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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for E2F2_E2F5
Z-value: 14.38
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | hg38_v1_chr1_-_23531206_23531241 | -0.44 | 9.7e-12 | Click! |
| E2F5 | hg38_v1_chr8_+_85187650_85187685 | 0.41 | 4.6e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 35.2 | 457.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 8.4 | 303.1 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 11.1 | 277.5 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 3.8 | 250.6 | GO:0006301 | postreplication repair(GO:0006301) |
| 30.0 | 239.7 | GO:0090166 | regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166) |
| 45.3 | 226.6 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 18.1 | 217.6 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 11.9 | 143.3 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 11.0 | 131.8 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 37.1 | 111.3 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 44.4 | 577.6 | GO:0042555 | MCM complex(GO:0042555) |
| 69.4 | 277.5 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 59.9 | 239.7 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 7.6 | 159.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.3 | 152.7 | GO:0005874 | microtubule(GO:0005874) |
| 0.8 | 131.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 30.2 | 120.9 | GO:0000811 | GINS complex(GO:0000811) |
| 0.1 | 93.5 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 8.1 | 89.3 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.5 | 86.8 | GO:0005819 | spindle(GO:0005819) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 377.5 | GO:0042393 | histone binding(GO:0042393) |
| 8.6 | 343.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 69.4 | 277.5 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 10.9 | 239.7 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 1.8 | 198.8 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 10.4 | 177.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.4 | 154.9 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.4 | 151.4 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 8.7 | 122.0 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 10.1 | 120.9 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 616.7 | PID E2F PATHWAY | E2F transcription factor network |
| 5.4 | 326.8 | PID ATR PATHWAY | ATR signaling pathway |
| 18.2 | 254.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 10.9 | 217.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.6 | 109.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.1 | 100.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 3.4 | 98.1 | PID ATM PATHWAY | ATM pathway |
| 1.9 | 67.6 | PID MYC PATHWAY | C-MYC pathway |
| 1.1 | 61.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.7 | 41.8 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 26.5 | 795.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 46.5 | 697.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 13.4 | 200.7 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 1.4 | 124.1 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 2.1 | 107.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.8 | 89.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 4.4 | 78.6 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 1.7 | 77.0 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 1.9 | 75.0 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 1.3 | 72.3 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |