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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CUACAGU

Z-value: 0.21

Motif logo

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miRNA associated with seed CUACAGU

NamemiRBASE accession
hsa-miR-139-5p
MIMAT0000250

Activity profile of CUACAGU motif

Sorted Z-values of CUACAGU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CUACAGU

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_115071333 0.76 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_137499293 0.74 ENST00000510689.5
ENST00000394945.6
SPOCK1
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
chr3_-_123884290 0.54 ENST00000346322.9
ENST00000360772.7
ENST00000360304.8
MYLK
myosin light chain kinase
chr15_+_39581068 0.48 ENST00000397591.2
ENST00000260356.6
THBS1
thrombospondin 1
chr1_-_225653045 0.40 ENST00000366843.6
ENST00000366844.7
ENAH
ENAH actin regulator
chr9_-_14314067 0.33 ENST00000397575.7
NFIB
nuclear factor I B
chr3_-_125055987 0.31 ENST00000311127.9
HEG1
heart development protein with EGF like domains 1
chr2_+_112275588 0.29 ENST00000409871.6
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr18_+_3451647 0.28 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGIF1
TGFB induced factor homeobox 1
chr3_-_98901656 0.27 ENST00000326840.11
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr16_-_10580577 0.26 ENST00000359543.8
EMP2
epithelial membrane protein 2
chr2_+_73984902 0.26 ENST00000409262.8
TET3
tet methylcytosine dioxygenase 3
chrX_-_74614612 0.25 ENST00000349225.2
ENST00000332687.11
RLIM
ring finger protein, LIM domain interacting
chr1_-_155562693 0.23 ENST00000368346.7
ENST00000392403.8
ENST00000679333.1
ENST00000679133.1
ASH1L
ASH1 like histone lysine methyltransferase
chr8_-_66613208 0.20 ENST00000522677.8
MYBL1
MYB proto-oncogene like 1
chr2_-_38377256 0.20 ENST00000443098.5
ENST00000449130.5
ENST00000651368.1
ENST00000378954.9
ENST00000419554.6
ENST00000451483.1
ENST00000406122.5
ATL2
atlastin GTPase 2
chr1_+_29236544 0.19 ENST00000428026.6
ENST00000460170.2
PTPRU
protein tyrosine phosphatase receptor type U
chr16_+_58463663 0.19 ENST00000258187.9
NDRG4
NDRG family member 4
chr3_+_159839847 0.17 ENST00000445224.6
SCHIP1
schwannomin interacting protein 1
chrX_+_16786421 0.16 ENST00000398155.4
ENST00000380122.10
TXLNG
taxilin gamma
chr3_-_129688691 0.15 ENST00000432054.6
TMCC1
transmembrane and coiled-coil domain family 1
chr10_-_68527498 0.15 ENST00000609923.6
SLC25A16
solute carrier family 25 member 16
chr15_-_79090760 0.14 ENST00000419573.7
ENST00000558480.7
RASGRF1
Ras protein specific guanine nucleotide releasing factor 1
chr11_-_95924067 0.12 ENST00000676027.1
ENST00000675489.1
ENST00000409459.5
ENST00000676261.1
ENST00000352297.11
ENST00000346299.10
ENST00000676272.1
ENST00000393223.8
ENST00000675022.1
ENST00000675362.1
ENST00000675174.1
ENST00000674989.1
ENST00000675848.1
ENST00000675652.1
ENST00000481642.6
MTMR2
myotubularin related protein 2
chr9_-_98708856 0.12 ENST00000259455.4
GABBR2
gamma-aminobutyric acid type B receptor subunit 2
chr7_-_56051288 0.11 ENST00000419984.6
ENST00000413218.5
ENST00000275605.8
ENST00000424596.1
ENST00000421312.5
ENST00000416592.1
PSPH
phosphoserine phosphatase
chr15_-_37098281 0.11 ENST00000559085.5
ENST00000397624.7
MEIS2
Meis homeobox 2
chr5_+_15500172 0.10 ENST00000504595.2
FBXL7
F-box and leucine rich repeat protein 7
chr3_-_160565560 0.10 ENST00000334256.9
ENST00000676866.1
ENST00000469804.1
KPNA4
karyopherin subunit alpha 4
chrX_-_33128360 0.10 ENST00000378677.6
DMD
dystrophin
chr5_-_115625972 0.10 ENST00000333314.3
ENST00000456936.4
TMED7-TICAM2
TMED7
TMED7-TICAM2 readthrough
transmembrane p24 trafficking protein 7
chr10_-_74150781 0.10 ENST00000355264.9
ENST00000372745.1
AP3M1
adaptor related protein complex 3 subunit mu 1
chr10_-_689613 0.10 ENST00000280886.12
ENST00000634311.1
DIP2C
disco interacting protein 2 homolog C
chr1_-_72282457 0.09 ENST00000357731.10
NEGR1
neuronal growth regulator 1
chr17_-_80476597 0.09 ENST00000306773.5
NPTX1
neuronal pentraxin 1
chr2_-_11344580 0.09 ENST00000616279.4
ENST00000315872.11
ROCK2
Rho associated coiled-coil containing protein kinase 2
chr1_-_21345475 0.08 ENST00000415912.6
ECE1
endothelin converting enzyme 1
chr15_-_77071099 0.08 ENST00000267970.9
ENST00000346495.6
ENST00000424443.7
ENST00000561277.5
TSPAN3
tetraspanin 3
chr20_-_49482645 0.08 ENST00000371741.6
KCNB1
potassium voltage-gated channel subfamily B member 1
chr10_-_931684 0.08 ENST00000316157.8
LARP4B
La ribonucleoprotein 4B
chr18_+_57352541 0.08 ENST00000324000.4
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr18_+_52340179 0.07 ENST00000442544.7
DCC
DCC netrin 1 receptor
chr11_+_87037820 0.07 ENST00000340353.11
TMEM135
transmembrane protein 135
chr17_+_66302606 0.07 ENST00000413366.8
PRKCA
protein kinase C alpha
chr10_-_11611754 0.07 ENST00000609104.5
USP6NL
USP6 N-terminal like
chr5_-_115262851 0.06 ENST00000379615.3
ENST00000419445.6
PGGT1B
protein geranylgeranyltransferase type I subunit beta
chr1_-_84690406 0.06 ENST00000605755.5
ENST00000342203.8
ENST00000437941.6
SSX2IP
SSX family member 2 interacting protein
chr5_+_149730260 0.06 ENST00000360453.8
ENST00000394320.7
ENST00000309241.10
PPARGC1B
PPARG coactivator 1 beta
chr3_-_116445458 0.06 ENST00000490035.7
LSAMP
limbic system associated membrane protein
chr8_+_60678705 0.06 ENST00000423902.7
CHD7
chromodomain helicase DNA binding protein 7
chr8_-_104588998 0.06 ENST00000424843.6
LRP12
LDL receptor related protein 12
chr5_+_72816643 0.05 ENST00000337273.10
ENST00000523768.5
TNPO1
transportin 1
chr6_+_37819680 0.05 ENST00000287218.9
ENST00000373391.6
ZFAND3
zinc finger AN1-type containing 3
chr5_-_128538230 0.05 ENST00000262464.9
FBN2
fibrillin 2
chr1_+_37474572 0.05 ENST00000373087.7
ZC3H12A
zinc finger CCCH-type containing 12A
chr19_+_10420474 0.05 ENST00000380702.7
PDE4A
phosphodiesterase 4A
chr7_+_77696423 0.04 ENST00000334955.13
RSBN1L
round spermatid basic protein 1 like
chr1_+_200027702 0.04 ENST00000367362.8
NR5A2
nuclear receptor subfamily 5 group A member 2
chr9_+_74497308 0.04 ENST00000376896.8
RORB
RAR related orphan receptor B
chr21_-_34888683 0.04 ENST00000344691.8
ENST00000358356.9
RUNX1
RUNX family transcription factor 1
chr13_+_112067143 0.04 ENST00000330949.3
SOX1
SRY-box transcription factor 1
chr10_+_96832252 0.03 ENST00000676187.1
ENST00000675687.1
ENST00000676123.1
ENST00000675471.1
ENST00000371103.8
ENST00000421806.4
ENST00000675250.1
ENST00000540664.6
ENST00000676414.1
LCOR
ligand dependent nuclear receptor corepressor
chr1_-_217089627 0.03 ENST00000361525.7
ESRRG
estrogen related receptor gamma
chr4_+_76949743 0.03 ENST00000502584.5
ENST00000264893.11
ENST00000510641.5
SEPTIN11
septin 11
chr12_+_26195543 0.03 ENST00000242729.7
SSPN
sarcospan
chr2_-_175181663 0.03 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP5MC3
ATP synthase membrane subunit c locus 3
chr7_-_139777986 0.03 ENST00000406875.8
HIPK2
homeodomain interacting protein kinase 2
chr1_-_41918858 0.02 ENST00000372583.6
HIVEP3
HIVEP zinc finger 3
chr2_-_69643703 0.02 ENST00000406297.7
ENST00000409085.9
AAK1
AP2 associated kinase 1
chr2_+_190408324 0.02 ENST00000417958.5
ENST00000432036.5
ENST00000392328.6
MFSD6
major facilitator superfamily domain containing 6
chr11_+_130069882 0.01 ENST00000533195.5
ENST00000533713.5
ENST00000528499.5
ENST00000338167.10
ENST00000263574.9
APLP2
amyloid beta precursor like protein 2
chr1_+_87328860 0.01 ENST00000370544.10
LMO4
LIM domain only 4
chr5_-_132737518 0.01 ENST00000403231.6
ENST00000378735.5
ENST00000618515.4
ENST00000378746.8
KIF3A
kinesin family member 3A
chr12_+_123384078 0.01 ENST00000402868.8
KMT5A
lysine methyltransferase 5A
chr9_-_10612966 0.01 ENST00000381196.9
PTPRD
protein tyrosine phosphatase receptor type D
chr2_+_26848093 0.00 ENST00000288699.11
DPYSL5
dihydropyrimidinase like 5
chr5_-_59893718 0.00 ENST00000340635.11
PDE4D
phosphodiesterase 4D
chr2_-_100104530 0.00 ENST00000432037.5
ENST00000673232.1
ENST00000423966.6
ENST00000409236.6
AFF3
AF4/FMR2 family member 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0010752 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752)
0.1 0.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.2 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.0 0.3 GO:0090270 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.0 0.3 GO:2000795 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.3 GO:0070836 caveola assembly(GO:0070836)
0.0 0.3 GO:0043045 DNA methylation involved in embryo development(GO:0043045) histone H3-K4 trimethylation(GO:0080182) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.2 GO:0009048 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0 0.1 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.0 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.1 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.2 GO:2001135 regulation of endocytic recycling(GO:2001135)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0001940 male pronucleus(GO:0001940)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.7 GO:0033268 node of Ranvier(GO:0033268)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0070052 collagen V binding(GO:0070052)
0.1 0.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway