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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for DMBX1

Z-value: 0.05

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
DMBX1
ENSG00000197587.11 DMBX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg38_v1_chr1_+_46489800_464898420.291.0e-05Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_174846405 7.66 ENST00000409597.5
ENST00000413882.6
CHN1
chimerin 1
chr5_+_72107453 3.27 ENST00000296755.12
ENST00000511641.2
MAP1B
microtubule associated protein 1B
chr9_-_21995301 3.25 ENST00000498628.6
CDKN2A
cyclin dependent kinase inhibitor 2A
chr8_-_109644766 3.06 ENST00000533065.5
ENST00000276646.14
SYBU
syntabulin
chr14_-_21022817 2.90 ENST00000554104.5
NDRG2
NDRG family member 2
chr9_-_21995262 2.90 ENST00000494262.5
CDKN2A
cyclin dependent kinase inhibitor 2A
chr17_-_19748285 2.89 ENST00000570414.1
ENST00000225740.11
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr17_-_19748341 2.88 ENST00000395555.7
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr17_-_19748355 2.47 ENST00000494157.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr20_+_35968566 2.41 ENST00000373973.7
ENST00000349339.5
ENST00000489667.1
ENST00000538900.1
CNBD2
cyclic nucleotide binding domain containing 2
chr18_-_24272179 2.27 ENST00000399443.7
OSBPL1A
oxysterol binding protein like 1A
chr19_-_17075038 1.88 ENST00000593360.1
HAUS8
HAUS augmin like complex subunit 8
chr12_+_53300027 1.81 ENST00000549488.5
MYG1
MYG1 exonuclease
chr3_-_49021045 1.65 ENST00000440857.5
DALRD3
DALR anticodon binding domain containing 3
chr1_-_145095528 1.62 ENST00000612199.4
ENST00000641863.1
SRGAP2B
SLIT-ROBO Rho GTPase activating protein 2B
chr5_-_140564245 1.58 ENST00000412920.7
ENST00000511201.2
ENST00000354402.9
ENST00000356738.6
APBB3
amyloid beta precursor protein binding family B member 3
chr11_+_121576760 1.57 ENST00000532694.5
ENST00000534286.5
SORL1
sortilin related receptor 1
chr9_-_21994345 1.52 ENST00000579755.2
ENST00000530628.2
CDKN2A
cyclin dependent kinase inhibitor 2A
chr7_+_29122274 1.45 ENST00000582692.2
ENST00000644824.1
ENSG00000285412.1
ENSG00000285162.1
novel transcript, antisense to CPVL
chimerin 2
chr16_-_3372666 1.42 ENST00000399974.5
MTRNR2L4
MT-RNR2 like 4
chr2_-_207624983 1.38 ENST00000448007.6
ENST00000432416.5
ENST00000411432.5
ENST00000458426.5
ENST00000406927.6
ENST00000425132.5
METTL21A
methyltransferase like 21A
chr1_+_121184964 1.37 ENST00000367123.8
SRGAP2C
SLIT-ROBO Rho GTPase activating protein 2C
chr3_-_149752443 1.34 ENST00000473414.6
COMMD2
COMM domain containing 2
chr1_+_19882374 1.17 ENST00000375120.4
OTUD3
OTU deubiquitinase 3
chr20_-_45101112 1.08 ENST00000306117.5
ENST00000537075.3
KCNS1
potassium voltage-gated channel modifier subfamily S member 1
chr12_-_49187369 1.03 ENST00000547939.6
TUBA1A
tubulin alpha 1a
chr17_+_17042433 0.98 ENST00000651222.2
MPRIP
myosin phosphatase Rho interacting protein
chr14_+_22450089 0.96 ENST00000390473.1
TRDJ1
T cell receptor delta joining 1
chr10_+_84245038 0.92 ENST00000650682.1
ENST00000358110.7
ENST00000651237.1
ENST00000652122.1
ENST00000652092.2
ENST00000359452.9
ENST00000483744.6
RGR
retinal G protein coupled receptor
chr4_-_169757873 0.85 ENST00000393381.3
HPF1
histone PARylation factor 1
chr17_+_9825906 0.75 ENST00000262441.10
GLP2R
glucagon like peptide 2 receptor
chr18_+_44680875 0.72 ENST00000649279.2
ENST00000677699.1
SETBP1
SET binding protein 1
chr1_-_13347134 0.72 ENST00000334600.7
PRAMEF14
PRAME family member 14
chr7_+_148339452 0.66 ENST00000463592.3
CNTNAP2
contactin associated protein 2
chr10_-_99732070 0.64 ENST00000370483.9
ENST00000016171.6
COX15
cytochrome c oxidase assembly homolog COX15
chr1_-_165445088 0.62 ENST00000359842.10
RXRG
retinoid X receptor gamma
chr3_-_149576203 0.60 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr3_+_49021071 0.60 ENST00000395458.6
NDUFAF3
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr12_-_21334858 0.59 ENST00000445053.1
ENST00000458504.5
ENST00000422327.5
ENST00000683939.1
SLCO1A2
solute carrier organic anion transporter family member 1A2
chr1_-_165445220 0.58 ENST00000619224.1
RXRG
retinoid X receptor gamma
chr19_+_40778216 0.57 ENST00000594800.5
ENST00000357052.8
ENST00000602173.5
RAB4B
RAB4B, member RAS oncogene family
chr6_-_106975616 0.55 ENST00000610952.1
CD24
CD24 molecule
chr8_-_124565699 0.55 ENST00000519168.5
MTSS1
MTSS I-BAR domain containing 1
chr4_-_75990919 0.52 ENST00000395711.8
ENST00000356260.10
SDAD1
SDA1 domain containing 1
chr7_-_135728177 0.48 ENST00000682651.1
ENST00000354042.8
SLC13A4
solute carrier family 13 member 4
chr14_-_106875069 0.47 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr19_+_17337539 0.43 ENST00000324894.13
ENST00000358792.11
ENST00000600625.5
GTPBP3
GTP binding protein 3, mitochondrial
chr3_-_121749704 0.41 ENST00000393667.7
ENST00000340645.9
ENST00000614479.4
GOLGB1
golgin B1
chr11_-_45918789 0.41 ENST00000532681.5
PEX16
peroxisomal biogenesis factor 16
chr1_+_206203541 0.39 ENST00000573034.8
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr15_-_61229297 0.37 ENST00000335670.11
RORA
RAR related orphan receptor A
chr1_-_47314089 0.36 ENST00000360380.7
ENST00000371877.8
ENST00000447475.7
STIL
STIL centriolar assembly protein
chr16_-_20327426 0.34 ENST00000575582.5
ENST00000341642.9
ENST00000381362.8
ENST00000572347.5
ENST00000572478.5
ENST00000302555.10
GP2
glycoprotein 2
chr3_+_49020443 0.33 ENST00000326912.8
NDUFAF3
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr4_+_41935114 0.33 ENST00000508448.5
ENST00000513702.5
ENST00000325094.9
TMEM33
transmembrane protein 33
chr3_-_11643871 0.31 ENST00000430365.7
VGLL4
vestigial like family member 4
chr12_-_118190510 0.22 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr16_-_31065011 0.21 ENST00000539836.3
ENST00000535577.5
ENST00000442862.2
ZNF668
zinc finger protein 668
chr12_-_56333893 0.20 ENST00000547572.1
ENST00000257931.9
ENST00000610546.4
ENST00000440411.7
PAN2
poly(A) specific ribonuclease subunit PAN2
chr12_+_7789393 0.19 ENST00000229307.9
NANOG
Nanog homeobox
chr12_-_56333693 0.17 ENST00000425394.7
ENST00000548043.5
PAN2
poly(A) specific ribonuclease subunit PAN2
chr1_+_109213887 0.17 ENST00000234677.7
ENST00000369923.4
SARS1
seryl-tRNA synthetase 1
chr2_-_70553638 0.16 ENST00000444975.5
ENST00000445399.5
ENST00000295400.11
ENST00000418333.6
TGFA
transforming growth factor alpha
chr4_+_625555 0.15 ENST00000496514.6
ENST00000255622.10
PDE6B
phosphodiesterase 6B
chr18_-_55587335 0.14 ENST00000638154.3
TCF4
transcription factor 4
chr11_+_44565627 0.10 ENST00000532544.5
ENST00000525210.5
ENST00000227155.9
ENST00000527737.5
ENST00000524704.5
CD82
CD82 molecule
chrX_-_15854743 0.09 ENST00000450644.2
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr3_-_151203201 0.09 ENST00000480322.1
ENST00000309180.6
GPR171
G protein-coupled receptor 171
chr3_+_138621207 0.09 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr19_-_5286163 0.09 ENST00000592099.5
ENST00000588012.5
ENST00000262963.10
ENST00000587303.5
ENST00000590509.5
PTPRS
protein tyrosine phosphatase receptor type S
chrX_-_15854791 0.08 ENST00000545766.7
ENST00000380291.5
ENST00000672987.1
ENST00000329235.6
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr2_+_73234282 0.08 ENST00000399032.2
ENST00000398422.2
ENST00000258091.10
CCT7
chaperonin containing TCP1 subunit 7
chr18_+_31447732 0.08 ENST00000257189.5
DSG3
desmoglein 3
chr1_-_12898270 0.08 ENST00000235347.4
PRAMEF10
PRAME family member 10
chr2_+_73234236 0.07 ENST00000540468.5
ENST00000539919.5
CCT7
chaperonin containing TCP1 subunit 7
chrX_-_32155462 0.07 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
DMD
dystrophin
chr16_-_31064952 0.02 ENST00000426488.6
ZNF668
zinc finger protein 668
chr1_+_13068677 0.01 ENST00000614839.4
PRAMEF25
PRAME family member 25

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.7 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.5 1.6 GO:1902948 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.4 1.2 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.3 0.9 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.2 7.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.2 1.4 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.2 3.3 GO:0061162 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.2 2.9 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.5 GO:0032595 B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
0.1 0.5 GO:0030035 microspike assembly(GO:0030035)
0.1 0.7 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.4 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.3 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.1 8.2 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.4 GO:0033504 floor plate development(GO:0033504)
0.1 0.6 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 0.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 2.3 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.5 GO:0008272 sulfate transport(GO:0008272)
0.0 0.4 GO:0021814 cell motility involved in cerebral cortex radial glia guided migration(GO:0021814) modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.0 1.1 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.5 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 3.1 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.2 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.4 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.2 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.1 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.0 0.7 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 1.9 GO:0051225 spindle assembly(GO:0051225)
0.0 0.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.4 GO:0043462 regulation of ATPase activity(GO:0043462)
0.0 0.2 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 1.9 GO:0070652 HAUS complex(GO:0070652)
0.2 3.1 GO:0097433 dense body(GO:0097433)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 1.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.7 GO:0033010 paranodal junction(GO:0033010)
0.0 3.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.6 GO:0070069 cytochrome complex(GO:0070069)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.5 7.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 1.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 0.7 GO:0004967 glucagon receptor activity(GO:0004967)
0.2 7.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 3.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 1.7 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 2.3 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.5 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 2.4 GO:0030552 cAMP binding(GO:0030552)
0.0 3.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 3.3 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 7.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 3.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 0.9 REACTOME OPSINS Genes involved in Opsins
0.0 8.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression