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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ESRRB_ESRRG

Z-value: 8.75

Motif logo

Transcription factors associated with ESRRB_ESRRG

Gene Symbol Gene ID Gene Info
ENSG00000119715.15 ESRRB
ENSG00000196482.18 ESRRG

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ESRRGhg38_v1_chr1_-_217076889_217076997-0.546.4e-18Click!

Activity profile of ESRRB_ESRRG motif

Sorted Z-values of ESRRB_ESRRG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ESRRB_ESRRG

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr8_+_144095054 108.81 ENST00000318911.5
cytochrome c1
chr2_-_175181663 85.47 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP synthase membrane subunit c locus 3
chr1_+_40988513 67.94 ENST00000649215.1
CTP synthase 1
chr20_-_63499074 65.50 ENST00000217182.6
ENST00000642899.1
eukaryotic translation elongation factor 1 alpha 2
chr15_-_72231583 50.14 ENST00000566809.1
ENST00000567087.5
ENST00000569050.1
ENST00000568883.5
pyruvate kinase M1/2
chr15_-_72231113 48.91 ENST00000565154.6
ENST00000565184.6
ENST00000335181.10
pyruvate kinase M1/2
chr10_+_79347491 43.69 ENST00000448165.1
peptidylprolyl isomerase F
chr7_-_29990113 42.22 ENST00000426154.5
ENST00000421434.5
ENST00000434476.6
secernin 1
chr14_-_58427114 41.70 ENST00000556007.6
translocase of inner mitochondrial membrane 9
chr14_-_103521342 41.42 ENST00000553610.5
creatine kinase B
chr16_-_47143934 41.34 ENST00000562435.6
neuropilin and tolloid like 2
chr2_+_197500398 41.17 ENST00000604458.1
HSPE1-MOB4 readthrough
chr7_+_128758947 40.99 ENST00000493278.1
calumenin
chr14_-_103522696 40.81 ENST00000553878.5
ENST00000348956.7
ENST00000557530.1
creatine kinase B
chr3_-_42804451 40.41 ENST00000418900.6
ENST00000321331.12
ENST00000430190.5
ENST00000648550.1
HIG1 hypoxia inducible domain family member 1A
novel protein
chr11_+_68030896 39.89 ENST00000525628.1
NADH:ubiquinone oxidoreductase core subunit S8
chr19_-_29213110 38.39 ENST00000304863.6
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr2_+_197500371 38.21 ENST00000409468.1
ENST00000233893.10
heat shock protein family E (Hsp10) member 1
chr7_-_29989774 38.17 ENST00000242059.10
secernin 1
chr1_-_17054015 38.13 ENST00000375499.8
succinate dehydrogenase complex iron sulfur subunit B
chr12_+_6867420 37.90 ENST00000613953.4
ENST00000396705.10
triosephosphate isomerase 1
chr2_-_43995999 37.47 ENST00000683213.1
ENST00000409946.6
leucine rich pentatricopeptide repeat containing
chr17_+_81703356 37.17 ENST00000333676.8
ENST00000571730.1
mitochondrial ribosomal protein L12
novel protein
chr16_+_21953341 37.12 ENST00000268379.9
ENST00000561553.5
ENST00000565331.5
ubiquinol-cytochrome c reductase core protein 2
chr1_-_149917826 36.81 ENST00000369145.1
ENST00000369146.8
synaptic vesicle glycoprotein 2A
chr12_-_56645955 36.50 ENST00000552959.5
ENST00000551020.5
ENST00000553007.2
ENST00000262030.8
ATP synthase F1 subunit beta
chr12_+_120438107 36.33 ENST00000229379.3
ENST00000551806.1
cytochrome c oxidase subunit 6A1
novel protein
chr20_+_3796288 36.26 ENST00000439880.6
ENST00000245960.10
cell division cycle 25B
chr16_-_85799554 35.08 ENST00000435200.2
ER membrane protein complex subunit 8
chr2_-_43995950 34.82 ENST00000683590.1
ENST00000683623.1
ENST00000682779.1
ENST00000682546.1
ENST00000683220.1
ENST00000683125.1
ENST00000683833.1
ENST00000683989.1
ENST00000682480.1
ENST00000260665.12
ENST00000682308.1
ENST00000682885.1
ENST00000409659.6
ENST00000447246.2
leucine rich pentatricopeptide repeat containing
chr15_+_43593054 34.47 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
creatine kinase, mitochondrial 1B
chr11_+_57712574 34.45 ENST00000278422.9
ENST00000378312.8
thioredoxin related transmembrane protein 2
chr11_+_66002754 34.40 ENST00000527348.1
BAF nuclear assembly factor 1
chr12_+_6534510 34.16 ENST00000229239.10
ENST00000396856.5
ENST00000396861.5
glyceraldehyde-3-phosphate dehydrogenase
chr1_+_165631199 34.07 ENST00000367888.8
ENST00000367889.8
ENST00000367885.5
ENST00000367884.6
microsomal glutathione S-transferase 3
chr14_-_58427158 33.98 ENST00000555097.1
ENST00000556367.6
ENST00000555404.5
translocase of inner mitochondrial membrane 9
chr11_+_34916611 33.75 ENST00000227868.9
ENST00000430469.6
ENST00000533262.1
pyruvate dehydrogenase complex component X
chr3_+_179604785 33.66 ENST00000611971.4
ENST00000493866.5
ENST00000259037.8
ENST00000472629.5
ENST00000482604.5
NADH:ubiquinone oxidoreductase subunit B5
chr14_-_58427134 33.13 ENST00000555930.6
translocase of inner mitochondrial membrane 9
chr2_-_105438503 33.12 ENST00000393352.7
ENST00000607522.1
four and a half LIM domains 2
chr4_-_70839343 33.09 ENST00000514161.5
ENST00000499044.6
G-rich RNA sequence binding factor 1
chr2_-_86194972 32.53 ENST00000254636.9
inner membrane mitochondrial protein
chr1_+_201955496 32.51 ENST00000367287.5
translocase of inner mitochondrial membrane 17A
chr8_-_99893697 32.07 ENST00000518171.5
ENST00000520468.7
cytochrome c oxidase subunit 6C
chr16_-_85799503 31.86 ENST00000253457.8
ER membrane protein complex subunit 8
chr1_-_241519701 31.63 ENST00000366560.4
ENST00000683521.1
fumarate hydratase
chr19_-_12801787 31.59 ENST00000334482.9
ENST00000301522.3
peroxiredoxin 2
chr10_+_58269132 31.34 ENST00000333926.6
CDGSH iron sulfur domain 1
chr2_+_86199355 31.15 ENST00000254644.12
ENST00000605125.5
ENST00000337109.9
ENST00000409180.1
mitochondrial ribosomal protein L35
chr20_-_37527723 30.89 ENST00000397135.1
ENST00000397137.5
BLCAP apoptosis inducing factor
chr20_-_37527862 30.79 ENST00000373537.7
ENST00000445723.5
ENST00000414080.1
BLCAP apoptosis inducing factor
chr9_-_32573150 30.66 ENST00000379847.8
ENST00000350021.2
NADH:ubiquinone oxidoreductase subunit B6
chr16_-_46973634 30.65 ENST00000317089.10
DnaJ heat shock protein family (Hsp40) member A2
chr8_-_99893622 29.88 ENST00000520271.5
ENST00000522940.5
ENST00000523016.1
ENST00000517682.6
ENST00000297564.6
cytochrome c oxidase subunit 6C
chr7_+_44796677 29.42 ENST00000451562.5
ENST00000489459.5
ENST00000355968.10
ENST00000677107.1
ENST00000468812.6
ENST00000620047.5
peptidylprolyl isomerase A
chr3_-_167734465 29.22 ENST00000487947.6
programmed cell death 10
chr19_+_34365173 29.07 ENST00000589640.5
ENST00000591204.5
ENST00000589399.6
ENST00000356487.11
glucose-6-phosphate isomerase
chr9_-_128127711 28.94 ENST00000449878.1
ENST00000338961.11
ENST00000678174.1
prostaglandin E synthase 2
chr5_-_140647590 28.69 ENST00000252102.9
ENST00000512088.1
NADH:ubiquinone oxidoreductase subunit A2
chr19_+_34365240 27.66 ENST00000586425.2
glucose-6-phosphate isomerase
chr8_+_54135203 27.25 ENST00000260102.9
ENST00000519831.5
mitochondrial ribosomal protein L15
chr11_-_790062 27.20 ENST00000330106.5
cell cycle exit and neuronal differentiation 1
chr21_-_25734887 26.63 ENST00000400094.5
ENST00000284971.8
ATP synthase peripheral stalk subunit F6
chr9_-_127874964 26.56 ENST00000373156.5
adenylate kinase 1
chr20_-_37527891 26.53 ENST00000414542.6
BLCAP apoptosis inducing factor
chr7_-_10940123 26.47 ENST00000339600.6
NDUFA4 mitochondrial complex associated
chr21_-_25735026 25.65 ENST00000400099.5
ENST00000457143.6
ATP synthase peripheral stalk subunit F6
chr3_-_9986682 25.58 ENST00000429759.5
ER membrane protein complex subunit 3
chr11_-_707063 25.57 ENST00000683307.1
DEAF1 transcription factor
chr15_+_78149354 25.47 ENST00000558554.5
ENST00000557826.5
ENST00000561279.5
ENST00000299518.7
ENST00000559186.5
ENST00000560770.5
ENST00000559881.5
ENST00000559205.1
ENST00000629769.2
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
chr9_-_32573173 25.22 ENST00000366466.5
NADH:ubiquinone oxidoreductase subunit B6
chr8_+_109334317 25.21 ENST00000521662.5
ENST00000520147.5
ENST00000521688.6
ENY2 transcription and export complex 2 subunit
chr2_-_219254558 24.99 ENST00000392088.6
tubulin alpha 4a
chr3_-_48609625 24.99 ENST00000203407.6
ubiquinol-cytochrome c reductase core protein 1
chr11_+_68030644 24.96 ENST00000453471.6
ENST00000313468.10
ENST00000528492.1
ENST00000526339.5
ENST00000525419.5
NADH:ubiquinone oxidoreductase core subunit S8
chr11_+_66002475 24.84 ENST00000312175.7
ENST00000533166.5
BAF nuclear assembly factor 1
chr10_-_99430617 24.79 ENST00000370508.7
glutamic-oxaloacetic transaminase 1
chr1_+_228083061 24.45 ENST00000541182.1
ADP ribosylation factor 1
chr18_-_46098275 24.11 ENST00000589252.5
ENST00000398752.11
ENST00000590665.5
ENST00000593152.6
ATP synthase F1 subunit alpha
chr1_-_205750167 23.87 ENST00000367142.5
nuclear casein kinase and cyclin dependent kinase substrate 1
chr8_-_99893135 23.86 ENST00000524245.5
cytochrome c oxidase subunit 6C
chr3_-_98523013 23.70 ENST00000394181.6
ENST00000508902.5
ENST00000394180.6
claudin domain containing 1
chr1_-_8879170 23.68 ENST00000489867.2
enolase 1
chr7_+_48089257 23.47 ENST00000436673.5
ENST00000395564.9
uridine phosphorylase 1
chr17_-_29176752 23.19 ENST00000533112.5
myosin XVIIIA
chr1_-_8878706 22.28 ENST00000646156.1
enolase 1
chr16_+_81006486 22.26 ENST00000299572.9
centromere protein N
chr16_+_4624811 22.19 ENST00000415496.5
ENST00000262370.12
ENST00000587747.5
ENST00000399577.9
ENST00000588994.5
ENST00000586183.5
mahogunin ring finger 1
chr3_-_98522869 22.11 ENST00000502288.5
ENST00000512147.5
ENST00000341181.11
ENST00000510541.5
ENST00000503621.5
ENST00000511081.5
ENST00000507874.5
ENST00000502299.5
ENST00000508659.5
ENST00000510545.5
ENST00000511667.5
ENST00000394185.6
claudin domain containing 1
chr11_+_73787853 21.28 ENST00000310614.12
ENST00000497094.6
ENST00000411840.6
ENST00000535277.5
ENST00000398483.7
ENST00000542303.5
mitochondrial ribosomal protein L48
chr12_-_52926459 20.93 ENST00000552150.5
keratin 8
chr5_+_218241 20.93 ENST00000617470.4
ENST00000504309.5
ENST00000510361.5
ENST00000264932.11
succinate dehydrogenase complex flavoprotein subunit A
chr10_+_97426162 20.79 ENST00000334828.6
phosphoglycerate mutase 1
chrX_-_23884017 20.60 ENST00000633372.1
apolipoprotein O
chr3_-_98522514 20.50 ENST00000503004.5
ENST00000506575.1
ENST00000513452.5
ENST00000515620.5
claudin domain containing 1
chr1_+_161202147 20.37 ENST00000392179.5
ENST00000678511.1
ENST00000677453.1
ENST00000678783.1
ENST00000679218.1
ENST00000676972.1
NADH:ubiquinone oxidoreductase core subunit S2
chrX_+_47193796 20.35 ENST00000442035.5
ENST00000335972.11
ENST00000457753.5
ubiquitin like modifier activating enzyme 1
chrX_+_103776831 20.30 ENST00000621218.5
ENST00000619236.1
proteolipid protein 1
chr15_+_43692886 20.26 ENST00000434505.5
ENST00000411750.5
creatine kinase, mitochondrial 1A
chr7_+_55964577 20.19 ENST00000446778.5
ENST00000322090.8
nipsnap homolog 2
chr1_-_8878646 20.08 ENST00000643438.1
enolase 1
chr9_-_128204218 20.00 ENST00000634901.1
ENST00000372948.7
CDKN1A interacting zinc finger protein 1
chr2_+_97646034 19.68 ENST00000258424.3
cytochrome c oxidase subunit 5B
chr1_-_25906931 19.68 ENST00000357865.6
stathmin 1
chr19_-_3063101 19.43 ENST00000221561.12
TLE family member 5, transcriptional modulator
chr13_-_48001265 19.05 ENST00000646932.1
ENST00000433022.1
ENST00000470760.2
ENST00000644338.1
ENST00000646602.1
succinate-CoA ligase ADP-forming subunit beta
chrX_+_103776493 18.75 ENST00000433491.5
ENST00000612423.4
ENST00000443502.5
proteolipid protein 1
chr20_+_32277626 18.29 ENST00000375712.4
kinesin family member 3B
chr16_-_81006810 18.27 ENST00000564174.5
ENST00000562713.3
ENST00000570195.5
ENST00000565925.5
ENST00000219400.8
ENST00000565108.5
ENST00000565650.5
ENST00000486645.5
ENST00000630396.1
ENST00000650780.1
C-X9-C motif containing 2
novel protein
chr5_-_134004635 18.19 ENST00000425992.2
ENST00000395044.7
ENST00000395047.6
voltage dependent anion channel 1
chr11_+_66857056 18.13 ENST00000309602.5
ENST00000393952.3
leucine rich repeat and fibronectin type III domain containing 4
chr19_+_17305801 18.00 ENST00000602206.1
ENST00000252602.2
mitochondrial ribosomal protein L34
chr2_-_197499826 17.92 ENST00000439605.2
ENST00000388968.8
ENST00000418022.2
heat shock protein family D (Hsp60) member 1
chr17_+_68512878 17.63 ENST00000585981.5
ENST00000589480.5
ENST00000585815.5
protein kinase cAMP-dependent type I regulatory subunit alpha
chr22_+_29307005 17.40 ENST00000406549.7
ENST00000610653.4
ENST00000621062.4
ENST00000611648.2
ENST00000618518.3
growth arrest specific 2 like 1
chr3_-_167734510 17.27 ENST00000475915.6
ENST00000462725.6
ENST00000461494.5
programmed cell death 10
chr6_-_43059367 16.92 ENST00000230413.9
ENST00000487429.1
ENST00000388752.8
ENST00000489623.1
ENST00000468957.1
mitochondrial ribosomal protein L2
chr10_+_79347460 16.69 ENST00000225174.8
peptidylprolyl isomerase F
chr2_-_206159410 16.57 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NADH:ubiquinone oxidoreductase core subunit S1
chr3_+_184320283 16.37 ENST00000428387.5
ENST00000434061.6
eukaryotic translation initiation factor 4 gamma 1
chr1_-_8878677 16.35 ENST00000234590.10
ENST00000647408.1
enolase 1
chr1_-_153628180 15.83 ENST00000339556.8
ENST00000440685.7
S100 calcium binding protein A13
chr6_-_43229451 15.81 ENST00000509253.5
ENST00000393987.2
ENST00000230431.11
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr3_-_113746185 15.71 ENST00000616174.1
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr19_+_46347063 15.69 ENST00000012443.9
ENST00000391919.1
protein phosphatase 5 catalytic subunit
chr22_+_29767351 15.68 ENST00000330029.6
ENST00000401406.3
ubiquinol-cytochrome c reductase, complex III subunit X
chr21_-_33915762 15.59 ENST00000290299.7
ATP synthase peripheral stalk subunit OSCP
chr8_-_130016622 15.29 ENST00000518283.5
ENST00000519110.5
CYFIP related Rac1 interactor B
chr14_-_21024092 15.21 ENST00000554398.5
NDRG family member 2
chr8_-_130016414 15.20 ENST00000401979.6
ENST00000517654.5
ENST00000522361.1
ENST00000518167.5
CYFIP related Rac1 interactor B
chr12_+_6535278 15.18 ENST00000396858.5
glyceraldehyde-3-phosphate dehydrogenase
chr11_+_63974578 15.08 ENST00000314133.4
ENST00000535431.1
cytochrome c oxidase subunit 8A
novel transcript
chr2_-_197499857 15.04 ENST00000428204.6
ENST00000678170.1
ENST00000676933.1
ENST00000678621.1
heat shock protein family D (Hsp60) member 1
chr20_-_59042748 15.01 ENST00000355937.9
ENST00000371033.9
PRELI domain containing 3B
chr5_-_138575359 14.95 ENST00000297185.9
ENST00000678300.1
ENST00000677425.1
ENST00000677064.1
ENST00000507115.6
heat shock protein family A (Hsp70) member 9
chr3_-_64023986 14.88 ENST00000394431.6
proteasome 26S subunit, non-ATPase 6
chr1_-_33036927 14.65 ENST00000354858.11
adenylate kinase 2
chr17_-_44067585 14.57 ENST00000591247.6
LSM12 homolog
chr6_-_13814490 14.44 ENST00000379170.8
mitochondrial calcium uniporter regulator 1
chr2_+_74206384 14.30 ENST00000678623.1
ENST00000678731.1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr9_+_128566741 14.15 ENST00000630866.1
spectrin alpha, non-erythrocytic 1
chr3_-_196082078 14.07 ENST00000360110.9
ENST00000392396.7
ENST00000420415.5
transferrin receptor
chr4_+_41612892 14.00 ENST00000509454.5
ENST00000396595.7
ENST00000381753.8
LIM and calponin homology domains 1
chr3_+_113747022 13.90 ENST00000273398.8
ENST00000496747.5
ENST00000475322.1
ATPase H+ transporting V1 subunit A
chr2_-_42361198 13.87 ENST00000234301.3
cytochrome c oxidase subunit 7A2 like
chr5_+_72107453 13.83 ENST00000296755.12
ENST00000511641.2
microtubule associated protein 1B
chr8_-_52714414 13.81 ENST00000435644.6
ENST00000518710.5
ENST00000025008.10
ENST00000517963.1
RB1 inducible coiled-coil 1
chr1_+_203026481 13.77 ENST00000367240.6
PTPRF interacting protein alpha 4
chr10_+_69318831 13.75 ENST00000359426.7
hexokinase 1
chr16_-_3717505 13.67 ENST00000538171.5
ENST00000246957.10
TNF receptor associated protein 1
chr3_+_52198086 13.62 ENST00000469224.5
ENST00000394965.6
5'-aminolevulinate synthase 1
chr2_+_222861423 13.59 ENST00000681383.1
ENST00000413316.1
ENST00000679558.1
ENST00000680684.1
acyl-CoA synthetase long chain family member 3
chr16_-_30526518 13.51 ENST00000380412.7
zinc finger protein 768
chr20_-_3767716 13.44 ENST00000217195.12
ENST00000379772.4
chromosome 20 open reading frame 27
chr2_-_206159509 13.44 ENST00000423725.5
NADH:ubiquinone oxidoreductase core subunit S1
chr2_-_54987578 13.44 ENST00000486085.5
reticulon 4
chr20_-_3767769 13.42 ENST00000399672.5
chromosome 20 open reading frame 27
chr7_-_123557875 13.24 ENST00000611607.4
ENST00000618945.4
NADH:ubiquinone oxidoreductase subunit A5
chr1_-_241357225 13.24 ENST00000366565.5
regulator of G protein signaling 7
chr1_-_241357085 13.23 ENST00000366564.5
regulator of G protein signaling 7
chr1_+_84144260 13.17 ENST00000370685.7
protein kinase cAMP-activated catalytic subunit beta
chr19_-_3062464 13.09 ENST00000327141.9
TLE family member 5, transcriptional modulator
chr4_-_73223082 13.05 ENST00000509867.6
ankyrin repeat domain 17
chr22_+_23966880 13.03 ENST00000215770.6
D-dopachrome tautomerase like
chr14_-_103921494 13.03 ENST00000557040.5
ENST00000414262.6
ENST00000555030.5
ENST00000554713.2
ENST00000286953.8
ENST00000553430.5
ATP synthase membrane subunit j
chr2_-_10447771 12.98 ENST00000405333.5
ENST00000443218.1
ornithine decarboxylase 1
chr3_+_52198152 12.97 ENST00000484952.6
5'-aminolevulinate synthase 1
chr1_-_33036840 12.92 ENST00000548033.5
ENST00000487289.1
ENST00000626911.1
ENST00000673291.1
ENST00000480134.5
ENST00000373449.7
ENST00000672715.1
ENST00000467905.5
ENST00000629371.2
adenylate kinase 2
chr2_+_10368645 12.90 ENST00000613496.4
hippocalcin like 1
chr1_-_241357171 12.88 ENST00000440928.6
regulator of G protein signaling 7
chr2_-_206159194 12.83 ENST00000455934.6
ENST00000449699.5
ENST00000454195.1
NADH:ubiquinone oxidoreductase core subunit S1
chr8_+_123416766 12.81 ENST00000287387.7
ENST00000650311.1
ENST00000523356.1
N-terminal glutamine amidase 1
chr2_+_10368764 12.80 ENST00000620771.4
hippocalcin like 1
chr16_+_58500047 12.72 ENST00000566192.5
ENST00000565088.5
ENST00000568640.5
NDRG family member 4
chr11_-_64246190 12.69 ENST00000392210.6
protein phosphatase 1 regulatory inhibitor subunit 14B
chr9_+_137255277 12.69 ENST00000343053.6
negative elongation factor complex member B
chr15_-_41402445 12.56 ENST00000676906.1
ENST00000679094.1
ENST00000558719.2
ENST00000260361.9
ENST00000560978.2
ENST00000676533.1
NADH:ubiquinone oxidoreductase complex assembly factor 1
chr7_-_123557679 12.52 ENST00000677264.1
ENST00000471770.5
ENST00000676730.1
ENST00000677391.1
ENST00000677251.1
ENST00000470123.2
ENST00000679163.1
ENST00000676614.1
ENST00000378795.9
ENST00000676516.1
ENST00000355749.7
ENST00000678090.1
NADH:ubiquinone oxidoreductase subunit A5
chr11_-_112086727 12.50 ENST00000504148.3
ENST00000541231.1
translocase of inner mitochondrial membrane 8 homolog B
chr12_+_98593591 12.44 ENST00000401722.7
ENST00000188376.9
ENST00000551917.5
ENST00000551265.5
ENST00000550695.1
ENST00000547534.5
ENST00000228318.8
ENST00000552981.6
ENST00000549338.5
ENST00000548847.1
solute carrier family 25 member 3
chr14_-_21023954 12.42 ENST00000554094.5
NDRG family member 2
chr12_+_78864768 12.42 ENST00000261205.9
ENST00000457153.6
synaptotagmin 1
chrX_-_130165825 12.26 ENST00000675240.1
ENST00000319908.8
ENST00000674546.1
ENST00000287295.8
apoptosis inducing factor mitochondria associated 1
chr15_-_42491105 12.25 ENST00000565380.5
ENST00000564754.7
zinc finger protein 106
chr6_+_70667863 12.14 ENST00000370455.8
small ArfGAP 1
chr6_-_34392627 12.12 ENST00000607016.2
nudix hydrolase 3
chr1_+_153628393 12.06 ENST00000368696.3
ENST00000292169.6
ENST00000436839.1
S100 calcium binding protein A1
chr3_-_113746218 12.03 ENST00000497255.1
ENST00000240922.8
ENST00000478020.1
ENST00000493900.5
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr5_+_86617967 12.02 ENST00000515763.1
cytochrome c oxidase subunit 7C
chr20_+_1895365 11.91 ENST00000358771.5
signal regulatory protein alpha
chr11_-_57530714 11.86 ENST00000525158.1
ENST00000257245.9
ENST00000525587.1
translocase of inner mitochondrial membrane 10
chr3_+_52198113 11.82 ENST00000310271.6
5'-aminolevulinate synthase 1
chr7_-_151080833 11.80 ENST00000353841.6
ENST00000482571.2
Fas activated serine/threonine kinase
chr16_-_19522062 11.77 ENST00000353258.8
glycerophosphodiester phosphodiesterase 1
chrX_+_51893533 11.76 ENST00000375722.5
ENST00000326587.12
ENST00000375695.2
MAGE family member D1
chr16_-_19886133 11.74 ENST00000568214.1
ENST00000569479.5
G protein-coupled receptor class C group 5 member B
chr2_+_191276885 11.60 ENST00000392316.5
myosin IB
chr18_-_5544250 11.50 ENST00000540638.6
ENST00000342933.7
erythrocyte membrane protein band 4.1 like 3
chr12_-_21657792 11.45 ENST00000396076.5
lactate dehydrogenase B
chr12_-_21657831 11.45 ENST00000450584.5
ENST00000350669.5
ENST00000673047.2
lactate dehydrogenase B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
32.1 128.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
20.1 60.4 GO:2000276 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
18.8 56.4 GO:0006106 fumarate metabolic process(GO:0006106)
18.1 72.3 GO:0000961 negative regulation of mitochondrial RNA catabolic process(GO:0000961)
17.0 67.9 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
13.7 82.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
13.7 13.7 GO:1901856 negative regulation of cellular respiration(GO:1901856)
12.4 99.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
12.3 49.3 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
12.0 48.0 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
12.0 35.9 GO:0097212 lysosomal membrane organization(GO:0097212)
11.8 106.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
11.0 33.0 GO:0002368 B cell cytokine production(GO:0002368)
10.8 204.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
9.5 56.7 GO:0009438 methylglyoxal metabolic process(GO:0009438)
9.3 46.5 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
9.3 37.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
9.2 27.6 GO:0006172 ADP biosynthetic process(GO:0006172)
8.4 33.4 GO:1904045 cellular response to aldosterone(GO:1904045)
8.3 33.1 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
8.0 23.9 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
7.7 23.2 GO:1903028 positive regulation of opsonization(GO:1903028)
7.7 23.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
7.5 82.4 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
7.4 22.3 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
6.9 6.9 GO:0006533 aspartate catabolic process(GO:0006533)
6.6 79.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
6.3 19.0 GO:0006781 succinyl-CoA pathway(GO:0006781)
5.6 67.3 GO:0042407 cristae formation(GO:0042407)
5.4 27.2 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
4.8 4.8 GO:0002339 B cell selection(GO:0002339)
4.8 304.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
4.7 88.7 GO:0075713 establishment of integrated proviral latency(GO:0075713)
4.4 65.5 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
4.2 33.7 GO:0044206 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
3.8 11.3 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
3.8 33.8 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
3.7 37.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
3.5 13.9 GO:1990928 response to amino acid starvation(GO:1990928)
3.5 20.8 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
3.4 41.4 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
3.4 10.3 GO:0006097 glyoxylate cycle(GO:0006097)
3.4 13.6 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
3.3 36.3 GO:0007144 female meiosis I(GO:0007144)
3.3 19.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
3.1 12.5 GO:0072321 chaperone-mediated protein transport(GO:0072321)
3.0 26.8 GO:0002175 protein localization to paranode region of axon(GO:0002175)
2.9 20.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
2.9 26.0 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
2.9 31.5 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
2.8 13.8 GO:0030242 pexophagy(GO:0030242)
2.7 8.2 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
2.7 10.8 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
2.7 42.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
2.6 13.0 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.6 13.0 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
2.6 12.9 GO:1903027 regulation of opsonization(GO:1903027)
2.5 10.1 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
2.5 60.8 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
2.5 25.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
2.5 67.2 GO:0006099 tricarboxylic acid cycle(GO:0006099)
2.4 41.6 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
2.4 7.3 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
2.4 12.1 GO:1901911 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
2.4 9.5 GO:0003290 septum secundum development(GO:0003285) atrial septum secundum morphogenesis(GO:0003290)
2.4 7.1 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
2.3 32.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
2.2 15.7 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.2 22.2 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
2.2 13.2 GO:0097338 response to clozapine(GO:0097338)
2.2 19.7 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
2.2 88.2 GO:0030262 apoptotic nuclear changes(GO:0030262)
2.0 38.4 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
1.8 27.7 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
1.8 16.5 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
1.8 3.6 GO:0061198 fungiform papilla formation(GO:0061198)
1.8 7.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
1.8 5.3 GO:0090234 regulation of kinetochore assembly(GO:0090234)
1.8 131.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
1.7 10.0 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
1.6 6.5 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.6 45.6 GO:0042026 protein refolding(GO:0042026)
1.6 38.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
1.6 15.8 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
1.5 20.9 GO:0051599 response to hydrostatic pressure(GO:0051599)
1.5 23.9 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
1.5 31.3 GO:0043457 regulation of cellular respiration(GO:0043457)
1.5 7.4 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
1.4 25.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.4 7.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
1.4 12.6 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
1.4 18.2 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
1.4 39.0 GO:0033599 regulation of mammary gland epithelial cell proliferation(GO:0033599)
1.4 17.6 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
1.3 31.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.3 11.4 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
1.2 3.7 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.2 6.2 GO:0016080 synaptic vesicle targeting(GO:0016080)
1.2 12.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
1.2 13.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
1.1 34.1 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
1.1 2.2 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
1.1 6.3 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
1.0 13.2 GO:0006600 creatine metabolic process(GO:0006600)
1.0 1.9 GO:0034759 detoxification of copper ion(GO:0010273) regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759) stress response to copper ion(GO:1990169)
0.9 4.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.9 4.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.9 13.8 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.9 7.8 GO:0006089 lactate metabolic process(GO:0006089)
0.8 0.8 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.8 6.7 GO:0072719 cellular response to cisplatin(GO:0072719)
0.8 2.5 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.8 14.1 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.8 2.5 GO:0046521 sphingoid catabolic process(GO:0046521)
0.8 6.1 GO:0009249 protein lipoylation(GO:0009249)
0.7 2.9 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.7 11.7 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.7 5.9 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.7 41.3 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.7 48.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.7 26.6 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.7 11.1 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.7 15.8 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.7 8.2 GO:0051665 membrane raft localization(GO:0051665)
0.7 12.7 GO:0060973 negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642) cell migration involved in heart development(GO:0060973)
0.6 17.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.6 17.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 9.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.6 13.9 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.6 7.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.6 3.7 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of lung blood pressure(GO:0061767) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.6 22.3 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.6 1.8 GO:1903281 regulation of the force of heart contraction by cardiac conduction(GO:0086092) positive regulation of calcium:sodium antiporter activity(GO:1903281)
0.6 9.7 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.6 17.5 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.6 9.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.6 6.3 GO:0006783 heme biosynthetic process(GO:0006783)
0.6 2.8 GO:0018065 protein-cofactor linkage(GO:0018065)
0.5 9.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.5 3.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.5 12.7 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.5 3.7 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.5 5.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.5 6.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.5 7.5 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.5 65.5 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.5 11.8 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.5 14.3 GO:0046655 tetrahydrofolate metabolic process(GO:0046653) folic acid metabolic process(GO:0046655)
0.5 1.9 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.5 4.8 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.5 1.9 GO:0099558 maintenance of synapse structure(GO:0099558)
0.5 6.5 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.5 5.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.4 5.2 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.4 3.0 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.4 2.6 GO:0060356 leucine import(GO:0060356)
0.4 7.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.4 9.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.4 2.0 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.4 6.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.4 1.9 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.4 3.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.4 2.9 GO:1902570 protein localization to nucleolus(GO:1902570)
0.4 81.9 GO:0006457 protein folding(GO:0006457)
0.3 7.7 GO:0052695 cellular glucuronidation(GO:0052695)
0.3 11.1 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.3 33.1 GO:0008033 tRNA processing(GO:0008033)
0.3 5.5 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.3 15.5 GO:0045333 cellular respiration(GO:0045333)
0.3 27.9 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.3 11.0 GO:0042438 melanin biosynthetic process(GO:0042438)
0.3 7.8 GO:0030252 growth hormone secretion(GO:0030252)
0.3 13.8 GO:0014047 glutamate secretion(GO:0014047)
0.3 7.2 GO:0019372 lipoxygenase pathway(GO:0019372)
0.2 2.5 GO:0019695 choline metabolic process(GO:0019695)
0.2 5.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.2 5.0 GO:0007614 short-term memory(GO:0007614)
0.2 11.9 GO:0006301 postreplication repair(GO:0006301)
0.2 1.1 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 0.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 5.8 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.2 2.0 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.2 2.0 GO:0051601 exocyst localization(GO:0051601)
0.2 7.3 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.2 3.9 GO:1901032 negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.2 2.8 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 2.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 1.9 GO:0051683 establishment of Golgi localization(GO:0051683)
0.2 2.6 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.2 7.3 GO:0051693 actin filament capping(GO:0051693)
0.1 10.7 GO:0006334 nucleosome assembly(GO:0006334)
0.1 10.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 3.7 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 1.9 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1 8.4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 3.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 5.7 GO:0043620 regulation of DNA-templated transcription in response to stress(GO:0043620)
0.1 0.7 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.1 1.3 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 3.0 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 8.9 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.1 1.9 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 5.6 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 7.7 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 0.2 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.1 14.1 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.1 6.9 GO:0050905 neuromuscular process(GO:0050905)
0.1 1.8 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.1 10.1 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 4.3 GO:0007032 endosome organization(GO:0007032)
0.1 0.6 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 2.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:1903795 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) regulation of intracellular calcium activated chloride channel activity(GO:1902938) regulation of inorganic anion transmembrane transport(GO:1903795)
0.0 0.7 GO:1901798 positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 1.8 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)
0.0 1.7 GO:0060071 Wnt signaling pathway, planar cell polarity pathway(GO:0060071)
0.0 0.4 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.0 0.3 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.5 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.2 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.9 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
17.3 225.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
15.7 94.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
12.3 61.3 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
11.8 129.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
10.6 63.4 GO:0061617 MICOS complex(GO:0061617)
10.3 82.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
10.3 92.5 GO:0072546 ER membrane protein complex(GO:0072546)
8.6 42.8 GO:0070470 plasma membrane respiratory chain complex I(GO:0045272) plasma membrane respiratory chain(GO:0070470)
6.1 18.3 GO:0016939 kinesin II complex(GO:0016939)
6.1 24.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
6.0 65.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
5.5 49.3 GO:0097452 GAIT complex(GO:0097452)
4.8 24.2 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
4.5 353.3 GO:0098800 inner mitochondrial membrane protein complex(GO:0098800)
4.4 39.8 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
4.1 41.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
4.0 27.7 GO:0031415 NatA complex(GO:0031415)
3.8 151.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
3.4 23.9 GO:0032021 NELF complex(GO:0032021)
3.0 15.1 GO:0043291 RAVE complex(GO:0043291)
2.9 35.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
2.9 5.9 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
2.8 36.8 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
2.8 33.8 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
2.8 47.1 GO:0070469 respiratory chain(GO:0070469)
2.7 141.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.5 7.4 GO:0035517 PR-DUB complex(GO:0035517)
2.4 48.5 GO:0033270 paranode region of axon(GO:0033270)
2.4 16.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
2.4 7.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
2.3 13.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
2.2 15.7 GO:1990635 proximal dendrite(GO:1990635)
1.8 25.2 GO:0000124 SAGA complex(GO:0000124)
1.7 24.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
1.7 442.6 GO:0043209 myelin sheath(GO:0043209)
1.7 31.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.6 28.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
1.5 5.9 GO:0030915 Smc5-Smc6 complex(GO:0030915)
1.5 30.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.4 11.4 GO:0097450 astrocyte end-foot(GO:0097450)
1.3 8.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
1.3 7.5 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.0 14.4 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
1.0 83.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
1.0 2.0 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
1.0 26.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.9 40.9 GO:0031430 M band(GO:0031430)
0.8 8.4 GO:0097433 dense body(GO:0097433)
0.8 25.1 GO:0005838 proteasome regulatory particle(GO:0005838)
0.8 7.1 GO:0042382 paraspeckles(GO:0042382)
0.8 6.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.7 4.5 GO:0005879 axonemal microtubule(GO:0005879) asymmetric synapse(GO:0032279)
0.7 20.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.7 20.3 GO:0030057 desmosome(GO:0030057)
0.6 17.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.6 5.0 GO:0031931 TORC1 complex(GO:0031931)
0.6 7.3 GO:0008091 spectrin(GO:0008091)
0.6 2.8 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.5 6.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.5 32.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 6.7 GO:0046930 pore complex(GO:0046930)
0.4 13.7 GO:0097228 sperm principal piece(GO:0097228)
0.4 15.8 GO:0042629 mast cell granule(GO:0042629)
0.4 6.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.4 3.7 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 14.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.4 17.5 GO:0048786 presynaptic active zone(GO:0048786)
0.3 86.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 51.4 GO:0001650 fibrillar center(GO:0001650)
0.3 93.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 6.6 GO:0005652 nuclear lamina(GO:0005652)
0.3 10.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 25.5 GO:0016459 myosin complex(GO:0016459)
0.3 3.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 1.8 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.3 6.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 6.5 GO:0031528 microvillus membrane(GO:0031528)
0.2 6.5 GO:0030673 axolemma(GO:0030673)
0.2 26.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.2 85.1 GO:0031965 nuclear membrane(GO:0031965)
0.2 3.6 GO:0016580 Sin3 complex(GO:0016580)
0.2 28.0 GO:0000922 spindle pole(GO:0000922)
0.2 1.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 28.4 GO:0000793 condensed chromosome(GO:0000793)
0.1 10.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.8 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 7.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 21.9 GO:0031968 organelle outer membrane(GO:0031968)
0.1 1.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 25.1 GO:0030426 growth cone(GO:0030426)
0.1 2.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 39.4 GO:0005874 microtubule(GO:0005874)
0.1 3.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 4.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 12.4 GO:0005635 nuclear envelope(GO:0005635)
0.1 5.9 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 9.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.3 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0005899 insulin receptor complex(GO:0005899) zonula adherens(GO:0005915)
0.0 1.3 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.4 GO:0000775 chromosome, centromeric region(GO:0000775)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
24.8 99.1 GO:0004743 pyruvate kinase activity(GO:0004743)
17.0 67.9 GO:0003883 CTP synthase activity(GO:0003883)
16.4 49.3 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
15.3 61.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
11.9 95.4 GO:0004111 creatine kinase activity(GO:0004111)
10.3 82.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
9.9 79.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
8.8 43.9 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
8.4 91.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
8.3 24.8 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
7.7 38.4 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
7.5 217.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
6.4 25.5 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
5.8 46.6 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
5.5 33.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
5.3 281.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
5.0 15.0 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
5.0 89.8 GO:0016018 cyclosporin A binding(GO:0016018)
4.8 19.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
4.5 22.3 GO:0030348 syntaxin-3 binding(GO:0030348)
4.2 33.8 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
4.2 20.8 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
3.9 31.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
3.7 48.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
3.7 11.0 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
3.6 54.1 GO:0004017 adenylate kinase activity(GO:0004017)
3.6 14.3 GO:0004487 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
3.5 76.9 GO:0016805 dipeptidase activity(GO:0016805)
3.4 10.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
3.4 20.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
3.4 10.1 GO:0009041 uridylate kinase activity(GO:0009041) nucleoside phosphate kinase activity(GO:0050145)
3.3 22.9 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
3.3 39.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
3.1 9.4 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
3.0 39.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
2.8 33.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
2.7 8.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
2.5 10.1 GO:0004802 transketolase activity(GO:0004802)
2.5 20.2 GO:0015288 porin activity(GO:0015288)
2.5 67.2 GO:0003746 translation elongation factor activity(GO:0003746)
2.4 7.3 GO:0031403 lithium ion binding(GO:0031403)
2.4 12.1 GO:0052842 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
2.4 11.8 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
2.3 11.5 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
2.2 10.8 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
2.1 39.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
2.0 27.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
2.0 21.7 GO:0033691 sialic acid binding(GO:0033691)
1.9 7.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.7 12.2 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
1.7 211.4 GO:0051087 chaperone binding(GO:0051087)
1.7 5.1 GO:0031753 endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755)
1.6 4.8 GO:0048030 disaccharide binding(GO:0048030)
1.5 13.7 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.5 98.9 GO:0009055 electron carrier activity(GO:0009055)
1.4 7.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.4 11.4 GO:0046870 cadmium ion binding(GO:0046870)
1.4 5.6 GO:0004461 lactose synthase activity(GO:0004461)
1.4 8.4 GO:0003998 acylphosphatase activity(GO:0003998)
1.4 9.5 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
1.4 34.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.3 66.0 GO:0048487 beta-tubulin binding(GO:0048487)
1.3 4.0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
1.3 5.3 GO:0032184 SUMO polymer binding(GO:0032184)
1.2 12.3 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
1.2 3.6 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
1.1 6.9 GO:0004046 aminoacylase activity(GO:0004046)
1.1 21.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.9 5.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.9 9.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.9 10.0 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.9 13.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.8 11.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.7 3.7 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.7 9.5 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.7 16.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.7 12.8 GO:0031005 filamin binding(GO:0031005)
0.7 18.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6 13.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.6 5.7 GO:0034511 U3 snoRNA binding(GO:0034511)
0.6 8.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.6 135.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 17.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.6 3.7 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.6 2.5 GO:0033265 choline binding(GO:0033265)
0.6 33.1 GO:0050681 androgen receptor binding(GO:0050681)
0.6 5.9 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.6 12.4 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.6 4.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.5 3.2 GO:0004359 glutaminase activity(GO:0004359)
0.5 61.5 GO:0051082 unfolded protein binding(GO:0051082)
0.5 9.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.5 11.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.5 12.1 GO:0044548 S100 protein binding(GO:0044548)
0.5 2.9 GO:0008097 5S rRNA binding(GO:0008097)
0.5 14.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 31.6 GO:0016836 hydro-lyase activity(GO:0016836)
0.5 15.8 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.5 9.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.5 6.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 0.8 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.4 70.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.4 6.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 12.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 5.7 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.4 3.0 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.4 1.8 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.4 2.5 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.3 23.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.3 10.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 14.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.3 2.8 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.3 6.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 7.8 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 1.5 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113) peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.3 7.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 1.2 GO:0017018 myosin phosphatase activity(GO:0017018)
0.3 1.1 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.3 15.7 GO:0097110 scaffold protein binding(GO:0097110)
0.3 2.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 1.7 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.2 9.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 36.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 13.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 7.2 GO:0043531 ADP binding(GO:0043531)
0.2 29.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 6.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 0.6 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 25.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 6.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.2 13.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 4.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 2.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 19.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 7.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 21.6 GO:0017124 SH3 domain binding(GO:0017124)
0.2 6.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 33.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.0 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 9.9 GO:0030276 clathrin binding(GO:0030276)
0.1 8.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 4.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 29.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 10.6 GO:0016829 lyase activity(GO:0016829)
0.1 3.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 5.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 15.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 3.9 GO:0030145 manganese ion binding(GO:0030145)
0.1 6.7 GO:0002039 p53 binding(GO:0002039)
0.1 2.9 GO:0005123 death receptor binding(GO:0005123)
0.1 0.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 3.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 4.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 5.2 GO:0019003 GDP binding(GO:0019003)
0.1 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.0 GO:0005109 frizzled binding(GO:0005109)
0.1 5.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.8 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 2.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.0 48.0 GO:0003723 RNA binding(GO:0003723)
0.0 3.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 3.7 GO:0001047 core promoter binding(GO:0001047)
0.0 0.3 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 36.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.8 256.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
1.1 34.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
1.1 24.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.0 19.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.8 89.3 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.6 12.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.5 22.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.5 4.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.5 39.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.5 32.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 27.0 PID IFNG PATHWAY IFN-gamma pathway
0.5 13.8 PID REELIN PATHWAY Reelin signaling pathway
0.4 46.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.4 29.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.4 7.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 20.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.4 7.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.3 8.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 5.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.3 29.8 PID P73PATHWAY p73 transcription factor network
0.3 17.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.3 18.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 13.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 10.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 4.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 6.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 6.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 2.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 5.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.5 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 7.6 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 11.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID INSULIN PATHWAY Insulin Pathway
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 781.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
8.1 88.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
5.1 76.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
4.3 283.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
4.0 220.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
2.2 24.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
2.0 31.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
1.9 64.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.9 34.9 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
1.8 27.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
1.7 33.2 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
1.4 32.6 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
1.3 38.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.3 36.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.1 31.9 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
1.0 22.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.9 25.0 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.8 11.8 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.8 25.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.7 15.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.7 10.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.7 18.3 REACTOME KINESINS Genes involved in Kinesins
0.6 23.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.6 11.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.6 12.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.6 11.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.6 21.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.6 147.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.5 16.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.5 6.2 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.4 9.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 7.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 3.7 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 30.3 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.3 7.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 6.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 5.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.2 7.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 5.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 8.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 3.7 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 5.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.2 31.8 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 3.9 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.2 2.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 5.7 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 3.7 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 4.9 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 4.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 5.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 5.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.7 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 3.0 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 13.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 3.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 5.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.8 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+