Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CENPB

Z-value: 5.40

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Transcription factors associated with CENPB

Gene Symbol Gene ID Gene Info
CENPB
ENSG00000125817.8 CENPB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CENPBhg38_v1_chr20_-_3786677_3786797-0.541.3e-17Click!

Activity profile of CENPB motif

Sorted Z-values of CENPB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CENPB

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_72080313 33.71 ENST00000307198.11
ENST00000538413.6
ENST00000642648.1
ENST00000289488.7
ENSG00000284922.2
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
leucine rich transmembrane and O-methyltransferase domain containing
chr11_+_72080803 32.16 ENST00000423494.6
ENST00000539587.6
ENST00000536917.2
ENST00000538478.5
ENST00000324866.11
ENST00000643715.1
ENST00000439209.5
LRTOMT
ENSG00000284922.2
leucine rich transmembrane and O-methyltransferase domain containing
leucine rich transmembrane and O-methyltransferase domain containing
chr11_+_72080595 30.84 ENST00000647530.1
ENST00000539271.6
ENST00000642510.1
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
chr11_+_82901698 23.80 ENST00000524921.5
ENST00000528759.5
ENST00000525361.5
ENST00000532764.5
ENST00000532589.5
ENST00000533655.6
ENST00000525388.5
DDIAS
DNA damage induced apoptosis suppressor
chr15_+_45587366 13.25 ENST00000220531.9
BLOC1S6
biogenesis of lysosomal organelles complex 1 subunit 6
chr9_-_124771238 13.08 ENST00000344523.8
ENST00000373584.7
NR6A1
nuclear receptor subfamily 6 group A member 1
chr1_-_85259633 12.96 ENST00000344356.5
ENST00000471115.6
C1orf52
chromosome 1 open reading frame 52
chr10_+_38010617 12.67 ENST00000307441.13
ENST00000374618.7
ENST00000628825.2
ENST00000458705.6
ENST00000432900.7
ENST00000469037.2
ZNF33A
zinc finger protein 33A
chrX_+_71366222 11.57 ENST00000683202.1
ENST00000373790.9
TAF1
TATA-box binding protein associated factor 1
chr3_+_15427551 11.07 ENST00000396842.7
EAF1
ELL associated factor 1
chr5_+_81301570 10.93 ENST00000407610.8
ENST00000254037.6
ENST00000380199.9
ZCCHC9
zinc finger CCHC-type containing 9
chr19_+_48364361 10.77 ENST00000344846.7
SYNGR4
synaptogyrin 4
chr19_+_57320461 10.58 ENST00000321545.5
ZNF543
zinc finger protein 543
chr20_-_43189896 10.46 ENST00000373193.7
ENST00000373198.8
ENST00000373201.5
PTPRT
protein tyrosine phosphatase receptor type T
chr20_-_43189733 10.40 ENST00000373187.5
ENST00000356100.6
ENST00000373184.5
ENST00000373190.5
PTPRT
protein tyrosine phosphatase receptor type T
chr7_-_150341615 10.10 ENST00000223271.8
ENST00000466675.5
ENST00000482669.1
ENST00000467793.5
RARRES2
retinoic acid receptor responder 2
chr9_-_136205122 10.08 ENST00000371748.10
LHX3
LIM homeobox 3
chr9_-_124771304 9.79 ENST00000416460.6
ENST00000487099.7
NR6A1
nuclear receptor subfamily 6 group A member 1
chr1_+_11664191 9.66 ENST00000376753.9
FBXO6
F-box protein 6
chrX_+_71366290 9.50 ENST00000683782.1
ENST00000423759.6
TAF1
TATA-box binding protein associated factor 1
chr15_-_55588337 9.42 ENST00000563719.4
PYGO1
pygopus family PHD finger 1
chr11_+_126283059 9.34 ENST00000392679.6
ENST00000392678.7
ENST00000392680.6
TIRAP
TIR domain containing adaptor protein
chr5_+_137889469 8.90 ENST00000290431.5
PKD2L2
polycystin 2 like 2, transient receptor potential cation channel
chr17_-_74872961 8.88 ENST00000581530.5
ENST00000420580.6
ENST00000413947.6
ENST00000581219.1
ENST00000582944.5
ENST00000293195.10
ENST00000583917.5
ENST00000442102.6
FDXR
ferredoxin reductase
chr16_+_66934439 8.66 ENST00000417689.6
ENST00000561697.5
CES2
carboxylesterase 2
chr10_+_129467178 8.56 ENST00000306010.8
ENST00000651593.1
MGMT
O-6-methylguanine-DNA methyltransferase
chr2_+_232633551 7.80 ENST00000264059.8
EFHD1
EF-hand domain family member D1
chr9_+_32552305 7.30 ENST00000451672.2
ENST00000644531.1
SMIM27
small integral membrane protein 27
chr7_-_159144852 7.29 ENST00000421760.2
ENST00000402066.5
ENST00000262178.7
VIPR2
vasoactive intestinal peptide receptor 2
chr9_-_120580125 7.20 ENST00000360190.8
ENST00000349780.9
ENST00000360822.7
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr6_-_39229465 7.15 ENST00000359534.4
KCNK5
potassium two pore domain channel subfamily K member 5
chr3_-_15427497 7.01 ENST00000443029.5
ENST00000383789.9
ENST00000450816.6
ENST00000383790.8
METTL6
methyltransferase like 6
chr1_-_18902520 6.95 ENST00000538839.5
ENST00000290597.9
ENST00000375341.8
ALDH4A1
aldehyde dehydrogenase 4 family member A1
chr9_-_32552553 6.33 ENST00000379858.1
ENST00000360538.7
ENST00000681750.1
ENST00000680198.1
TOPORS
ENSG00000288684.1
TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
novel protein
chr16_-_30558356 6.21 ENST00000395091.3
ZNF764
zinc finger protein 764
chr1_-_151346806 6.02 ENST00000392746.7
RFX5
regulatory factor X5
chrX_+_136148440 5.93 ENST00000627383.2
ENST00000630084.2
FHL1
four and a half LIM domains 1
chr4_-_81215185 5.85 ENST00000264399.6
PRKG2
protein kinase cGMP-dependent 2
chr4_-_81214960 5.81 ENST00000395578.3
ENST00000628926.1
PRKG2
protein kinase cGMP-dependent 2
chr19_+_51927435 5.79 ENST00000391794.8
ENST00000599683.5
ENST00000293471.11
ENST00000600853.1
ZNF613
zinc finger protein 613
chr19_-_16472003 5.73 ENST00000248070.10
ENST00000594975.5
EPS15L1
epidermal growth factor receptor pathway substrate 15 like 1
chr18_+_56651335 5.70 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WDR7
WD repeat domain 7
chr6_-_166168700 5.64 ENST00000366871.7
TBXT
T-box transcription factor T
chr19_-_16471943 5.63 ENST00000602151.1
ENST00000597937.5
ENST00000455140.7
ENST00000535753.6
EPS15L1
epidermal growth factor receptor pathway substrate 15 like 1
chr5_+_137889437 5.62 ENST00000508638.5
ENST00000508883.6
ENST00000502810.5
PKD2L2
polycystin 2 like 2, transient receptor potential cation channel
chr6_-_166168612 5.50 ENST00000296946.6
TBXT
T-box transcription factor T
chr18_+_56651385 5.44 ENST00000615645.4
WDR7
WD repeat domain 7
chr18_+_12093839 5.39 ENST00000587848.3
ANKRD62
ankyrin repeat domain 62
chr11_+_73308237 5.33 ENST00000263674.4
ARHGEF17
Rho guanine nucleotide exchange factor 17
chr18_+_33578213 5.20 ENST00000681521.1
ENST00000269197.12
ASXL3
ASXL transcriptional regulator 3
chr16_-_30558263 5.08 ENST00000252797.6
ZNF764
zinc finger protein 764
chr6_+_27388748 4.79 ENST00000244576.9
ZNF391
zinc finger protein 391
chr9_-_37025733 4.74 ENST00000651550.1
PAX5
paired box 5
chr17_-_7590072 4.70 ENST00000538513.6
ENST00000570788.1
ENST00000250055.3
SOX15
SRY-box transcription factor 15
chr4_-_11428868 4.69 ENST00000002596.6
HS3ST1
heparan sulfate-glucosamine 3-sulfotransferase 1
chr10_+_1056776 4.65 ENST00000650072.1
WDR37
WD repeat domain 37
chr11_-_72080389 4.63 ENST00000351960.10
ENST00000541719.5
ENST00000535111.5
NUMA1
nuclear mitotic apparatus protein 1
chr3_-_142448028 4.42 ENST00000392981.7
XRN1
5'-3' exoribonuclease 1
chr7_+_149262165 4.31 ENST00000434415.6
ZNF783
zinc finger family member 783
chr8_-_143609547 4.30 ENST00000433751.5
ENST00000495276.6
ENST00000220966.10
PYCR3
pyrroline-5-carboxylate reductase 3
chr8_+_27311471 4.27 ENST00000397501.5
PTK2B
protein tyrosine kinase 2 beta
chr9_+_101028721 4.27 ENST00000374874.8
PLPPR1
phospholipid phosphatase related 1
chr11_-_72080472 4.19 ENST00000537217.5
ENST00000366394.7
ENST00000358965.10
ENST00000546131.1
ENST00000393695.8
ENST00000543937.5
ENST00000368959.9
ENST00000541641.5
NUMA1
nuclear mitotic apparatus protein 1
chr18_-_54224578 4.16 ENST00000583046.1
ENST00000398398.6
ENST00000256429.8
MBD2
methyl-CpG binding domain protein 2
chr20_-_57266342 4.08 ENST00000395864.7
BMP7
bone morphogenetic protein 7
chr17_-_66192125 3.99 ENST00000535342.7
CEP112
centrosomal protein 112
chr4_+_56436233 3.73 ENST00000512576.3
PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr17_+_74431338 3.70 ENST00000342648.9
ENST00000652232.1
ENST00000481232.2
GPRC5C
G protein-coupled receptor class C group 5 member C
chr6_+_30557274 3.66 ENST00000376557.3
PRR3
proline rich 3
chr19_+_44025326 3.45 ENST00000587846.5
ENST00000187879.12
ENST00000391960.4
ZNF222
zinc finger protein 222
chr2_+_73202570 3.40 ENST00000398468.4
NOTO
notochord homeobox
chr20_-_57266606 3.26 ENST00000450594.6
ENST00000395863.8
BMP7
bone morphogenetic protein 7
chrX_-_140505058 3.25 ENST00000370536.5
SOX3
SRY-box transcription factor 3
chr22_+_23070496 3.23 ENST00000615612.2
GNAZ
G protein subunit alpha z
chr6_+_30557287 3.18 ENST00000376560.8
PRR3
proline rich 3
chr1_+_63773966 3.09 ENST00000371079.6
ENST00000371080.5
ROR1
receptor tyrosine kinase like orphan receptor 1
chr11_-_72080680 3.08 ENST00000613205.4
NUMA1
nuclear mitotic apparatus protein 1
chr11_-_61429934 2.97 ENST00000541963.5
ENST00000477890.6
ENST00000439958.8
CPSF7
cleavage and polyadenylation specific factor 7
chr11_-_72244166 2.94 ENST00000298231.5
PHOX2A
paired like homeobox 2A
chr3_-_142448060 2.93 ENST00000264951.8
XRN1
5'-3' exoribonuclease 1
chr19_+_11965029 2.84 ENST00000592625.5
ENST00000358987.8
ENST00000586494.1
ENST00000343949.9
ZNF763
zinc finger protein 763
chr2_-_102736819 2.59 ENST00000258436.10
MFSD9
major facilitator superfamily domain containing 9
chr6_-_46652786 2.50 ENST00000275016.3
ENST00000619708.4
CYP39A1
cytochrome P450 family 39 subfamily A member 1
chr11_-_61430008 2.50 ENST00000394888.8
CPSF7
cleavage and polyadenylation specific factor 7
chr16_-_87936529 2.47 ENST00000649794.3
ENST00000649158.1
ENST00000648177.1
CA5A
carbonic anhydrase 5A
chr15_-_34795541 2.46 ENST00000290378.6
ACTC1
actin alpha cardiac muscle 1
chr4_-_169612571 2.45 ENST00000507142.6
ENST00000510533.5
ENST00000439128.6
ENST00000511633.5
ENST00000512193.5
NEK1
NIMA related kinase 1
chr16_+_569931 2.39 ENST00000439574.1
ENST00000321878.10
ENST00000422307.6
ENST00000026218.9
ENST00000470411.2
PIGQ
phosphatidylinositol glycan anchor biosynthesis class Q
chr20_+_64063105 2.33 ENST00000395053.7
ENST00000343484.10
ENST00000339217.8
TCEA2
transcription elongation factor A2
chr16_+_56669832 2.29 ENST00000569155.1
MT1H
metallothionein 1H
chr15_-_74433942 2.24 ENST00000543145.6
ENST00000261918.9
SEMA7A
semaphorin 7A (John Milton Hagen blood group)
chr16_+_56669807 2.21 ENST00000332374.5
MT1H
metallothionein 1H
chr10_+_30434021 2.16 ENST00000542547.5
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr22_+_39456996 2.10 ENST00000341184.7
MGAT3
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
chrX_+_101098165 2.05 ENST00000684367.1
ENST00000423383.3
ENST00000682304.1
ENST00000682095.1
ENST00000403304.6
ENST00000435570.1
CENPI
centromere protein I
chr12_-_124914304 1.90 ENST00000535859.1
ENST00000546271.1
ENST00000540700.1
ENST00000546120.2
ENST00000339647.6
UBC
ubiquitin C
chr10_+_30434176 1.79 ENST00000263056.6
ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr11_+_59755427 1.76 ENST00000529177.5
STX3
syntaxin 3
chr14_-_50312212 1.73 ENST00000555423.5
ENST00000267436.9
ENST00000421284.7
L2HGDH
L-2-hydroxyglutarate dehydrogenase
chr13_+_48233171 1.72 ENST00000378549.5
ENST00000647800.2
ITM2B
integral membrane protein 2B
chr18_-_268019 1.42 ENST00000631280.2
ENST00000616322.4
ENST00000261600.11
THOC1
THO complex 1
chr5_+_151447576 1.18 ENST00000243389.8
ENST00000616007.4
ENST00000517945.5
ENST00000521925.5
SLC36A1
solute carrier family 36 member 1
chr1_-_7940825 1.09 ENST00000377507.8
TNFRSF9
TNF receptor superfamily member 9
chr1_-_5992407 0.98 ENST00000378156.9
ENST00000622020.4
NPHP4
nephrocystin 4
chr2_-_136118142 0.87 ENST00000241393.4
CXCR4
C-X-C motif chemokine receptor 4
chr11_+_59755398 0.79 ENST00000633708.1
STX3
syntaxin 3
chr1_-_221742074 0.65 ENST00000366899.4
DUSP10
dual specificity phosphatase 10
chr7_+_983175 0.59 ENST00000308919.12
CYP2W1
cytochrome P450 family 2 subfamily W member 1
chr11_-_82901654 0.51 ENST00000534631.5
ENST00000531801.6
ENST00000680524.1
ENST00000531128.5
ENST00000680566.1
PRCP
prolylcarboxypeptidase
chr5_-_59768631 0.47 ENST00000502575.1
ENST00000507116.5
PDE4D
phosphodiesterase 4D
chr16_-_11636357 0.46 ENST00000576334.1
ENST00000574848.5
LITAF
lipopolysaccharide induced TNF factor
chr6_-_30556477 0.46 ENST00000376621.8
GNL1
G protein nucleolar 1 (putative)
chr10_-_14954018 0.46 ENST00000378241.5
ENST00000456122.1
ENST00000418843.5
ENST00000378249.5
ENST00000396817.6
ENST00000378255.5
ENST00000378254.5
ENST00000357717.6
ENST00000378258.5
ENST00000378246.6
ENST00000378278.7
DCLRE1C
DNA cross-link repair 1C
chr7_+_50308672 0.41 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKZF1
IKAROS family zinc finger 1
chr2_+_74513441 0.34 ENST00000621092.1
TLX2
T cell leukemia homeobox 2
chr1_-_28176665 0.28 ENST00000373857.8
PTAFR
platelet activating factor receptor
chr15_-_43330537 0.26 ENST00000305641.7
ENST00000567039.1
LCMT2
leucine carboxyl methyltransferase 2
chr20_+_408147 0.24 ENST00000441733.5
ENST00000353660.7
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1
chr2_+_74530018 0.20 ENST00000437202.1
HTRA2
HtrA serine peptidase 2
chr11_+_64241053 0.19 ENST00000309366.9
ENST00000449942.6
ENST00000652762.2
FKBP2
ENSG00000286264.2
FKBP prolyl isomerase 2
novel protein
chr11_-_82901623 0.19 ENST00000681637.1
ENST00000679387.1
PRCP
prolylcarboxypeptidase
chr11_-_82901594 0.04 ENST00000679623.1
PRCP
prolylcarboxypeptidase
chr6_+_26124161 0.02 ENST00000377791.4
ENST00000602637.1
H2AC6
H2A clustered histone 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 21.1 GO:0036369 transcription factor catabolic process(GO:0036369)
5.1 96.7 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
4.0 11.9 GO:1902363 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
3.9 11.7 GO:2001226 negative regulation of chloride transport(GO:2001226)
3.4 10.1 GO:0061760 antifungal innate immune response(GO:0061760)
2.3 7.0 GO:0010133 proline catabolic process to glutamate(GO:0010133)
2.2 13.0 GO:0021523 somatic motor neuron differentiation(GO:0021523)
1.8 7.3 GO:1900104 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme morphogenesis(GO:0072134) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) allantois development(GO:1905069)
1.8 7.3 GO:0071409 cellular response to cycloheximide(GO:0071409)
1.4 4.3 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
1.2 4.7 GO:0048627 myoblast development(GO:0048627)
1.1 9.6 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
1.1 8.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.9 14.0 GO:0016081 synaptic vesicle docking(GO:0016081)
0.8 2.5 GO:0030573 bile acid catabolic process(GO:0030573)
0.7 6.3 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.6 9.7 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.6 7.2 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.6 7.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.5 4.3 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.5 2.5 GO:0090131 mesenchyme migration(GO:0090131)
0.5 8.9 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.4 3.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.4 4.7 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.3 4.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.3 1.0 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.3 14.5 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.3 1.4 GO:0045829 negative regulation of isotype switching(GO:0045829)
0.2 1.2 GO:0015808 L-alanine transport(GO:0015808)
0.2 0.7 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.2 13.2 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.2 4.5 GO:0071294 cellular response to zinc ion(GO:0071294)
0.2 1.1 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.2 8.7 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.2 3.4 GO:0030903 notochord development(GO:0030903)
0.2 1.7 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.2 4.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 20.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 2.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 7.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 9.4 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 3.3 GO:0007530 sex determination(GO:0007530)
0.1 2.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 10.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.3 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.1 4.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 0.6 GO:0046222 mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376)
0.1 0.7 GO:0002353 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 3.1 GO:0014002 astrocyte development(GO:0014002)
0.1 17.7 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.1 0.9 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1 1.7 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.1 11.1 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 1.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 5.9 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 5.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 4.0 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 2.0 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 2.4 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.2 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.0 0.5 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 2.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 3.2 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 4.7 GO:0006023 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.0 0.3 GO:0048484 enteric nervous system development(GO:0048484)
0.0 2.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 3.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 6.1 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.5 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.3 GO:0030488 tRNA methylation(GO:0030488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:0061673 cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
0.8 13.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.8 4.6 GO:0070545 PeBoW complex(GO:0070545)
0.6 21.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.5 10.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.5 2.5 GO:0042643 actomyosin, actin portion(GO:0042643)
0.5 9.6 GO:0000242 pericentriolar material(GO:0000242)
0.4 11.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 11.4 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.3 4.0 GO:0060077 inhibitory synapse(GO:0060077)
0.3 6.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 5.5 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.2 12.5 GO:0045171 intercellular bridge(GO:0045171)
0.2 4.3 GO:0097440 apical dendrite(GO:0097440)
0.2 0.8 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.1 10.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 11.1 GO:0008021 synaptic vesicle(GO:0008021)
0.1 1.0 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.5 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.1 0.5 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 28.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.6 GO:0000792 heterochromatin(GO:0000792)
0.1 7.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 7.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 3.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 4.7 GO:0001650 fibrillar center(GO:0001650)
0.0 12.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 23.3 GO:0009986 cell surface(GO:0009986)
0.0 0.7 GO:0045178 basal part of cell(GO:0045178)
0.0 85.8 GO:0016021 integral component of membrane(GO:0016021)
0.0 7.3 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 96.7 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
5.3 21.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
4.2 20.9 GO:0070097 delta-catenin binding(GO:0070097)
3.1 9.3 GO:0035663 Toll-like receptor 4 binding(GO:0035662) Toll-like receptor 2 binding(GO:0035663)
2.4 7.3 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
2.3 11.7 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
1.7 8.7 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
1.5 7.3 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
1.2 3.7 GO:0004638 phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
1.2 8.6 GO:0008172 S-methyltransferase activity(GO:0008172)
1.2 11.9 GO:0051011 microtubule minus-end binding(GO:0051011)
1.2 4.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.8 6.3 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.7 4.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.7 7.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.6 7.3 GO:0070700 BMP receptor binding(GO:0070700)
0.5 4.2 GO:0003696 satellite DNA binding(GO:0003696)
0.4 3.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.4 4.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.4 1.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.3 7.0 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.3 4.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577)
0.3 2.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 22.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 3.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 2.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 13.3 GO:0019905 syntaxin binding(GO:0019905)
0.1 2.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.8 GO:1901567 icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567)
0.1 4.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 14.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 3.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.9 GO:0032027 myosin light chain binding(GO:0032027)
0.1 3.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.3 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.1 2.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 10.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 5.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.1 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 1.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 2.5 GO:0017022 myosin binding(GO:0017022)
0.0 6.4 GO:0044325 ion channel binding(GO:0044325)
0.0 7.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 40.3 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 17.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 4.4 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 17.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0008175 tRNA methyltransferase activity(GO:0008175)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.7 PID ALK2 PATHWAY ALK2 signaling events
0.2 4.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 2.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 4.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 19.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 3.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 8.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 11.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 8.7 PID E2F PATHWAY E2F transcription factor network
0.1 2.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 9.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 4.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 4.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 4.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.9 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 2.1 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 11.9 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.6 11.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 4.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 7.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.4 21.1 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.3 11.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.3 5.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.3 9.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 22.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 2.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 4.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 2.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 0.9 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 4.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 7.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 3.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 2.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.0 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 32.5 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 2.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 7.2 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.1 8.6 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 2.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 4.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.7 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 1.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.9 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events