70 ENST00000442263.4
ENST00000311234.9
INTS6
integrator complex subunit 6
chr12_+_94148553 0.68 ENST00000258526.9
PLXNC1
plexin C1
chr1_-_10796636 0.67 ENST00000377022.8
ENST00000344008.5
CASZ1
castor zinc finger 1
chr11_-_128522264 0.60 ENST00000531611.5
ETS1
ETS proto-oncogene 1, transcription factor
chr7_-_11832190 0.59 ENST00000423059.9
ENST00000617773.1
THSD7A
thrombospondin type 1 domain containing 7A
chr21_-_15064934 0.56 ENST00000400199.5
ENST00000400202.5
ENST00000318948.7
NRIP1
nuclear receptor interacting protein 1
chr20_+_36306325 0.50 ENST00000373913.7
ENST00000339266.10
DLGAP4
DLG associated protein 4
chr15_+_58987652 0.45 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr12_-_57430956 0.45 ENST00000347140.7
ENST00000402412.5
R3HDM2
R3H domain containing 2
chr20_+_19758245 0.41 ENST00000255006.12
RIN2
Ras and Rab interactor 2
chr17_-_5486157 0.34 ENST00000572834.5
ENST00000158771.9
ENST00000570848.5
ENST00000571971.1
DERL2
derlin 2
chr1_-_114511160 0.26 ENST00000369543.6
ENST00000358465.7
TRIM33
tripartite motif containing 33
chr10_+_19816395 0.26 ENST00000377252.5
PLXDC2
plexin domain containing 2
chr17_-_48604959 0.26 ENST00000225648.4
ENST00000484302.3
HOXB6
homeobox B6
chr10_-_92243246 0.24 ENST00000412050.8
ENST00000614585.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr8_+_105318428 0.20 ENST00000407775.7
ZFPM2
zinc finger protein, FOG family member 2
chr5_+_103120149 0.18 ENST00000515845.5
ENST00000321521.13
ENST00000507921.5
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr5_+_142108753 0.11 ENST00000253814.6
NDFIP1
Nedd4 family interacting protein 1
chr7_+_38977904 0.09 ENST00000518318.7
ENST00000403058.6
POU6F2
POU class 6 homeobox 2
chr2_-_201451446 0.08 ENST00000332624.8
ENST00000430254.1
TRAK2
trafficking kinesin protein 2
chr18_+_65751000 0.06 ENST00000397968.4
CDH7
cadherin 7
chr7_-_155812454 0.06 ENST00000297261.7
SHH
sonic hedgehog signaling molecule

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
1.0 4.2 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.8 2.3 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.7 2.2 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.7 2.1 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.6 4.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.6 1.9 GO:0075732 viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594)
0.5 3.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.5 4.0 GO:0042256 mature ribosome assembly(GO:0042256) positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.5 2.0 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.4 3.8 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.4 3.8 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3 1.3 GO:0018201 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
0.3 2.8 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.3 1.5 GO:0006344 optic cup formation involved in camera-type eye development(GO:0003408) maintenance of chromatin silencing(GO:0006344)
0.3 7.7 GO:0016578 histone deubiquitination(GO:0016578)
0.3 4.0 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.3 5.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.3 2.3 GO:0060613 fat pad development(GO:0060613)
0.3 1.5 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.2 5.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 7.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 2.2 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 3.0 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.1 4.8 GO:0003016 respiratory system process(GO:0003016)
0.1 2.2 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.2 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.1 0.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.6 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1 2.4 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 0.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 1.0 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 1.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.3 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.9 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 3.0 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.6 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0072199 positive regulation of skeletal muscle cell proliferation(GO:0014858) mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199)
0.0 0.7 GO:0016180 snRNA processing(GO:0016180)
0.0 3.9 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.1 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.1 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 1.3 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0048865 stem cell fate commitment(GO:0048865)
0.0 0.7 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.6 7.7 GO:0070938 contractile ring(GO:0070938)
0.4 2.2 GO:0097422 tubular endosome(GO:0097422)
0.4 4.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.4 2.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.3 3.0 GO:0001739 sex chromatin(GO:0001739)
0.3 4.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.3 1.0 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.2 2.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 3.8 GO:0032433 filopodium tip(GO:0032433)
0.2 3.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 4.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 5.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 4.0 GO:0031143 pseudopodium(GO:0031143)
0.1 1.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.7 GO:0032039 integrator complex(GO:0032039)
0.1 1.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.5 GO:0071564 SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564)
0.0 5.1 GO:0005643 nuclear pore(GO:0005643)
0.0 5.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 1.3 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.0 4.3 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 4.5 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0043273 CTPase activity(GO:0043273)
0.6 3.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.4 5.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.3 1.3 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.3 5.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.3 4.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 3.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 2.8 GO:0015266 protein channel activity(GO:0015266)
0.2 3.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 2.3 GO:0046625 sphingolipid binding(GO:0046625)
0.1 0.7 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.1 4.0 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 1.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 7.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 3.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 4.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 3.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.0 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 5.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 2.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 15.9 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 4.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 6.6 PID FOXO PATHWAY FoxO family signaling
0.1 4.5 PID BMP PATHWAY BMP receptor signaling
0.1 2.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 2.3 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 2.4 PID IL1 PATHWAY IL1-mediated signaling events
0.1 5.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.5 PID IGF1 PATHWAY IGF1 pathway
0.0 2.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 4.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 4.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 7.6 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 5.6 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 2.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 4.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 4.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.9 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes