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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for EMX2

Z-value: 5.24

Motif logo

Transcription factors associated with EMX2

Gene Symbol Gene ID Gene Info
ENSG00000170370.12 EMX2

Activity-expression correlation:

Activity profile of EMX2 motif

Sorted Z-values of EMX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr11_-_5227063 46.16 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
hemoglobin subunit beta
chr4_+_25160631 26.85 ENST00000510415.1
ENST00000507794.2
ENST00000512921.4
SEPSECS antisense RNA 1 (head to head)
phosphatidylinositol 4-kinase type 2 beta
chr1_+_244835616 25.95 ENST00000366528.3
ENST00000411948.7
cytochrome c oxidase assembly factor COX20
chr12_-_16600703 22.47 ENST00000616247.4
LIM domain only 3
chr2_+_17541157 18.95 ENST00000406397.1
visinin like 1
chr2_-_2324323 17.82 ENST00000648339.1
ENST00000647694.1
myelin transcription factor 1 like
chr16_+_85027735 17.69 ENST00000258180.7
ENST00000538274.5
KIAA0513
chr19_+_53962925 17.56 ENST00000270458.4
calcium voltage-gated channel auxiliary subunit gamma 8
chr5_+_36608146 16.80 ENST00000381918.4
ENST00000513646.1
solute carrier family 1 member 3
chr6_-_52840843 15.04 ENST00000370989.6
glutathione S-transferase alpha 5
chr17_+_1771688 14.37 ENST00000572048.1
ENST00000573763.1
serpin family F member 1
chr18_+_24113341 14.02 ENST00000540918.2
tetratricopeptide repeat domain 39C
chr6_+_72216442 13.06 ENST00000425662.6
ENST00000453976.6
regulating synaptic membrane exocytosis 1
chr1_+_152878312 12.26 ENST00000368765.4
sperm mitochondria associated cysteine rich protein
chr15_-_65133780 11.16 ENST00000204549.9
programmed cell death 7
chr6_-_52763473 10.51 ENST00000493422.3
glutathione S-transferase alpha 2
chr1_+_111230725 10.49 ENST00000533831.6
chitinase 3 like 2
chr1_+_92168915 10.22 ENST00000637221.2
BTB domain containing 8
chr5_+_140875299 9.86 ENST00000613593.1
ENST00000398631.3
protocadherin alpha 12
chr3_+_131026844 9.36 ENST00000510769.5
ENST00000383366.9
ENST00000510688.5
ENST00000511262.5
NIMA related kinase 11
chr16_+_56191476 9.34 ENST00000262493.12
G protein subunit alpha o1
chr1_-_92486916 9.28 ENST00000294702.6
growth factor independent 1 transcriptional repressor
chr11_-_129024157 9.06 ENST00000392657.7
Rho GTPase activating protein 32
chr4_-_88284553 8.81 ENST00000608933.6
ENST00000295908.11
protein phosphatase, Mg2+/Mn2+ dependent 1K
chr16_-_11281322 8.76 ENST00000312511.4
protamine 1
chr5_-_112419251 8.31 ENST00000261486.6
erythrocyte membrane protein band 4.1 like 4A
chr10_-_69409275 8.18 ENST00000373307.5
tachykinin receptor 2
chrX_-_73214793 8.09 ENST00000373517.4
nucleosome assembly protein 1 like 2
chr5_-_11588842 8.06 ENST00000503622.5
catenin delta 2
chr17_-_55511434 7.91 ENST00000636752.1
small integral membrane protein 36
chrY_+_14056226 7.89 ENST00000250823.5
variable charge Y-linked 1B
chr12_-_91180365 7.78 ENST00000547937.5
decorin
chr9_+_108862255 7.71 ENST00000333999.5
actin like 7A
chr2_+_89936859 7.57 ENST00000474213.1
immunoglobulin kappa variable 2D-30
chr5_+_55160161 7.52 ENST00000296734.6
ENST00000515370.1
ENST00000503787.6
glutathione peroxidase 8 (putative)
chr3_-_186570308 7.30 ENST00000446782.5
TBCC domain containing 1
chr19_-_51417791 7.24 ENST00000353836.9
sialic acid binding Ig like lectin 10
chr19_-_38849923 7.01 ENST00000601813.1
ENST00000221419.10
heterogeneous nuclear ribonucleoprotein L
chr8_-_33599935 7.01 ENST00000523956.1
ENST00000256261.9
dual specificity phosphatase 26
chr4_-_119322128 6.96 ENST00000274024.4
fatty acid binding protein 2
chrX_+_154304923 6.85 ENST00000426989.5
ENST00000426203.5
ENST00000369912.2
transketolase like 1
chr11_+_72216774 6.82 ENST00000619261.4
ENST00000454954.6
ENST00000541003.5
ENST00000539412.5
ENST00000298223.11
ENST00000536778.5
ENST00000535625.5
ENST00000321324.11
folate receptor beta
chr6_-_110179995 6.80 ENST00000392586.5
ENST00000419252.1
ENST00000359451.6
ENST00000392588.5
WASP family member 1
chrX_+_18425597 6.66 ENST00000623535.2
ENST00000674046.1
cyclin dependent kinase like 5
chr19_-_9107475 6.33 ENST00000641081.1
olfactory receptor family 7 subfamily G member 2
chr10_-_91633057 6.19 ENST00000238994.6
protein phosphatase 1 regulatory subunit 3C
chr5_+_162067858 6.16 ENST00000361925.9
gamma-aminobutyric acid type A receptor subunit gamma2
chr5_+_162067990 6.15 ENST00000641017.1
gamma-aminobutyric acid type A receptor subunit gamma2
chr3_-_131026726 6.03 ENST00000514044.5
ENST00000264992.8
asteroid homolog 1
chr17_-_76141240 5.99 ENST00000322957.7
forkhead box J1
chr15_-_42208153 5.97 ENST00000348544.4
ENST00000318006.10
VPS39 subunit of HOPS complex
chr5_-_140633690 5.93 ENST00000512545.1
ENST00000401743.6
CD14 molecule
chr16_-_28623560 5.91 ENST00000350842.8
sulfotransferase family 1A member 1
chr3_-_49429304 5.77 ENST00000636166.1
ENST00000273598.8
ENST00000436744.2
novel protein
nicolin 1
chr5_-_177780633 5.73 ENST00000513554.5
ENST00000440605.7
family with sequence similarity 153 member A
chr12_-_10130241 5.71 ENST00000353231.9
ENST00000525605.1
C-type lectin domain containing 7A
chr1_+_84181630 5.68 ENST00000610457.1
protein kinase cAMP-activated catalytic subunit beta
chr5_+_162068031 5.65 ENST00000356592.8
gamma-aminobutyric acid type A receptor subunit gamma2
chr17_-_4263847 5.62 ENST00000570535.5
ENST00000574367.5
ENST00000341657.9
ankyrin repeat and FYVE domain containing 1
chrX_+_18425579 5.61 ENST00000379996.7
cyclin dependent kinase like 5
chrX_-_6535118 5.61 ENST00000381089.7
ENST00000612369.4
ENST00000398729.1
variable charge X-linked 3A
chr3_+_38039199 5.53 ENST00000346219.7
ENST00000308059.11
DLEC1 cilia and flagella associated protein
chr5_-_56116946 5.47 ENST00000434982.2
ankyrin repeat domain 55
chr2_+_32277883 5.33 ENST00000238831.9
Yip1 domain family member 4
chr11_+_27055215 5.30 ENST00000525090.1
gamma-butyrobetaine hydroxylase 1
chr12_+_93677556 5.27 ENST00000542893.2
CASP2 and RIPK1 domain containing adaptor with death domain
chr19_-_32869741 5.25 ENST00000590341.5
ENST00000587772.1
ENST00000023064.9
solute carrier family 7 member 9
chr16_+_18983927 5.11 ENST00000569532.5
ENST00000304381.10
transmembrane channel like 7
chr6_+_27865308 5.08 ENST00000613174.2
H2A clustered histone 16
chr2_+_48568981 5.04 ENST00000394754.5
STON1-GTF2A1L readthrough
chr11_+_7088991 5.02 ENST00000306904.7
RBMX like 2
chr3_+_119579676 5.00 ENST00000357003.7
ADP-ribosylarginine hydrolase
chr9_-_21368057 4.97 ENST00000449498.2
interferon alpha 13
chr6_+_101398788 4.80 ENST00000369138.5
ENST00000413795.5
ENST00000358361.7
glutamate ionotropic receptor kainate type subunit 2
chr10_+_100462969 4.74 ENST00000343737.6
Wnt family member 8B
chr18_+_32190015 4.69 ENST00000581447.1
meprin A subunit beta
chr12_-_10130143 4.64 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
C-type lectin domain containing 7A
chr18_+_32190033 4.57 ENST00000269202.11
meprin A subunit beta
chr6_+_28349907 4.54 ENST00000252211.7
ENST00000341464.9
ENST00000377255.3
zinc finger with KRAB and SCAN domains 3
chr15_-_78620964 4.53 ENST00000326828.6
cholinergic receptor nicotinic alpha 3 subunit
chr16_-_30091226 4.50 ENST00000279386.6
ENST00000627355.2
T-box transcription factor 6
chr5_-_138139382 4.46 ENST00000265191.4
NME/NM23 family member 5
chr9_-_96778053 4.43 ENST00000375231.5
ENST00000223428.9
zinc finger protein 510
chr3_+_98147479 4.42 ENST00000641380.1
olfactory receptor family 5 subfamily H member 14
chr9_-_21202205 4.40 ENST00000239347.3
interferon alpha 7
chr11_-_63608542 4.39 ENST00000540943.1
phospholipase A and acyltransferase 3
chr12_-_118359105 4.38 ENST00000541186.5
ENST00000539872.5
TAO kinase 3
chr3_-_127736329 4.34 ENST00000398101.7
monoglyceride lipase
chr9_+_100099233 4.29 ENST00000262457.7
ENST00000262456.6
ENST00000374921.3
inversin
chr6_+_150368892 4.24 ENST00000229447.9
ENST00000392256.6
iodotyrosine deiodinase
chr17_-_40937641 4.20 ENST00000209718.8
keratin 23
chr17_-_36264514 4.19 ENST00000618620.4
ENST00000621034.1
TBC1 domain family member 3I
chr16_-_28363508 4.18 ENST00000532254.1
nuclear pore complex interacting protein family member B6
chr9_-_76906041 4.06 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
prune homolog 2 with BCH domain
chr20_+_9514562 4.03 ENST00000246070.3
lysosomal associated membrane protein family member 5
chr5_+_129748091 4.00 ENST00000564719.2
membrane integral NOTCH2 associated receptor 2
chr17_-_40937445 3.97 ENST00000436344.7
ENST00000485751.1
keratin 23
chr9_-_21368962 3.91 ENST00000610660.1
interferon alpha 13
chr19_+_14583076 3.86 ENST00000547437.5
ENST00000417570.6
C-type lectin domain containing 17A
chr18_-_26865732 3.83 ENST00000672188.1
aquaporin 4
chrY_-_6872608 3.81 ENST00000383036.1
amelogenin Y-linked
chr1_+_192809031 3.78 ENST00000235382.7
regulator of G protein signaling 2
chr12_+_101594849 3.77 ENST00000547405.5
ENST00000452455.6
ENST00000392934.7
ENST00000547509.5
ENST00000361685.6
ENST00000549145.5
ENST00000361466.7
ENST00000553190.5
ENST00000545503.6
ENST00000536007.5
ENST00000541119.5
ENST00000551300.5
ENST00000550270.1
myosin binding protein C1
chr11_-_60183191 3.76 ENST00000412309.6
membrane spanning 4-domains A6A
chr17_-_15341577 3.73 ENST00000543896.1
ENST00000395930.6
ENST00000539245.5
ENST00000539316.1
tektin 3
chr1_+_117420597 3.73 ENST00000449370.6
mannosidase alpha class 1A member 2
chr16_-_28623330 3.72 ENST00000677940.1
novel protein
chr15_+_58410543 3.69 ENST00000356113.10
ENST00000414170.7
lipase C, hepatic type
chr1_-_19923617 3.66 ENST00000375116.3
phospholipase A2 group IIE
chr17_-_37989048 3.64 ENST00000617678.2
ENST00000612727.5
TBC1 domain family member 3L
chr17_+_38003976 3.63 ENST00000616101.4
TBC1 domain family member 3D
chr14_-_89954518 3.62 ENST00000556005.1
ENST00000555872.5
EF-hand calcium binding domain 11
chr5_-_76623391 3.55 ENST00000296641.5
ENST00000504899.1
coagulation factor II thrombin receptor like 2
chr1_+_196774813 3.52 ENST00000471440.6
ENST00000391985.7
ENST00000617219.1
ENST00000367425.9
complement factor H related 3
chr22_+_37686331 3.52 ENST00000359114.9
ENST00000611699.1
nucleolar protein 12
chr17_+_38127951 3.51 ENST00000621587.2
TBC1 domain family member 3E
chr3_+_119579577 3.48 ENST00000478927.5
ADP-ribosylarginine hydrolase
chr18_-_26865689 3.47 ENST00000675739.1
ENST00000383168.9
ENST00000672981.2
ENST00000578776.1
aquaporin 4
chr22_+_21665994 3.44 ENST00000680393.1
ENST00000679534.1
ENST00000679827.1
ENST00000681956.1
ENST00000681338.1
ENST00000680061.1
ENST00000679540.1
ENST00000679795.1
ENST00000335025.12
ENST00000398831.8
ENST00000679477.1
ENST00000626352.2
ENST00000458567.5
ENST00000680094.1
ENST00000680109.1
ENST00000406385.1
ENST00000680860.1
peptidylprolyl isomerase like 2
chr8_+_103880412 3.44 ENST00000436393.6
regulating synaptic membrane exocytosis 2
chr6_+_101181254 3.42 ENST00000682090.1
ENST00000421544.6
glutamate ionotropic receptor kainate type subunit 2
chr12_+_29149238 3.36 ENST00000536681.8
fatty acyl-CoA reductase 2
chr3_+_48241046 3.33 ENST00000427617.6
ENST00000412564.5
ENST00000354698.8
ENST00000440261.6
zinc finger protein 589
chr11_+_66509079 3.29 ENST00000419755.3
novel protein
chr4_-_99435396 3.26 ENST00000209665.8
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr3_-_151329539 3.20 ENST00000325602.6
purinergic receptor P2Y13
chr1_-_212414815 3.17 ENST00000261455.9
ENST00000535273.2
proton activated chloride channel 1
chr12_-_57826295 3.13 ENST00000549039.5
CTD small phosphatase 2
chr17_-_5035418 3.13 ENST00000254853.10
ENST00000424747.1
solute carrier family 52 member 1
chr1_+_149782671 3.13 ENST00000444948.5
ENST00000369168.5
Fc fragment of IgG receptor Ia
chr19_+_49513353 3.10 ENST00000596975.5
Fc fragment of IgG receptor and transporter
chr4_+_55346213 3.02 ENST00000679836.1
ENST00000264228.9
ENST00000679707.1
steroid 5 alpha-reductase 3
novel protein, SRD5A3-RP11-177J6.1 readthrough
chr3_-_101320558 3.00 ENST00000193391.8
interphotoreceptor matrix proteoglycan 2
chrX_+_55717733 2.95 ENST00000414239.5
ENST00000374941.9
Ras related GTP binding B
chr16_+_10944547 2.94 ENST00000409790.6
ENST00000409552.4
C-type lectin domain containing 16A
chr9_+_128566741 2.93 ENST00000630866.1
spectrin alpha, non-erythrocytic 1
chr1_+_36084079 2.91 ENST00000207457.8
tektin 2
chr6_-_138218491 2.89 ENST00000527246.3
prostate and breast cancer overexpressed 1
chr1_+_111290848 2.89 ENST00000369740.6
ENST00000422815.5
ENST00000483391.5
chitinase acidic
chr19_-_14835162 2.88 ENST00000322301.5
olfactory receptor family 7 subfamily A member 5
chr6_+_72212802 2.87 ENST00000401910.7
regulating synaptic membrane exocytosis 1
chr5_-_41213505 2.81 ENST00000337836.10
ENST00000433294.1
complement C6
chr4_-_99435336 2.81 ENST00000437033.7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr16_+_86566821 2.77 ENST00000649859.1
forkhead box C2
chrX_+_55717796 2.75 ENST00000262850.7
Ras related GTP binding B
chr2_+_233917371 2.73 ENST00000324695.9
ENST00000433712.6
transient receptor potential cation channel subfamily M member 8
chr16_-_21652598 2.69 ENST00000569602.1
ENST00000268389.6
immunoglobulin superfamily member 6
chr3_+_113897470 2.68 ENST00000440446.2
ENST00000488680.1
GRAM domain containing 1C
chr4_+_87832917 2.67 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr18_-_55423757 2.60 ENST00000675707.1
transcription factor 4
chr11_-_60183011 2.60 ENST00000533023.5
ENST00000420732.6
ENST00000528851.6
membrane spanning 4-domains A6A
chr1_+_119368802 2.56 ENST00000361035.8
ENST00000419144.1
hydroxyacid oxidase 2
HAO2 intronic transcript 1
chr1_-_170074568 2.51 ENST00000367767.5
ENST00000361580.7
ENST00000538366.5
kinesin associated protein 3
chr10_-_122845850 2.49 ENST00000392790.6
CUB and zona pellucida like domains 1
chr4_-_185956348 2.49 ENST00000431902.5
ENST00000284776.11
ENST00000415274.5
sorbin and SH3 domain containing 2
chr6_+_27957241 2.47 ENST00000244623.1
olfactory receptor family 2 subfamily B member 6
chr1_+_160739286 2.46 ENST00000359331.8
ENST00000495334.1
SLAM family member 7
chr8_+_12945667 2.46 ENST00000524591.7
tRNA methyltransferase 9B (putative)
chr12_+_18242955 2.44 ENST00000676171.1
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr4_-_185956652 2.43 ENST00000355634.9
sorbin and SH3 domain containing 2
chr1_+_119368773 2.43 ENST00000457318.5
ENST00000622548.4
ENST00000325945.4
hydroxyacid oxidase 2
chr2_-_166149204 2.41 ENST00000635750.1
sodium voltage-gated channel alpha subunit 1
chr5_+_141412979 2.38 ENST00000612503.1
ENST00000398610.3
protocadherin gamma subfamily A, 10
chr5_-_74866958 2.35 ENST00000389156.9
family with sequence similarity 169 member A
chr4_-_99219230 2.35 ENST00000394897.5
ENST00000508558.1
ENST00000394899.6
alcohol dehydrogenase 6 (class V)
chr3_-_122793772 2.33 ENST00000306103.3
HSPB1 associated protein 1
chr10_+_52128343 2.33 ENST00000672084.1
protein kinase cGMP-dependent 1
chr10_+_89332484 2.32 ENST00000371811.4
ENST00000680037.1
ENST00000679583.1
ENST00000679897.1
interferon induced protein with tetratricopeptide repeats 3
chr19_-_14835252 2.32 ENST00000641666.1
ENST00000642030.1
ENST00000642000.1
olfactory receptor family 7 subfamily C member 1
chr1_+_170935526 2.31 ENST00000367758.7
ENST00000367759.9
maestro heat like repeat family member 9
chr6_+_72212887 2.30 ENST00000523963.5
regulating synaptic membrane exocytosis 1
chr1_-_66801276 2.30 ENST00000304526.3
insulin like 5
chr4_+_94974984 2.26 ENST00000672698.1
bone morphogenetic protein receptor type 1B
chr2_-_110577101 2.20 ENST00000330331.9
ENST00000446930.1
ENST00000329516.8
RANBP2 like and GRIP domain containing 6
chr15_-_99249523 2.19 ENST00000560235.1
ENST00000394132.7
ENST00000560860.5
ENST00000558078.5
ENST00000560772.5
tetratricopeptide repeat domain 23
chr4_+_87650277 2.17 ENST00000339673.11
ENST00000282479.8
dentin matrix acidic phosphoprotein 1
chr14_+_21990357 2.16 ENST00000390444.1
T cell receptor alpha variable 16
chr7_+_90709530 2.14 ENST00000406263.5
cyclin dependent kinase 14
chr10_+_88664439 2.14 ENST00000394375.7
ENST00000608620.5
ENST00000238983.9
ENST00000355843.2
lipase F, gastric type
chr14_+_94561435 2.05 ENST00000557004.6
ENST00000555095.5
ENST00000298841.5
ENST00000554220.5
ENST00000553780.5
serpin family A member 4
serpin family A member 5
chr3_-_109337572 2.03 ENST00000335658.6
developmental pluripotency associated 4
chr8_-_132675533 2.00 ENST00000620350.5
ENST00000518642.5
ENST00000250173.5
leucine rich repeat containing 6
chr17_-_69141878 1.99 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr12_-_122716790 1.98 ENST00000528880.3
hydroxycarboxylic acid receptor 3
chr20_+_10034963 1.98 ENST00000378392.6
ankyrin repeat and EF-hand domain containing 1
chr16_+_72054477 1.94 ENST00000355906.10
ENST00000570083.5
ENST00000228226.12
ENST00000398131.6
ENST00000569639.5
ENST00000564499.5
ENST00000357763.8
ENST00000613898.1
ENST00000562526.5
ENST00000565574.5
ENST00000568417.6
haptoglobin
chr20_+_10035029 1.94 ENST00000378380.4
ankyrin repeat and EF-hand domain containing 1
chr1_+_115029823 1.94 ENST00000256592.3
thyroid stimulating hormone subunit beta
chr18_+_31447732 1.92 ENST00000257189.5
desmoglein 3
chr12_-_122703346 1.92 ENST00000328880.6
hydroxycarboxylic acid receptor 2
chr12_+_74537787 1.91 ENST00000519948.4
ataxin 7 like 3B
chr10_-_114144599 1.91 ENST00000428953.1
coiled-coil domain containing 186
chr11_-_89808575 1.89 ENST00000329758.5
tripartite motif containing 49
chr1_+_117001744 1.89 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101 molecule
chr14_+_103385374 1.87 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
microtubule affinity regulating kinase 3
chr8_-_132675567 1.84 ENST00000519595.5
leucine rich repeat containing 6
chr6_+_20534441 1.79 ENST00000274695.8
ENST00000613575.4
CDK5 regulatory subunit associated protein 1 like 1
chr9_-_33473884 1.78 ENST00000297990.9
ENST00000353159.6
ENST00000379471.3
nucleolar protein 6
chr1_+_84144260 1.72 ENST00000370685.7
protein kinase cAMP-activated catalytic subunit beta
chr4_+_95091462 1.72 ENST00000264568.8
bone morphogenetic protein receptor type 1B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.4 46.2 GO:0030185 nitric oxide transport(GO:0030185)
3.2 22.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
3.1 9.3 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
2.4 7.3 GO:0051684 maintenance of Golgi location(GO:0051684)
2.3 7.0 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
2.1 14.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
2.0 12.3 GO:0007341 penetration of zona pellucida(GO:0007341)
2.0 25.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
1.8 7.3 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.7 13.8 GO:0014055 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056)
1.7 6.8 GO:0050758 thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) cellular response to folic acid(GO:0071231)
1.7 8.5 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
1.7 16.8 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.6 8.1 GO:2000035 regulation of stem cell division(GO:2000035)
1.4 6.9 GO:0006772 thiamine metabolic process(GO:0006772)
1.4 21.7 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
1.2 7.4 GO:0097338 response to clozapine(GO:0097338)
1.2 13.4 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
1.2 6.0 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
1.2 6.0 GO:1902774 late endosome to lysosome transport(GO:1902774)
1.2 5.9 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
1.1 3.4 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
1.0 3.1 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
1.0 2.9 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
1.0 6.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.9 5.6 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.9 3.7 GO:0080154 regulation of fertilization(GO:0080154)
0.9 3.7 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.9 2.8 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.8 2.5 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.8 5.7 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.8 6.1 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.8 3.0 GO:0016095 polyprenol catabolic process(GO:0016095)
0.7 5.2 GO:0015811 L-cystine transport(GO:0015811)
0.7 2.8 GO:0045917 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.7 8.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.7 18.0 GO:0071420 cellular response to histamine(GO:0071420)
0.7 16.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 1.9 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.6 4.5 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.6 7.8 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.6 4.0 GO:1902731 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.5 5.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.5 9.4 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.5 2.5 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.5 4.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.5 6.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.5 1.4 GO:0032761 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.5 17.8 GO:0048665 neuron fate specification(GO:0048665)
0.5 2.7 GO:0050955 thermoception(GO:0050955)
0.5 10.4 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.4 3.1 GO:0032218 riboflavin transport(GO:0032218)
0.4 18.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.4 2.0 GO:0061107 seminal vesicle development(GO:0061107)
0.4 1.2 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.4 4.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.4 1.9 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.4 2.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.4 4.5 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.4 8.7 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.4 4.5 GO:0003351 epithelial cilium movement(GO:0003351)
0.4 1.1 GO:1902161 transepithelial water transport(GO:0035377) positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.4 1.4 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.3 10.5 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.3 3.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.3 25.6 GO:0007032 endosome organization(GO:0007032)
0.3 8.3 GO:0006067 ethanol metabolic process(GO:0006067)
0.3 4.9 GO:0048263 determination of dorsal identity(GO:0048263)
0.3 7.3 GO:0006833 water transport(GO:0006833)
0.3 3.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.3 1.0 GO:0034201 response to oleic acid(GO:0034201)
0.3 0.8 GO:0035425 autocrine signaling(GO:0035425)
0.3 6.5 GO:0002323 natural killer cell activation involved in immune response(GO:0002323)
0.3 8.8 GO:0030261 chromosome condensation(GO:0030261)
0.3 0.8 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.2 0.7 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883) regulation of locomotion involved in locomotory behavior(GO:0090325)
0.2 2.2 GO:0070166 enamel mineralization(GO:0070166)
0.2 6.9 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.2 3.8 GO:0034505 tooth mineralization(GO:0034505)
0.2 20.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 12.3 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.2 2.1 GO:0006108 malate metabolic process(GO:0006108)
0.2 2.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 1.5 GO:0061709 reticulophagy(GO:0061709)
0.2 7.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 2.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 3.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 0.8 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 1.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 8.1 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.2 1.4 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 0.9 GO:0035063 nuclear speck organization(GO:0035063)
0.2 13.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 9.3 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 4.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 3.6 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 2.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 2.0 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.1 7.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.9 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 0.3 GO:1902617 response to fluoride(GO:1902617)
0.1 1.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 1.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.1 GO:0045794 negative regulation of cell volume(GO:0045794) smooth muscle contraction involved in micturition(GO:0060083)
0.1 6.2 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 11.7 GO:0070268 cornification(GO:0070268)
0.1 0.1 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 1.7 GO:0005513 detection of calcium ion(GO:0005513)
0.1 7.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.3 GO:0045475 locomotor rhythm(GO:0045475)
0.1 2.4 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 1.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 3.6 GO:1901998 toxin transport(GO:1901998)
0.1 2.0 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 1.1 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 0.6 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 1.6 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 10.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 1.9 GO:0033189 response to vitamin A(GO:0033189)
0.1 5.3 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 2.9 GO:0051693 actin filament capping(GO:0051693)
0.1 1.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 4.8 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 4.3 GO:0098869 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.9 GO:0030825 positive regulation of cGMP metabolic process(GO:0030825) positive regulation of cGMP biosynthetic process(GO:0030828)
0.0 2.1 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 1.5 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.4 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 1.1 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 3.1 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 1.8 GO:0006400 tRNA modification(GO:0006400)
0.0 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.2 GO:0044351 macropinocytosis(GO:0044351)
0.0 1.9 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.0 0.1 GO:2000523 defense response to nematode(GO:0002215) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.4 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.4 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 1.6 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 1.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.1 GO:1990822 basic amino acid transmembrane transport(GO:1990822)
0.0 0.9 GO:0007588 excretion(GO:0007588)
0.0 2.7 GO:0007601 visual perception(GO:0007601)
0.0 0.1 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 1.2 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.0 0.7 GO:0006501 C-terminal protein lipidation(GO:0006501)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.0 48.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
1.4 12.3 GO:0044294 dendritic growth cone(GO:0044294)
1.3 14.4 GO:0043203 axon hillock(GO:0043203)
1.0 5.7 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.8 3.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.8 2.5 GO:0016939 kinesin II complex(GO:0016939)
0.8 5.6 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.7 2.0 GO:0036028 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.7 4.0 GO:0032584 growth cone membrane(GO:0032584)
0.7 5.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.6 7.8 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6 6.8 GO:0031209 SCAR complex(GO:0031209)
0.6 7.7 GO:0001673 male germ cell nucleus(GO:0001673)
0.5 8.8 GO:0000786 nucleosome(GO:0000786)
0.5 17.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.5 11.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.5 6.0 GO:0030897 HOPS complex(GO:0030897)
0.4 18.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 7.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 21.7 GO:0048786 presynaptic active zone(GO:0048786)
0.4 1.1 GO:0071752 dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752) IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
0.4 2.8 GO:0005579 membrane attack complex(GO:0005579)
0.3 4.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 8.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 5.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 1.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.2 2.9 GO:0008091 spectrin(GO:0008091)
0.2 5.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 1.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 3.7 GO:0002080 acrosomal membrane(GO:0002080)
0.1 3.8 GO:0032982 myosin filament(GO:0032982)
0.1 2.9 GO:0036020 endolysosome membrane(GO:0036020)
0.1 2.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 3.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 2.4 GO:0043194 axon initial segment(GO:0043194)
0.1 3.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 2.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.5 GO:1990130 Iml1 complex(GO:1990130)
0.1 3.6 GO:0001533 cornified envelope(GO:0001533)
0.1 5.2 GO:0031526 brush border membrane(GO:0031526)
0.1 18.6 GO:0005802 trans-Golgi network(GO:0005802)
0.1 4.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.8 GO:0030686 90S preribosome(GO:0030686)
0.1 9.3 GO:0016363 nuclear matrix(GO:0016363)
0.1 9.1 GO:0043197 dendritic spine(GO:0043197)
0.1 8.5 GO:0043204 perikaryon(GO:0043204)
0.1 3.8 GO:0036126 sperm flagellum(GO:0036126)
0.0 8.0 GO:0030018 Z disc(GO:0030018)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 3.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 7.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 7.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 2.8 GO:0019898 extrinsic component of membrane(GO:0019898)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 48.1 GO:0030492 hemoglobin binding(GO:0030492)
4.5 26.9 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
2.7 8.2 GO:0016497 substance K receptor activity(GO:0016497)
2.1 8.5 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
1.8 7.3 GO:0004031 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
1.8 5.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
1.8 7.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
1.7 6.9 GO:0004802 transketolase activity(GO:0004802)
1.7 6.8 GO:0061714 folic acid receptor activity(GO:0061714)
1.7 5.0 GO:0052854 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
1.5 5.9 GO:0016019 peptidoglycan receptor activity(GO:0016019)
1.4 5.6 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
1.3 3.9 GO:0042806 fucose binding(GO:0042806)
1.2 13.4 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
1.2 16.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.1 18.0 GO:0008503 benzodiazepine receptor activity(GO:0008503)
1.1 3.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
1.0 3.0 GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
1.0 5.9 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.9 8.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.8 4.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.8 3.1 GO:0019770 IgG receptor activity(GO:0019770)
0.7 5.2 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.7 2.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.7 2.7 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.6 3.6 GO:0015057 thrombin receptor activity(GO:0015057)
0.6 7.0 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.5 26.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 3.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.5 3.8 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.5 2.3 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.5 3.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.5 2.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.5 7.4 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.5 7.3 GO:0015250 water channel activity(GO:0015250)
0.4 3.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.4 1.3 GO:0017129 triglyceride binding(GO:0017129)
0.4 7.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.4 4.4 GO:0005549 odorant binding(GO:0005549)
0.4 6.5 GO:0005132 type I interferon receptor binding(GO:0005132)
0.4 10.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.4 9.3 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.4 1.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.3 4.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.3 1.9 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.3 1.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.3 17.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.3 0.9 GO:0008502 melatonin receptor activity(GO:0008502)
0.3 5.3 GO:0070513 death domain binding(GO:0070513)
0.3 4.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 3.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3 5.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 2.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 15.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 3.1 GO:0019864 IgG binding(GO:0019864)
0.2 1.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 3.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 2.0 GO:0032190 acrosin binding(GO:0032190)
0.2 3.8 GO:0031432 titin binding(GO:0031432)
0.2 1.1 GO:0019862 IgA binding(GO:0019862)
0.2 40.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 4.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 3.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 0.9 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.2 15.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 1.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 31.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 3.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 4.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 14.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 4.7 GO:0005109 frizzled binding(GO:0005109)
0.1 2.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 10.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 6.9 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.4 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 3.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.4 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 1.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.0 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.1 1.7 GO:0031005 filamin binding(GO:0031005)
0.1 2.4 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 3.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.6 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 5.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 8.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 8.1 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 40.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.5 GO:0019894 kinesin binding(GO:0019894)
0.0 3.5 GO:0019843 rRNA binding(GO:0019843)
0.0 2.7 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.2 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 3.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 6.2 GO:0042393 histone binding(GO:0042393)
0.0 3.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.4 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 4.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0019956 chemokine binding(GO:0019956)
0.0 4.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.6 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 11.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 1.8 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.6 GO:0022843 voltage-gated cation channel activity(GO:0022843)
0.0 4.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 4.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 3.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 10.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 4.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 7.4 PID IL3 PATHWAY IL3-mediated signaling events
0.1 6.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 9.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 7.2 PID BMP PATHWAY BMP receptor signaling
0.1 9.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 13.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 2.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 6.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 23.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 1.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.4 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 3.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 26.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
1.0 9.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.8 18.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.6 7.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 17.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.5 18.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.5 5.9 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.4 8.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 11.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 6.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.3 47.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 7.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 22.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 5.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.3 5.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 3.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 3.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 13.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 15.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 3.6 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2 3.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 3.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 2.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 3.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 4.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 4.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 8.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 4.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 4.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 12.6 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 1.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 3.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 3.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 8.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 5.7 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 1.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 7.4 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation