Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for E4F1

Z-value: 0.60

Motif logo

logo of

Transcription factors associated with E4F1

Gene Symbol Gene ID Gene Info
E4F1
ENSG00000167967.16 E4F1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4F1hg38_v1_chr16_+_2223555_22236360.351.4e-07Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_32844643 10.12 ENST00000374881.3
PSMB8
proteasome 20S subunit beta 8
chr6_+_32844789 9.58 ENST00000414474.5
PSMB9
proteasome 20S subunit beta 9
chr6_+_139135063 8.91 ENST00000367658.3
HECA
hdc homolog, cell cycle regulator
chr7_-_140924699 6.14 ENST00000288602.11
ENST00000469930.2
ENST00000496384.7
BRAF
B-Raf proto-oncogene, serine/threonine kinase
chr7_-_140924900 5.95 ENST00000646891.1
ENST00000644969.2
BRAF
B-Raf proto-oncogene, serine/threonine kinase
chr2_-_60553618 5.24 ENST00000643716.1
ENST00000359629.10
ENST00000642384.2
ENST00000335712.11
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr19_+_13747887 5.14 ENST00000221554.13
ENST00000586666.5
CCDC130
coiled-coil domain containing 130
chr19_+_1941118 4.88 ENST00000255641.13
CSNK1G2
casein kinase 1 gamma 2
chr22_-_38506320 4.88 ENST00000396821.8
DDX17
DEAD-box helicase 17
chr14_-_22919124 4.76 ENST00000555209.5
ENST00000554256.5
ENST00000557403.5
ENST00000359890.8
ENST00000557549.5
ENST00000555676.5
ENST00000557571.5
ENST00000557464.5
ENST00000554618.5
ENST00000556862.5
ENST00000555722.5
ENST00000346528.9
ENST00000542016.6
ENST00000399922.6
ENST00000557227.5
RBM23
RNA binding motif protein 23
chr22_-_38506295 4.67 ENST00000403230.3
DDX17
DEAD-box helicase 17
chr2_-_60553558 4.64 ENST00000642439.1
ENST00000356842.9
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr2_-_60553409 4.07 ENST00000358510.6
ENST00000643004.1
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr4_+_1871373 4.06 ENST00000508803.6
ENST00000507820.5
ENST00000514045.5
NSD2
nuclear receptor binding SET domain protein 2
chr17_+_28744002 3.98 ENST00000618771.1
ENST00000262395.10
ENST00000422344.5
TRAF4
TNF receptor associated factor 4
chr17_+_28744034 3.80 ENST00000444415.7
ENST00000262396.10
TRAF4
TNF receptor associated factor 4
chr19_+_54201122 3.76 ENST00000391753.6
ENST00000441429.1
RPS9
ribosomal protein S9
chr16_-_3717505 3.75 ENST00000538171.5
ENST00000246957.10
TRAP1
TNF receptor associated protein 1
chr19_+_54200849 3.60 ENST00000626547.2
ENST00000302907.9
ENST00000391752.5
ENST00000402367.5
ENST00000391751.7
RPS9
ribosomal protein S9
chr11_+_809961 3.48 ENST00000321153.9
ENST00000530797.5
RPLP2
ribosomal protein lateral stalk subunit P2
chr11_+_810227 3.17 ENST00000530398.1
RPLP2
ribosomal protein lateral stalk subunit P2
chr17_+_45132600 3.13 ENST00000619916.4
ENST00000431281.5
ENST00000591859.5
ACBD4
acyl-CoA binding domain containing 4
chr12_+_122078740 3.09 ENST00000319080.12
MLXIP
MLX interacting protein
chr14_+_100239121 3.08 ENST00000262238.10
YY1
YY1 transcription factor
chr22_+_38705922 3.05 ENST00000216044.10
GTPBP1
GTP binding protein 1
chr10_-_133308844 3.05 ENST00000682905.1
ENST00000682515.1
ENST00000683612.1
ENST00000252936.8
ENST00000417178.7
ENST00000682161.1
ENST00000683014.1
ENST00000683060.1
ENST00000683383.1
TUBGCP2
tubulin gamma complex associated protein 2
chr3_+_38165484 2.97 ENST00000446845.5
ENST00000311806.8
OXSR1
oxidative stress responsive kinase 1
chr11_-_6612141 2.90 ENST00000527248.2
ENST00000299424.9
TAF10
TATA-box binding protein associated factor 10
chr6_+_15248855 2.83 ENST00000397311.4
JARID2
jumonji and AT-rich interaction domain containing 2
chr6_+_26204552 2.82 ENST00000615164.2
H4C5
H4 clustered histone 5
chr11_-_77474041 2.64 ENST00000278568.8
PAK1
p21 (RAC1) activated kinase 1
chr2_+_10044175 2.60 ENST00000440320.5
ENST00000535335.1
KLF11
Kruppel like factor 11
chr20_-_45972171 2.54 ENST00000322927.3
ZNF335
zinc finger protein 335
chr16_+_68023249 2.53 ENST00000358896.10
ENST00000568099.6
DUS2
dihydrouridine synthase 2
chr14_-_49586325 2.48 ENST00000557519.1
ENST00000396020.7
ENST00000554075.2
ENST00000245458.11
RPS29
ribosomal protein S29
chr6_-_144095556 2.45 ENST00000367569.4
SF3B5
splicing factor 3b subunit 5
chr19_+_45001430 2.45 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB
RELB proto-oncogene, NF-kB subunit
chr16_+_68023276 2.35 ENST00000567100.5
ENST00000565263.6
ENST00000432752.5
ENST00000569289.5
ENST00000564781.1
DUS2
dihydrouridine synthase 2
chr1_+_26169891 2.32 ENST00000374266.7
ENST00000270812.6
ZNF593
zinc finger protein 593
chr6_-_27473058 2.30 ENST00000683788.1
ENST00000211936.10
ZNF184
zinc finger protein 184
chr3_+_139935176 2.30 ENST00000458420.7
CLSTN2
calsyntenin 2
chr1_-_228103235 2.29 ENST00000272139.5
C1orf35
chromosome 1 open reading frame 35
chr14_+_60249387 2.29 ENST00000325658.3
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent 1A
chr17_-_42388360 2.27 ENST00000678960.1
ENST00000404395.3
ENST00000389272.7
ENST00000677421.1
ENST00000585517.5
ENST00000264657.10
ENST00000678048.1
ENST00000678674.1
ENST00000678913.1
ENST00000678572.1
ENST00000678906.1
STAT3
signal transducer and activator of transcription 3
chr11_-_77474087 2.26 ENST00000356341.8
PAK1
p21 (RAC1) activated kinase 1
chr6_-_34696839 2.25 ENST00000374026.7
ILRUN
inflammation and lipid regulator with UBA-like and NBR1-like domains
chr11_-_3797490 2.23 ENST00000397004.8
ENST00000397007.8
ENST00000532475.1
ENST00000324932.12
NUP98
nucleoporin 98 and 96 precursor
chr10_-_133308817 2.20 ENST00000543663.6
TUBGCP2
tubulin gamma complex associated protein 2
chr7_-_129952901 2.16 ENST00000472396.5
ENST00000355621.8
UBE2H
ubiquitin conjugating enzyme E2 H
chr7_-_87220567 2.16 ENST00000433078.5
TMEM243
transmembrane protein 243
chr14_+_60249191 2.10 ENST00000395076.9
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent 1A
chr2_+_10043524 2.09 ENST00000305883.6
KLF11
Kruppel like factor 11
chr7_-_100428657 2.08 ENST00000360951.8
ENST00000398027.6
ENST00000684423.1
ENST00000472716.1
ZCWPW1
zinc finger CW-type and PWWP domain containing 1
chr5_-_95961830 2.08 ENST00000513343.1
ENST00000237853.9
ELL2
elongation factor for RNA polymerase II 2
chr17_-_42388467 2.08 ENST00000678792.1
ENST00000679166.1
ENST00000677442.1
ENST00000677723.1
ENST00000678905.1
ENST00000677479.1
ENST00000678043.1
ENST00000677152.1
ENST00000677603.1
ENST00000588969.5
ENST00000678535.1
ENST00000679185.1
ENST00000677030.1
ENST00000679014.1
ENST00000678044.1
ENST00000678827.1
STAT3
signal transducer and activator of transcription 3
chr11_+_67606894 2.03 ENST00000532303.5
ENST00000532244.5
ENST00000528328.1
ENST00000322776.11
ENST00000529927.5
ENST00000532343.5
ENST00000415352.6
ENST00000533075.5
ENST00000529867.5
ENST00000530638.1
NDUFV1
NADH:ubiquinone oxidoreductase core subunit V1
chr18_+_22933321 1.95 ENST00000327155.10
RBBP8
RB binding protein 8, endonuclease
chr6_-_34696733 1.90 ENST00000374023.8
ILRUN
inflammation and lipid regulator with UBA-like and NBR1-like domains
chr6_-_27472681 1.83 ENST00000377419.1
ZNF184
zinc finger protein 184
chr21_-_39349048 1.81 ENST00000380748.5
ENST00000380749.10
HMGN1
high mobility group nucleosome binding domain 1
chr9_-_128881922 1.69 ENST00000320665.10
ENST00000436267.7
ENST00000302586.8
ENST00000651925.1
KYAT1
ENSG00000286112.1
kynurenine aminotransferase 1
kynurenine aminotransferase 1
chr1_+_63322558 1.66 ENST00000371116.4
FOXD3
forkhead box D3
chr6_+_33208488 1.65 ENST00000374656.5
RING1
ring finger protein 1
chr4_-_110636963 1.55 ENST00000394595.8
PITX2
paired like homeodomain 2
chr19_-_10231293 1.48 ENST00000646641.1
S1PR2
sphingosine-1-phosphate receptor 2
chr6_-_53348902 1.45 ENST00000370913.5
ENST00000304434.11
ELOVL5
ELOVL fatty acid elongase 5
chr12_-_51173067 1.44 ENST00000549867.5
ENST00000257915.10
TFCP2
transcription factor CP2
chr19_-_29213110 1.44 ENST00000304863.6
UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr16_-_68023201 1.43 ENST00000332395.7
DDX28
DEAD-box helicase 28
chr18_+_26226417 1.38 ENST00000269142.10
TAF4B
TATA-box binding protein associated factor 4b
chr4_+_47485268 1.37 ENST00000273859.8
ENST00000504445.1
ATP10D
ATPase phospholipid transporting 10D (putative)
chr17_+_7572818 1.30 ENST00000293831.13
ENST00000582169.5
ENST00000578754.5
ENST00000578495.5
ENST00000585024.5
ENST00000583802.5
ENST00000577269.5
ENST00000584784.5
ENST00000582746.5
ENST00000581621.1
EIF4A1
ENSG00000264772.6
eukaryotic translation initiation factor 4A1
novel transcript
chr18_+_48539112 1.25 ENST00000382998.8
CTIF
cap binding complex dependent translation initiation factor
chr13_+_111153708 1.23 ENST00000218789.9
ARHGEF7
Rho guanine nucleotide exchange factor 7
chr2_-_240025380 1.22 ENST00000676782.1
ENST00000677407.1
ENST00000678914.1
ENST00000677294.1
ENST00000676491.1
ENST00000677567.1
ENST00000679158.1
ENST00000448880.6
ENST00000677263.1
ENST00000678289.1
ENST00000678737.1
NDUFA10
NADH:ubiquinone oxidoreductase subunit A10
chr18_+_26226472 1.22 ENST00000578121.5
TAF4B
TATA-box binding protein associated factor 4b
chr11_+_3797819 1.15 ENST00000396986.6
ENST00000300730.10
ENST00000396993.8
ENST00000532523.5
ENST00000459679.5
ENST00000464229.5
ENST00000464261.5
ENST00000490830.5
ENST00000464906.6
ENST00000464441.5
PGAP2
post-GPI attachment to proteins 2
chr2_-_240025299 1.14 ENST00000404554.5
ENST00000407129.3
ENST00000307300.8
ENST00000678455.1
ENST00000444548.6
ENST00000252711.7
ENST00000620965.5
ENST00000443626.5
NDUFA10
NADH:ubiquinone oxidoreductase subunit A10
chr11_-_3797458 1.13 ENST00000355260.7
NUP98
nucleoporin 98 and 96 precursor
chr3_-_185938006 1.12 ENST00000342294.4
ENST00000453386.7
ENST00000382191.4
TRA2B
transformer 2 beta homolog
chr1_-_214551556 1.12 ENST00000366956.10
PTPN14
protein tyrosine phosphatase non-receptor type 14
chr6_-_31806937 1.07 ENST00000375661.6
LSM2
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr6_-_29628038 0.99 ENST00000355973.7
ENST00000377012.8
GABBR1
gamma-aminobutyric acid type B receptor subunit 1
chr10_-_62816341 0.95 ENST00000242480.4
ENST00000637191.1
EGR2
early growth response 2
chr1_-_31644866 0.95 ENST00000373703.5
PEF1
penta-EF-hand domain containing 1
chr11_-_3797746 0.92 ENST00000359171.8
NUP98
nucleoporin 98 and 96 precursor
chr4_+_74445126 0.92 ENST00000395748.8
AREG
amphiregulin
chr10_-_62816309 0.92 ENST00000411732.3
EGR2
early growth response 2
chr5_-_133612524 0.91 ENST00000265342.12
FSTL4
follistatin like 4
chr2_-_156332694 0.90 ENST00000424077.1
ENST00000426264.5
ENST00000421709.1
ENST00000339562.9
NR4A2
nuclear receptor subfamily 4 group A member 2
chr14_+_94026314 0.87 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr12_-_51172779 0.86 ENST00000548108.1
ENST00000548115.5
TFCP2
transcription factor CP2
chr6_-_162727748 0.85 ENST00000366892.5
ENST00000366898.6
ENST00000366897.5
ENST00000366896.5
ENST00000674250.1
PRKN
parkin RBR E3 ubiquitin protein ligase
chrX_-_153971810 0.83 ENST00000310441.12
HCFC1
host cell factor C1
chr17_+_782340 0.83 ENST00000304478.9
MRM3
mitochondrial rRNA methyltransferase 3
chr6_+_109978297 0.76 ENST00000275169.5
GPR6
G protein-coupled receptor 6
chr12_+_121712740 0.69 ENST00000449592.7
TMEM120B
transmembrane protein 120B
chr19_-_58554960 0.69 ENST00000596708.1
ENST00000601220.5
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A
chr4_+_74445302 0.68 ENST00000502307.1
AREG
amphiregulin
chr19_-_58555085 0.68 ENST00000312547.7
CHMP2A
charged multivesicular body protein 2A
chr17_+_27294076 0.67 ENST00000581440.5
ENST00000583742.1
ENST00000579733.5
ENST00000583193.5
ENST00000581185.5
ENST00000427287.6
ENST00000262394.7
ENST00000348811.6
WSB1
WD repeat and SOCS box containing 1
chr2_-_75199511 0.64 ENST00000305249.10
TACR1
tachykinin receptor 1
chr1_-_46719074 0.64 ENST00000371933.8
ENST00000672422.2
ENST00000674263.1
ENST00000674415.1
ENST00000674435.1
EFCAB14
EF-hand calcium binding domain 14
chr11_-_33161461 0.63 ENST00000323959.9
ENST00000431742.2
ENST00000524827.6
CSTF3
cleavage stimulation factor subunit 3
chr9_-_96619378 0.62 ENST00000375240.7
ENST00000463569.5
CDC14B
cell division cycle 14B
chr6_+_162727941 0.62 ENST00000366888.6
PACRG
parkin coregulated
chr6_+_47477731 0.60 ENST00000359314.5
CD2AP
CD2 associated protein
chr18_+_33578213 0.54 ENST00000681521.1
ENST00000269197.12
ASXL3
ASXL transcriptional regulator 3
chr14_+_58637934 0.50 ENST00000395153.8
DACT1
dishevelled binding antagonist of beta catenin 1
chr16_-_27549887 0.46 ENST00000561623.5
ENST00000356183.9
GTF3C1
general transcription factor IIIC subunit 1
chr5_-_134371004 0.43 ENST00000521755.1
ENST00000523054.5
ENST00000518409.1
CDKL3
ENSG00000273345.5
cyclin dependent kinase like 3
novel transcript
chr19_+_3506355 0.42 ENST00000652521.1
FZR1
fizzy and cell division cycle 20 related 1
chr10_-_49762276 0.41 ENST00000374103.9
OGDHL
oxoglutarate dehydrogenase L
chr2_-_61888570 0.40 ENST00000394440.8
ENST00000544079.2
CCT4
chaperonin containing TCP1 subunit 4
chr3_+_140941901 0.39 ENST00000453248.6
SLC25A36
solute carrier family 25 member 36
chr4_-_67701113 0.39 ENST00000420827.2
ENST00000322244.10
UBA6
ubiquitin like modifier activating enzyme 6
chr5_-_32444722 0.38 ENST00000265069.13
ZFR
zinc finger RNA binding protein
chr7_-_129952631 0.36 ENST00000473814.6
ENST00000490974.1
UBE2H
ubiquitin conjugating enzyme E2 H
chr6_+_109978256 0.34 ENST00000414000.3
GPR6
G protein-coupled receptor 6
chr3_+_140941792 0.34 ENST00000446041.6
ENST00000324194.12
ENST00000507429.5
SLC25A36
solute carrier family 25 member 36
chr10_+_63133279 0.33 ENST00000277746.11
NRBF2
nuclear receptor binding factor 2
chr19_+_34254543 0.32 ENST00000588470.5
ENST00000299505.8
ENST00000589583.5
GARRE1
granule associated Rac and RHOG effector 1
chr19_+_3506251 0.31 ENST00000441788.7
FZR1
fizzy and cell division cycle 20 related 1
chr11_-_1572261 0.31 ENST00000397374.8
DUSP8
dual specificity phosphatase 8
chr5_+_113513674 0.30 ENST00000161863.9
ENST00000515883.5
YTHDC2
YTH domain containing 2
chr19_+_42076129 0.28 ENST00000359044.5
ZNF574
zinc finger protein 574
chr10_+_117241107 0.27 ENST00000644641.2
SLC18A2
solute carrier family 18 member A2
chr19_-_45584769 0.26 ENST00000263275.5
OPA3
outer mitochondrial membrane lipid metabolism regulator OPA3
chr11_+_4094775 0.25 ENST00000300738.10
RRM1
ribonucleotide reductase catalytic subunit M1
chr6_+_75749272 0.23 ENST00000653423.1
MYO6
myosin VI
chr22_+_40857076 0.22 ENST00000614001.1
ENST00000357137.9
XPNPEP3
X-prolyl aminopeptidase 3
chr16_-_46748337 0.14 ENST00000394809.9
MYLK3
myosin light chain kinase 3
chr5_+_134371561 0.13 ENST00000265339.7
ENST00000506787.5
ENST00000507277.1
UBE2B
ubiquitin conjugating enzyme E2 B
chr19_+_35641728 0.11 ENST00000619399.4
ENST00000379026.6
ENST00000379023.8
ENST00000402764.6
ENST00000479824.5
ETV2
ETS variant transcription factor 2
chr17_+_73164977 0.10 ENST00000580671.1
ENST00000357585.4
ENSG00000264860.1
SSTR2
novel transcript
somatostatin receptor 2
chr3_+_185586270 0.08 ENST00000296257.10
SENP2
SUMO specific peptidase 2
chr3_-_101677119 0.07 ENST00000312938.5
ZBTB11
zinc finger and BTB domain containing 11
chr17_+_41688879 0.02 ENST00000469257.2
ENST00000591776.5
EIF1
eukaryotic translation initiation factor 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 13.9 GO:2000173 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
2.0 12.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
1.8 7.4 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.4 4.3 GO:1902724 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
1.3 3.8 GO:0009386 translational attenuation(GO:0009386)
1.1 5.3 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
1.0 4.1 GO:0003290 atrial septum secundum morphogenesis(GO:0003290)
1.0 3.0 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.8 4.9 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.8 14.4 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.7 4.3 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.6 4.4 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.6 1.9 GO:0021593 rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
0.5 1.5 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.5 1.4 GO:1903722 regulation of centriole elongation(GO:1903722)
0.4 7.8 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.4 1.4 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.3 5.5 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.3 0.9 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.3 2.3 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.3 0.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.3 1.7 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.3 1.9 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.3 0.8 GO:0019046 release from viral latency(GO:0019046)
0.3 2.5 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.2 0.7 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.2 0.9 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.2 0.6 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.2 0.8 GO:0000451 rRNA 2'-O-methylation(GO:0000451)
0.2 2.8 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 1.6 GO:0060750 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.2 19.7 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.2 1.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 1.5 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.2 2.9 GO:0070365 hepatocyte differentiation(GO:0070365)
0.1 1.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 1.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 4.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.0 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.1 0.6 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 0.3 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.1 0.9 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 1.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.5 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 0.4 GO:0021764 amygdala development(GO:0021764)
0.1 1.7 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 3.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 2.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 3.1 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.1 4.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 6.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.5 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 1.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.1 0.4 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.1 1.8 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.1 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.1 GO:0048769 sarcomerogenesis(GO:0048769) positive regulation of sarcomere organization(GO:0060298)
0.0 1.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.4 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 4.9 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 8.9 GO:0030323 respiratory tube development(GO:0030323)
0.0 0.3 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.0 1.1 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 1.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 2.1 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 2.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 1.1 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.6 GO:0006379 mRNA cleavage(GO:0006379)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 1.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 2.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 3.1 GO:0006109 regulation of carbohydrate metabolic process(GO:0006109)
0.0 0.4 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 5.1 GO:0009615 response to virus(GO:0009615)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 19.7 GO:1990111 spermatoproteasome complex(GO:1990111)
1.3 5.3 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.6 4.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.3 2.9 GO:0000125 PCAF complex(GO:0000125)
0.2 1.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 2.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 1.7 GO:0001739 sex chromatin(GO:0001739)
0.2 3.1 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.2 3.1 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.2 1.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 1.2 GO:0000322 storage vacuole(GO:0000322)
0.1 2.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.9 GO:0071797 LUBAC complex(GO:0071797)
0.1 4.9 GO:0071437 invadopodium(GO:0071437)
0.1 9.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.5 GO:0005686 U2 snRNP(GO:0005686)
0.1 1.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex III(GO:0045275)
0.1 1.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.4 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 4.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 2.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 6.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.4 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 0.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 1.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 15.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 3.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.3 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 4.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 1.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.0 14.2 GO:0044297 cell body(GO:0044297)
0.0 8.7 GO:0016607 nuclear speck(GO:0016607)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.0 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.4 GO:1990932 5.8S rRNA binding(GO:1990932)
0.8 4.9 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.8 2.3 GO:0000035 acyl binding(GO:0000035)
0.7 19.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6 4.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.5 5.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.5 4.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5 4.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 7.8 GO:0031996 thioesterase binding(GO:0031996)
0.4 1.7 GO:0070546 cysteine-S-conjugate beta-lyase activity(GO:0047804) L-phenylalanine aminotransferase activity(GO:0070546)
0.4 12.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.3 0.8 GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039)
0.2 1.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 0.7 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2 0.9 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.2 2.4 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.2 12.4 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 2.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 1.4 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 1.4 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 2.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 0.5 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.1 4.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 3.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.6 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 1.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 3.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.8 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 2.0 GO:0010181 FMN binding(GO:0010181)
0.1 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 3.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.1 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.9 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.2 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.1 13.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.3 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.3 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 2.8 GO:0032452 histone demethylase activity(GO:0032452)
0.1 0.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 3.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 2.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.3 GO:0000339 RNA cap binding(GO:0000339)
0.1 4.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 9.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.4 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 1.4 GO:0019843 rRNA binding(GO:0019843)
0.0 4.9 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 1.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 1.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 3.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 1.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 1.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 2.6 GO:0001047 core promoter binding(GO:0001047)
0.0 1.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 7.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 1.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 4.3 ST STAT3 PATHWAY STAT3 Pathway
0.2 6.4 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 4.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 9.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 7.8 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.9 PID MYC PATHWAY C-MYC pathway
0.1 9.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 2.0 PID AURORA A PATHWAY Aurora A signaling
0.0 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 3.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.5 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.6 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.5 5.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 19.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 4.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 4.9 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 4.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.2 4.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 9.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 5.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 5.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 7.9 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 1.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.0 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 4.5 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation