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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.27

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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol Gene ID Gene Info
ENSG00000180828.3 BHLHE22
ENSG00000180535.4 BHLHA15
ENSG00000125533.6 BHLHE23

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr3_-_121660892 23.83 ENST00000428394.6
ENST00000314583.8
hematopoietic cell-specific Lyn substrate 1
chrX_+_129779930 13.99 ENST00000356892.4
SAM and SH3 domain containing 3
chr10_+_5094405 13.22 ENST00000380554.5
aldo-keto reductase family 1 member C3
chr5_-_111976925 8.31 ENST00000395634.7
neuronal regeneration related protein
chr19_-_54364983 8.22 ENST00000434277.6
leukocyte associated immunoglobulin like receptor 1
chr14_-_106025628 8.04 ENST00000631943.1
immunoglobulin heavy variable 7-4-1
chr11_+_17295322 7.22 ENST00000458064.6
ENST00000622082.4
nucleobindin 2
chr11_+_65638085 7.04 ENST00000534313.6
ENST00000533361.1
ENST00000526137.1
signal-induced proliferation-associated 1
chr5_-_170297746 6.23 ENST00000046794.10
lymphocyte cytosolic protein 2
chr1_+_244051275 5.47 ENST00000358704.4
zinc finger and BTB domain containing 18
chr6_+_135181361 5.35 ENST00000527615.5
ENST00000420123.6
ENST00000525369.5
ENST00000528774.5
ENST00000533624.5
ENST00000534044.5
ENST00000534121.5
MYB proto-oncogene, transcription factor
chr3_-_18438767 5.02 ENST00000454909.6
SATB homeobox 1
chr7_-_27165517 4.63 ENST00000396345.1
ENST00000343483.7
homeobox A9
chr6_-_111793871 4.57 ENST00000368667.6
FYN proto-oncogene, Src family tyrosine kinase
chr2_+_180981108 4.34 ENST00000602710.5
ubiquitin conjugating enzyme E2 E3
chr3_-_114758940 4.17 ENST00000464560.5
zinc finger and BTB domain containing 20
chr4_+_159267737 3.99 ENST00000264431.8
Rap guanine nucleotide exchange factor 2
chr3_-_114759115 3.98 ENST00000471418.5
zinc finger and BTB domain containing 20
chr18_+_13277351 3.86 ENST00000679091.1
low density lipoprotein receptor class A domain containing 4
chr5_+_138338256 3.01 ENST00000513056.5
ENST00000239906.10
ENST00000511276.1
family with sequence similarity 53 member C
chr7_+_116862552 2.67 ENST00000361183.8
ENST00000639546.1
ENST00000490693.5
capping actin protein of muscle Z-line subunit alpha 2
chrX_+_108044967 2.25 ENST00000415430.7
V-set and immunoglobulin domain containing 1
chrX_+_108045050 2.23 ENST00000458383.1
ENST00000217957.10
V-set and immunoglobulin domain containing 1
chr8_-_23457618 2.07 ENST00000358689.9
ENST00000518718.1
ectonucleoside triphosphate diphosphohydrolase 4
chr5_-_59430600 2.07 ENST00000636120.1
phosphodiesterase 4D
chr15_-_63156774 2.00 ENST00000462430.5
ribosomal protein S27 like
chr19_-_11339573 1.99 ENST00000222120.8
RAB3D, member RAS oncogene family
chr5_+_157180816 1.97 ENST00000422843.8
IL2 inducible T cell kinase
chr15_+_67067780 1.95 ENST00000679624.1
SMAD family member 3
chr1_+_110339323 1.92 ENST00000602849.1
ENST00000487146.8
ENST00000618772.4
ENST00000369784.9
ENST00000650953.2
ENST00000652342.2
ENST00000654015.1
RNA binding motif protein 15
chr3_+_172040554 1.91 ENST00000336824.8
ENST00000423424.5
fibronectin type III domain containing 3B
chr1_+_110339462 1.89 ENST00000617047.1
RNA binding motif protein 15
chr6_+_37433197 1.79 ENST00000455891.5
ENST00000373451.9
cap methyltransferase 1
chr17_+_7307961 1.75 ENST00000419711.6
ENST00000571955.5
ENST00000573714.5
eukaryotic translation initiation factor 5A
chr10_-_46030585 1.69 ENST00000580070.5
ENST00000578454.5
ENST00000585056.5
ENST00000579039.2
ENST00000581486.6
nuclear receptor coactivator 4
chr1_-_205121986 1.62 ENST00000367164.1
RB binding protein 5, histone lysine methyltransferase complex subunit
chr4_-_73223082 1.59 ENST00000509867.6
ankyrin repeat domain 17
chr17_+_7308339 1.48 ENST00000416016.2
eukaryotic translation initiation factor 5A
chr2_+_218245426 1.43 ENST00000456575.1
actin related protein 2/3 complex subunit 2
chr3_+_113532508 1.36 ENST00000264852.9
SID1 transmembrane family member 1
chr5_-_138338325 1.34 ENST00000510119.1
ENST00000513970.5
cell division cycle 25C
chr3_-_50350710 1.31 ENST00000232501.8
NPR2 like, GATOR1 complex subunit
chrX_+_106611930 1.30 ENST00000372544.6
ENST00000372548.9
RPA1 related single stranded DNA binding protein, X-linked
chr10_-_92497727 1.30 ENST00000496903.5
ENST00000678824.1
ENST00000371581.9
insulin degrading enzyme
chr15_+_57219411 1.29 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
transcription factor 12
chr14_-_106875069 1.26 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr15_+_40358207 1.21 ENST00000267889.5
dispatched RND transporter family member 2
chr4_+_143433491 1.17 ENST00000512843.1
GRB2 associated binding protein 1
chr2_-_181680490 1.16 ENST00000684145.1
ENST00000295108.4
ENST00000684079.1
ENST00000683430.1
ceramide kinase like
neuronal differentiation 1
chr3_-_179266971 1.13 ENST00000349697.2
ENST00000497599.5
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr1_+_12464912 1.10 ENST00000543766.2
vacuolar protein sorting 13 homolog D
chr1_+_100345018 1.06 ENST00000635056.2
ENST00000647005.1
cell division cycle 14A
chr1_+_159302321 1.03 ENST00000368114.1
Fc fragment of IgE receptor Ia
chr8_+_21966215 0.96 ENST00000433566.8
exportin 7
chr1_+_103750406 0.92 ENST00000370079.3
amylase alpha 1C
chr1_+_170664121 0.91 ENST00000239461.11
paired related homeobox 1
chr9_+_2158487 0.89 ENST00000634706.1
ENST00000634338.1
ENST00000635688.1
ENST00000634435.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_162243375 0.82 ENST00000188790.9
ENST00000443424.5
fibroblast activation protein alpha
chr6_+_30571393 0.78 ENST00000376545.7
ENST00000441867.6
ENST00000468958.1
ENST00000326195.13
ATP binding cassette subfamily F member 1
chrX_+_108091752 0.77 ENST00000457035.5
ENST00000372232.8
autophagy related 4A cysteine peptidase
chr17_+_41689862 0.76 ENST00000586699.1
eukaryotic translation initiation factor 1
chr15_-_55408018 0.75 ENST00000569205.5
cell cycle progression 1
chr9_+_2158239 0.72 ENST00000635133.1
ENST00000634931.1
ENST00000423555.6
ENST00000382185.6
ENST00000302401.8
ENST00000382183.6
ENST00000417599.6
ENST00000382186.6
ENST00000635530.1
ENST00000635388.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr19_+_57363469 0.71 ENST00000282282.4
ENST00000543226.2
ENST00000596755.1
ENST00000597658.1
zinc finger protein 547
trafficking protein particle complex 2B
novel protein
chr16_+_72108296 0.68 ENST00000563819.5
ENST00000567142.2
DEAH-box helicase 38
chr7_-_41703062 0.63 ENST00000242208.5
inhibin subunit beta A
chrX_+_108091665 0.61 ENST00000345734.7
autophagy related 4A cysteine peptidase
chr2_-_187513641 0.60 ENST00000392365.5
ENST00000435414.5
tissue factor pathway inhibitor
chr22_+_35717872 0.58 ENST00000249044.2
apolipoprotein L5
chr5_+_136160986 0.58 ENST00000507637.1
SMAD family member 5
chr1_+_180928133 0.52 ENST00000367587.1
KIAA1614
chr10_+_134465 0.47 ENST00000439456.5
ENST00000397962.8
ENST00000309776.8
ENST00000397959.7
zinc finger MYND-type containing 11
chr8_-_94436926 0.46 ENST00000481490.3
fibrinogen silencer binding protein
chr18_+_34710307 0.45 ENST00000679796.1
dystrobrevin alpha
chr5_+_175872741 0.44 ENST00000502265.5
complexin 2
chr2_-_153478753 0.43 ENST00000325926.4
reprimo, TP53 dependent G2 arrest mediator homolog
chr22_-_28306645 0.39 ENST00000612946.4
tetratricopeptide repeat domain 28
chr12_-_102478539 0.39 ENST00000424202.6
insulin like growth factor 1
chr7_-_55862750 0.35 ENST00000388975.4
septin 14
chr16_+_31108294 0.34 ENST00000287507.7
ENST00000394950.7
ENST00000219794.11
ENST00000561755.1
branched chain keto acid dehydrogenase kinase
chr4_-_69639642 0.33 ENST00000604629.6
ENST00000604021.1
UDP glucuronosyltransferase family 2 member A2
chr1_+_148748774 0.31 ENST00000322209.5
nudix hydrolase 4B
chr1_+_186375813 0.30 ENST00000419367.8
ENST00000287859.11
ENST00000367470.8
odr-4 GPCR localization factor homolog
chr16_-_4846196 0.30 ENST00000589389.5
glyoxylate reductase 1 homolog
chrX_+_70290077 0.25 ENST00000374403.4
kinesin family member 4A
chr12_-_108320635 0.24 ENST00000412676.5
ENST00000550573.5
chemerin chemokine-like receptor 1
chr17_-_676348 0.21 ENST00000681510.1
ENST00000679680.1
VPS53 subunit of GARP complex
chr7_+_107891135 0.21 ENST00000639772.1
ENST00000440410.5
ENST00000437604.6
ENST00000205402.10
dihydrolipoamide dehydrogenase
chr19_+_18097763 0.19 ENST00000262811.10
microtubule associated serine/threonine kinase 3
chr12_-_39619782 0.16 ENST00000308666.4
ATP binding cassette subfamily D member 2
chr2_+_99337364 0.15 ENST00000617677.1
ENST00000289371.11
eukaryotic translation initiation factor 5B
chrX_-_15384402 0.14 ENST00000297904.4
vascular endothelial growth factor D
chr10_-_72354895 0.13 ENST00000444643.8
ENST00000338820.7
ENST00000394903.6
DnaJ heat shock protein family (Hsp40) member B12
chr4_-_158173004 0.11 ENST00000585682.6
golgi associated kinase 1B
chr12_-_30735014 0.09 ENST00000433722.6
caprin family member 2
chr12_-_91179517 0.08 ENST00000551354.1
decorin
chr3_-_42875871 0.08 ENST00000316161.6
ENST00000437102.1
cytochrome P450 family 8 subfamily B member 1
chr12_+_50400809 0.04 ENST00000293618.12
ENST00000429001.7
ENST00000398473.7
ENST00000548174.5
ENST00000548697.5
ENST00000548993.5
ENST00000614335.4
ENST00000522085.5
ENST00000615080.4
ENST00000518444.5
ENST00000551886.5
ENST00000523389.5
ENST00000518561.5
ENST00000347328.9
ENST00000550260.1
La ribonucleoprotein 4
chr8_+_67064316 0.03 ENST00000675306.2
ENST00000678017.1
ENST00000262210.11
ENST00000675869.1
ENST00000677009.1
ENST00000676847.1
ENST00000676471.1
ENST00000678542.1
ENST00000677619.1
ENST00000676605.1
ENST00000678553.1
ENST00000674993.1
ENST00000678318.1
ENST00000676573.1
ENST00000676317.1
ENST00000677592.1
ENST00000679226.1
ENST00000675955.1
ENST00000676882.1
ENST00000678616.1
ENST00000678645.1
ENST00000678747.1
centrosome and spindle pole associated protein 1
chr20_+_43565115 0.02 ENST00000423407.7
serum/glucocorticoid regulated kinase 2
chr4_+_54229261 0.01 ENST00000508170.5
ENST00000512143.1
ENST00000257290.10
platelet derived growth factor receptor alpha

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.2 GO:0006714 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
1.8 5.3 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.8 7.0 GO:0042631 cellular response to water deprivation(GO:0042631)
1.4 23.8 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.8 4.0 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.6 14.0 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.5 4.6 GO:0042118 endothelial cell activation(GO:0042118)
0.5 2.0 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.5 1.8 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.5 4.6 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.4 0.8 GO:0097325 melanocyte proliferation(GO:0097325)
0.4 3.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 1.4 GO:0051697 protein delipidation(GO:0051697)
0.3 1.0 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.3 5.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3 2.0 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.3 1.3 GO:1901143 insulin catabolic process(GO:1901143)
0.3 3.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.3 1.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.3 5.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.3 3.9 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 1.8 GO:0080009 mRNA methylation(GO:0080009)
0.2 2.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 0.6 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 1.4 GO:0033227 dsRNA transport(GO:0033227)
0.2 2.0 GO:0001865 NK T cell differentiation(GO:0001865)
0.2 8.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.6 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 2.7 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 1.4 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 4.3 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 1.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 2.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.4 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.8 GO:0009048 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 0.9 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 6.7 GO:0045576 mast cell activation(GO:0045576)
0.1 0.6 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.5 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 1.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.2 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 1.3 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 1.6 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 16.5 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 4.9 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.2 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759) negative regulation of interleukin-12 production(GO:0032695)
0.0 0.1 GO:0060753 regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.5 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 1.0 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.3 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.3 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.2 GO:0036398 TCR signalosome(GO:0036398)
0.6 1.8 GO:0097636 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.5 1.4 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 2.7 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 2.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 0.6 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.2 3.2 GO:0005642 annulate lamellae(GO:0005642)
0.2 1.7 GO:0044754 autolysosome(GO:0044754)
0.2 1.3 GO:1990130 Iml1 complex(GO:1990130)
0.2 1.1 GO:0060091 kinocilium(GO:0060091)
0.1 1.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 5.0 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 5.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.0 GO:0042588 zymogen granule(GO:0042588)
0.1 0.4 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 0.2 GO:0043159 acrosomal matrix(GO:0043159)
0.1 0.3 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 8.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 26.9 GO:0005667 transcription factor complex(GO:0005667)
0.1 0.8 GO:0071438 invadopodium membrane(GO:0071438)
0.1 7.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 5.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 6.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 3.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 3.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.3 GO:0000786 nucleosome(GO:0000786)
0.0 5.3 GO:0030133 transport vesicle(GO:0030133)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.2 GO:0045550 geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.9 4.6 GO:0042610 CD8 receptor binding(GO:0042610)
0.5 5.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 1.3 GO:0031626 beta-endorphin binding(GO:0031626)
0.4 1.8 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.3 2.0 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.3 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.8 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.2 4.0 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.2 1.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 3.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 1.0 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE binding(GO:0019863)
0.1 23.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.2 GO:0046625 sphingolipid binding(GO:0046625)
0.1 0.3 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 4.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 2.0 GO:0008494 translation activator activity(GO:0008494)
0.1 1.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 2.0 GO:0031489 myosin V binding(GO:0031489)
0.1 0.6 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 2.1 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 1.3 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 3.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 9.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 9.3 GO:0003823 antigen binding(GO:0003823)
0.0 5.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.3 GO:0050699 WW domain binding(GO:0050699)
0.0 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.6 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.2 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 2.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 6.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.2 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 1.7 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 37.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 5.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 2.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 9.6 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 5.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.3 PID ATM PATHWAY ATM pathway
0.0 0.4 PID IGF1 PATHWAY IGF1 pathway
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.6 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.2 8.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 7.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 3.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 2.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 0.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 5.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 5.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.2 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 2.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation