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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for E2F8

Z-value: 12.56

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Transcription factors associated with E2F8

Gene Symbol Gene ID Gene Info
E2F8
ENSG00000129173.13 E2F8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F8hg38_v1_chr11_-_19241598_19241628,
hg38_v1_chr11_-_19240936_19240968		0.571.6e-20Click!

Activity profile of E2F8 motif

Sorted Z-values of E2F8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F8

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_10123171 72.11 ENST00000615152.5
RRM2
ribonucleotide reductase regulatory subunit M2
chr2_+_10122730 64.69 ENST00000304567.10
RRM2
ribonucleotide reductase regulatory subunit M2
chr4_-_173333672 56.55 ENST00000438704.6
HMGB2
high mobility group box 2
chr2_-_135876382 51.46 ENST00000264156.3
MCM6
minichromosome maintenance complex component 6
chr6_+_135181268 47.17 ENST00000341911.10
ENST00000442647.7
ENST00000618728.4
ENST00000316528.12
ENST00000616088.4
MYB
MYB proto-oncogene, transcription factor
chr6_+_135181323 46.09 ENST00000367814.8
MYB
MYB proto-oncogene, transcription factor
chr20_+_43667105 38.98 ENST00000217026.5
MYBL2
MYB proto-oncogene like 2
chr8_+_127736046 35.11 ENST00000641036.1
ENST00000377970.6
MYC
MYC proto-oncogene, bHLH transcription factor
chr1_-_159923717 35.08 ENST00000368096.5
TAGLN2
transgelin 2
chr3_+_127598400 34.55 ENST00000265056.12
MCM2
minichromosome maintenance complex component 2
chr14_-_55191534 33.87 ENST00000395425.6
ENST00000247191.7
DLGAP5
DLG associated protein 5
chr1_-_43172504 33.43 ENST00000431635.6
EBNA1BP2
EBNA1 binding protein 2
chr8_+_127736220 33.14 ENST00000524013.2
ENST00000621592.8
MYC
MYC proto-oncogene, bHLH transcription factor
chr22_+_35400115 32.63 ENST00000382011.9
ENST00000216122.9
ENST00000416905.1
MCM5
minichromosome maintenance complex component 5
chr4_-_1712250 31.84 ENST00000318386.8
SLBP
stem-loop binding protein
chr9_+_128683645 31.71 ENST00000372692.8
SET
SET nuclear proto-oncogene
chr12_-_56752311 31.30 ENST00000338193.11
ENST00000550770.1
PRIM1
DNA primase subunit 1
chr1_-_43172244 30.25 ENST00000236051.3
EBNA1BP2
EBNA1 binding protein 2
chr1_+_156054761 30.16 ENST00000368305.9
ENST00000368304.9
ENST00000368302.3
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr7_+_135557904 29.84 ENST00000285968.11
NUP205
nucleoporin 205
chr15_+_64136330 29.41 ENST00000560861.1
SNX1
sorting nexin 1
chr10_-_17617235 29.22 ENST00000466335.1
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr22_+_19479826 29.19 ENST00000437685.6
ENST00000263201.7
ENST00000404724.7
CDC45
cell division cycle 45
chr2_-_214809650 28.60 ENST00000260947.9
ENST00000613706.5
BARD1
BRCA1 associated RING domain 1
chr7_+_2244476 28.51 ENST00000397049.2
NUDT1
nudix hydrolase 1
chr4_-_173334249 27.99 ENST00000506267.1
ENST00000296503.10
HMGB2
high mobility group box 2
chr22_+_20117734 27.94 ENST00000416427.5
ENST00000421656.5
ENST00000423859.5
ENST00000418705.2
RANBP1
RAN binding protein 1
chr10_-_27154226 27.78 ENST00000427324.5
ENST00000375972.7
ENST00000326799.7
YME1L1
YME1 like 1 ATPase
chr22_+_40346508 27.41 ENST00000636714.1
ENST00000216194.11
ENST00000623978.3
ENST00000636265.1
ENST00000680378.1
ADSL
adenylosuccinate lyase
chr4_-_1712310 27.16 ENST00000488267.5
ENST00000429429.6
ENST00000489418.6
ENST00000480936.1
SLBP
stem-loop binding protein
chr1_+_52927254 26.70 ENST00000371514.8
ENST00000528311.5
ENST00000371509.8
ENST00000407246.6
ENST00000371513.9
SCP2
sterol carrier protein 2
chr16_-_66830903 26.58 ENST00000566336.5
ENST00000394074.6
ENST00000563185.6
ENST00000359087.8
ENST00000290810.8
ENST00000379463.6
ENST00000565535.5
NAE1
NEDD8 activating enzyme E1 subunit 1
chr12_-_56752366 26.36 ENST00000672280.1
PRIM1
DNA primase subunit 1
chrX_-_130165825 25.56 ENST00000675240.1
ENST00000319908.8
ENST00000674546.1
ENST00000287295.8
AIFM1
apoptosis inducing factor mitochondria associated 1
chr10_-_43396831 25.45 ENST00000443950.6
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr11_+_72227881 25.35 ENST00000538751.5
ENST00000541756.5
INPPL1
inositol polyphosphate phosphatase like 1
chr13_+_37000774 24.84 ENST00000389704.4
EXOSC8
exosome component 8
chr14_+_51240205 24.83 ENST00000457354.7
TMX1
thioredoxin related transmembrane protein 1
chr10_-_27154365 24.74 ENST00000396296.7
ENST00000376016.8
ENST00000491542.6
ENST00000613434.4
YME1L1
YME1 like 1 ATPase
chr2_-_151289613 24.58 ENST00000243346.10
NMI
N-myc and STAT interactor
chr12_-_53677397 24.55 ENST00000338662.6
ENST00000552242.5
ATP5MC2
ATP synthase membrane subunit c locus 2
chr14_+_64388296 24.47 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chrX_-_130165873 23.42 ENST00000676229.1
AIFM1
apoptosis inducing factor mitochondria associated 1
chr15_-_64381431 22.91 ENST00000558008.3
ENST00000300035.9
ENST00000559519.5
ENST00000380258.6
PCLAF
PCNA clamp associated factor
chr13_-_113208087 22.41 ENST00000375459.5
PCID2
PCI domain containing 2
chrX_+_132023294 22.32 ENST00000481105.5
ENST00000354719.10
ENST00000394334.7
ENST00000394335.6
STK26
serine/threonine kinase 26
chr2_+_216109323 22.24 ENST00000392132.7
ENST00000417391.1
XRCC5
X-ray repair cross complementing 5
chr17_+_58692563 21.43 ENST00000461271.5
ENST00000583539.5
ENST00000337432.9
ENST00000421782.3
RAD51C
RAD51 paralog C
chr11_-_107858777 21.42 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chrX_+_24054931 21.39 ENST00000253039.9
ENST00000423068.1
EIF2S3
eukaryotic translation initiation factor 2 subunit gamma
chr7_-_141014939 21.10 ENST00000324787.10
ENST00000467334.1
MRPS33
mitochondrial ribosomal protein S33
chr4_-_139302460 21.04 ENST00000394223.2
ENST00000676245.1
NDUFC1
NADH:ubiquinone oxidoreductase subunit C1
chrX_-_23743201 20.76 ENST00000492081.1
ENST00000379303.10
ENST00000336430.11
ACOT9
acyl-CoA thioesterase 9
chr22_+_20117497 20.17 ENST00000331821.7
ENST00000411892.5
RANBP1
RAN binding protein 1
chr1_-_8878646 20.08 ENST00000643438.1
ENO1
enolase 1
chr2_-_206159194 19.90 ENST00000455934.6
ENST00000449699.5
ENST00000454195.1
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr22_+_40346461 19.82 ENST00000623632.4
ENST00000625194.4
ENST00000637666.2
ENST00000680978.1
ENST00000623063.3
ENST00000679723.1
ENST00000342312.9
ADSL
adenylosuccinate lyase
chr4_-_139302516 19.69 ENST00000394228.5
ENST00000539387.5
NDUFC1
NADH:ubiquinone oxidoreductase subunit C1
chr22_-_41690462 19.68 ENST00000648350.1
ENST00000402458.1
SNU13
small nuclear ribonucleoprotein 13
chr1_+_32651164 19.17 ENST00000373493.10
ENST00000373485.5
ENST00000458695.6
RBBP4
RB binding protein 4, chromatin remodeling factor
chr2_-_58241259 18.83 ENST00000481670.2
ENST00000403676.5
ENST00000427708.6
ENST00000403295.7
ENST00000233741.9
ENST00000446381.5
ENST00000417361.1
ENST00000402135.7
ENST00000449070.5
FANCL
FA complementation group L
chr4_-_99088704 18.79 ENST00000626055.2
ENST00000296412.14
ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
chr20_-_2470749 18.63 ENST00000381342.7
ENST00000438552.6
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr20_+_43667019 18.42 ENST00000396863.8
MYBL2
MYB proto-oncogene like 2
chr1_-_244862381 18.34 ENST00000640001.1
ENST00000639628.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr1_-_6235945 18.29 ENST00000343813.10
ICMT
isoprenylcysteine carboxyl methyltransferase
chr1_+_46303646 17.91 ENST00000311672.10
UQCRH
ubiquinol-cytochrome c reductase hinge protein
chr4_+_56978877 17.55 ENST00000433463.1
ENST00000314595.6
POLR2B
RNA polymerase II subunit B
chr16_+_53820 17.52 ENST00000293861.8
ENST00000383018.7
ENST00000417493.1
SNRNP25
small nuclear ribonucleoprotein U11/U12 subunit 25
chr7_+_141551278 17.52 ENST00000629555.2
ENST00000473247.5
ENST00000648690.1
ENST00000649286.2
ENST00000649914.1
ENST00000648395.1
ENST00000648068.1
ENST00000650547.1
AGK
acylglycerol kinase
chr7_+_128739395 17.48 ENST00000479257.5
CALU
calumenin
chr11_+_17276708 17.45 ENST00000531172.5
ENST00000529010.6
ENST00000533738.6
ENST00000323688.10
NUCB2
nucleobindin 2
chr1_-_32817311 16.75 ENST00000373477.9
ENST00000675785.1
YARS1
tyrosyl-tRNA synthetase 1
chr11_+_125626229 16.72 ENST00000532449.6
ENST00000534070.5
CHEK1
checkpoint kinase 1
chr11_+_125625967 16.58 ENST00000428830.6
ENST00000278916.8
ENST00000544373.5
ENST00000532669.5
ENST00000527013.6
ENST00000526937.5
ENST00000534685.5
CHEK1
checkpoint kinase 1
chr8_+_30095649 16.19 ENST00000518192.5
LEPROTL1
leptin receptor overlapping transcript like 1
chr11_+_35180279 16.16 ENST00000531873.5
CD44
CD44 molecule (Indian blood group)
chr3_+_197950509 16.13 ENST00000442341.5
RPL35A
ribosomal protein L35a
chr7_+_128739292 16.02 ENST00000535011.6
ENST00000542996.6
ENST00000249364.9
ENST00000449187.6
CALU
calumenin
chr18_-_49491586 15.95 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr15_-_34343112 15.91 ENST00000557912.1
ENST00000328848.6
NOP10
NOP10 ribonucleoprotein
chr1_-_114581589 15.84 ENST00000369541.4
BCAS2
BCAS2 pre-mRNA processing factor
chr5_+_83471925 15.55 ENST00000502527.2
VCAN
versican
chr5_+_31532277 15.49 ENST00000507818.6
ENST00000325366.14
C5orf22
chromosome 5 open reading frame 22
chr9_-_35079923 14.91 ENST00000378643.8
ENST00000448890.1
FANCG
FA complementation group G
chrX_-_53422170 14.36 ENST00000675504.1
SMC1A
structural maintenance of chromosomes 1A
chr4_+_112637120 13.74 ENST00000509061.5
ENST00000344442.10
ENST00000508577.5
ENST00000513553.5
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr1_-_205750167 13.58 ENST00000367142.5
NUCKS1
nuclear casein kinase and cyclin dependent kinase substrate 1
chr5_+_83471764 13.48 ENST00000512590.6
ENST00000513960.5
ENST00000513984.5
VCAN
versican
chr19_+_39655907 13.00 ENST00000392051.4
LGALS16
galectin 16
chr3_+_197950176 12.68 ENST00000448864.6
ENST00000647248.2
RPL35A
ribosomal protein L35a
chr17_+_63827406 12.32 ENST00000310144.11
ENST00000581842.5
ENST00000582130.5
ENST00000584320.5
ENST00000585123.5
ENST00000580864.5
PSMC5
proteasome 26S subunit, ATPase 5
chr3_+_44761765 12.26 ENST00000326047.9
KIF15
kinesin family member 15
chr5_+_83471668 12.20 ENST00000342785.8
ENST00000343200.9
VCAN
versican
chr20_-_2664186 12.19 ENST00000474315.5
ENST00000380843.9
ENST00000380851.9
ENST00000613370.1
IDH3B
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
chr1_+_159010002 12.01 ENST00000359709.7
IFI16
interferon gamma inducible protein 16
chr19_+_57363469 11.85 ENST00000282282.4
ENST00000543226.2
ENST00000596755.1
ENST00000597658.1
ZNF547
TRAPPC2B
ENSG00000268133.1
zinc finger protein 547
trafficking protein particle complex 2B
novel protein
chr19_+_2270280 11.79 ENST00000588673.3
OAZ1
ornithine decarboxylase antizyme 1
chr8_+_30095400 11.64 ENST00000321250.13
ENST00000518001.1
ENST00000520682.5
ENST00000442880.6
ENST00000523116.5
LEPROTL1
leptin receptor overlapping transcript like 1
chr3_-_119677346 11.58 ENST00000484810.5
ENST00000497116.1
ENST00000261070.7
COX17
cytochrome c oxidase copper chaperone COX17
chr4_-_39366342 11.49 ENST00000503784.1
ENST00000349703.7
ENST00000381897.5
RFC1
replication factor C subunit 1
chr1_-_23980345 11.32 ENST00000484146.6
SRSF10
serine and arginine rich splicing factor 10
chr11_+_47215032 11.25 ENST00000622090.4
ENST00000378600.7
ENST00000378603.7
DDB2
damage specific DNA binding protein 2
chr2_-_130181542 11.12 ENST00000441135.1
ENST00000680679.1
ENST00000680401.1
ENST00000351288.10
ENST00000680298.1
ENST00000431183.6
SMPD4
sphingomyelin phosphodiesterase 4
chr5_+_83471736 10.97 ENST00000265077.8
VCAN
versican
chr5_-_135399211 10.79 ENST00000312469.8
ENST00000423969.6
MACROH2A1
macroH2A.1 histone
chr3_-_79767987 10.59 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr12_-_56643499 10.55 ENST00000551570.5
ATP5F1B
ATP synthase F1 subunit beta
chr8_+_47960883 10.49 ENST00000648407.1
ENST00000649838.1
ENST00000649919.1
ENST00000262105.6
ENST00000649973.1
MCM4
minichromosome maintenance complex component 4
chr2_+_63589135 10.48 ENST00000432309.6
MDH1
malate dehydrogenase 1
chr6_+_135181361 10.15 ENST00000527615.5
ENST00000420123.6
ENST00000525369.5
ENST00000528774.5
ENST00000533624.5
ENST00000534044.5
ENST00000534121.5
MYB
MYB proto-oncogene, transcription factor
chr12_+_56128217 9.95 ENST00000267113.4
ENST00000394048.10
ESYT1
extended synaptotagmin 1
chr22_-_50525548 9.49 ENST00000395693.8
ENST00000252785.3
SCO2
synthesis of cytochrome C oxidase 2
chr11_-_78139258 9.48 ENST00000530910.6
ENST00000681417.1
ENST00000681225.1
ENST00000681765.1
ENST00000525870.6
ENST00000530608.6
ENST00000532306.6
ENST00000376156.7
ENST00000681699.1
ENST00000681221.1
ENST00000679444.1
ENST00000680829.1
ENST00000680761.1
ENST00000680256.1
ENST00000525783.6
ENST00000529139.6
ENST00000680580.1
ENST00000526849.6
ENST00000680399.1
ENST00000527099.2
ENST00000681489.1
ENST00000299626.10
ENST00000679497.1
ENST00000680101.1
ENST00000532440.6
ENST00000530454.6
ENST00000525761.3
ENST00000681575.1
ENST00000679559.1
ENST00000680398.1
ENST00000615266.5
ENST00000680643.1
ALG8
ALG8 alpha-1,3-glucosyltransferase
chr19_+_50384323 9.34 ENST00000599857.7
ENST00000613923.6
ENST00000601098.6
ENST00000440232.7
ENST00000595904.6
ENST00000593887.1
POLD1
DNA polymerase delta 1, catalytic subunit
chr11_+_47214937 9.28 ENST00000256996.9
DDB2
damage specific DNA binding protein 2
chr12_-_102061946 9.22 ENST00000240079.11
WASHC3
WASH complex subunit 3
chr17_-_82065783 9.18 ENST00000578907.5
ENST00000577907.1
ENST00000578176.5
ENST00000306796.10
ENST00000582529.5
DUS1L
dihydrouridine synthase 1 like
chr16_+_2682515 9.13 ENST00000301738.9
ENST00000564195.1
KCTD5
potassium channel tetramerization domain containing 5
chrX_+_55000329 8.89 ENST00000374987.4
APEX2
apurinic/apyrimidinic endodeoxyribonuclease 2
chr20_-_543718 8.85 ENST00000643600.1
ENST00000645260.1
ENST00000645091.1
ENST00000608066.6
ENST00000400217.7
ENST00000643660.1
ENST00000642689.1
ENST00000646477.1
ENST00000647026.1
ENST00000644710.1
ENST00000644003.1
ENST00000645623.1
ENST00000643680.1
ENST00000644177.1
CSNK2A1
casein kinase 2 alpha 1
chr1_-_25905989 8.83 ENST00000399728.5
STMN1
stathmin 1
chrX_-_10620419 8.76 ENST00000380782.6
MID1
midline 1
chr8_+_47961028 8.70 ENST00000650216.1
MCM4
minichromosome maintenance complex component 4
chr18_-_51197671 8.68 ENST00000406189.4
MEX3C
mex-3 RNA binding family member C
chr17_+_41819201 8.64 ENST00000455106.1
FKBP10
FKBP prolyl isomerase 10
chr22_+_37675629 8.61 ENST00000215909.10
LGALS1
galectin 1
chr9_-_132079856 8.59 ENST00000651555.1
ENST00000651950.1
ENST00000357028.6
ENST00000474263.1
ENST00000292035.10
MED27
mediator complex subunit 27
chr3_-_194672175 8.55 ENST00000265245.10
LSG1
large 60S subunit nuclear export GTPase 1
chr3_+_124730428 8.53 ENST00000628619.1
ENST00000232607.7
UMPS
uridine monophosphate synthetase
chr20_-_543696 8.48 ENST00000400227.8
ENST00000609525.2
ENST00000646305.1
ENST00000645234.1
ENST00000646814.1
ENST00000644885.1
CSNK2A1
casein kinase 2 alpha 1
chr12_-_102062079 8.42 ENST00000545679.5
WASHC3
WASH complex subunit 3
chr2_-_86563382 8.41 ENST00000263856.9
CHMP3
charged multivesicular body protein 3
chr2_+_63588953 8.24 ENST00000409908.5
ENST00000442225.5
ENST00000233114.13
ENST00000539945.7
ENST00000409476.5
ENST00000436321.5
MDH1
malate dehydrogenase 1
chr22_-_50526130 8.15 ENST00000535425.5
ENST00000638598.2
SCO2
synthesis of cytochrome C oxidase 2
chr2_-_37324826 8.07 ENST00000234179.8
PRKD3
protein kinase D3
chr19_+_11436044 7.94 ENST00000589838.5
PRKCSH
protein kinase C substrate 80K-H
chr4_+_107989880 7.94 ENST00000309522.8
ENST00000403312.6
ENST00000638559.1
ENST00000682373.1
HADH
hydroxyacyl-CoA dehydrogenase
chr17_-_9575811 7.92 ENST00000306357.9
ENST00000574431.5
STX8
syntaxin 8
chr1_+_7961894 7.86 ENST00000377491.5
ENST00000377488.5
PARK7
Parkinsonism associated deglycase
chr12_+_2959870 7.80 ENST00000397122.6
TEAD4
TEA domain transcription factor 4
chr1_+_35268663 7.74 ENST00000314607.11
ZMYM4
zinc finger MYM-type containing 4
chr17_-_43545636 7.58 ENST00000393664.6
ETV4
ETS variant transcription factor 4
chr2_+_237487239 7.20 ENST00000338530.8
ENST00000264605.8
ENST00000409373.5
MLPH
melanophilin
chr7_-_56051544 7.08 ENST00000395471.7
PSPH
phosphoserine phosphatase
chr2_+_130181662 7.01 ENST00000425361.5
ENST00000457492.5
MZT2B
mitotic spindle organizing protein 2B
chr9_-_120926752 7.00 ENST00000373887.8
TRAF1
TNF receptor associated factor 1
chrX_-_10620534 6.93 ENST00000317552.9
MID1
midline 1
chr6_+_43635832 6.86 ENST00000372171.5
MAD2L1BP
MAD2L1 binding protein
chr2_+_12716893 6.82 ENST00000381465.2
ENST00000155926.9
TRIB2
tribbles pseudokinase 2
chr6_-_43014254 6.47 ENST00000642748.1
MEA1
male-enhanced antigen 1
chr15_+_43826961 6.45 ENST00000381246.6
ENST00000452115.1
ENST00000263795.11
WDR76
WD repeat domain 76
chr14_-_50668287 6.45 ENST00000556735.1
ENST00000324679.5
SAV1
salvador family WW domain containing protein 1
chrX_-_53422644 6.36 ENST00000322213.9
ENST00000375340.10
ENST00000674590.1
SMC1A
structural maintenance of chromosomes 1A
chr5_+_134371561 6.29 ENST00000265339.7
ENST00000506787.5
ENST00000507277.1
UBE2B
ubiquitin conjugating enzyme E2 B
chr19_-_46788586 6.25 ENST00000542575.6
SLC1A5
solute carrier family 1 member 5
chr12_-_122526929 6.01 ENST00000331738.12
ENST00000528279.1
ENST00000344591.8
ENST00000526560.6
RSRC2
arginine and serine rich coiled-coil 2
chr1_-_16980607 5.94 ENST00000375535.4
MFAP2
microfibril associated protein 2
chr6_+_10585748 5.72 ENST00000265012.5
GCNT2
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr1_+_88684513 5.68 ENST00000370513.9
PKN2
protein kinase N2
chr11_+_74171266 5.64 ENST00000328257.13
ENST00000398427.6
PPME1
protein phosphatase methylesterase 1
chr12_+_122527229 5.53 ENST00000450485.6
ENST00000333479.12
KNTC1
kinetochore associated 1
chr19_-_19138442 5.46 ENST00000587583.6
ENST00000450333.6
ENST00000587096.5
ENST00000162044.14
ENST00000592369.1
ENST00000587915.1
TMEM161A
transmembrane protein 161A
chr20_+_62387086 5.42 ENST00000343986.9
RPS21
ribosomal protein S21
chr8_-_23404076 5.39 ENST00000524168.1
ENST00000389131.8
ENST00000523833.2
ENST00000519243.1
LOXL2
lysyl oxidase like 2
chr2_+_230416156 5.26 ENST00000427101.6
SP100
SP100 nuclear antigen
chr17_-_58007217 5.25 ENST00000258962.5
ENST00000582730.6
ENST00000584773.5
ENST00000585096.1
SRSF1
serine and arginine rich splicing factor 1
chr17_-_43545707 5.22 ENST00000545089.5
ETV4
ETS variant transcription factor 4
chr20_-_33686371 5.17 ENST00000343380.6
E2F1
E2F transcription factor 1
chr12_+_1629197 5.16 ENST00000397196.7
WNT5B
Wnt family member 5B
chr17_+_39738317 5.04 ENST00000394211.7
GRB7
growth factor receptor bound protein 7
chr17_+_59565598 5.03 ENST00000251241.9
ENST00000425628.7
ENST00000584385.5
ENST00000580030.1
DHX40
DEAH-box helicase 40
chr22_+_41092585 4.93 ENST00000263253.9
EP300
E1A binding protein p300
chr19_+_2236816 4.87 ENST00000221494.10
SF3A2
splicing factor 3a subunit 2
chr1_+_1471751 4.87 ENST00000673477.1
ENST00000308647.8
ATAD3B
ATPase family AAA domain containing 3B
chr12_-_70609788 4.75 ENST00000547715.1
ENST00000538708.5
ENST00000550857.5
ENST00000261266.9
PTPRB
protein tyrosine phosphatase receptor type B
chr10_+_69278492 4.65 ENST00000643399.2
HK1
hexokinase 1
chr8_-_56074312 4.59 ENST00000523936.5
RPS20
ribosomal protein S20
chr2_+_231710417 4.52 ENST00000412128.1
PTMA
prothymosin alpha
chr19_+_48900305 4.46 ENST00000405315.9
ENST00000407032.5
ENST00000452087.5
ENST00000411700.5
NUCB1
nucleobindin 1
chr1_-_23980278 4.43 ENST00000374453.7
ENST00000453840.7
SRSF10
serine and arginine rich splicing factor 10
chr1_-_27914513 4.17 ENST00000313433.11
ENST00000373912.8
ENST00000444045.1
RPA2
replication protein A2
chr5_+_93583212 4.08 ENST00000327111.8
NR2F1
nuclear receptor subfamily 2 group F member 1
chr1_-_23980308 4.06 ENST00000374452.9
ENST00000492112.3
ENST00000343255.9
ENST00000344989.10
SRSF10
serine and arginine rich splicing factor 10
chr7_-_22220226 4.02 ENST00000420196.5
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr15_+_40439721 4.01 ENST00000561234.5
BAHD1
bromo adjacent homology domain containing 1
chr6_+_109978297 3.91 ENST00000275169.5
GPR6
G protein-coupled receptor 6
chr6_+_26251607 3.88 ENST00000619466.2
H2BC9
H2B clustered histone 9
chr10_-_119872754 3.87 ENST00000360003.7
MCMBP
minichromosome maintenance complex binding protein
chr4_+_107989714 3.80 ENST00000505878.4
ENST00000603302.5
ENST00000638621.1
HADH
hydroxyacyl-CoA dehydrogenase
chr21_-_44262216 3.77 ENST00000270172.7
DNMT3L
DNA methyltransferase 3 like
chr2_+_79025696 3.65 ENST00000272324.10
REG3G
regenerating family member 3 gamma
chr7_-_56051288 3.60 ENST00000419984.6
ENST00000413218.5
ENST00000275605.8
ENST00000424596.1
ENST00000421312.5
ENST00000416592.1
PSPH
phosphoserine phosphatase
chr6_-_165987914 3.59 ENST00000672859.1
PDE10A
phosphodiesterase 10A
chr4_-_4542034 3.59 ENST00000306200.7
STX18
syntaxin 18
chr10_+_84139491 3.44 ENST00000372134.6
GHITM
growth hormone inducible transmembrane protein
chr19_+_11435619 3.37 ENST00000589126.5
ENST00000588269.1
ENST00000587509.5
ENST00000591462.6
ENST00000592741.5
ENST00000677123.1
ENST00000593101.5
ENST00000587327.5
PRKCSH
protein kinase C substrate 80K-H
chr17_-_43545891 3.32 ENST00000591713.5
ENST00000538265.5
ETV4
ETS variant transcription factor 4
chr6_+_30067190 3.31 ENST00000376772.8
ENST00000376769.6
PPP1R11
protein phosphatase 1 regulatory inhibitor subunit 11
chr14_+_105526568 3.21 ENST00000392519.7
TMEM121
transmembrane protein 121

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
34.5 103.4 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
17.1 68.3 GO:0090094 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
14.4 57.7 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
12.2 49.0 GO:1904045 cellular response to aldosterone(GO:1904045)
9.8 59.0 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
9.7 29.2 GO:0031938 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
9.4 47.2 GO:0006167 AMP biosynthetic process(GO:0006167)
8.3 33.3 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
8.3 24.8 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
8.2 24.6 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
8.1 105.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
7.4 22.2 GO:1904430 negative regulation of t-circle formation(GO:1904430)
7.0 84.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
6.6 52.5 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
6.3 18.8 GO:0046292 formaldehyde metabolic process(GO:0046292)
6.1 24.5 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
5.6 33.9 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
5.5 136.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
5.3 15.9 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
4.5 13.6 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
4.5 22.4 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
4.5 26.7 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
4.4 26.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
4.1 20.7 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
4.0 27.8 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
3.9 31.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
3.9 11.6 GO:1904732 regulation of electron carrier activity(GO:1904732)
3.6 21.4 GO:0051177 meiotic DNA recombinase assembly(GO:0000707) meiotic sister chromatid cohesion(GO:0051177)
3.6 28.5 GO:0046060 dGTP catabolic process(GO:0006203) dATP metabolic process(GO:0046060) dATP catabolic process(GO:0046061)
3.4 43.9 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
2.8 8.5 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
2.8 8.5 GO:0044278 cell wall disruption in other organism(GO:0044278)
2.5 2.5 GO:0033364 mast cell secretory granule organization(GO:0033364)
2.4 11.8 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
2.4 21.2 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.2 52.2 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
2.2 8.6 GO:0002317 plasma cell differentiation(GO:0002317)
2.1 6.3 GO:0060903 regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of meiosis I(GO:0060903)
2.1 29.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.8 20.1 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
1.7 12.2 GO:0006102 isocitrate metabolic process(GO:0006102)
1.7 5.2 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.7 29.2 GO:0030497 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
1.7 6.8 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.6 6.3 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
1.6 9.3 GO:0006287 base-excision repair, gap-filling(GO:0006287)
1.5 9.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
1.5 19.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
1.5 10.6 GO:0016199 axon midline choice point recognition(GO:0016199)
1.5 8.8 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.5 20.5 GO:0006290 pyrimidine dimer repair(GO:0006290)
1.4 8.7 GO:0003415 chondrocyte hypertrophy(GO:0003415)
1.4 19.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
1.3 18.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.2 29.8 GO:0051292 nuclear pore complex assembly(GO:0051292)
1.2 16.2 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.2 4.9 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
1.2 3.6 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
1.2 17.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.1 31.7 GO:0035067 negative regulation of histone acetylation(GO:0035067)
1.1 15.7 GO:0035372 protein localization to microtubule(GO:0035372)
1.1 12.3 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
1.0 3.1 GO:0090176 microtubule cytoskeleton organization involved in establishment of planar polarity(GO:0090176)
1.0 17.6 GO:0006878 cellular copper ion homeostasis(GO:0006878)
1.0 11.1 GO:0006108 malate metabolic process(GO:0006108)
1.0 11.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.0 60.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
1.0 33.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.9 78.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.9 5.4 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.9 8.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.9 13.0 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.9 22.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.8 5.9 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.8 8.4 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.8 30.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.8 10.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.8 5.7 GO:0036438 maintenance of lens transparency(GO:0036438)
0.8 18.6 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.8 41.4 GO:0019985 translesion synthesis(GO:0019985)
0.7 57.4 GO:0043525 positive regulation of neuron apoptotic process(GO:0043525)
0.7 4.9 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.7 19.2 GO:0006270 DNA replication initiation(GO:0006270)
0.7 5.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.6 4.5 GO:0072718 response to cisplatin(GO:0072718)
0.6 2.5 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.5 2.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.5 4.7 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.5 12.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.5 7.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.5 17.3 GO:0071174 mitotic spindle checkpoint(GO:0071174)
0.5 9.5 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.5 2.4 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.5 11.3 GO:0006491 N-glycan processing(GO:0006491)
0.4 18.8 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.4 3.8 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.4 25.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.4 4.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.4 2.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.4 1.1 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.4 0.7 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.3 5.8 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.3 19.6 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.3 22.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.3 2.4 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.3 6.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 25.5 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.3 6.4 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.3 24.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 12.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 11.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.3 18.3 GO:0018410 C-terminal protein amino acid modification(GO:0018410)
0.2 1.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 8.9 GO:0006284 base-excision repair(GO:0006284)
0.2 5.5 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.2 2.5 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.2 3.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.2 8.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 2.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.2 5.4 GO:0030199 collagen fibril organization(GO:0030199)
0.2 1.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 4.0 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.3 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 12.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.2 GO:0040016 embryonic cleavage(GO:0040016)
0.1 9.9 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 5.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 15.8 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 2.1 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.1 26.7 GO:0006413 translational initiation(GO:0006413)
0.1 4.4 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 0.5 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 0.7 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.5 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.1 2.3 GO:0021591 ventricular system development(GO:0021591)
0.1 4.2 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.1 12.0 GO:0002576 platelet degranulation(GO:0002576)
0.1 5.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 2.1 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 8.6 GO:0051168 nuclear export(GO:0051168)
0.0 4.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 6.8 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 2.3 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 1.6 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 8.6 GO:0043687 post-translational protein modification(GO:0043687)
0.0 1.3 GO:0007032 endosome organization(GO:0007032)
0.0 7.2 GO:0006511 ubiquitin-dependent protein catabolic process(GO:0006511)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
34.2 136.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
11.5 57.7 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
11.5 57.4 GO:0031523 Myb complex(GO:0031523)
11.0 143.1 GO:0042555 MCM complex(GO:0042555)
9.9 29.8 GO:0044611 nuclear pore inner ring(GO:0044611)
9.7 29.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
7.5 30.2 GO:0071986 Ragulator complex(GO:0071986)
7.1 77.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
5.7 28.6 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
5.3 21.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
5.3 21.2 GO:0033186 CAF-1 complex(GO:0033186)
4.4 22.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)
4.1 29.0 GO:0030905 retromer, tubulation complex(GO:0030905)
4.0 19.9 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
3.9 19.7 GO:0001651 dense fibrillar component(GO:0001651)
3.6 21.4 GO:0033063 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
3.4 33.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
3.1 12.3 GO:0005873 plus-end kinesin complex(GO:0005873)
3.0 20.7 GO:0030893 meiotic cohesin complex(GO:0030893)
2.8 33.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
2.5 20.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
2.5 17.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
2.3 15.9 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
2.0 18.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
1.9 63.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
1.9 24.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
1.9 9.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.9 20.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.7 5.2 GO:0035189 Rb-E2F complex(GO:0035189)
1.7 33.9 GO:0031616 spindle pole centrosome(GO:0031616)
1.6 11.5 GO:0005663 DNA replication factor C complex(GO:0005663)
1.5 17.6 GO:0071203 WASH complex(GO:0071203)
1.5 16.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
1.4 7.0 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
1.4 5.5 GO:1990423 RZZ complex(GO:1990423)
1.4 17.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.3 22.8 GO:0005662 DNA replication factor A complex(GO:0005662)
1.3 6.3 GO:0033503 HULC complex(GO:0033503)
1.2 12.3 GO:0031595 nuclear proteasome complex(GO:0031595)
1.0 22.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.9 17.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.8 48.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.8 21.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.7 7.4 GO:0030870 Mre11 complex(GO:0030870)
0.7 17.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.6 8.4 GO:0000815 ESCRT III complex(GO:0000815)
0.5 51.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.5 26.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.5 10.0 GO:0044232 organelle membrane contact site(GO:0044232)
0.5 72.6 GO:0016363 nuclear matrix(GO:0016363)
0.4 98.3 GO:0000793 condensed chromosome(GO:0000793)
0.4 3.1 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.4 4.9 GO:0005686 U2 snRNP(GO:0005686)
0.4 57.4 GO:0005796 Golgi lumen(GO:0005796)
0.4 4.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.3 32.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.3 5.7 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.3 15.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 27.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 24.6 GO:0005811 lipid particle(GO:0005811)
0.3 5.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.3 87.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 2.5 GO:0042588 zymogen granule(GO:0042588)
0.2 3.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 18.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 24.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 11.5 GO:0031201 SNARE complex(GO:0031201)
0.2 15.4 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.2 9.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 25.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 1.2 GO:0000439 core TFIIH complex(GO:0000439)
0.1 21.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.2 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 27.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 4.0 GO:0015030 Cajal body(GO:0015030)
0.1 5.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 73.5 GO:0005730 nucleolus(GO:0005730)
0.1 5.0 GO:0005681 spliceosomal complex(GO:0005681)
0.1 17.4 GO:0030027 lamellipodium(GO:0030027)
0.1 0.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.6 GO:0070449 elongin complex(GO:0070449)
0.0 6.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 4.7 GO:0035579 specific granule membrane(GO:0035579)
0.0 8.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 18.2 GO:0005635 nuclear envelope(GO:0005635)
0.0 2.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.4 GO:0000502 proteasome complex(GO:0000502)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 2.3 GO:0055037 recycling endosome(GO:0055037)
0.0 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 12.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 5.1 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 0.9 GO:0043202 lysosomal lumen(GO:0043202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
34.2 136.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
21.1 84.5 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
19.4 77.6 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
19.2 57.7 GO:0003896 DNA primase activity(GO:0003896)
14.6 160.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
9.7 29.2 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
9.5 28.5 GO:0044713 GTP diphosphatase activity(GO:0036219) 2-hydroxy-adenosine triphosphate pyrophosphatase activity(GO:0044713) 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity(GO:0044714) ATP diphosphatase activity(GO:0047693)
8.9 26.7 GO:0070538 oleic acid binding(GO:0070538)
8.3 33.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
7.2 21.6 GO:0048030 disaccharide binding(GO:0048030)
6.6 52.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
6.6 19.7 GO:0034512 box C/D snoRNA binding(GO:0034512)
6.1 24.5 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
5.8 29.0 GO:1990460 leptin receptor binding(GO:1990460)
5.2 47.2 GO:0016842 amidine-lyase activity(GO:0016842)
4.9 82.9 GO:0003688 DNA replication origin binding(GO:0003688)
4.1 49.0 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
3.7 18.3 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
3.5 20.7 GO:0036033 mediator complex binding(GO:0036033)
3.2 9.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
3.1 25.1 GO:0050733 RS domain binding(GO:0050733)
3.1 21.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
3.0 12.2 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
2.7 18.7 GO:0004470 malic enzyme activity(GO:0004470)
2.7 10.7 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
2.5 25.4 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
2.5 20.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.5 22.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
2.4 19.4 GO:0016531 copper chaperone activity(GO:0016531)
2.4 11.8 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
2.3 15.9 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
2.2 17.9 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
2.2 8.9 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
2.0 26.6 GO:0008641 small protein activating enzyme activity(GO:0008641)
2.0 13.9 GO:0070492 oligosaccharide binding(GO:0070492)
1.8 68.4 GO:0005540 hyaluronic acid binding(GO:0005540)
1.8 17.5 GO:0001727 lipid kinase activity(GO:0001727)
1.7 18.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.6 11.5 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.6 17.6 GO:0004645 phosphorylase activity(GO:0004645)
1.5 70.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.5 9.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
1.4 12.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
1.3 10.6 GO:0008046 axon guidance receptor activity(GO:0008046)
1.2 11.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
1.2 31.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.2 20.8 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
1.1 60.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.1 22.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
1.0 24.8 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
1.0 29.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
1.0 70.3 GO:0070888 E-box binding(GO:0070888)
1.0 17.6 GO:0001055 RNA polymerase II activity(GO:0001055)
0.9 9.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.8 9.3 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.8 25.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.8 2.5 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.8 11.7 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.8 18.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.8 5.7 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.8 6.3 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.7 28.8 GO:0000049 tRNA binding(GO:0000049)
0.7 7.9 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.7 24.8 GO:0004532 exoribonuclease activity(GO:0004532)
0.6 5.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.6 13.7 GO:0004697 protein kinase C activity(GO:0004697)
0.5 2.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.5 8.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.5 4.7 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.5 4.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.5 9.1 GO:0097602 cullin family protein binding(GO:0097602)
0.5 47.4 GO:0003684 damaged DNA binding(GO:0003684)
0.5 2.5 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.5 19.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 6.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.4 7.0 GO:0031996 thioesterase binding(GO:0031996)
0.3 8.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 17.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 21.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 36.6 GO:0032947 protein complex scaffold(GO:0032947)
0.3 4.0 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 0.9 GO:0004348 glucosylceramidase activity(GO:0004348)
0.2 3.1 GO:0034452 dynactin binding(GO:0034452)
0.2 11.3 GO:0005080 protein kinase C binding(GO:0005080)
0.2 5.6 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.2 2.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 8.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 38.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 5.2 GO:0005109 frizzled binding(GO:0005109)
0.1 36.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 13.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 10.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 26.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 1.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 9.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 6.4 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 4.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 19.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 7.2 GO:0017022 myosin binding(GO:0017022)
0.1 2.6 GO:0042165 neurotransmitter binding(GO:0042165)
0.1 2.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 7.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.7 GO:0036122 BMP binding(GO:0036122)
0.1 0.6 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 4.9 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 2.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.5 GO:0043295 glutathione binding(GO:0043295)
0.0 5.0 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 2.2 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.2 GO:0045296 cadherin binding(GO:0045296)
0.0 2.1 GO:0001047 core promoter binding(GO:0001047)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 176.8 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
2.5 34.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
2.1 84.6 PID BARD1 PATHWAY BARD1 signaling events
2.1 249.5 PID E2F PATHWAY E2F transcription factor network
1.1 54.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
1.0 25.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.9 45.7 PID AURORA A PATHWAY Aurora A signaling
0.9 41.5 PID ATR PATHWAY ATR signaling pathway
0.8 17.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.7 20.7 PID ATM PATHWAY ATM pathway
0.5 40.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.5 16.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 34.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.4 8.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 7.0 PID CD40 PATHWAY CD40/CD40L signaling
0.3 25.2 PID NOTCH PATHWAY Notch signaling pathway
0.3 26.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.3 5.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.2 13.2 PID LKB1 PATHWAY LKB1 signaling events
0.2 11.5 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 2.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 7.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 5.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 11.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 19.2 PID CMYB PATHWAY C-MYB transcription factor network
0.2 30.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 20.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 5.7 PID RHOA PATHWAY RhoA signaling pathway
0.1 3.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 5.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
11.1 167.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
5.6 84.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
5.2 77.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
5.2 67.0 REACTOME POL SWITCHING Genes involved in Polymerase switching
4.7 142.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
3.1 47.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
2.5 54.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
2.3 34.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
2.1 24.8 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
1.9 52.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.6 68.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.5 33.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
1.5 26.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
1.2 22.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
1.1 28.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.9 78.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.9 29.8 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.8 16.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.8 21.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.8 17.6 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.8 11.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.7 120.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.7 11.7 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6 12.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.6 76.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.5 25.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.5 8.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.5 31.2 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.4 10.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 22.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 5.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 24.1 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.3 60.9 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.3 9.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3 7.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3 8.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.3 6.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.3 12.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.3 7.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 34.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 11.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 3.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 11.5 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 1.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 5.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 7.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 3.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 9.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.1 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 3.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation