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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EBF1
Z-value: 12.22
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Transcription factors associated with EBF1
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 308.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 12.6 | 214.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 2.3 | 157.4 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 4.5 | 125.7 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 1.0 | 95.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 2.3 | 92.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 1.2 | 92.1 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 1.5 | 92.0 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 14.8 | 88.7 | GO:0010731 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 2.2 | 73.8 | GO:0014072 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 601.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 15.4 | 246.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.3 | 205.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.7 | 155.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 7.5 | 135.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.8 | 130.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.4 | 125.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 122.1 | GO:0005615 | extracellular space(GO:0005615) |
| 1.3 | 119.5 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 2.3 | 115.6 | GO:0019814 | immunoglobulin complex(GO:0019814) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 396.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 8.0 | 239.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.7 | 222.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.4 | 181.1 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 2.2 | 129.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 3.8 | 127.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 1.9 | 119.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 1.9 | 104.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.8 | 98.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 9.6 | 86.0 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 102.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 2.8 | 78.7 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.3 | 71.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 68.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.4 | 66.9 | ST ADRENERGIC | Adrenergic Pathway |
| 1.6 | 66.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 1.5 | 58.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 1.3 | 55.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 53.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.5 | 48.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 199.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.5 | 187.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 2.0 | 113.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 3.2 | 106.0 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 2.9 | 79.2 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 4.1 | 77.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.2 | 73.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 69.4 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 2.5 | 65.9 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 1.3 | 64.9 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |