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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CCUUGGC

Z-value: 0.76

Motif logo

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miRNA associated with seed CCUUGGC

NamemiRBASE accession
hsa-miR-212-5p
MIMAT0022695

Activity profile of CCUUGGC motif

Sorted Z-values of CCUUGGC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CCUUGGC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_72336995 0.66 ENST00000329008.9
CALN1
calneuron 1
chr19_+_42220283 0.54 ENST00000301215.8
ENST00000597945.1
ZNF526
zinc finger protein 526
chr9_-_107489754 0.47 ENST00000610832.1
ENST00000374672.5
KLF4
Kruppel like factor 4
chr3_-_115071333 0.47 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_66435558 0.43 ENST00000488550.5
MEIS1
Meis homeobox 1
chr4_+_127632926 0.41 ENST00000335251.11
INTU
inturned planar cell polarity protein
chrY_+_12904860 0.39 ENST00000336079.8
DDX3Y
DEAD-box helicase 3 Y-linked
chr17_+_40443441 0.38 ENST00000269593.5
IGFBP4
insulin like growth factor binding protein 4
chr16_-_46831134 0.33 ENST00000394806.6
ENST00000285697.9
C16orf87
chromosome 16 open reading frame 87
chr5_+_177133741 0.33 ENST00000439151.7
NSD1
nuclear receptor binding SET domain protein 1
chr8_-_81112055 0.27 ENST00000220597.4
PAG1
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
chr8_+_55102012 0.26 ENST00000327381.7
XKR4
XK related 4
chr17_-_78717018 0.26 ENST00000585509.5
CYTH1
cytohesin 1
chr8_-_65842051 0.25 ENST00000401827.8
PDE7A
phosphodiesterase 7A
chr16_-_88941198 0.25 ENST00000327483.9
ENST00000564416.1
CBFA2T3
CBFA2/RUNX1 partner transcriptional co-repressor 3
chr15_+_74826603 0.24 ENST00000395018.6
CPLX3
complexin 3
chr6_-_90296824 0.24 ENST00000257749.9
BACH2
BTB domain and CNC homolog 2
chr2_-_201071579 0.24 ENST00000453765.5
ENST00000452799.5
ENST00000446678.5
ENST00000418596.7
ENST00000681958.1
FAM126B
family with sequence similarity 126 member B
chr3_+_30606574 0.24 ENST00000295754.10
ENST00000359013.4
TGFBR2
transforming growth factor beta receptor 2
chr7_+_77696423 0.23 ENST00000334955.13
RSBN1L
round spermatid basic protein 1 like
chr15_-_34336749 0.23 ENST00000397707.6
ENST00000560611.5
SLC12A6
solute carrier family 12 member 6
chr17_+_49788672 0.22 ENST00000454930.6
ENST00000259021.9
ENST00000509773.5
ENST00000510819.5
ENST00000424009.6
KAT7
lysine acetyltransferase 7
chr17_+_49495286 0.22 ENST00000172229.8
NGFR
nerve growth factor receptor
chr2_+_218399838 0.22 ENST00000273062.7
CTDSP1
CTD small phosphatase 1
chr15_+_41660397 0.22 ENST00000219905.12
ENST00000566586.6
MGA
MAX dimerization protein MGA
chr21_+_31873010 0.21 ENST00000270112.7
HUNK
hormonally up-regulated Neu-associated kinase
chr10_+_70404129 0.21 ENST00000373218.5
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr4_-_86934700 0.21 ENST00000473559.5
ENSG00000285458.1
novel protein
chr1_-_89126066 0.20 ENST00000370466.4
GBP2
guanylate binding protein 2
chr3_-_53846374 0.20 ENST00000315251.11
CHDH
choline dehydrogenase
chr1_+_54053573 0.20 ENST00000234827.6
TCEANC2
transcription elongation factor A N-terminal and central domain containing 2
chr9_-_124771304 0.20 ENST00000416460.6
ENST00000487099.7
NR6A1
nuclear receptor subfamily 6 group A member 1
chr9_-_124507382 0.19 ENST00000373588.9
ENST00000620110.4
NR5A1
nuclear receptor subfamily 5 group A member 1
chr16_-_71577082 0.19 ENST00000355962.5
TAT
tyrosine aminotransferase
chrX_-_50814095 0.19 ENST00000376020.8
SHROOM4
shroom family member 4
chr18_+_13218769 0.18 ENST00000677055.1
ENST00000399848.7
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr5_+_140547632 0.18 ENST00000310331.3
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr16_-_2214776 0.17 ENST00000333503.8
PGP
phosphoglycolate phosphatase
chr1_+_11691688 0.17 ENST00000294485.6
DRAXIN
dorsal inhibitory axon guidance protein
chr17_-_64130125 0.17 ENST00000680433.1
ENST00000433197.4
ERN1
endoplasmic reticulum to nucleus signaling 1
chrX_+_123859976 0.16 ENST00000371199.8
XIAP
X-linked inhibitor of apoptosis
chr15_-_42920638 0.16 ENST00000566931.1
ENST00000564431.5
ENST00000567274.5
ENST00000267890.11
TTBK2
tau tubulin kinase 2
chr2_+_60881515 0.16 ENST00000295025.12
REL
REL proto-oncogene, NF-kB subunit
chr9_-_20622479 0.15 ENST00000380338.9
MLLT3
MLLT3 super elongation complex subunit
chr11_-_119729158 0.15 ENST00000264025.8
NECTIN1
nectin cell adhesion molecule 1
chr12_-_116881431 0.15 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein
chr17_+_59155726 0.15 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
PRR11
proline rich 11
chr9_+_129665603 0.15 ENST00000372469.6
PRRX2
paired related homeobox 2
chr2_-_20225123 0.14 ENST00000254351.9
SDC1
syndecan 1
chr1_+_180912876 0.14 ENST00000367588.9
KIAA1614
KIAA1614
chr9_-_27529705 0.14 ENST00000262244.6
MOB3B
MOB kinase activator 3B
chr17_-_40501615 0.14 ENST00000254051.11
TNS4
tensin 4
chr5_+_109689915 0.14 ENST00000261483.5
MAN2A1
mannosidase alpha class 2A member 1
chr1_-_151006795 0.13 ENST00000312210.9
ENST00000683666.1
MINDY1
MINDY lysine 48 deubiquitinase 1
chr17_+_8310220 0.13 ENST00000583529.1
ENST00000361926.8
ARHGEF15
Rho guanine nucleotide exchange factor 15
chr9_-_133121228 0.12 ENST00000372050.8
RALGDS
ral guanine nucleotide dissociation stimulator
chr2_+_27148997 0.12 ENST00000296096.6
TCF23
transcription factor 23
chr19_+_7888499 0.12 ENST00000618098.4
ENST00000306708.11
ENST00000600345.1
ENST00000598224.5
LRRC8E
leucine rich repeat containing 8 VRAC subunit E
chr10_-_102114935 0.12 ENST00000361198.9
LDB1
LIM domain binding 1
chr22_+_49853801 0.12 ENST00000216268.6
ZBED4
zinc finger BED-type containing 4
chr3_-_15332526 0.12 ENST00000383791.8
SH3BP5
SH3 domain binding protein 5
chr1_+_3069160 0.11 ENST00000511072.5
PRDM16
PR/SET domain 16
chr1_-_23168847 0.11 ENST00000418342.5
LUZP1
leucine zipper protein 1
chr9_-_16870662 0.11 ENST00000380672.9
BNC2
basonuclin 2
chr10_-_72354895 0.11 ENST00000444643.8
ENST00000338820.7
ENST00000394903.6
DNAJB12
DnaJ heat shock protein family (Hsp40) member B12
chr5_-_107670897 0.11 ENST00000333274.11
EFNA5
ephrin A5
chr5_+_140401860 0.11 ENST00000532219.5
ENST00000394722.7
ANKHD1-EIF4EBP3
ANKHD1
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr7_+_44748832 0.10 ENST00000309315.9
ENST00000457123.5
ZMIZ2
zinc finger MIZ-type containing 2
chr11_-_83071819 0.10 ENST00000524635.1
ENST00000526205.5
ENST00000533486.5
ENST00000533276.6
ENST00000527633.6
RAB30
RAB30, member RAS oncogene family
chr1_+_213987929 0.10 ENST00000498508.6
ENST00000366958.9
PROX1
prospero homeobox 1
chr1_-_117121692 0.10 ENST00000256649.9
ENST00000369464.7
ENST00000485032.1
TRIM45
tripartite motif containing 45
chr3_+_38453832 0.10 ENST00000352511.5
ACVR2B
activin A receptor type 2B
chr5_-_37840035 0.10 ENST00000326524.7
GDNF
glial cell derived neurotrophic factor
chr16_-_15643105 0.10 ENST00000548025.5
ENST00000551742.5
ENST00000396368.8
MARF1
meiosis regulator and mRNA stability factor 1
chr1_-_39639626 0.09 ENST00000372852.4
HEYL
hes related family bHLH transcription factor with YRPW motif like
chr11_-_64778502 0.09 ENST00000681407.1
ENST00000377390.8
SF1
splicing factor 1
chr2_+_167868948 0.09 ENST00000392690.3
B3GALT1
beta-1,3-galactosyltransferase 1
chr1_+_16004228 0.08 ENST00000329454.2
SRARP
steroid receptor associated and regulated protein
chrX_+_49922605 0.08 ENST00000376088.7
CLCN5
chloride voltage-gated channel 5
chr12_-_57846686 0.08 ENST00000548823.1
ENST00000398073.7
CTDSP2
CTD small phosphatase 2
chr9_+_137139139 0.08 ENST00000371561.8
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr1_-_37034492 0.07 ENST00000373091.8
GRIK3
glutamate ionotropic receptor kainate type subunit 3
chr13_-_78603539 0.07 ENST00000377208.7
POU4F1
POU class 4 homeobox 1
chr9_+_101398841 0.07 ENST00000339664.7
ENST00000374861.7
ENST00000259395.4
ENST00000615466.1
ZNF189
zinc finger protein 189
chr10_-_103918128 0.07 ENST00000224950.8
STN1
STN1 subunit of CST complex
chr1_+_25430854 0.07 ENST00000399766.7
MACO1
macoilin 1
chr20_+_38805686 0.06 ENST00000299824.6
ENST00000373331.2
PPP1R16B
protein phosphatase 1 regulatory subunit 16B
chr6_+_50818857 0.06 ENST00000393655.4
TFAP2B
transcription factor AP-2 beta
chr2_-_40452046 0.06 ENST00000406785.6
SLC8A1
solute carrier family 8 member A1
chr16_-_18926408 0.06 ENST00000446231.7
SMG1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
chr1_-_51297990 0.06 ENST00000530004.5
TTC39A
tetratricopeptide repeat domain 39A
chr7_+_127652186 0.06 ENST00000354725.8
SND1
staphylococcal nuclease and tudor domain containing 1
chr8_-_8893548 0.05 ENST00000276282.7
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr6_-_98947911 0.05 ENST00000369244.7
ENST00000229971.2
FBXL4
F-box and leucine rich repeat protein 4
chr8_+_75539862 0.04 ENST00000396423.4
HNF4G
hepatocyte nuclear factor 4 gamma
chr2_-_207769889 0.04 ENST00000295417.4
FZD5
frizzled class receptor 5
chr2_-_96265942 0.04 ENST00000432959.1
ENST00000258439.8
TMEM127
transmembrane protein 127
chr14_-_95319863 0.03 ENST00000298912.9
CLMN
calmin
chr20_+_35226676 0.03 ENST00000246186.8
MMP24
matrix metallopeptidase 24
chr2_+_191678122 0.03 ENST00000425611.9
ENST00000410026.7
NABP1
nucleic acid binding protein 1
chr15_+_96330691 0.03 ENST00000394166.8
NR2F2
nuclear receptor subfamily 2 group F member 2
chr17_-_47189176 0.03 ENST00000531206.5
ENST00000527547.5
ENST00000575483.5
ENST00000066544.8
CDC27
cell division cycle 27
chr14_+_103385506 0.03 ENST00000303622.13
MARK3
microtubule affinity regulating kinase 3
chr3_-_116445458 0.03 ENST00000490035.7
LSAMP
limbic system associated membrane protein
chrX_+_70444855 0.02 ENST00000194900.8
DLG3
discs large MAGUK scaffold protein 3
chr11_+_75815180 0.02 ENST00000356136.8
UVRAG
UV radiation resistance associated
chr7_-_139777986 0.02 ENST00000406875.8
HIPK2
homeodomain interacting protein kinase 2
chr3_-_11720728 0.02 ENST00000445411.5
ENST00000273038.7
VGLL4
vestigial like family member 4
chr10_+_110207587 0.02 ENST00000332674.9
ENST00000453116.5
MXI1
MAX interactor 1, dimerization protein
chr15_-_34969688 0.02 ENST00000156471.10
AQR
aquarius intron-binding spliceosomal factor
chr3_-_156555083 0.02 ENST00000265044.7
ENST00000476217.5
SSR3
signal sequence receptor subunit 3
chr1_+_205043204 0.01 ENST00000331830.7
CNTN2
contactin 2
chr3_-_50359480 0.01 ENST00000266025.4
TMEM115
transmembrane protein 115
chr7_-_92833896 0.01 ENST00000265734.8
CDK6
cyclin dependent kinase 6
chr1_-_214551556 0.01 ENST00000366956.10
PTPN14
protein tyrosine phosphatase non-receptor type 14
chr1_-_208244375 0.01 ENST00000367033.4
PLXNA2
plexin A2
chr12_+_120534342 0.01 ENST00000542438.1
ENST00000325954.9
RNF10
ring finger protein 10
chr5_+_176448363 0.01 ENST00000261942.7
FAF2
Fas associated factor family member 2
chr8_+_127409026 0.01 ENST00000465342.4
POU5F1B
POU class 5 homeobox 1B
chr11_+_120336357 0.00 ENST00000397843.7
ARHGEF12
Rho guanine nucleotide exchange factor 12
chr7_-_45921264 0.00 ENST00000613132.5
ENST00000381083.9
ENST00000381086.9
IGFBP3
insulin like growth factor binding protein 3
chr20_-_49482645 0.00 ENST00000371741.6
KCNB1
potassium voltage-gated channel subfamily B member 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.1 0.2 GO:0060434 bronchus morphogenesis(GO:0060434)
0.1 0.2 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.2 GO:0007538 primary sex determination(GO:0007538)
0.0 0.3 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0 0.2 GO:0072716 response to sorbitol(GO:0072708) response to actinomycin D(GO:0072716)
0.0 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.2 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.0 0.1 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.0 0.3 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:0048627 myoblast development(GO:0048627)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.2 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.1 GO:0008355 olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.1 GO:0072107 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:0097272 ammonia homeostasis(GO:0097272)
0.0 0.4 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0072014 proximal tubule development(GO:0072014)
0.0 0.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0002934 desmosome organization(GO:0002934)
0.0 0.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.1 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990597 AIP1-IRE1 complex(GO:1990597)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:1990879 CST complex(GO:1990879)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.2 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.2 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.3 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0070004 cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains