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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CBFB

Z-value: 1.76

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.15 CBFB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg38_v1_chr16_+_67029093_670291160.426.3e-11Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_114439424 9.22 ENST00000544196.5
ENST00000265881.10
ENST00000539754.5
ENST00000539275.5
REXO2
RNA exonuclease 2
chr11_+_114439515 9.18 ENST00000539119.5
REXO2
RNA exonuclease 2
chr2_-_64653906 6.16 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr10_+_17229267 6.13 ENST00000224237.9
VIM
vimentin
chr11_-_58575846 5.74 ENST00000395074.7
LPXN
leupaxin
chr3_-_190122317 3.89 ENST00000427335.6
P3H2
prolyl 3-hydroxylase 2
chr13_-_46182136 3.79 ENST00000323076.7
LCP1
lymphocyte cytosolic protein 1
chr2_-_157444044 3.58 ENST00000264192.8
CYTIP
cytohesin 1 interacting protein
chr12_+_25052634 3.34 ENST00000548766.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr3_+_157436842 3.28 ENST00000295927.4
PTX3
pentraxin 3
chr12_+_25052512 2.65 ENST00000557489.5
ENST00000354454.7
ENST00000536173.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr2_+_68365274 2.59 ENST00000234313.8
PLEK
pleckstrin
chr3_-_99850976 2.56 ENST00000487087.5
FILIP1L
filamin A interacting protein 1 like
chr17_-_36090133 2.47 ENST00000613922.2
CCL3
C-C motif chemokine ligand 3
chr5_+_35856883 2.06 ENST00000506850.5
ENST00000303115.8
ENST00000511982.1
IL7R
interleukin 7 receptor
chr22_+_31082860 2.04 ENST00000619644.4
SMTN
smoothelin
chr17_+_34255274 1.94 ENST00000580907.5
ENST00000225831.4
CCL2
C-C motif chemokine ligand 2
chr19_-_13937991 1.65 ENST00000254320.7
ENST00000586075.1
PODNL1
podocan like 1
chr17_-_48101087 1.65 ENST00000393408.7
CBX1
chromobox 1
chr16_+_85611401 1.65 ENST00000405402.6
GSE1
Gse1 coiled-coil protein
chr19_-_13938371 1.53 ENST00000588872.3
ENST00000339560.10
PODNL1
podocan like 1
chr12_-_53200443 1.50 ENST00000550743.6
ITGB7
integrin subunit beta 7
chr17_-_48101379 1.44 ENST00000581003.5
ENST00000225603.9
CBX1
chromobox 1
chr14_+_22450089 1.43 ENST00000390473.1
TRDJ1
T cell receptor delta joining 1
chr1_+_161197372 1.40 ENST00000677550.1
ENST00000676600.1
ENST00000678507.1
ENST00000677579.1
ENST00000677231.1
ENST00000678911.1
ENST00000677846.1
NDUFS2
NADH:ubiquinone oxidoreductase core subunit S2
chr11_+_18322253 1.39 ENST00000453096.6
GTF2H1
general transcription factor IIH subunit 1
chr20_+_46008900 1.39 ENST00000372330.3
MMP9
matrix metallopeptidase 9
chr12_+_14973020 1.30 ENST00000266395.3
PDE6H
phosphodiesterase 6H
chr3_-_11568764 1.28 ENST00000424529.6
VGLL4
vestigial like family member 4
chr7_+_120988683 1.25 ENST00000340646.9
ENST00000310396.10
CPED1
cadherin like and PC-esterase domain containing 1
chr11_-_18322122 1.23 ENST00000349215.8
ENST00000396253.7
ENST00000438420.6
HPS5
HPS5 biogenesis of lysosomal organelles complex 2 subunit 2
chrX_-_49184789 1.22 ENST00000453382.5
ENST00000432913.5
PRICKLE3
prickle planar cell polarity protein 3
chr18_-_28177934 1.20 ENST00000676445.1
CDH2
cadherin 2
chr5_+_76403266 1.12 ENST00000274364.11
IQGAP2
IQ motif containing GTPase activating protein 2
chr3_+_98763331 1.11 ENST00000485391.5
ENST00000492254.5
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr2_-_206159194 1.07 ENST00000455934.6
ENST00000449699.5
ENST00000454195.1
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr10_-_46023445 1.01 ENST00000585132.5
NCOA4
nuclear receptor coactivator 4
chr2_-_206159410 1.00 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr9_-_35079923 0.99 ENST00000378643.8
ENST00000448890.1
FANCG
FA complementation group G
chr15_+_49423233 0.83 ENST00000560270.1
ENST00000267843.9
ENST00000560979.1
FGF7
fibroblast growth factor 7
chr14_-_60649449 0.82 ENST00000645694.3
SIX1
SIX homeobox 1
chr20_+_56412112 0.80 ENST00000360314.7
CASS4
Cas scaffold protein family member 4
chr8_-_28890164 0.77 ENST00000416984.6
INTS9
integrator complex subunit 9
chr8_-_28889958 0.72 ENST00000521022.6
INTS9
integrator complex subunit 9
chr8_-_28889909 0.72 ENST00000523436.5
ENST00000521777.5
ENST00000520184.1
INTS9
integrator complex subunit 9
chr20_+_56412249 0.68 ENST00000679887.1
ENST00000434344.2
CASS4
Cas scaffold protein family member 4
chr1_-_179143044 0.67 ENST00000504405.5
ENST00000512653.5
ENST00000344730.7
ABL2
ABL proto-oncogene 2, non-receptor tyrosine kinase
chr12_-_14696571 0.67 ENST00000261170.5
GUCY2C
guanylate cyclase 2C
chr18_-_55422306 0.61 ENST00000566777.5
ENST00000626584.2
TCF4
transcription factor 4
chr8_-_59119121 0.60 ENST00000361421.2
TOX
thymocyte selection associated high mobility group box
chr18_-_55422492 0.51 ENST00000561992.5
ENST00000630712.2
TCF4
transcription factor 4
chr1_-_184754808 0.49 ENST00000318130.13
ENST00000367512.7
EDEM3
ER degradation enhancing alpha-mannosidase like protein 3
chr1_-_206772484 0.46 ENST00000423557.1
IL10
interleukin 10
chr20_+_56412393 0.44 ENST00000679529.1
CASS4
Cas scaffold protein family member 4
chr6_+_52186373 0.39 ENST00000648244.1
IL17A
interleukin 17A
chr16_+_53054973 0.38 ENST00000447540.6
ENST00000615216.4
ENST00000566029.5
CHD9
chromodomain helicase DNA binding protein 9
chr14_+_22281097 0.38 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr14_-_24508251 0.38 ENST00000250378.7
ENST00000206446.4
CMA1
chymase 1
chr4_-_155376797 0.34 ENST00000650955.1
ENST00000515654.5
MAP9
microtubule associated protein 9
chr5_-_88785493 0.32 ENST00000503554.4
MEF2C
myocyte enhancer factor 2C
chr12_-_68159732 0.30 ENST00000229135.4
IFNG
interferon gamma
chr6_+_26500296 0.26 ENST00000684113.1
BTN1A1
butyrophilin subfamily 1 member A1
chr5_+_132073782 0.22 ENST00000296871.4
CSF2
colony stimulating factor 2
chr13_+_75636311 0.18 ENST00000377499.9
ENST00000377534.8
LMO7
LIM domain 7
chr17_+_66302606 0.11 ENST00000413366.8
PRKCA
protein kinase C alpha
chr8_-_133060347 0.11 ENST00000427060.6
SLA
Src like adaptor
chr11_-_66336396 0.05 ENST00000627248.1
ENST00000311320.9
RIN1
Ras and Rab interactor 1
chr18_-_48409292 0.05 ENST00000589194.5
ENST00000591279.5
ENST00000590855.5
ENST00000587107.5
ENST00000588970.5
ENST00000586525.5
ENST00000592387.5
ENST00000590800.6
ZBTB7C
zinc finger and BTB domain containing 7C

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.7 5.7 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.6 1.9 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.5 6.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.4 2.6 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.4 18.4 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.4 2.5 GO:2000501 regulation of natural killer cell chemotaxis(GO:2000501)
0.4 1.5 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.2 2.2 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.2 2.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.2 4.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 0.8 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199)
0.2 3.9 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.2 0.7 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.2 2.2 GO:0016180 snRNA processing(GO:0016180)
0.2 0.5 GO:0032661 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) regulation of interleukin-18 production(GO:0032661)
0.1 1.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1 0.4 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.1 0.5 GO:0035977 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.1 1.1 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 1.4 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.7 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 3.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.3 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 1.1 GO:0097503 sialylation(GO:0097503)
0.0 1.3 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 2.0 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0061110 desmosome assembly(GO:0002159) dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 1.0 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.0 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.7 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 2.0 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 3.3 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:0001940 male pronucleus(GO:0001940)
0.4 2.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.4 1.5 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.2 2.2 GO:0032039 integrator complex(GO:0032039)
0.2 9.5 GO:0002102 podosome(GO:0002102)
0.2 18.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.4 GO:0000439 core TFIIH complex(GO:0000439)
0.1 1.0 GO:0044754 autolysosome(GO:0044754)
0.1 1.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.2 GO:0031082 BLOC complex(GO:0031082)
0.1 1.2 GO:0016342 catenin complex(GO:0016342)
0.1 4.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 6.1 GO:0005882 intermediate filament(GO:0005882)
0.0 0.3 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 3.9 GO:0005604 basement membrane(GO:0005604)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 3.6 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.1 GO:1990254 keratin filament binding(GO:1990254)
1.0 3.9 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.6 1.9 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.6 2.6 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.5 18.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.5 3.3 GO:0001849 complement component C1q binding(GO:0001849)
0.4 1.1 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.3 3.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 1.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 2.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 2.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.4 GO:0048038 quinone binding(GO:0048038)
0.1 1.1 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 4.5 GO:0051015 actin filament binding(GO:0051015)
0.0 0.8 GO:0042056 chemoattractant activity(GO:0042056)
0.0 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 7.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 4.9 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.4 GO:0005518 collagen binding(GO:0005518)
0.0 1.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.0 GO:0003684 damaged DNA binding(GO:0003684)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.1 PID AURORA B PATHWAY Aurora B signaling
0.1 1.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.0 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 2.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 PID IL27 PATHWAY IL27-mediated signaling events
0.0 3.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 4.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.4 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 3.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.0 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 2.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.8 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 2.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor