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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for DRGX_PROP1

Z-value: 2.21

Motif logo

Transcription factors associated with DRGX_PROP1

Gene Symbol Gene ID Gene Info
ENSG00000165606.10 DRGX
ENSG00000175325.2 PROP1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PROP1hg38_v1_chr5_-_177996242_177996242-0.235.1e-04Click!

Activity profile of DRGX_PROP1 motif

Sorted Z-values of DRGX_PROP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DRGX_PROP1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_+_34236865 9.28 ENST00000674029.1
ENST00000447654.5
ENST00000347617.10
ENST00000401473.7
ENST00000311487.9
high mobility group AT-hook 1
chrX_+_120604199 7.86 ENST00000371315.3
MCTS1 re-initiation and release factor
chr8_+_26293112 7.22 ENST00000523925.5
ENST00000315985.7
protein phosphatase 2 regulatory subunit Balpha
chr6_-_41071825 7.10 ENST00000468811.5
O-acyl-ADP-ribose deacylase 1
chr11_-_11353241 7.00 ENST00000528848.3
casein kinase 2 alpha 3
chrX_+_120604084 6.78 ENST00000371317.10
MCTS1 re-initiation and release factor
chr17_+_44957907 6.58 ENST00000678938.1
N-myristoyltransferase 1
chr3_+_138621225 5.78 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr11_+_108116688 5.68 ENST00000672284.1
acetyl-CoA acetyltransferase 1
chr12_-_119804472 5.48 ENST00000678087.1
ENST00000677993.1
citron rho-interacting serine/threonine kinase
chr5_-_135399863 5.47 ENST00000510038.1
ENST00000304332.8
macroH2A.1 histone
chr12_-_119804298 5.28 ENST00000678652.1
ENST00000678494.1
citron rho-interacting serine/threonine kinase
chr14_-_75069478 4.01 ENST00000555463.1
acylphosphatase 1
chr3_+_138621207 3.97 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr3_-_158106408 3.53 ENST00000483851.7
short stature homeobox 2
chr15_+_43800586 3.34 ENST00000442995.4
ENST00000458412.2
huntingtin interacting protein K
chr15_+_57219411 3.32 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
transcription factor 12
chr20_+_31547367 3.25 ENST00000394552.3
MCTS family member 2, pseudogene
chr3_-_142029108 3.23 ENST00000497579.5
transcription factor Dp-2
chr16_-_69339493 3.13 ENST00000562595.5
ENST00000615447.1
ENST00000306875.10
ENST00000562081.2
component of oligomeric golgi complex 8
chr13_+_97960192 3.07 ENST00000496368.6
ENST00000421861.7
ENST00000357602.7
importin 5
chr1_+_50103903 3.06 ENST00000371827.5
ELAV like RNA binding protein 4
chr2_-_17800195 3.06 ENST00000402989.5
ENST00000428868.1
structural maintenance of chromosomes 6
chr5_+_141192330 3.01 ENST00000239446.6
protocadherin beta 10
chr16_-_67483541 2.76 ENST00000290953.3
agouti related neuropeptide
chr2_-_58241259 2.66 ENST00000481670.2
ENST00000403676.5
ENST00000427708.6
ENST00000403295.7
ENST00000233741.9
ENST00000446381.5
ENST00000417361.1
ENST00000402135.7
ENST00000449070.5
FA complementation group L
chr4_-_99435134 2.63 ENST00000476959.5
ENST00000482593.5
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr16_-_74666839 2.54 ENST00000576652.1
ENST00000572337.5
ENST00000571750.5
ENST00000572990.5
ENST00000361070.9
ring finger and WD repeat domain 3
chr1_-_21050952 2.52 ENST00000264211.12
eukaryotic translation initiation factor 4 gamma 3
chr6_+_112236806 2.51 ENST00000588837.5
ENST00000590293.5
ENST00000585450.5
ENST00000629766.2
ENST00000590804.5
ENST00000590584.4
ENST00000628122.2
ENST00000627025.1
ENST00000590673.5
ENST00000585611.5
ENST00000587816.2
LAMA4 antisense RNA 1
novel ret finger protein-like 4B
chr16_+_24537693 2.50 ENST00000564314.5
ENST00000567686.5
RB binding protein 6, ubiquitin ligase
chr11_+_18412292 2.45 ENST00000541669.6
ENST00000280704.8
lactate dehydrogenase C
chr15_+_75336018 2.40 ENST00000567195.5
COMM domain containing 4
chr18_+_58196736 2.40 ENST00000675221.1
NEDD4 like E3 ubiquitin protein ligase
chr7_+_107583919 2.38 ENST00000491150.5
B cell receptor associated protein 29
chr4_-_142305935 2.37 ENST00000511838.5
inositol polyphosphate-4-phosphatase type II B
chr15_+_75336078 2.35 ENST00000567377.5
ENST00000562789.5
ENST00000568301.1
COMM domain containing 4
chr11_-_95910748 2.31 ENST00000675933.1
myotubularin related protein 2
chr11_-_95910665 2.26 ENST00000674610.1
ENST00000675660.1
myotubularin related protein 2
chr4_+_112647059 2.23 ENST00000511529.1
La ribonucleoprotein 7, transcriptional regulator
chr15_+_75336053 2.21 ENST00000564815.5
ENST00000338995.10
ENST00000267935.13
COMM domain containing 4
chr22_+_25219633 2.12 ENST00000398215.3
crystallin beta B2
chr14_+_34993240 2.04 ENST00000677647.1
signal recognition particle 54
chr9_+_65700287 2.01 ENST00000489273.1
COBW domain containing 5
chr12_-_110445540 1.99 ENST00000547365.1
actin related protein 2/3 complex subunit 3
chr2_-_70302048 1.98 ENST00000430566.6
ENST00000037869.7
family with sequence similarity 136 member A
chr6_-_136550407 1.91 ENST00000354570.8
microtubule associated protein 7
chr16_+_68085344 1.87 ENST00000575270.5
ENST00000346183.8
nuclear factor of activated T cells 3
chr12_-_118359639 1.82 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr10_-_110304894 1.79 ENST00000369603.10
survival motor neuron domain containing 1
chr4_-_99435396 1.78 ENST00000209665.8
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr5_-_11588842 1.76 ENST00000503622.5
catenin delta 2
chr14_+_23630109 1.67 ENST00000432832.6
dehydrogenase/reductase 2
chr2_-_55334529 1.65 ENST00000645860.1
ENST00000642563.1
ENST00000647396.1
coiled-coil domain containing 88A
chr3_-_197573323 1.64 ENST00000358186.6
ENST00000431056.5
3-hydroxybutyrate dehydrogenase 1
chr13_-_94479671 1.61 ENST00000377028.10
ENST00000446125.1
dopachrome tautomerase
chr22_-_28711931 1.56 ENST00000434810.5
ENST00000456369.5
checkpoint kinase 2
chr12_-_49187369 1.53 ENST00000547939.6
tubulin alpha 1a
chr17_-_40867200 1.52 ENST00000647902.1
ENST00000251643.5
keratin 12
chr16_+_68085552 1.52 ENST00000329524.8
nuclear factor of activated T cells 3
chr2_+_75646775 1.48 ENST00000393909.7
ENST00000358788.10
ENST00000409374.5
mitochondrial ribosomal protein L19
chr22_-_28712136 1.40 ENST00000464581.6
checkpoint kinase 2
chr16_+_68085420 1.39 ENST00000349223.9
nuclear factor of activated T cells 3
chr17_-_13017952 1.38 ENST00000578071.1
ENST00000426905.7
ENST00000395962.6
ENST00000338034.9
ENST00000583371.5
elaC ribonuclease Z 2
chr6_+_149400260 1.36 ENST00000326669.6
small ubiquitin like modifier 4
chr15_+_48191648 1.36 ENST00000646012.1
ENST00000561127.5
ENST00000647546.1
ENST00000559641.5
ENST00000417307.3
solute carrier family 12 member 1
cortexin 2
chr8_-_85341659 1.31 ENST00000522389.5
carbonic anhydrase 1
chr15_-_55249029 1.31 ENST00000566877.5
RAB27A, member RAS oncogene family
chr2_+_10368764 1.28 ENST00000620771.4
hippocalcin like 1
chr2_+_86907953 1.28 ENST00000409776.6
RANBP2 like and GRIP domain containing 1
chr2_+_10368645 1.27 ENST00000613496.4
hippocalcin like 1
chrX_+_109535775 1.26 ENST00000218004.5
nuclear transport factor 2 like export factor 2
chr3_-_146528750 1.25 ENST00000483300.5
phospholipid scramblase 1
chr11_+_57712574 1.19 ENST00000278422.9
ENST00000378312.8
thioredoxin related transmembrane protein 2
chr9_+_74615582 1.18 ENST00000396204.2
RAR related orphan receptor B
chr8_-_85341705 1.14 ENST00000517618.5
carbonic anhydrase 1
chr1_+_244051275 1.09 ENST00000358704.4
zinc finger and BTB domain containing 18
chr1_+_151254709 1.06 ENST00000368881.8
ENST00000368884.8
proteasome 26S subunit, non-ATPase 4
chrX_+_108044967 1.05 ENST00000415430.7
V-set and immunoglobulin domain containing 1
chr20_-_35742207 1.05 ENST00000397370.3
ENST00000528062.7
ENST00000374038.7
ENST00000253363.11
ENST00000361162.10
RNA binding motif protein 39
chr3_-_47892743 1.05 ENST00000420772.6
microtubule associated protein 4
chr4_-_75724386 1.00 ENST00000677606.1
ENST00000678798.1
ENST00000677970.1
ENST00000677620.1
ENST00000679281.1
ENST00000677333.1
ENST00000676470.1
ENST00000499709.3
ENST00000511868.6
ENST00000678971.1
ENST00000677265.1
ENST00000677952.1
ENST00000678122.1
ENST00000678100.1
ENST00000678062.1
ENST00000676666.1
G3BP stress granule assembly factor 2
chr9_+_2159672 1.00 ENST00000634343.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_-_99435336 0.99 ENST00000437033.7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr1_+_84164962 0.96 ENST00000614872.4
ENST00000394839.6
protein kinase cAMP-activated catalytic subunit beta
chr3_-_12545499 0.96 ENST00000564146.4
MKRN2 opposite strand
chr2_-_55010348 0.95 ENST00000394609.6
reticulon 4
chrX_+_108045050 0.95 ENST00000458383.1
ENST00000217957.10
V-set and immunoglobulin domain containing 1
chr9_+_2159850 0.92 ENST00000416751.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_-_165837412 0.92 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
butyrylcholinesterase
chr2_+_54456311 0.89 ENST00000615901.4
ENST00000356805.9
spectrin beta, non-erythrocytic 1
chr2_-_182427014 0.88 ENST00000409365.5
ENST00000351439.9
phosphodiesterase 1A
chr12_+_19205294 0.87 ENST00000424268.5
pleckstrin homology domain containing A5
chr4_-_142305826 0.87 ENST00000514525.1
inositol polyphosphate-4-phosphatase type II B
chr9_+_12693327 0.87 ENST00000388918.10
tyrosinase related protein 1
chr1_+_109213887 0.85 ENST00000234677.7
ENST00000369923.4
seryl-tRNA synthetase 1
chr4_-_75724362 0.83 ENST00000677583.1
G3BP stress granule assembly factor 2
chr12_-_68225806 0.83 ENST00000229134.5
interleukin 26
chr4_-_175812746 0.80 ENST00000393658.6
glycoprotein M6A
chr1_+_74235377 0.79 ENST00000326637.8
TNNI3 interacting kinase
chr12_-_118190510 0.79 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr21_-_14658812 0.79 ENST00000647101.1
SAM domain, SH3 domain and nuclear localization signals 1
chr18_-_63644250 0.78 ENST00000341074.10
ENST00000436264.1
serpin family B member 4
chr12_+_75391078 0.72 ENST00000550916.6
ENST00000378692.7
ENST00000320460.8
ENST00000547164.1
GLIPR1 like 2
chr14_+_22516273 0.71 ENST00000390510.1
T cell receptor alpha joining 27
chr3_-_165196369 0.71 ENST00000475390.2
SLIT and NTRK like family member 3
chr5_-_111976925 0.69 ENST00000395634.7
neuronal regeneration related protein
chr3_+_149474688 0.68 ENST00000305354.5
ENST00000465758.1
transmembrane 4 L six family member 4
chr5_-_111758061 0.66 ENST00000509979.5
ENST00000513100.5
ENST00000508161.5
ENST00000455559.6
neuronal regeneration related protein
chr9_+_133636355 0.66 ENST00000393056.8
dopamine beta-hydroxylase
chr5_-_9630351 0.65 ENST00000382492.4
taste 2 receptor member 1
chr2_+_108621260 0.65 ENST00000409441.5
LIM zinc finger domain containing 1
chr3_-_98523013 0.61 ENST00000394181.6
ENST00000508902.5
ENST00000394180.6
claudin domain containing 1
chr3_-_11582330 0.58 ENST00000451674.6
vestigial like family member 4
chr7_-_25228485 0.58 ENST00000222674.2
neuropeptide VF precursor
chr2_+_233691607 0.57 ENST00000373424.5
ENST00000441351.1
UDP glucuronosyltransferase family 1 member A6
chr6_-_111483700 0.56 ENST00000435970.5
ENST00000358835.7
REV3 like, DNA directed polymerase zeta catalytic subunit
chr3_-_9249623 0.55 ENST00000383836.8
SLIT-ROBO Rho GTPase activating protein 3
chr4_+_159267737 0.55 ENST00000264431.8
Rap guanine nucleotide exchange factor 2
chr5_+_137867868 0.54 ENST00000515645.1
myotilin
chr3_-_98522869 0.53 ENST00000502288.5
ENST00000512147.5
ENST00000341181.11
ENST00000510541.5
ENST00000503621.5
ENST00000511081.5
ENST00000507874.5
ENST00000502299.5
ENST00000508659.5
ENST00000510545.5
ENST00000511667.5
ENST00000394185.6
claudin domain containing 1
chr8_-_56211257 0.48 ENST00000316981.8
ENST00000423799.6
ENST00000429357.2
PLAG1 zinc finger
chrX_+_77910656 0.48 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr13_-_46897021 0.47 ENST00000542664.4
ENST00000543956.5
5-hydroxytryptamine receptor 2A
chrX_-_11265975 0.45 ENST00000303025.10
ENST00000657361.1
Rho GTPase activating protein 6
chr2_-_171231314 0.40 ENST00000521943.5
tousled like kinase 1
chr6_+_27824084 0.39 ENST00000355057.3
H4 clustered histone 11
chr17_-_41467386 0.39 ENST00000225899.4
keratin 32
chr9_+_21440437 0.38 ENST00000276927.3
interferon alpha 1
chr1_+_14929734 0.38 ENST00000376028.8
ENST00000400798.6
kazrin, periplakin interacting protein
chr5_-_11589019 0.37 ENST00000511377.5
catenin delta 2
chr5_-_67196791 0.37 ENST00000256447.5
CD180 molecule
chr13_-_40982880 0.37 ENST00000635415.1
E74 like ETS transcription factor 1
chr5_-_138139382 0.37 ENST00000265191.4
NME/NM23 family member 5
chr7_-_123199960 0.36 ENST00000194130.7
solute carrier family 13 member 1
chr14_-_21098848 0.35 ENST00000556174.5
ENST00000554478.5
ENST00000553980.1
ENST00000421093.6
zinc finger protein 219
chr17_+_73232400 0.34 ENST00000535032.7
ENST00000577615.5
ENST00000585109.5
chromosome 17 open reading frame 80
chr1_+_84181630 0.32 ENST00000610457.1
protein kinase cAMP-activated catalytic subunit beta
chr10_+_35175586 0.31 ENST00000494479.5
ENST00000463314.5
ENST00000342105.7
ENST00000495301.1
cAMP responsive element modulator
chr3_-_3109980 0.31 ENST00000256452.7
ENST00000311981.12
ENST00000430514.6
ENST00000456302.5
interleukin 5 receptor subunit alpha
chr1_-_186461089 0.31 ENST00000391997.3
phosducin
chr4_+_40196907 0.30 ENST00000622175.4
ENST00000619474.4
ENST00000615083.4
ENST00000610353.4
ENST00000614836.1
ras homolog family member H
chrX_-_111410420 0.30 ENST00000371993.7
ENST00000680476.1
doublecortin
chr1_-_165445088 0.29 ENST00000359842.10
retinoid X receptor gamma
chr7_+_136868622 0.29 ENST00000680005.1
ENST00000445907.6
cholinergic receptor muscarinic 2
chr3_+_12351470 0.29 ENST00000287820.10
peroxisome proliferator activated receptor gamma
chr17_-_40703744 0.28 ENST00000264651.3
keratin 24
chr4_+_67558719 0.28 ENST00000265404.7
ENST00000396225.1
signal transducing adaptor family member 1
chr17_+_77185210 0.27 ENST00000431431.6
SEC14 like lipid binding 1
chr22_-_30246739 0.26 ENST00000403987.3
ENST00000249075.4
LIF interleukin 6 family cytokine
chr1_-_219613069 0.26 ENST00000367211.6
ENST00000651890.1
zinc finger CCCH-type containing 11B
chr4_+_40197023 0.24 ENST00000381799.10
ras homolog family member H
chr11_-_102705737 0.23 ENST00000260229.5
matrix metallopeptidase 27
chr15_-_56243829 0.22 ENST00000559447.8
ENST00000673997.1
regulatory factor X7
chr1_-_169734064 0.21 ENST00000333360.12
selectin E
chr1_+_174964750 0.20 ENST00000367688.3
RAB GTPase activating protein 1 like
chr1_+_67166448 0.19 ENST00000347310.10
interleukin 23 receptor
chr13_+_53028806 0.18 ENST00000219022.3
olfactomedin 4
chr12_-_46825949 0.18 ENST00000547477.5
ENST00000447411.5
ENST00000266579.9
solute carrier family 38 member 4
chr17_+_46511511 0.18 ENST00000576629.5
leucine rich repeat containing 37 member A2
chr6_+_29111560 0.17 ENST00000377169.2
olfactory receptor family 2 subfamily J member 3
chr20_+_33562365 0.15 ENST00000346541.7
ENST00000397800.5
ENST00000492345.5
CBFA2/RUNX1 partner transcriptional co-repressor 2
chr7_+_120273129 0.14 ENST00000331113.9
potassium voltage-gated channel subfamily D member 2
chr5_-_56116946 0.11 ENST00000434982.2
ankyrin repeat domain 55
chr9_-_27005659 0.10 ENST00000380055.6
leucine rich repeat containing 19
chr3_-_165196689 0.09 ENST00000241274.3
SLIT and NTRK like family member 3
chr3_-_87276462 0.07 ENST00000561167.5
ENST00000560656.1
POU class 1 homeobox 1
chr5_+_137867852 0.07 ENST00000421631.6
ENST00000239926.9
myotilin
chr12_-_10172117 0.06 ENST00000545927.5
ENST00000309539.8
ENST00000432556.6
ENST00000544577.5
oxidized low density lipoprotein receptor 1
chr8_-_17895487 0.05 ENST00000427924.5
ENST00000381841.4
fibrinogen like 1
chrX_+_101623121 0.05 ENST00000491568.6
ENST00000479298.5
ENST00000471229.7
armadillo repeat containing X-linked 3
chr7_-_120858066 0.03 ENST00000222747.8
tetraspanin 12
chr3_+_46354072 0.02 ENST00000445132.3
ENST00000421659.1
C-C motif chemokine receptor 2
chr10_-_101229449 0.01 ENST00000370193.4
ladybird homeobox 1
chr1_-_93681829 0.01 ENST00000260502.11
BCAR3 adaptor protein, NSP family member
chr8_-_17895403 0.00 ENST00000381840.5
ENST00000398054.5
fibrinogen like 1
chr8_-_6563409 0.00 ENST00000325203.9
angiopoietin 2
chr5_+_170504005 0.00 ENST00000328939.9
ENST00000390656.8
potassium voltage-gated channel interacting protein 1
chr7_+_93906557 0.00 ENST00000248572.10
ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
G protein subunit gamma transducin 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.6 GO:0002188 translation reinitiation(GO:0002188)
3.1 9.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
1.9 5.7 GO:0072019 proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
1.6 6.6 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
1.4 5.4 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.0 3.0 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.6 2.5 GO:0019249 lactate biosynthetic process(GO:0019249)
0.5 2.0 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.5 1.4 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
0.4 4.6 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.4 1.6 GO:0046952 ketone body catabolic process(GO:0046952)
0.4 2.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.3 2.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.3 7.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.3 4.5 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.3 1.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.3 0.8 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.2 0.7 GO:0014016 neuroblast differentiation(GO:0014016)
0.2 0.5 GO:1990169 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 3.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 0.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.2 1.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 1.3 GO:0097338 response to clozapine(GO:0097338)
0.2 3.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 2.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 1.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 4.8 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.2 0.4 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.2 1.0 GO:0051012 microtubule sliding(GO:0051012)
0.2 10.5 GO:0000281 mitotic cytokinesis(GO:0000281)
0.2 1.6 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.2 1.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 2.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.5 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 1.8 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.9 GO:1902224 ketone body metabolic process(GO:1902224)
0.1 2.0 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.3 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 0.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.7 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.1 0.3 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.1 0.3 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.1 3.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.3 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 4.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 3.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.6 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 0.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 1.7 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.6 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 2.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 2.0 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.4 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 0.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 2.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 3.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.8 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.4 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 3.3 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.5 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.7 GO:0007635 chemosensory behavior(GO:0007635)
0.0 0.3 GO:0015871 choline transport(GO:0015871)
0.0 6.5 GO:0030307 positive regulation of cell growth(GO:0030307)
0.0 2.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.2 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 2.1 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.4 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.0 GO:1902567 negative regulation of eosinophil activation(GO:1902567)
0.0 0.8 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 1.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.4 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.4 GO:0051497 negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497)
0.0 3.3 GO:0050821 protein stabilization(GO:0050821)
0.0 1.9 GO:0007286 spermatid development(GO:0007286)
0.0 1.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 2.6 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 1.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 7.1 GO:0042278 purine nucleoside metabolic process(GO:0042278)
0.0 0.1 GO:0045475 locomotor rhythm(GO:0045475)
0.0 3.3 GO:0007601 visual perception(GO:0007601)
0.0 0.2 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 1.2 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.5 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.7 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0 1.5 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.8 3.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 3.1 GO:0017119 Golgi transport complex(GO:0017119)
0.2 2.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.2 2.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 2.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 14.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 3.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 7.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.9 GO:0032437 cuticular plate(GO:0032437)
0.1 2.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 10.8 GO:0031985 Golgi cisterna(GO:0031985)
0.1 2.5 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.9 GO:0016514 SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.5 GO:0070852 cell body fiber(GO:0070852)
0.0 1.6 GO:0098576 lumenal side of membrane(GO:0098576)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 4.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 3.1 GO:0005643 nuclear pore(GO:0005643)
0.0 1.8 GO:0015030 Cajal body(GO:0015030)
0.0 1.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 4.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.8 GO:0031514 motile cilium(GO:0031514)
0.0 3.0 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 2.8 GO:0043204 perikaryon(GO:0043204)
0.0 3.3 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.7 GO:0036064 ciliary basal body(GO:0036064)
0.0 6.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 5.5 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.6 GO:0019107 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
1.4 5.7 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
1.4 5.4 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.7 4.0 GO:0003998 acylphosphatase activity(GO:0003998)
0.6 3.2 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.6 7.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.5 1.6 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.5 1.4 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.4 2.5 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.3 2.0 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.3 1.7 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.3 1.6 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.3 7.2 GO:0048156 tau protein binding(GO:0048156)
0.2 2.5 GO:0004064 arylesterase activity(GO:0004064)
0.2 0.9 GO:0033265 acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.2 4.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 2.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 3.3 GO:0035497 cAMP response element binding(GO:0035497)
0.2 0.5 GO:0043682 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
0.1 0.9 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.3 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 3.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 2.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.7 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 2.5 GO:0000339 RNA cap binding(GO:0000339)
0.1 0.3 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 1.4 GO:0031386 protein tag(GO:0031386)
0.1 8.8 GO:0097110 scaffold protein binding(GO:0097110)
0.1 7.1 GO:0019213 deacetylase activity(GO:0019213)
0.1 1.4 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.1 1.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.8 GO:0031013 troponin I binding(GO:0031013)
0.1 0.9 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 3.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.7 GO:0043422 protein kinase B binding(GO:0043422)
0.1 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 4.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.2 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 0.5 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.1 0.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.3 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 1.8 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.3 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.5 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 9.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 3.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.3 GO:0019003 GDP binding(GO:0019003)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 2.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.0 0.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.0 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.8 PID RHOA PATHWAY RhoA signaling pathway
0.1 7.7 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 12.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 9.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 2.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.1 9.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 1.3 PID IL3 PATHWAY IL3-mediated signaling events
0.1 2.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 5.1 PID E2F PATHWAY E2F transcription factor network
0.0 1.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 2.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.5 5.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 7.8 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 5.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 3.0 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 2.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 6.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 7.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 2.0 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.9 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.0 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 2.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 3.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 1.1 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases