Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for EVX2

Z-value: 2.08

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Transcription factors associated with EVX2

Gene Symbol Gene ID Gene Info
EVX2
ENSG00000174279.4 EVX2

Activity profile of EVX2 motif

Sorted Z-values of EVX2 motif

Network of associatons between targets according to the STRING database.

Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_111999189 19.25 ENST00000455401.6
TAGLN3
transgelin 3
chr3_+_111998739 19.15 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr3_+_111999326 18.66 ENST00000494932.1
TAGLN3
transgelin 3
chr3_+_111998915 18.17 ENST00000478951.6
TAGLN3
transgelin 3
chr4_+_112860981 16.89 ENST00000671704.1
ANK2
ankyrin 2
chr4_+_112860912 16.75 ENST00000671951.1
ANK2
ankyrin 2
chr4_+_112861053 16.35 ENST00000672221.1
ANK2
ankyrin 2
chr6_+_39792298 14.73 ENST00000633794.1
ENST00000274867.9
DAAM2
dishevelled associated activator of morphogenesis 2
chr17_-_10026265 9.02 ENST00000437099.6
ENST00000396115.6
GAS7
growth arrest specific 7
chr11_-_115504389 8.83 ENST00000545380.5
ENST00000452722.7
ENST00000331581.11
ENST00000537058.5
ENST00000536727.5
ENST00000542447.6
CADM1
cell adhesion molecule 1
chr21_-_31160904 8.17 ENST00000636887.1
TIAM1
TIAM Rac1 associated GEF 1
chr5_+_141484997 8.12 ENST00000617094.1
ENST00000306593.2
ENST00000610539.1
ENST00000618371.4
PCDHGC4
protocadherin gamma subfamily C, 4
chr1_-_151459471 3.91 ENST00000271715.7
POGZ
pogo transposable element derived with ZNF domain
chr6_-_62286161 3.87 ENST00000281156.5
KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
chr4_-_145180496 2.78 ENST00000447906.8
OTUD4
OTU deubiquitinase 4
chr1_-_151459169 2.59 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
POGZ
pogo transposable element derived with ZNF domain
chr4_-_73620629 1.89 ENST00000342081.7
RASSF6
Ras association domain family member 6
chrX_-_63755187 1.56 ENST00000635729.1
ENST00000623566.3
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr1_+_27935022 1.49 ENST00000411604.5
ENST00000373888.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr12_+_15546344 0.85 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chr17_-_42185452 0.71 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr4_+_94974984 0.57 ENST00000672698.1
BMPR1B
bone morphogenetic protein receptor type 1B
chr12_+_119668109 0.53 ENST00000229328.10
ENST00000630317.1
PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
chr1_+_27934980 0.19 ENST00000373894.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 50.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.0 8.2 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
1.3 8.8 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.4 6.5 GO:0051382 kinetochore assembly(GO:0051382)
0.2 0.8 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 1.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 14.7 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 0.7 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.6 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.1 2.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 75.0 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 8.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0035878 nail development(GO:0035878)
0.0 3.9 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 9.0 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 50.0 GO:0031430 M band(GO:0031430)
0.3 8.2 GO:0044295 axonal growth cone(GO:0044295)
0.3 75.2 GO:0043209 myelin sheath(GO:0043209)
0.1 8.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 6.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 50.0 GO:0030507 spectrin binding(GO:0030507)
0.3 75.2 GO:0051015 actin filament binding(GO:0051015)
0.3 8.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 1.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 3.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 14.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 8.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 2.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 9.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP