Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CAGUAGU
Z-value: 4.23
Motif logo
miRNA associated with seed CAGUAGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-199a-3p
|
MIMAT0000232 |
|
hsa-miR-199b-3p
|
MIMAT0004563 |
|
hsa-miR-3129-5p
|
MIMAT0014992 |
Activity profile of CAGUAGU motif
Sorted Z-values of CAGUAGU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CAGUAGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 16.0 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 2.2 | 6.7 | GO:0019089 | negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010768) transmission of virus(GO:0019089) dissemination or transmission of symbiont from host(GO:0044007) dissemination or transmission of organism from other organism involved in symbiotic interaction(GO:0051821) |
| 2.1 | 10.6 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 2.1 | 8.3 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 1.8 | 5.4 | GO:2000793 | negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) cell proliferation involved in heart valve development(GO:2000793) |
| 1.8 | 5.3 | GO:0060623 | regulation of chromosome condensation(GO:0060623) |
| 1.7 | 5.0 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 1.5 | 9.2 | GO:0008218 | bioluminescence(GO:0008218) |
| 1.5 | 4.5 | GO:1903778 | protein localization to vacuolar membrane(GO:1903778) |
| 1.3 | 9.3 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 1.2 | 6.1 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 1.2 | 3.6 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 1.2 | 3.5 | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells(GO:1903691) |
| 1.1 | 3.2 | GO:2000687 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 1.1 | 7.5 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 1.0 | 3.1 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
| 1.0 | 4.2 | GO:0007538 | primary sex determination(GO:0007538) |
| 1.0 | 3.1 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 1.0 | 5.1 | GO:0044789 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 1.0 | 11.0 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 1.0 | 4.9 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.8 | 3.2 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.7 | 9.4 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.7 | 13.0 | GO:0051195 | negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198) |
| 0.7 | 2.0 | GO:1902309 | regulation of heart rate by hormone(GO:0003064) negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.7 | 6.0 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.7 | 4.0 | GO:0061687 | detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501) |
| 0.6 | 3.0 | GO:0021824 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) sensory system development(GO:0048880) facioacoustic ganglion development(GO:1903375) |
| 0.6 | 7.0 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.6 | 5.2 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.6 | 8.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.6 | 5.2 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 0.6 | 3.9 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.5 | 2.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.5 | 4.3 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 0.5 | 3.6 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.5 | 1.9 | GO:0031064 | negative regulation of histone deacetylation(GO:0031064) |
| 0.5 | 4.3 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.5 | 12.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.5 | 4.1 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.4 | 2.0 | GO:0035801 | adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.4 | 3.2 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.4 | 2.7 | GO:0032417 | positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) |
| 0.4 | 2.3 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.3 | 0.7 | GO:0072275 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 0.3 | 5.4 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.3 | 5.6 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.3 | 0.9 | GO:0003257 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) |
| 0.3 | 1.8 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 0.3 | 1.2 | GO:0060437 | lung growth(GO:0060437) |
| 0.3 | 3.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 6.1 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.3 | 0.8 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.3 | 3.3 | GO:1904896 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 0.3 | 4.0 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.3 | 13.0 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 0.2 | 1.0 | GO:0035977 | protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382) |
| 0.2 | 1.7 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 0.2 | 5.7 | GO:2000637 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.2 | 1.8 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.2 | 1.8 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.2 | 7.2 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.2 | 1.8 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.2 | 10.4 | GO:0018196 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.2 | 5.6 | GO:0009226 | nucleotide-sugar biosynthetic process(GO:0009226) |
| 0.2 | 1.9 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.2 | 2.0 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.2 | 1.0 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.2 | 0.8 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.2 | 0.6 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.2 | 1.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.1 | 1.9 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.1 | 4.5 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.1 | 3.4 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.1 | 2.0 | GO:0060252 | positive regulation of glial cell proliferation(GO:0060252) |
| 0.1 | 7.0 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.1 | 1.2 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.1 | 0.9 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.1 | 0.7 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.1 | 0.7 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.1 | 1.2 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.1 | 1.0 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.1 | 1.8 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.1 | 1.5 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 3.7 | GO:0034067 | protein localization to Golgi apparatus(GO:0034067) |
| 0.1 | 0.2 | GO:0000710 | meiotic mismatch repair(GO:0000710) |
| 0.1 | 4.1 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.1 | 2.6 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.1 | 3.4 | GO:0046949 | fatty-acyl-CoA biosynthetic process(GO:0046949) |
| 0.1 | 1.9 | GO:0071711 | basement membrane organization(GO:0071711) |
| 0.1 | 1.4 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.0 | 5.1 | GO:0031016 | pancreas development(GO:0031016) |
| 0.0 | 7.8 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 2.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.4 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 0.2 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.0 | 6.2 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 0.3 | GO:0003344 | pericardium morphogenesis(GO:0003344) |
| 0.0 | 0.9 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 0.3 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.0 | 0.8 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 1.2 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 0.9 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.0 | 3.3 | GO:0007292 | female gamete generation(GO:0007292) |
| 0.0 | 0.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 2.0 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.0 | 0.4 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 0.6 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.8 | GO:0032878 | regulation of establishment or maintenance of cell polarity(GO:0032878) |
| 0.0 | 1.2 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 4.2 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 0.1 | GO:0001692 | histamine metabolic process(GO:0001692) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805) |
| 0.0 | 1.3 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 1.5 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.0 | 0.1 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.0 | 0.1 | GO:0021702 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.0 | 0.3 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.2 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 1.2 | 4.9 | GO:0034665 | integrin alpha1-beta1 complex(GO:0034665) |
| 1.1 | 5.4 | GO:0042025 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 0.9 | 9.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.8 | 7.7 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.7 | 7.0 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.6 | 3.1 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.5 | 5.3 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.5 | 5.0 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.4 | 3.4 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.3 | 5.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.3 | 4.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.3 | 13.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.3 | 16.7 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.2 | 1.9 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.2 | 3.6 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.2 | 7.5 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.2 | 1.2 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.2 | 1.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.2 | 6.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 3.0 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 5.1 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.2 | 1.1 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 8.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.2 | 9.3 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 10.4 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 4.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 1.8 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.1 | 4.2 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 7.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 15.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 5.7 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 10.6 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 5.0 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 6.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 0.3 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 0.1 | 8.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 1.2 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 6.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 4.6 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 12.2 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 3.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 21.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 1.0 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 3.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 1.0 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 4.0 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.6 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 0.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 2.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 2.7 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 6.4 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 0.2 | GO:0042567 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 4.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 2.3 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 1.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.5 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 1.8 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.0 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.3 | GO:0044295 | axonal growth cone(GO:0044295) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.7 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 2.5 | 7.5 | GO:0034189 | very-low-density lipoprotein particle binding(GO:0034189) |
| 2.1 | 6.2 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 1.3 | 5.0 | GO:0070363 | mitochondrial light strand promoter sense binding(GO:0070363) |
| 1.2 | 8.7 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 1.2 | 16.9 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 1.0 | 3.1 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 1.0 | 3.1 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.9 | 3.6 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.9 | 3.4 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.7 | 10.6 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.7 | 2.0 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.6 | 4.9 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.5 | 2.7 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.4 | 5.7 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.4 | 4.1 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.4 | 1.9 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.4 | 7.0 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.4 | 10.3 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
| 0.4 | 1.8 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.3 | 12.2 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.3 | 5.4 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.3 | 4.1 | GO:0031386 | protein tag(GO:0031386) |
| 0.3 | 0.8 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) |
| 0.3 | 8.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.3 | 9.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 3.9 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.2 | 1.5 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.2 | 9.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 3.7 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.2 | 3.4 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.2 | 1.0 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 0.2 | 0.7 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 5.6 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.2 | 4.0 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.2 | 6.1 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.2 | 0.6 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.2 | 5.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 3.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 4.6 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.2 | 3.6 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 1.2 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.1 | 5.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 6.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 1.0 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.1 | 1.1 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 1.2 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 3.3 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 1.8 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.1 | 1.0 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 3.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 2.0 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 1.3 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.1 | 6.0 | GO:0004407 | histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558) |
| 0.1 | 2.3 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 3.4 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 0.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 4.1 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.1 | 13.0 | GO:0020037 | heme binding(GO:0020037) |
| 0.1 | 1.2 | GO:0001163 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.1 | 5.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 8.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 0.3 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 8.6 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 7.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 10.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 17.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 1.9 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 0.1 | 3.1 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 2.4 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.8 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.2 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.0 | 0.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 2.7 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 5.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.1 | GO:0001222 | transcription corepressor binding(GO:0001222) oxysterol binding(GO:0008142) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 2.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 1.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.4 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.9 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 1.2 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.0 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.3 | 14.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.3 | 9.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 21.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 4.9 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.2 | 7.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 5.2 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 10.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 10.6 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 6.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 7.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 6.7 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 4.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 6.2 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 4.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 1.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 3.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 4.7 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 5.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 2.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 1.2 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.6 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 6.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.4 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.0 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.4 | 15.3 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.4 | 9.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.4 | 9.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 16.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 3.2 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 7.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.2 | 4.3 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.2 | 4.0 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 3.0 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 4.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 10.4 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.2 | 3.3 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 5.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.2 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.1 | 12.8 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 5.5 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 2.5 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 3.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 1.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 7.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 5.0 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.0 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 1.2 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 5.0 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.1 | 1.0 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 5.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 6.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 3.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 4.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.8 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.2 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 5.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 3.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.6 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |