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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for DLX3_EVX1_MEOX1
Z-value: 3.06
Motif logo
Transcription factors associated with DLX3_EVX1_MEOX1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
DLX3
|
ENSG00000064195.7 | DLX3 |
|
EVX1
|
ENSG00000106038.13 | EVX1 |
|
MEOX1
|
ENSG00000005102.14 | MEOX1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEOX1 | hg38_v1_chr17_-_43661915_43661929 | -0.46 | 7.7e-13 | Click! |
| EVX1 | hg38_v1_chr7_+_27242796_27242807 | -0.44 | 6.4e-12 | Click! |
Activity profile of DLX3_EVX1_MEOX1 motif
Sorted Z-values of DLX3_EVX1_MEOX1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX3_EVX1_MEOX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 31.4 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 2.8 | 11.3 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 2.1 | 6.3 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 1.8 | 5.4 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 1.7 | 14.9 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 1.6 | 4.9 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 1.6 | 9.3 | GO:0042997 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 1.4 | 5.5 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 1.1 | 3.2 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 1.1 | 12.6 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 1.0 | 5.9 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.0 | 3.8 | GO:0002501 | peptide antigen assembly with MHC protein complex(GO:0002501) |
| 0.9 | 2.6 | GO:1904908 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.9 | 8.7 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.8 | 9.3 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.8 | 3.1 | GO:0036060 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
| 0.8 | 2.3 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
| 0.7 | 3.4 | GO:0061743 | motor learning(GO:0061743) |
| 0.6 | 2.5 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.6 | 7.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.6 | 4.5 | GO:0061709 | reticulophagy(GO:0061709) |
| 0.5 | 2.1 | GO:1904117 | response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117) |
| 0.5 | 4.5 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 0.5 | 1.5 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.5 | 5.9 | GO:0042407 | cristae formation(GO:0042407) |
| 0.4 | 11.8 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.4 | 5.0 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.4 | 16.4 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.4 | 2.3 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.3 | 2.8 | GO:2000074 | regulation of type B pancreatic cell development(GO:2000074) |
| 0.3 | 1.3 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 0.3 | 2.6 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.3 | 1.6 | GO:0070370 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 0.3 | 1.2 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 0.3 | 3.0 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.3 | 2.4 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.3 | 3.3 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 0.3 | 2.2 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.3 | 2.4 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.3 | 2.3 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.3 | 6.3 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.2 | 2.4 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
| 0.2 | 1.9 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.2 | 4.9 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.2 | 1.4 | GO:0001692 | histamine metabolic process(GO:0001692) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805) |
| 0.2 | 3.2 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.2 | 1.6 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.2 | 5.3 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.2 | 14.4 | GO:0008542 | visual learning(GO:0008542) |
| 0.2 | 2.1 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.2 | 0.9 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.2 | 2.4 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.2 | 0.6 | GO:0002881 | negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881) |
| 0.1 | 1.0 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.1 | 1.3 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.1 | 2.8 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.1 | 7.6 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.1 | 8.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 3.4 | GO:0072662 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 6.9 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 2.9 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 0.9 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 0.7 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.1 | 4.6 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.1 | 2.3 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.1 | 0.6 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.1 | 0.6 | GO:1901315 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.1 | 4.1 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.1 | 2.2 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.1 | 0.4 | GO:0009956 | radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.1 | 7.4 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.1 | 1.9 | GO:0031063 | regulation of histone deacetylation(GO:0031063) |
| 0.1 | 10.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 1.2 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.1 | 0.7 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.1 | 0.4 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.1 | 0.8 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.1 | 0.9 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.1 | 1.2 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 0.2 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.1 | 0.8 | GO:0009086 | methionine biosynthetic process(GO:0009086) |
| 0.1 | 1.0 | GO:0042789 | mRNA transcription from RNA polymerase II promoter(GO:0042789) |
| 0.1 | 1.0 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 5.2 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 2.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.5 | GO:0046548 | retinal rod cell development(GO:0046548) |
| 0.0 | 0.1 | GO:0036233 | glycine import(GO:0036233) |
| 0.0 | 3.8 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 3.5 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.0 | 2.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.4 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 1.0 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 0.9 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 1.2 | GO:0060292 | long term synaptic depression(GO:0060292) |
| 0.0 | 0.3 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.0 | 2.3 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 0.0 | 0.3 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 2.7 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 1.2 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 6.0 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.0 | 1.1 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.2 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.0 | 1.3 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 0.6 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.0 | 0.2 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.0 | 1.4 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.0 | 0.7 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 0.3 | GO:0090331 | negative regulation of platelet aggregation(GO:0090331) |
| 0.0 | 0.5 | GO:0006706 | steroid catabolic process(GO:0006706) |
| 0.0 | 0.1 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.0 | 15.8 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.0 | 1.3 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 0.0 | 0.7 | GO:0090307 | mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850) |
| 0.0 | 0.8 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.0 | 0.4 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.3 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 23.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 1.0 | 3.0 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 1.0 | 5.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.7 | 2.1 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 0.7 | 2.7 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 0.6 | 3.8 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.6 | 2.4 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.5 | 4.9 | GO:0072687 | microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687) |
| 0.5 | 9.5 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.4 | 5.4 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.4 | 2.3 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.3 | 2.1 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.3 | 4.5 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.3 | 5.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 12.8 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 2.2 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.2 | 2.3 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.2 | 12.6 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.2 | 2.4 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.2 | 0.9 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.2 | 3.2 | GO:0031045 | dense core granule(GO:0031045) |
| 0.2 | 6.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.2 | 8.7 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 11.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 0.7 | GO:0031523 | Myb complex(GO:0031523) |
| 0.1 | 3.8 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.1 | 3.5 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 0.5 | GO:0035841 | new growing cell tip(GO:0035841) |
| 0.1 | 1.9 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 3.9 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 1.7 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.1 | 27.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 4.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 0.7 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.1 | 1.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 2.5 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.1 | 4.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 0.8 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 1.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 17.0 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.1 | 2.3 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 2.6 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 1.0 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 12.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 3.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 1.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 7.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 3.0 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 0.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 12.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 8.4 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.2 | GO:0032838 | cell projection cytoplasm(GO:0032838) axon cytoplasm(GO:1904115) |
| 0.0 | 2.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 5.3 | GO:0099568 | cytoplasmic region(GO:0099568) |
| 0.0 | 14.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 1.1 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.6 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 5.1 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 8.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.7 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 11.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 0.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 1.0 | GO:0030027 | lamellipodium(GO:0030027) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 17.2 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 1.2 | 31.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 1.1 | 11.8 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 1.0 | 3.0 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.8 | 7.5 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.8 | 5.5 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.8 | 11.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.7 | 14.9 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.7 | 12.6 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.6 | 9.5 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.6 | 2.5 | GO:0050211 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211) |
| 0.5 | 3.8 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.5 | 2.4 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.4 | 5.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.4 | 2.1 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.4 | 1.2 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.4 | 1.2 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
| 0.4 | 4.9 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.4 | 16.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.4 | 5.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 7.1 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 9.3 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.3 | 9.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.3 | 3.4 | GO:0003774 | motor activity(GO:0003774) |
| 0.3 | 3.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.3 | 2.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.3 | 1.3 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.2 | 2.8 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.2 | 1.0 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
| 0.2 | 2.3 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.2 | 1.2 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.2 | 8.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 2.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 0.6 | GO:0016495 | C-X3-C chemokine receptor activity(GO:0016495) |
| 0.1 | 8.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 33.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 0.7 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.1 | 0.5 | GO:0004773 | steryl-sulfatase activity(GO:0004773) |
| 0.1 | 3.8 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.8 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.1 | 2.0 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 0.9 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 2.4 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 0.7 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.1 | 2.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 3.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 0.9 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 0.7 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 0.8 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 0.3 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 0.9 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 3.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 1.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 2.1 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 1.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 2.6 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 1.3 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 1.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 4.1 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 2.6 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.9 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 1.9 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.6 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 0.2 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 1.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 2.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.6 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.0 | 0.3 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.0 | 2.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 2.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.5 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 1.9 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 1.0 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 1.4 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 0.4 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 8.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.1 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 1.0 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.0 | 4.6 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 3.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 4.0 | GO:0003779 | actin binding(GO:0003779) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.3 | 10.6 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 11.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.2 | 5.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 6.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 5.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 14.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 3.8 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 7.5 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 4.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 7.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 4.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 2.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 4.1 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 2.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 6.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 3.8 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.7 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.6 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 31.4 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.9 | 14.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.6 | 17.2 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.6 | 11.3 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.3 | 9.3 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.3 | 3.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 5.4 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.2 | 4.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 3.3 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.2 | 5.9 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 9.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 2.8 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 6.9 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 1.3 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 2.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 3.5 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 5.9 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.6 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 5.1 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 3.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 4.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 3.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 2.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.5 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 1.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 2.1 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.0 | 5.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 1.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.9 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.7 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.0 | 0.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |