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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for DMC1

Z-value: 2.40

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.10 DMC1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg38_v1_chr22_-_38570167_38570204-0.212.2e-03Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_41286011 11.47 ENST00000661438.1
ENSG00000285920.2
novel protein
chr22_+_20116099 10.39 ENST00000430524.6
RANBP1
RAN binding protein 1
chr12_-_50283472 9.38 ENST00000551691.5
ENST00000394943.7
ENST00000341247.8
LIMA1
LIM domain and actin binding 1
chr3_-_52535006 8.35 ENST00000307076.8
NT5DC2
5'-nucleotidase domain containing 2
chr10_+_60778331 6.92 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
CDK1
cyclin dependent kinase 1
chr10_+_60778490 6.22 ENST00000448257.6
ENST00000614696.4
CDK1
cyclin dependent kinase 1
chr6_-_149746497 5.87 ENST00000367404.8
ENST00000340413.7
ENST00000543637.1
NUP43
nucleoporin 43
chr10_-_73096974 5.86 ENST00000440381.5
ENST00000263556.3
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr8_-_100722587 5.32 ENST00000523555.6
PABPC1
poly(A) binding protein cytoplasmic 1
chr10_-_73096850 5.25 ENST00000307116.6
ENST00000373008.6
ENST00000394890.7
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr8_-_100722731 4.50 ENST00000521865.6
ENST00000520804.2
ENST00000522720.2
ENST00000521067.1
PABPC1
poly(A) binding protein cytoplasmic 1
chr2_+_186590022 4.32 ENST00000261023.8
ENST00000374907.7
ITGAV
integrin subunit alpha V
chr7_+_90154442 4.08 ENST00000297205.7
STEAP1
STEAP family member 1
chr11_+_6863057 4.08 ENST00000641461.1
OR10A2
olfactory receptor family 10 subfamily A member 2
chr11_-_86068929 3.78 ENST00000630913.2
PICALM
phosphatidylinositol binding clathrin assembly protein
chr2_-_85414039 3.66 ENST00000447219.6
ENST00000409670.5
ENST00000409724.5
CAPG
capping actin protein, gelsolin like
chr8_-_67062120 3.48 ENST00000357849.9
COPS5
COP9 signalosome subunit 5
chr11_+_71527267 3.22 ENST00000398536.6
KRTAP5-7
keratin associated protein 5-7
chr2_+_200308943 3.02 ENST00000619961.4
SPATS2L
spermatogenesis associated serine rich 2 like
chr1_+_81306096 2.93 ENST00000370721.5
ENST00000370727.5
ENST00000370725.5
ENST00000370723.5
ENST00000370728.5
ENST00000370730.5
ADGRL2
adhesion G protein-coupled receptor L2
chr11_+_134331874 2.61 ENST00000339772.9
ENST00000535456.7
GLB1L2
galactosidase beta 1 like 2
chr5_-_83673544 1.85 ENST00000503117.1
ENST00000510978.5
HAPLN1
hyaluronan and proteoglycan link protein 1
chr7_-_22500152 1.74 ENST00000406890.6
ENST00000678116.1
ENST00000424363.5
STEAP1B
STEAP family member 1B
chr11_-_86069043 1.69 ENST00000532317.5
ENST00000528256.1
ENST00000393346.8
ENST00000526033.5
PICALM
phosphatidylinositol binding clathrin assembly protein
chr10_-_96271553 1.62 ENST00000224337.10
BLNK
B cell linker
chr17_-_62065248 1.58 ENST00000397786.7
MED13
mediator complex subunit 13
chr3_+_148739798 1.32 ENST00000402260.2
AGTR1
angiotensin II receptor type 1
chr13_-_75366973 1.29 ENST00000648194.1
TBC1D4
TBC1 domain family member 4
chr3_+_101827982 1.02 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKBIZ
NFKB inhibitor zeta
chr2_+_135586250 0.99 ENST00000410054.5
ENST00000628915.2
R3HDM1
R3H domain containing 1
chr2_+_61017562 0.94 ENST00000401576.1
ENST00000295030.6
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chr6_+_26383176 0.94 ENST00000416795.6
ENST00000494184.1
BTN2A2
butyrophilin subfamily 2 member A2
chr17_+_79022908 0.80 ENST00000354124.7
ENST00000580454.5
C1QTNF1
C1q and TNF related 1
chr3_-_99850976 0.76 ENST00000487087.5
FILIP1L
filamin A interacting protein 1 like
chr17_+_4942805 0.70 ENST00000576965.1
RNF167
ring finger protein 167
chr10_-_102837406 0.68 ENST00000369887.4
ENST00000638272.1
ENST00000639393.1
ENST00000638971.1
ENST00000638190.1
CYP17A1
cytochrome P450 family 17 subfamily A member 1
chr21_-_36980789 0.67 ENST00000675307.1
ENST00000612277.4
HLCS
holocarboxylase synthetase
chr18_+_59225492 0.56 ENST00000456142.3
ENST00000530323.1
GRP
gastrin releasing peptide
chr3_-_119557728 0.54 ENST00000383669.3
CD80
CD80 molecule
chr20_-_21397513 0.53 ENST00000351817.5
NKX2-4
NK2 homeobox 4
chr19_+_11355386 0.50 ENST00000251473.9
ENST00000591329.5
ENST00000586380.5
PLPPR2
phospholipid phosphatase related 2
chr2_-_162152404 0.39 ENST00000375497.3
GCG
glucagon
chr2_+_218382265 0.32 ENST00000233202.11
SLC11A1
solute carrier family 11 member 1
chr2_-_162152239 0.30 ENST00000418842.7
GCG
glucagon
chrX_+_106611930 0.30 ENST00000372544.6
ENST00000372548.9
RADX
RPA1 related single stranded DNA binding protein, X-linked
chrX_-_50200988 0.22 ENST00000358526.7
AKAP4
A-kinase anchoring protein 4
chrX_-_50200358 0.21 ENST00000437370.2
ENST00000376064.7
ENST00000448865.5
AKAP4
A-kinase anchoring protein 4
chr10_-_96271508 0.18 ENST00000427367.6
ENST00000413476.6
ENST00000371176.6
BLNK
B cell linker
chr6_+_26383090 0.18 ENST00000469230.5
ENST00000490025.5
ENST00000352867.6
ENST00000356709.9
ENST00000493275.5
ENST00000472507.5
ENST00000482536.5
ENST00000432533.6
ENST00000482842.1
BTN2A2
butyrophilin subfamily 2 member A2
chrX_-_153470555 0.13 ENST00000370211.10
ENST00000330912.7
ENST00000334497.7
ENST00000338525.7
ENST00000370232.4
HAUS7
TREX2
HAUS augmin like complex subunit 7
three prime repair exonuclease 2
chr2_-_20823048 0.11 ENST00000402479.6
ENST00000237822.8
ENST00000626491.2
ENST00000432947.1
ENST00000403006.6
ENST00000419825.2
ENST00000381090.7
ENST00000412261.5
ENST00000619656.4
ENST00000541941.5
ENST00000440866.6
ENST00000435420.6
LDAH
lipid droplet associated hydrolase
chr2_-_18560616 0.10 ENST00000381249.4
RDH14
retinol dehydrogenase 14
chr7_+_92057602 0.03 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 13.1 GO:0090166 regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166)
1.4 4.3 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
1.3 10.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
1.2 11.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
1.2 5.8 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.8 5.5 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.8 9.8 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.3 1.3 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.3 0.9 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2 3.5 GO:0000338 protein deneddylation(GO:0000338)
0.2 13.0 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.2 1.3 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.2 0.7 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.2 0.7 GO:0071110 protein biotinylation(GO:0009305) histone biotinylation(GO:0071110)
0.2 0.8 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 5.9 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.6 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 0.3 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.1 0.5 GO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1 1.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 1.6 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 0.7 GO:0006702 androgen biosynthetic process(GO:0006702)
0.0 3.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 3.2 GO:0031424 keratinization(GO:0031424)
0.0 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 8.8 GO:0016311 dephosphorylation(GO:0016311)
0.0 1.8 GO:0030183 B cell differentiation(GO:0030183)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
3.3 13.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
1.4 4.3 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
1.1 5.5 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.4 9.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.3 5.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 3.7 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 9.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 3.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.7 GO:0005652 nuclear lamina(GO:0005652)
0.0 10.4 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 11.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
1.5 5.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
1.1 4.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.7 2.9 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.6 13.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.6 8.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.4 9.8 GO:0008494 translation activator activity(GO:0008494)
0.4 1.3 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.4 10.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 5.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.4 3.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.3 2.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 9.4 GO:0003785 actin monomer binding(GO:0003785)
0.2 0.7 GO:0018271 biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.1 1.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 1.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577)
0.0 0.3 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.7 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 13.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 4.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 9.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 10.4 PID E2F PATHWAY E2F transcription factor network
0.0 1.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 11.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 13.1 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.3 9.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.3 4.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.2 5.9 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 10.4 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 5.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.7 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)