Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CAGUGCA
Z-value: 3.41
Motif logo
miRNA associated with seed CAGUGCA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-148a-3p
|
MIMAT0000243 |
|
hsa-miR-148b-3p
|
MIMAT0000759 |
|
hsa-miR-152-3p
|
MIMAT0000438 |
Activity profile of CAGUGCA motif
Sorted Z-values of CAGUGCA motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CAGUGCA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 10.3 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 2.5 | 5.1 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 2.4 | 7.1 | GO:0090158 | endoplasmic reticulum membrane organization(GO:0090158) |
| 1.9 | 5.7 | GO:1901254 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 1.7 | 6.9 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 1.6 | 11.5 | GO:0008215 | spermine metabolic process(GO:0008215) |
| 1.4 | 4.3 | GO:0001300 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 1.4 | 5.4 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 1.3 | 5.1 | GO:0007538 | primary sex determination(GO:0007538) |
| 1.3 | 11.3 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 1.2 | 3.7 | GO:0060957 | endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445) |
| 1.2 | 23.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 1.2 | 3.5 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 1.2 | 3.5 | GO:2000283 | regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283) |
| 1.1 | 3.2 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) regulation of chromosome condensation(GO:0060623) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 1.1 | 4.2 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 1.0 | 3.1 | GO:0045897 | positive regulation of transcription during mitosis(GO:0045897) |
| 1.0 | 4.1 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 1.0 | 11.2 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 1.0 | 4.1 | GO:0050923 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 1.0 | 5.9 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.9 | 4.7 | GO:0060613 | fat pad development(GO:0060613) |
| 0.9 | 13.9 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.9 | 7.0 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.8 | 11.8 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.8 | 5.9 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.8 | 3.3 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.8 | 8.8 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.8 | 2.3 | GO:2000687 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 0.8 | 3.0 | GO:2000327 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 0.7 | 5.0 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.7 | 4.7 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.7 | 6.0 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.6 | 5.8 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.6 | 1.9 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.6 | 1.9 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of autophagosome maturation(GO:1901097) |
| 0.6 | 1.8 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 0.5 | 7.1 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.5 | 3.8 | GO:0090170 | regulation of Golgi inheritance(GO:0090170) |
| 0.5 | 4.2 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.5 | 1.5 | GO:0042704 | negative regulation of alkaline phosphatase activity(GO:0010693) uterine wall breakdown(GO:0042704) positive regulation of catagen(GO:0051795) |
| 0.5 | 1.5 | GO:0031064 | negative regulation of histone deacetylation(GO:0031064) |
| 0.5 | 8.6 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 0.4 | 3.9 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.4 | 3.8 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.4 | 6.0 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.4 | 5.1 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.4 | 2.9 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 0.4 | 2.4 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.4 | 2.4 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.4 | 2.7 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 0.4 | 1.5 | GO:0061552 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.4 | 1.4 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.4 | 3.6 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.4 | 5.0 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.4 | 3.2 | GO:0015886 | heme transport(GO:0015886) |
| 0.3 | 1.7 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.3 | 2.3 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.3 | 2.9 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.3 | 11.3 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.3 | 3.1 | GO:2000576 | positive regulation of microtubule motor activity(GO:2000576) |
| 0.3 | 0.9 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.3 | 8.2 | GO:1902284 | axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284) |
| 0.3 | 5.9 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.3 | 0.9 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.3 | 4.5 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.3 | 2.5 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.3 | 12.9 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.3 | 3.6 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.3 | 5.4 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.3 | 2.0 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.2 | 0.7 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.2 | 1.2 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.2 | 2.2 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.2 | 0.7 | GO:1904732 | copper ion export(GO:0060003) cellular response to lead ion(GO:0071284) regulation of electron carrier activity(GO:1904732) |
| 0.2 | 2.8 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.2 | 1.6 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.2 | 2.0 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.2 | 3.9 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.2 | 1.5 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.2 | 1.4 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.2 | 0.8 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.2 | 0.6 | GO:1904430 | negative regulation of t-circle formation(GO:1904430) |
| 0.2 | 6.4 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.2 | 2.8 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.2 | 0.6 | GO:1903094 | regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157) |
| 0.2 | 5.4 | GO:0097341 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 0.2 | 3.5 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.2 | 1.3 | GO:1902915 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.2 | 5.7 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.2 | 1.2 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.2 | 2.5 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.2 | 1.0 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.2 | 4.5 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.1 | 3.0 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 2.4 | GO:0010944 | negative regulation of transcription by competitive promoter binding(GO:0010944) |
| 0.1 | 3.0 | GO:2000637 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.1 | 1.0 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 0.5 | GO:0090283 | regulation of protein glycosylation in Golgi(GO:0090283) |
| 0.1 | 4.7 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.1 | 0.6 | GO:0071543 | diadenosine polyphosphate metabolic process(GO:0015959) diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 0.1 | 5.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 6.0 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 3.0 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 0.7 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.1 | 2.8 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.1 | 0.2 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
| 0.1 | 1.3 | GO:0010225 | response to UV-C(GO:0010225) |
| 0.1 | 0.2 | GO:0090107 | regulation of high-density lipoprotein particle assembly(GO:0090107) |
| 0.1 | 9.3 | GO:0032392 | DNA geometric change(GO:0032392) |
| 0.1 | 0.3 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.1 | 1.7 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 0.8 | GO:0019317 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.1 | 2.9 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 1.2 | GO:0070072 | proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.1 | 0.2 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 0.1 | 3.3 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 1.4 | GO:2000188 | regulation of cholesterol homeostasis(GO:2000188) |
| 0.1 | 0.5 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.1 | 0.6 | GO:1902916 | regulation of protein polyubiquitination(GO:1902914) positive regulation of protein polyubiquitination(GO:1902916) |
| 0.1 | 0.3 | GO:0044860 | protein localization to plasma membrane raft(GO:0044860) |
| 0.1 | 1.0 | GO:0046337 | phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337) |
| 0.1 | 0.5 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.1 | 7.8 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.1 | 4.3 | GO:0071806 | protein transmembrane transport(GO:0071806) |
| 0.0 | 1.5 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 2.5 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 4.6 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.0 | 10.0 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 0.6 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.0 | 0.7 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 2.3 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 1.5 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.0 | 0.5 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.0 | 1.4 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 2.0 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.0 | 1.5 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 1.0 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 1.1 | GO:0060976 | coronary vasculature development(GO:0060976) |
| 0.0 | 1.4 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.0 | 1.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 1.8 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.0 | 3.7 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 1.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.6 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.0 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.0 | 0.0 | GO:0033078 | extrathymic T cell differentiation(GO:0033078) extrathymic T cell selection(GO:0045062) |
| 0.0 | 1.9 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 0.2 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.0 | 1.2 | GO:0007569 | cell aging(GO:0007569) |
| 0.0 | 0.4 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 2.3 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 1.9 | GO:0051168 | nuclear export(GO:0051168) |
| 0.0 | 0.9 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.0 | 0.2 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
| 0.0 | 1.4 | GO:0008584 | male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546) |
| 0.0 | 0.5 | GO:0072431 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 10.2 | GO:0044094 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 1.3 | 5.3 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 1.2 | 7.1 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 1.1 | 8.0 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.9 | 3.7 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.7 | 4.3 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.7 | 4.7 | GO:0031415 | NatA complex(GO:0031415) |
| 0.6 | 11.8 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.6 | 8.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.6 | 1.7 | GO:1903349 | omegasome membrane(GO:1903349) |
| 0.6 | 5.0 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.5 | 2.2 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.5 | 4.3 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.5 | 3.5 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.5 | 2.9 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.5 | 1.9 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.5 | 8.5 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.5 | 6.0 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.5 | 3.2 | GO:0043196 | varicosity(GO:0043196) |
| 0.4 | 3.6 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.4 | 2.9 | GO:0030891 | VCB complex(GO:0030891) |
| 0.4 | 5.4 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.3 | 3.2 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.3 | 1.6 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.3 | 4.2 | GO:0032059 | bleb(GO:0032059) |
| 0.3 | 3.9 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.3 | 3.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.3 | 17.2 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.3 | 8.2 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.3 | 3.1 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.3 | 2.8 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.2 | 1.2 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.2 | 4.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.2 | 2.8 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.2 | 0.9 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.2 | 5.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.2 | 2.0 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.2 | 9.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 2.4 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.2 | 5.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.2 | 0.9 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.2 | 10.9 | GO:0043034 | costamere(GO:0043034) |
| 0.2 | 2.5 | GO:0090543 | Flemming body(GO:0090543) |
| 0.2 | 1.8 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.2 | 4.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.2 | 3.0 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.2 | 1.5 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.2 | 18.5 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.2 | 3.1 | GO:0044453 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.2 | 17.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 12.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 1.0 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 12.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 18.8 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 3.5 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 3.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 2.1 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 2.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 1.4 | GO:1990752 | microtubule end(GO:1990752) |
| 0.1 | 3.0 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 0.6 | GO:0070187 | telosome(GO:0070187) |
| 0.1 | 0.7 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.1 | 3.5 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.1 | 0.3 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.1 | 4.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 8.8 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 0.6 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 6.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 1.2 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 3.1 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 6.4 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 3.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 3.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.7 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 1.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.9 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 3.6 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 3.3 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 7.1 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 2.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.9 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 0.5 | GO:0016514 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.0 | 7.4 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 1.0 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 5.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 7.0 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 2.0 | GO:0044452 | nucleolar part(GO:0044452) |
| 0.0 | 1.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.2 | GO:0031201 | SNARE complex(GO:0031201) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 11.8 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 2.0 | 6.1 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 1.8 | 12.9 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 1.8 | 10.9 | GO:0034046 | poly(G) binding(GO:0034046) |
| 1.8 | 5.4 | GO:0051717 | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) |
| 1.6 | 8.0 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 1.3 | 11.3 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 1.2 | 6.0 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 1.2 | 3.5 | GO:0036487 | nitric-oxide synthase inhibitor activity(GO:0036487) |
| 1.0 | 3.1 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
| 1.0 | 3.1 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 1.0 | 5.1 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.9 | 7.0 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.8 | 3.8 | GO:0017018 | myosin phosphatase activity(GO:0017018) |
| 0.7 | 3.5 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.7 | 4.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.6 | 4.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.6 | 3.7 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.6 | 3.0 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.6 | 3.0 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.6 | 2.9 | GO:0038025 | reelin receptor activity(GO:0038025) |
| 0.5 | 5.4 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.5 | 4.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.5 | 5.5 | GO:0046790 | virion binding(GO:0046790) |
| 0.5 | 8.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.5 | 3.6 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.4 | 3.6 | GO:0004308 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 0.4 | 19.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.4 | 13.6 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.4 | 6.9 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.4 | 3.2 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.4 | 3.8 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.3 | 4.7 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.3 | 3.3 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.3 | 6.4 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.3 | 1.0 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.3 | 3.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.3 | 1.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.3 | 6.1 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.3 | 1.5 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.3 | 4.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.3 | 2.4 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 2.7 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.2 | 4.3 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.2 | 0.7 | GO:0004008 | copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) superoxide dismutase copper chaperone activity(GO:0016532) copper-transporting ATPase activity(GO:0043682) |
| 0.2 | 1.1 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.2 | 4.0 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.2 | 4.1 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.2 | 0.8 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.2 | 4.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.2 | 1.5 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.2 | 2.4 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.2 | 11.2 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.2 | 1.6 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.2 | 7.9 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.2 | 1.0 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.2 | 0.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.2 | 1.8 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 0.4 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.1 | 1.4 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 1.5 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.1 | 4.2 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.1 | 11.5 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.1 | 1.9 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 0.4 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.1 | 5.0 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 5.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 0.6 | GO:0008486 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848) |
| 0.1 | 2.0 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 1.4 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 0.7 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 2.4 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 3.2 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 2.0 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 4.4 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 5.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 2.5 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 0.2 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) |
| 0.1 | 0.8 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.1 | 3.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 0.6 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.1 | 3.2 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 0.7 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 0.7 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.1 | 14.4 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.1 | 3.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 1.8 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.3 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.1 | 2.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.2 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.1 | 0.4 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.1 | 1.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 0.7 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 4.7 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.1 | 0.3 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 0.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 1.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.2 | GO:0070644 | 9-cis retinoic acid receptor activity(GO:0004886) vitamin D response element binding(GO:0070644) |
| 0.0 | 3.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 7.1 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.5 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 4.9 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.0 | 1.4 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 5.0 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.0 | 12.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.0 | 0.3 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.1 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.0 | 0.4 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 2.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.5 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 3.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 5.1 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 3.5 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.5 | 10.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 10.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.3 | 11.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.3 | 10.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 4.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 5.8 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.2 | 11.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 3.2 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 15.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 8.0 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 4.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 5.6 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 2.9 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 14.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 5.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 1.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 4.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 7.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 2.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 1.6 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 2.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.7 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 0.7 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.1 | 1.5 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 3.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 2.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 2.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 0.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 3.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 4.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 2.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.5 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.6 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.6 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 23.1 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 1.0 | 14.6 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.6 | 12.1 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.6 | 8.5 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.6 | 11.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.5 | 5.4 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.4 | 10.6 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.4 | 8.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.4 | 11.8 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.3 | 15.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.3 | 4.2 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.2 | 3.8 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.2 | 8.2 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 1.4 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.2 | 9.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.2 | 4.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 7.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 0.4 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.1 | 4.4 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.7 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 5.1 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.5 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.0 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 2.9 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 2.9 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 7.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 4.6 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 5.3 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 3.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 0.6 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.0 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 3.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 3.5 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 8.0 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 1.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 2.1 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 1.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 1.1 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 3.9 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.9 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 0.3 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 2.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.2 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.0 | 0.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 2.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.2 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |