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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for EN2_GBX2_LBX2

Z-value: 2.48

Motif logo

Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol Gene ID Gene Info
ENSG00000164778.4 EN2
ENSG00000168505.7 GBX2
ENSG00000179528.16 LBX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EN2hg38_v1_chr7_+_155458129_1554581290.283.0e-05Click!
GBX2hg38_v1_chr2_-_236168376_2361683950.203.7e-03Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_-_223602284 12.69 ENST00000421386.1
ENST00000305409.3
ENST00000433889.1
secretogranin II
chr3_+_111999189 11.61 ENST00000455401.6
transgelin 3
chr3_+_111999326 11.43 ENST00000494932.1
transgelin 3
chr3_+_111998739 11.37 ENST00000393917.6
ENST00000273368.8
transgelin 3
chr3_+_115623502 10.96 ENST00000305124.11
ENST00000393780.3
growth associated protein 43
chr16_-_29899532 10.80 ENST00000308713.9
ENST00000617533.5
seizure related 6 homolog like 2
chr3_+_111998915 10.74 ENST00000478951.6
transgelin 3
chr5_+_141484997 9.34 ENST00000617094.1
ENST00000306593.2
ENST00000610539.1
ENST00000618371.4
protocadherin gamma subfamily C, 4
chr7_+_70596078 9.31 ENST00000644506.1
activator of transcription and developmental regulator AUTS2
chr4_+_112860981 9.00 ENST00000671704.1
ankyrin 2
chr4_+_112860912 8.89 ENST00000671951.1
ankyrin 2
chr12_-_6124662 8.74 ENST00000261405.10
von Willebrand factor
chr4_+_112861053 8.66 ENST00000672221.1
ankyrin 2
chr16_-_29899245 7.88 ENST00000537485.5
seizure related 6 homolog like 2
chr16_+_7303245 7.70 ENST00000674626.1
RNA binding fox-1 homolog 1
chr8_+_104223320 7.43 ENST00000339750.3
regulating synaptic membrane exocytosis 2
chr7_-_137343752 7.39 ENST00000393083.2
pleiotrophin
chr6_+_39792298 7.21 ENST00000633794.1
ENST00000274867.9
dishevelled associated activator of morphogenesis 2
chr14_+_103715724 6.88 ENST00000216602.10
zinc finger FYVE-type containing 21
chr14_+_103715767 6.72 ENST00000311141.7
zinc finger FYVE-type containing 21
chrM_+_12329 6.38 ENST00000361567.2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr11_-_117876719 5.70 ENST00000529335.6
ENST00000260282.8
FXYD domain containing ion transport regulator 6
chr8_+_104223344 5.69 ENST00000523362.5
regulating synaptic membrane exocytosis 2
chr11_-_117877463 5.58 ENST00000527717.5
FXYD domain containing ion transport regulator 6
chr11_-_117876892 5.56 ENST00000539526.5
FXYD domain containing ion transport regulator 6
chr3_+_167735704 5.46 ENST00000446050.7
ENST00000295777.9
ENST00000472747.2
serpin family I member 1
chr5_+_67004618 5.23 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr4_-_56681588 4.95 ENST00000554144.5
ENST00000381260.7
HOP homeobox
chr4_-_56681288 4.84 ENST00000556376.6
ENST00000420433.6
HOP homeobox
chr10_-_49762276 4.76 ENST00000374103.9
oxoglutarate dehydrogenase L
chr10_-_49762335 4.75 ENST00000419399.4
ENST00000432695.2
oxoglutarate dehydrogenase L
chr12_-_16606795 4.72 ENST00000447609.5
LIM domain only 3
chr14_+_99481395 4.64 ENST00000389879.9
ENST00000557441.5
ENST00000555049.5
ENST00000555842.1
cyclin K
chr10_-_97687191 4.23 ENST00000370626.4
arginine vasopressin induced 1
chr5_+_126423363 3.92 ENST00000285689.8
GRAM domain containing 2B
chr11_+_67483119 3.92 ENST00000682659.1
ENST00000525341.2
aryl hydrocarbon receptor interacting protein
chr11_-_129192198 3.88 ENST00000310343.13
Rho GTPase activating protein 32
chr6_+_31815532 3.80 ENST00000375651.7
ENST00000608703.1
heat shock protein family A (Hsp70) member 1A
chr5_+_126423176 3.79 ENST00000542322.5
ENST00000544396.5
GRAM domain containing 2B
chr5_+_126423122 3.78 ENST00000515200.5
GRAM domain containing 2B
chr1_-_117929557 3.77 ENST00000369442.3
ENST00000369443.10
ganglioside induced differentiation associated protein 2
chr12_+_26195313 3.77 ENST00000422622.3
sarcospan
chr14_-_103715433 3.71 ENST00000554913.5
ENST00000555055.6
ENST00000554974.5
ENST00000553361.5
ENST00000555964.5
ENST00000556682.5
ENST00000553332.5
ENST00000352127.11
X-ray repair cross complementing 3
chr6_-_39725387 3.65 ENST00000287152.12
kinesin family member 6
chr22_+_41381923 3.62 ENST00000266304.9
TEF transcription factor, PAR bZIP family member
chr17_-_10114546 3.35 ENST00000323816.8
growth arrest specific 7
chr12_+_6904733 3.23 ENST00000007969.12
ENST00000622489.4
ENST00000443597.7
ENST00000323702.9
leucine rich repeat containing 23
chr4_-_145180496 2.88 ENST00000447906.8
OTU deubiquitinase 4
chr14_-_74084393 2.87 ENST00000350259.8
ENST00000553458.6
aldehyde dehydrogenase 6 family member A1
chr11_+_67483019 2.62 ENST00000279146.8
ENST00000528641.7
ENST00000682324.1
ENST00000684006.1
ENST00000683237.1
ENST00000684657.1
aryl hydrocarbon receptor interacting protein
chr14_+_32329256 2.53 ENST00000280979.9
A-kinase anchoring protein 6
chr3_+_35680994 2.52 ENST00000441454.5
cAMP regulated phosphoprotein 21
chr8_+_42152946 2.50 ENST00000518421.5
ENST00000174653.3
ENST00000396926.8
ENST00000521280.5
ENST00000522288.5
adaptor related protein complex 3 subunit mu 2
chr7_-_83649097 2.47 ENST00000643230.2
semaphorin 3E
chr1_+_145927105 2.38 ENST00000437797.5
ENST00000601726.3
ENST00000599626.5
ENST00000599147.5
ENST00000595494.5
ENST00000595518.5
ENST00000597144.5
ENST00000599469.5
ENST00000598354.5
ENST00000598103.5
ENST00000600340.5
ENST00000630257.2
ENST00000625258.1
LIX1L antisense RNA 1
novel protein, lncRNA-POLR3GL readthrough
chr1_-_145095528 2.28 ENST00000612199.4
ENST00000641863.1
SLIT-ROBO Rho GTPase activating protein 2B
chr4_+_70721953 2.19 ENST00000381006.8
ENST00000226328.8
RUN and FYVE domain containing 3
chr8_-_18887018 2.08 ENST00000523619.5
pleckstrin and Sec7 domain containing 3
chr2_+_64989343 2.04 ENST00000234256.4
solute carrier family 1 member 4
chr14_+_74084947 2.00 ENST00000674221.1
ENST00000554938.2
lin-52 DREAM MuvB core complex component
chr1_+_121184964 1.98 ENST00000367123.8
SLIT-ROBO Rho GTPase activating protein 2C
chr10_-_97445850 1.96 ENST00000477692.6
ENST00000485122.6
ENST00000370886.9
ENST00000370885.8
ENST00000370902.8
ENST00000370884.5
exosome component 1
chr4_+_7043315 1.89 ENST00000310074.8
ENST00000512388.1
transcriptional adaptor 2B
chr8_+_9555900 1.76 ENST00000310430.11
ENST00000520408.5
ENST00000522110.1
tankyrase
chr12_+_80716906 1.75 ENST00000228644.4
myogenic factor 5
chr2_+_30146941 1.63 ENST00000379520.7
ENST00000379519.7
yippee like 5
chr1_-_151790475 1.57 ENST00000368825.7
ENST00000368823.5
ENST00000368824.8
ENST00000458431.6
ENST00000368827.10
ENST00000440583.6
tudor and KH domain containing
chr1_+_100538131 1.46 ENST00000315033.5
G protein-coupled receptor 88
chr10_-_73591330 1.45 ENST00000451492.5
ENST00000681793.1
ENST00000680396.1
ENST00000413442.5
ubiquitin specific peptidase 54
chr19_-_10010492 1.40 ENST00000264828.4
collagen type V alpha 3 chain
chr8_-_33567118 1.39 ENST00000256257.2
ring finger protein 122
chr2_+_30146993 1.38 ENST00000261353.9
ENST00000402003.7
yippee like 5
chr12_+_26195543 1.35 ENST00000242729.7
sarcospan
chr20_+_18507520 1.30 ENST00000336714.8
ENST00000646240.1
ENST00000450074.6
ENST00000262544.6
SEC23 homolog B, COPII coat complex component
chr19_-_19192122 1.27 ENST00000444486.7
ENST00000514819.7
ENST00000585679.1
ENST00000462790.8
myocyte enhancer factor 2B
BORCS8-MEF2B readthrough
BLOC-1 related complex subunit 8
chr6_-_62286161 1.27 ENST00000281156.5
KH RNA binding domain containing, signal transduction associated 2
chr19_+_4007714 1.27 ENST00000262971.3
protein inhibitor of activated STAT 4
chr19_+_14529580 1.25 ENST00000215567.10
trans-2,3-enoyl-CoA reductase
chr2_-_156332694 1.25 ENST00000424077.1
ENST00000426264.5
ENST00000421709.1
ENST00000339562.9
nuclear receptor subfamily 4 group A member 2
chr3_+_4680617 1.17 ENST00000648212.1
inositol 1,4,5-trisphosphate receptor type 1
chr8_+_49911396 1.16 ENST00000642720.2
syntrophin gamma 1
chr3_-_138329839 1.15 ENST00000333911.9
ENST00000383180.6
NME/NM23 family member 9
chr17_-_76167078 1.14 ENST00000591615.1
ring finger protein 157
chr15_-_37101205 1.13 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
Meis homeobox 2
chr2_+_170178136 1.09 ENST00000409044.7
ENST00000408978.9
myosin IIIB
chr6_-_99425269 1.08 ENST00000647811.1
ENST00000481229.2
ENST00000369239.10
ENST00000681611.1
ENST00000681615.1
ENST00000438806.5
PNN interacting serine and arginine rich protein
chr1_-_145927447 1.07 ENST00000632555.1
ENST00000369307.4
ENST00000583313.7
RNA binding motif protein 8A
chr12_-_89352487 0.97 ENST00000548755.1
ENST00000279488.8
dual specificity phosphatase 6
chr5_+_141923813 0.95 ENST00000194118.8
ENST00000432126.7
DAP3 binding cell death enhancer 1
chr14_-_81533800 0.95 ENST00000555824.5
ENST00000557372.1
ENST00000336735.9
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
chr5_+_54455661 0.94 ENST00000302005.3
heat shock protein family B (small) member 3
chr6_-_26199272 0.93 ENST00000650491.1
ENST00000635200.1
ENST00000341023.2
novel protein
H2A clustered histone 7
chr1_+_206203541 0.93 ENST00000573034.8
SLIT-ROBO Rho GTPase activating protein 2
chr10_+_84194527 0.89 ENST00000623527.4
cadherin related family member 1
chr22_-_38794111 0.86 ENST00000406622.5
ENST00000216068.9
ENST00000406199.3
Sad1 and UNC84 domain containing 2
dynein axonemal light chain 4
chr6_+_26020442 0.85 ENST00000613854.2
H3 clustered histone 1
chr19_-_14529193 0.82 ENST00000596853.6
ENST00000676515.1
ENST00000678338.1
ENST00000595992.6
ENST00000677848.1
ENST00000677762.1
ENST00000678009.1
ENST00000596075.2
ENST00000601533.6
ENST00000396969.8
ENST00000598692.2
ENST00000678098.1
DnaJ heat shock protein family (Hsp40) member B1
chr3_-_112641128 0.80 ENST00000206423.8
coiled-coil domain containing 80
chrX_+_130339941 0.80 ENST00000218197.9
solute carrier family 25 member 14
chr12_-_101210232 0.76 ENST00000536262.3
solute carrier family 5 member 8
chr7_-_73624492 0.69 ENST00000414749.6
ENST00000429400.6
ENST00000434326.5
ENST00000313375.8
ENST00000354613.5
ENST00000453275.1
MLX interacting protein like
chr22_-_33572227 0.63 ENST00000674780.1
LARGE xylosyl- and glucuronyltransferase 1
chr12_+_6904962 0.59 ENST00000415834.5
ENST00000436789.5
leucine rich repeat containing 23
chr1_-_68232539 0.58 ENST00000370976.7
ENST00000354777.6
Wnt ligand secretion mediator
chr1_-_152414256 0.57 ENST00000271835.3
cornulin
chr6_-_100464912 0.55 ENST00000369208.8
SIM bHLH transcription factor 1
chrX_+_96684801 0.50 ENST00000324765.13
diaphanous related formin 2
chr8_-_42768602 0.45 ENST00000534622.5
cholinergic receptor nicotinic alpha 6 subunit
chr1_-_68232514 0.45 ENST00000262348.9
ENST00000370973.2
ENST00000370971.1
Wnt ligand secretion mediator
chrX_+_101098165 0.43 ENST00000684367.1
ENST00000423383.3
ENST00000682304.1
ENST00000682095.1
ENST00000403304.6
ENST00000435570.1
centromere protein I
chr10_+_133237849 0.43 ENST00000325980.10
VENT homeobox
chr6_-_111606260 0.41 ENST00000340026.10
TRAF3 interacting protein 2
chr7_+_99828010 0.38 ENST00000631161.2
ENST00000354829.7
ENST00000342499.8
ENST00000417625.5
ENST00000415413.5
ENST00000444905.5
ENST00000222382.5
ENST00000312017.9
cytochrome P450 family 3 subfamily A member 43
chr17_-_8190154 0.35 ENST00000389017.6
BLOC-1 related complex subunit 6
chr6_-_111605859 0.33 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3 interacting protein 2
chr11_-_13496018 0.32 ENST00000529816.1
parathyroid hormone
chr21_-_42395943 0.32 ENST00000398405.5
transmembrane serine protease 3
chr19_-_15125659 0.29 ENST00000533747.1
ENST00000598709.1
ENST00000534378.5
ilvB acetolactate synthase like
chr1_-_117121692 0.28 ENST00000256649.9
ENST00000369464.7
ENST00000485032.1
tripartite motif containing 45
chr19_-_15125751 0.28 ENST00000263383.8
ilvB acetolactate synthase like
chr22_+_39520553 0.25 ENST00000674920.3
ENST00000679776.1
ENST00000675582.2
ENST00000337304.2
ENST00000676346.2
ENST00000396680.3
ENST00000680446.1
ENST00000674568.2
ENST00000680748.1
ENST00000674835.2
activating transcription factor 4
chr19_-_41364119 0.23 ENST00000243578.8
B9 domain containing 2
chr9_+_12693327 0.22 ENST00000388918.10
tyrosinase related protein 1
chr8_+_49911604 0.21 ENST00000642164.1
ENST00000644093.1
ENST00000643999.1
ENST00000647073.1
ENST00000646880.1
syntrophin gamma 1
chr13_-_36214521 0.21 ENST00000379881.8
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr2_-_162152404 0.18 ENST00000375497.3
glucagon
chr6_+_111087495 0.13 ENST00000612036.4
ENST00000368851.10
solute carrier family 16 member 10
chr14_+_32329341 0.12 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
A-kinase anchoring protein 6
chr6_-_161274010 0.09 ENST00000366911.9
ENST00000366905.3
1-acylglycerol-3-phosphate O-acyltransferase 4
chr8_-_86743626 0.07 ENST00000320005.6
cyclic nucleotide gated channel subunit beta 3
chr6_-_161274042 0.06 ENST00000320285.9
1-acylglycerol-3-phosphate O-acyltransferase 4
chrX_+_96684712 0.05 ENST00000373049.8
diaphanous related formin 2
chr3_+_173398438 0.02 ENST00000457714.5
neuroligin 1
chr17_-_48968587 0.02 ENST00000357424.2
gastric inhibitory polypeptide
chr12_-_89352395 0.01 ENST00000308385.6
dual specificity phosphatase 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.3 GO:0098582 innate vocalization behavior(GO:0098582)
2.7 26.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.5 7.4 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
1.5 4.6 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
1.5 13.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
1.2 3.7 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
1.2 11.0 GO:0016198 axon choice point recognition(GO:0016198)
1.0 2.9 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
1.0 3.8 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.9 12.7 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.7 4.7 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.6 6.5 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.6 1.8 GO:0034183 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) protein auto-ADP-ribosylation(GO:0070213) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of telomeric DNA binding(GO:1904742) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.4 9.8 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.4 2.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.4 1.3 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.4 2.0 GO:0015808 L-alanine transport(GO:0015808)
0.4 3.8 GO:0021814 cell motility involved in cerebral cortex radial glia guided migration(GO:0021814) modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.3 1.0 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.3 8.6 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.3 1.5 GO:0061743 motor learning(GO:0061743)
0.2 1.0 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 14.4 GO:0006458 'de novo' protein folding(GO:0006458)
0.2 1.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 1.3 GO:1902231 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 15.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 1.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 1.8 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 2.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.7 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 8.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 6.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 2.9 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.2 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 2.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.3 GO:0030497 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 2.5 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 0.2 GO:0072366 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.1 9.5 GO:0006757 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 7.2 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 1.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 2.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 2.0 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.8 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 1.9 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.0 0.2 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 5.5 GO:0007422 peripheral nervous system development(GO:0007422)
0.0 1.0 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.7 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 3.8 GO:0032526 response to retinoic acid(GO:0032526)
0.0 1.4 GO:0030199 collagen fibril organization(GO:0030199)
0.0 41.1 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 5.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.3 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 2.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 3.7 GO:0007018 microtubule-based movement(GO:0007018)
0.0 2.7 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.4 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0070327 aromatic amino acid transport(GO:0015801) thyroid hormone transport(GO:0070327)
0.0 0.0 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 11.0 GO:0032584 growth cone membrane(GO:0032584)
1.4 9.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
1.2 4.6 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
1.1 6.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.7 2.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.6 3.7 GO:0033063 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.6 12.7 GO:0031045 dense core granule(GO:0031045)
0.5 1.4 GO:0005588 collagen type V trimer(GO:0005588)
0.5 26.6 GO:0031430 M band(GO:0031430)
0.4 1.6 GO:0071546 pi-body(GO:0071546)
0.3 2.7 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.3 3.7 GO:0001673 male germ cell nucleus(GO:0001673)
0.2 13.1 GO:0048786 presynaptic active zone(GO:0048786)
0.2 1.0 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.2 0.9 GO:0044327 dendritic spine head(GO:0044327)
0.2 6.0 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 45.1 GO:0043209 myelin sheath(GO:0043209)
0.2 11.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 1.9 GO:0030914 STAGA complex(GO:0030914)
0.1 6.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.8 GO:0097431 pericentriolar material(GO:0000242) mitotic spindle pole(GO:0097431)
0.1 7.4 GO:0031594 neuromuscular junction(GO:0031594)
0.1 8.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 3.8 GO:0016235 aggresome(GO:0016235)
0.1 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 2.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 7.1 GO:0043204 perikaryon(GO:0043204)
0.0 3.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 3.6 GO:0043197 dendritic spine(GO:0043197)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 7.9 GO:0005925 focal adhesion(GO:0005925)
0.0 5.4 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 14.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 13.6 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
1.9 9.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
1.8 7.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.2 11.0 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.5 3.7 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.4 26.6 GO:0030507 spectrin binding(GO:0030507)
0.4 2.0 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.3 3.8 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.3 5.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.3 1.3 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.2 15.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 7.1 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 4.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 1.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 3.5 GO:0043495 protein anchor(GO:0043495)
0.2 42.1 GO:0051015 actin filament binding(GO:0051015)
0.2 2.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 2.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 6.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 4.7 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.6 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 13.1 GO:0044325 ion channel binding(GO:0044325)
0.1 5.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 2.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 6.2 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 5.9 GO:0003774 motor activity(GO:0003774)
0.0 1.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 2.0 GO:0004532 exoribonuclease activity(GO:0004532)
0.0 1.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 2.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.4 GO:0043394 proteoglycan binding(GO:0043394)
0.0 0.8 GO:0001968 fibronectin binding(GO:0001968)
0.0 7.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 2.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.6 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 11.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 3.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 5.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.0 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.2 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 4.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 2.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 2.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.0 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 2.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.9 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway