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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FIGLA

Z-value: 4.44

Motif logo

Transcription factors associated with FIGLA

Gene Symbol Gene ID Gene Info
ENSG00000183733.6 FIGLA

Activity profile of FIGLA motif

Sorted Z-values of FIGLA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FIGLA

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_22001654 19.31 ENST00000290122.8
chymotrypsin like elastase 3A
chr3_-_49029378 18.54 ENST00000442157.2
ENST00000326739.9
ENST00000677010.1
ENST00000678724.1
ENST00000429182.6
inosine monophosphate dehydrogenase 2
chr20_+_45812576 18.52 ENST00000405520.5
ENST00000617055.4
ubiquitin conjugating enzyme E2 C
chr7_+_12687625 18.41 ENST00000651779.1
ENST00000404894.1
ADP ribosylation factor like GTPase 4A
chr1_-_150697128 16.85 ENST00000427665.1
ENST00000271732.8
golgi phosphoprotein 3 like
chr20_+_45812632 16.52 ENST00000335046.7
ENST00000356455.9
ENST00000243893.10
ubiquitin conjugating enzyme E2 C
chr20_+_45812665 16.33 ENST00000352551.9
ubiquitin conjugating enzyme E2 C
chr3_+_49022077 15.93 ENST00000326925.11
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr6_-_31729260 15.38 ENST00000375789.7
dimethylarginine dimethylaminohydrolase 2
chr11_-_88337722 15.07 ENST00000677976.1
ENST00000528020.2
ENST00000393301.5
ENST00000529974.2
ENST00000227266.10
ENST00000678464.1
ENST00000679199.1
ENST00000527018.6
ENST00000679224.1
ENST00000678506.1
ENST00000678915.1
ENST00000524463.6
cathepsin C
chr6_-_31729478 14.15 ENST00000436437.2
dimethylarginine dimethylaminohydrolase 2
chr7_-_100100716 13.56 ENST00000354230.7
ENST00000425308.5
minichromosome maintenance complex component 7
chr6_-_31728877 13.48 ENST00000437288.5
dimethylarginine dimethylaminohydrolase 2
chr17_+_78168565 13.20 ENST00000225777.8
ENST00000585591.5
ENST00000589711.1
ENST00000588282.5
ENST00000589168.1
synaptogyrin 2
chr11_+_119087979 13.06 ENST00000535253.5
ENST00000392841.1
ENST00000648374.1
hydroxymethylbilane synthase
chr5_+_69167216 12.72 ENST00000508407.5
ENST00000505500.5
cyclin B1
chr16_-_11915991 12.50 ENST00000420576.6
G1 to S phase transition 1
chr17_+_78169127 11.77 ENST00000590201.1
synaptogyrin 2
chr18_+_31498168 11.17 ENST00000261590.13
ENST00000585206.1
ENST00000683654.1
desmoglein 2
chr4_-_102828022 10.78 ENST00000502690.5
ubiquitin conjugating enzyme E2 D3
chr11_+_67586104 10.76 ENST00000495996.1
glutathione S-transferase pi 1
chr17_+_50056095 10.64 ENST00000320031.13
integrin subunit alpha 3
chr6_-_31729785 10.63 ENST00000416410.6
dimethylarginine dimethylaminohydrolase 2
chr7_+_130380339 10.37 ENST00000481342.5
ENST00000604896.5
ENST00000011292.8
carboxypeptidase A1
chr4_-_139302516 10.30 ENST00000394228.5
ENST00000539387.5
NADH:ubiquinone oxidoreductase subunit C1
chr12_+_47963557 10.16 ENST00000256686.10
ENST00000549288.5
ENST00000429772.7
ENST00000552561.5
ENST00000546749.5
ENST00000552546.5
ENST00000550552.5
transmembrane protein 106C
chr12_+_47963618 10.09 ENST00000550161.5
ENST00000449758.6
transmembrane protein 106C
chr5_-_151087131 10.00 ENST00000315050.11
ENST00000523338.5
ENST00000522100.5
TNFAIP3 interacting protein 1
chr3_+_49021605 9.79 ENST00000451378.2
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr4_-_102828048 9.76 ENST00000508249.1
ubiquitin conjugating enzyme E2 D3
chr17_+_41255384 9.73 ENST00000394008.1
keratin associated protein 9-9
chr19_+_16076485 9.66 ENST00000643579.2
ENST00000646575.1
tropomyosin 4
chr3_+_148827800 9.65 ENST00000282957.9
ENST00000468341.1
carboxypeptidase B1
chr4_-_139302460 9.51 ENST00000394223.2
ENST00000676245.1
NADH:ubiquinone oxidoreductase subunit C1
chr1_-_112707056 9.10 ENST00000369633.6
ENST00000425265.6
ENST00000369632.6
ENST00000436685.6
ENST00000484054.3
ENST00000369636.6
ENST00000369637.5
ENST00000339083.12
ENST00000285735.6
ENST00000369638.6
ras homolog family member C
chr6_-_24719146 8.87 ENST00000378119.9
chromosome 6 open reading frame 62
chr1_-_167935987 8.78 ENST00000367846.8
mitochondrial pyruvate carrier 2
chr5_+_53560627 8.67 ENST00000296684.10
ENST00000506765.1
NADH:ubiquinone oxidoreductase subunit S4
chr1_+_21977014 8.64 ENST00000337107.11
chymotrypsin like elastase 3B
chr7_-_100101333 8.52 ENST00000303887.10
minichromosome maintenance complex component 7
chr4_-_151015713 8.39 ENST00000357115.9
LPS responsive beige-like anchor protein
chr8_+_144358633 8.39 ENST00000675280.1
solute carrier family 52 member 2
chr3_+_172750682 8.29 ENST00000232458.9
ENST00000540509.5
epithelial cell transforming 2
chr17_+_41084150 8.07 ENST00000391417.5
ENST00000621138.1
keratin associated protein 4-7
chr17_-_7262343 8.00 ENST00000571881.2
ENST00000360325.11
claudin 7
chr8_+_144358557 7.95 ENST00000530047.5
ENST00000527078.6
ENST00000674870.1
ENST00000526338.7
ENST00000402965.5
ENST00000329994.7
ENST00000526752.3
ENST00000533662.2
ENST00000534725.6
ENST00000674929.1
ENST00000675597.1
ENST00000643944.2
ENST00000675121.1
solute carrier family 52 member 2
chr1_-_112707314 7.83 ENST00000369642.7
ras homolog family member C
chr8_-_116755784 7.80 ENST00000518949.5
ENST00000522453.1
ENST00000518995.5
ENST00000521861.6
ENST00000611080.1
eukaryotic translation initiation factor 3 subunit H
chr2_-_162152239 7.62 ENST00000418842.7
glucagon
chr3_+_172750715 7.58 ENST00000392692.8
ENST00000417960.5
ENST00000428567.5
ENST00000366090.6
ENST00000426894.5
epithelial cell transforming 2
chr16_-_53572 7.15 ENST00000293860.6
RNA polymerase III subunit K
chr2_-_162152404 7.11 ENST00000375497.3
glucagon
chrX_-_134915232 7.07 ENST00000370783.8
motile sperm domain containing 1
chrX_-_16869840 6.89 ENST00000380084.8
RB binding protein 7, chromatin remodeling factor
chr5_+_34656446 6.87 ENST00000428746.6
retinoic acid induced 14
chr5_-_62403506 6.81 ENST00000680062.1
DIMT1 rRNA methyltransferase and ribosome maturation factor
chr19_+_35248728 6.80 ENST00000602003.1
ENST00000360798.7
ENST00000354900.7
lipolysis stimulated lipoprotein receptor
chr13_+_26254098 6.80 ENST00000381527.8
cyclin dependent kinase 8
chr9_+_133061981 6.62 ENST00000372080.8
carboxyl ester lipase
chr11_-_119101814 6.61 ENST00000682791.1
ENST00000639704.1
ENST00000354202.9
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
chr19_+_35248375 6.58 ENST00000602122.5
lipolysis stimulated lipoprotein receptor
chr19_+_35248656 6.56 ENST00000621372.4
lipolysis stimulated lipoprotein receptor
chr8_-_101204697 6.38 ENST00000517844.5
zinc finger protein 706
chr5_+_122775062 6.37 ENST00000379516.7
ENST00000505934.5
ENST00000514949.1
sorting nexin 2
chr1_-_12616762 6.36 ENST00000464917.5
dehydrogenase/reductase 3
chr1_-_16978276 6.36 ENST00000375534.7
microfibril associated protein 2
chr1_-_11060000 6.25 ENST00000376957.7
spermidine synthase
chr3_-_50322733 6.18 ENST00000428028.1
ENST00000357750.9
hyaluronidase 2
chr7_+_100867379 6.13 ENST00000200457.9
ENST00000619988.4
thyroid hormone receptor interactor 6
chr19_+_35248694 6.11 ENST00000361790.7
lipolysis stimulated lipoprotein receptor
chr7_-_149028452 5.90 ENST00000413966.1
ENST00000652332.1
protein disulfide isomerase family A member 4
chr7_-_149028651 5.88 ENST00000286091.9
protein disulfide isomerase family A member 4
chr17_+_75525682 5.86 ENST00000392550.8
ENST00000167462.9
ENST00000375227.8
ENST00000578363.5
ENST00000579392.5
LLGL scribble cell polarity complex component 2
chr2_-_219571529 5.81 ENST00000404537.6
obscurin like cytoskeletal adaptor 1
chr19_-_10119863 5.81 ENST00000589454.5
eukaryotic translation initiation factor 3 subunit G
chr8_-_80080816 5.77 ENST00000520527.5
ENST00000517427.5
ENST00000379097.7
ENST00000448733.3
tumor protein D52
chr20_-_50115935 5.77 ENST00000340309.7
ENST00000415862.6
ENST00000371677.7
ubiquitin conjugating enzyme E2 V1
chr19_-_10119886 5.76 ENST00000587146.5
ENST00000253108.9
ENST00000588709.5
eukaryotic translation initiation factor 3 subunit G
chr4_-_102827723 5.68 ENST00000349311.12
ubiquitin conjugating enzyme E2 D3
chr3_-_50322759 5.64 ENST00000442581.1
ENST00000447092.5
hyaluronidase 2
chr7_-_78771108 5.55 ENST00000626691.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_-_15944348 5.54 ENST00000444358.1
zinc finger and BTB domain containing 17
chr2_+_169733811 5.53 ENST00000392647.7
kelch like family member 23
chr6_+_135181323 5.49 ENST00000367814.8
MYB proto-oncogene, transcription factor
chr1_+_21981099 5.42 ENST00000400277.2
chymotrypsin like elastase 3B
chr1_+_167936559 5.36 ENST00000432587.6
ENST00000367843.7
ENST00000312263.10
DDB1 and CUL4 associated factor 6
chrX_-_154486578 5.35 ENST00000630530.1
ENST00000369660.9
ENST00000369653.8
ubiquitin like 4A
chr17_+_42833390 5.31 ENST00000590720.6
ENST00000586114.5
ENST00000585805.5
ENST00000441946.6
ENST00000591152.5
ENST00000589469.5
ENST00000293362.7
ENST00000592169.2
proteasome activator subunit 3
chr19_+_35248879 5.26 ENST00000347609.8
lipolysis stimulated lipoprotein receptor
chr17_+_47209035 5.20 ENST00000572316.5
ENST00000354968.5
ENST00000576874.5
ENST00000536623.6
myosin light chain 4
chr6_+_135181268 5.19 ENST00000341911.10
ENST00000442647.7
ENST00000618728.4
ENST00000316528.12
ENST00000616088.4
MYB proto-oncogene, transcription factor
chr11_-_2161158 5.11 ENST00000421783.1
ENST00000397262.5
ENST00000381330.5
ENST00000250971.7
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr14_-_54902807 5.09 ENST00000543643.6
ENST00000536224.2
ENST00000395514.5
ENST00000491895.7
GTP cyclohydrolase 1
chr12_+_6200759 5.04 ENST00000645565.1
ENST00000382515.7
CD9 molecule
chr13_+_114235044 4.92 ENST00000252457.9
ENST00000375308.5
cell division cycle 16
chr3_-_167474026 4.79 ENST00000466903.1
ENST00000264677.8
serpin family I member 2
chr14_+_20455185 4.75 ENST00000555414.5
ENST00000553681.5
apurinic/apyrimidinic endodeoxyribonuclease 1
chr1_+_103750406 4.72 ENST00000370079.3
amylase alpha 1C
chr12_+_6200327 4.71 ENST00000610354.5
CD9 molecule
chr12_+_6200351 4.67 ENST00000679331.1
ENST00000382519.9
ENST00000009180.10
ENST00000536586.7
CD9 molecule
chr16_-_11915878 4.67 ENST00000439887.6
ENST00000434724.7
G1 to S phase transition 1
chr1_-_41918858 4.65 ENST00000372583.6
HIVEP zinc finger 3
chr8_-_98825628 4.58 ENST00000617590.1
ENST00000518165.5
ENST00000419617.7
serine/threonine kinase 3
chr16_+_53820 4.54 ENST00000293861.8
ENST00000383018.7
ENST00000417493.1
small nuclear ribonucleoprotein U11/U12 subunit 25
chr15_+_80060113 4.54 ENST00000618205.4
zinc finger AN1-type containing 6
chr14_+_30874541 4.53 ENST00000396618.9
ENST00000644874.2
ENST00000555117.2
ENST00000475087.5
cochlin
chr16_-_2264221 4.44 ENST00000566397.5
RNA binding protein with serine rich domain 1
chr13_+_114234907 4.42 ENST00000375310.5
cell division cycle 16
chr12_-_123268244 4.24 ENST00000618072.4
cyclin dependent kinase 2 associated protein 1
chr11_-_1608463 4.06 ENST00000399685.1
keratin associated protein 5-3
chr3_-_184249520 4.04 ENST00000455059.5
ENST00000445626.6
ALG3 alpha-1,3- mannosyltransferase
chr11_-_123061173 4.02 ENST00000526110.5
ENST00000227378.7
heat shock protein family A (Hsp70) member 8
chr20_+_45416084 4.00 ENST00000279035.14
ENST00000543458.7
ENST00000372689.9
ENST00000639499.1
ENST00000279036.12
ENST00000638594.1
ENST00000638489.1
ENST00000638353.1
ENST00000639382.1
ENST00000640210.1
ENST00000639235.1
ENST00000638478.1
ENST00000432270.2
ENST00000545755.3
ENST00000640324.1
phosphatidylinositol glycan anchor biosynthesis class T
chr3_+_105367212 3.95 ENST00000472644.6
activated leukocyte cell adhesion molecule
chr12_-_123268077 3.82 ENST00000542174.5
cyclin dependent kinase 2 associated protein 1
chr15_+_88639009 3.77 ENST00000306072.10
interferon stimulated exonuclease gene 20
chr8_-_48921419 3.70 ENST00000020945.4
snail family transcriptional repressor 2
chr6_+_33204645 3.65 ENST00000374662.4
hydroxysteroid 17-beta dehydrogenase 8
chr4_-_102827948 3.64 ENST00000394804.6
ENST00000394801.8
ubiquitin conjugating enzyme E2 D3
chr1_-_26890237 3.61 ENST00000431781.2
ENST00000374135.9
GPN-loop GTPase 2
chr1_+_171557845 3.60 ENST00000644916.1
proline rich coiled-coil 2C
chr1_-_39901996 3.55 ENST00000397332.2
MYCL proto-oncogene, bHLH transcription factor
chr16_+_67199509 3.50 ENST00000477898.5
engulfment and cell motility 3
chr7_+_131110087 3.48 ENST00000421797.6
muskelin 1
chr6_-_10419638 3.47 ENST00000319516.8
transcription factor AP-2 alpha
chr4_-_102828159 3.45 ENST00000394803.9
ubiquitin conjugating enzyme E2 D3
chr3_+_156674579 3.45 ENST00000295924.12
TCDD inducible poly(ADP-ribose) polymerase
chr4_+_168497066 3.44 ENST00000261509.10
palladin, cytoskeletal associated protein
chr3_-_120450981 3.44 ENST00000424703.6
ENST00000469005.1
ENST00000295633.8
follistatin like 1
chr1_-_156705742 3.42 ENST00000368221.1
cellular retinoic acid binding protein 2
chr2_-_174248360 3.37 ENST00000409546.5
ENST00000428402.6
ENST00000284719.8
Obg like ATPase 1
chr5_+_142771119 3.30 ENST00000642734.1
Rho GTPase activating protein 26
chr20_+_17570046 3.24 ENST00000246069.12
ENST00000474024.5
destrin, actin depolymerizing factor
chr1_-_85708382 3.19 ENST00000370574.4
ENST00000431532.6
zinc finger HIT-type containing 6
chr2_-_164841812 3.17 ENST00000652658.2
ENST00000444537.5
ENST00000414843.5
cordon-bleu WH2 repeat protein like 1
chr4_+_168497044 3.17 ENST00000505667.6
palladin, cytoskeletal associated protein
chr5_-_54985579 3.13 ENST00000381405.5
ENST00000381403.4
endothelial cell specific molecule 1
chr22_+_49918626 3.00 ENST00000328268.9
ENST00000404488.7
cysteine rich with EGF like domains 2
chr12_-_13095628 2.97 ENST00000457134.6
ENST00000537302.5
germ cell associated 1
chr14_+_67241278 2.89 ENST00000676464.1
membrane palmitoylated protein 5
chr12_-_13095798 2.89 ENST00000396302.7
germ cell associated 1
chr17_-_47957824 2.89 ENST00000300557.3
proline rich 15 like
chr13_-_78603539 2.84 ENST00000377208.7
POU class 4 homeobox 1
chr2_+_37344594 2.81 ENST00000404976.5
ENST00000338415.8
glutaminyl-peptide cyclotransferase
chr8_+_32548303 2.81 ENST00000650967.1
neuregulin 1
chr3_+_52420955 2.80 ENST00000465863.1
PHD finger protein 7
chr3_-_52826834 2.78 ENST00000441637.2
inter-alpha-trypsin inhibitor heavy chain 4
chr1_+_150982268 2.77 ENST00000368947.9
annexin A9
chr15_+_88638947 2.74 ENST00000559876.2
interferon stimulated exonuclease gene 20
chr1_-_156705764 2.73 ENST00000621784.4
ENST00000368220.1
cellular retinoic acid binding protein 2
chr20_-_22585451 2.67 ENST00000377115.4
forkhead box A2
chr17_-_58352139 2.66 ENST00000225504.8
SPT4 homolog, DSIF elongation factor subunit
chr4_+_2829797 2.64 ENST00000513069.1
SH3 domain binding protein 2
chr1_-_45686501 2.60 ENST00000355105.8
ENST00000290795.7
GC-rich promoter binding protein 1 like 1
chr13_-_41061373 2.59 ENST00000405737.2
E74 like ETS transcription factor 1
chr4_-_75673360 2.58 ENST00000676584.1
ENST00000678329.1
ENST00000677889.1
ENST00000357854.7
ENST00000359707.9
ENST00000676974.1
ENST00000678273.1
ENST00000677201.1
ENST00000678244.1
ENST00000677125.1
ENST00000677162.1
G3BP stress granule assembly factor 2
chr9_+_137277698 2.56 ENST00000357503.3
torsin family 4 member A
chr10_-_122845850 2.56 ENST00000392790.6
CUB and zona pellucida like domains 1
chr8_+_32548210 2.55 ENST00000523079.5
ENST00000650919.1
neuregulin 1
chr6_+_41921491 2.54 ENST00000230340.9
bystin like
chr1_-_156705575 2.53 ENST00000368222.8
cellular retinoic acid binding protein 2
chr19_-_39391137 2.50 ENST00000595564.5
PAF1 homolog, Paf1/RNA polymerase II complex component
chr6_-_31970923 2.47 ENST00000495340.5
decapping exoribonuclease
chr5_+_76819022 2.43 ENST00000296677.5
F2R like trypsin receptor 1
chr17_-_41382298 2.42 ENST00000394001.3
keratin 34
chr11_-_117828068 2.33 ENST00000532119.5
ENST00000260287.2
FXYD domain containing ion transport regulator 2
chr7_-_11832190 2.30 ENST00000423059.9
ENST00000617773.1
thrombospondin type 1 domain containing 7A
chr11_+_120240135 2.30 ENST00000543440.7
POU class 2 homeobox 3
chr11_+_68312542 2.29 ENST00000294304.12
LDL receptor related protein 5
chr1_-_41918666 2.29 ENST00000372584.5
HIVEP zinc finger 3
chr14_-_36582593 2.26 ENST00000258829.6
NK2 homeobox 8
chr11_+_66011994 2.26 ENST00000312134.3
cystatin E/M
chr8_-_129939694 2.19 ENST00000522250.5
ENST00000522941.5
ENST00000522746.5
ENST00000520204.5
ENST00000519070.5
ENST00000520254.5
ENST00000519824.6
CYFIP related Rac1 interactor B
chr12_+_57782742 2.19 ENST00000540550.6
ENST00000323833.12
ENST00000652027.2
ENST00000550559.5
ENST00000548851.5
ENST00000543727.5
ENST00000434359.5
ENST00000457189.1
Ts translation elongation factor, mitochondrial
chr13_+_114234864 2.17 ENST00000360383.7
ENST00000628084.2
ENST00000356221.8
cell division cycle 16
chr11_+_60455839 2.17 ENST00000532491.5
ENST00000532073.5
ENST00000345732.9
ENST00000534668.6
ENST00000528313.1
ENST00000533306.6
ENST00000674194.1
membrane spanning 4-domains A1
chr3_-_179266971 2.14 ENST00000349697.2
ENST00000497599.5
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr16_-_11281322 2.14 ENST00000312511.4
protamine 1
chr17_+_7558774 2.12 ENST00000396545.4
TNF superfamily member 13
chr22_-_18518161 2.10 ENST00000619998.1
gamma-glutamyltransferase light chain family member 3
chr14_+_67240713 2.10 ENST00000677382.1
membrane palmitoylated protein 5
chr8_-_129939872 2.09 ENST00000519540.5
CYFIP related Rac1 interactor B
chr17_-_7241787 2.06 ENST00000577035.5
GABA type A receptor-associated protein
chr20_+_45416551 1.99 ENST00000639292.1
phosphatidylinositol glycan anchor biosynthesis class T
chr7_+_128830399 1.99 ENST00000325888.13
ENST00000346177.6
filamin C
chr4_-_138242325 1.98 ENST00000280612.9
solute carrier family 7 member 11
chr14_+_22271921 1.96 ENST00000390464.2
T cell receptor alpha variable 38-1
chr3_+_105366877 1.88 ENST00000306107.9
activated leukocyte cell adhesion molecule
chr6_-_31582415 1.82 ENST00000429299.3
ENST00000446745.2
lymphotoxin beta
chr1_+_154272589 1.80 ENST00000457918.6
ENST00000483970.6
ENST00000328703.12
ENST00000435087.1
ENST00000532105.1
HCLS1 associated protein X-1
chr7_-_157010615 1.76 ENST00000252971.11
motor neuron and pancreas homeobox 1
chr16_-_29995601 1.73 ENST00000279392.8
ENST00000564026.1
HIRA interacting protein 3
chr3_-_49685090 1.73 ENST00000448220.5
macrophage stimulating 1
chr13_+_114235066 1.70 ENST00000252458.6
cell division cycle 16
chr4_-_185535498 1.70 ENST00000284767.12
ENST00000284771.7
ENST00000284770.10
ENST00000620787.5
ENST00000629667.2
PDZ and LIM domain 3
chr19_+_50432885 1.69 ENST00000357701.6
myosin binding protein C2
chr18_+_57352541 1.67 ENST00000324000.4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr5_+_83471925 1.66 ENST00000502527.2
versican
chr10_+_113854610 1.66 ENST00000369301.3
NHL repeat containing 2
chr14_-_106324743 1.66 ENST00000390612.3
immunoglobulin heavy variable 4-28

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
5.7 51.4 GO:0031536 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536)
5.2 31.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
4.4 13.1 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
4.2 12.7 GO:0071283 regulation of chromosome condensation(GO:0060623) cellular response to iron(III) ion(GO:0071283)
4.0 11.9 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
3.7 18.5 GO:0006177 GMP biosynthetic process(GO:0006177)
3.7 14.7 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
3.6 10.8 GO:0035732 nitric oxide storage(GO:0035732)
3.4 16.9 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
2.7 53.6 GO:0006527 arginine catabolic process(GO:0006527)
2.4 11.8 GO:0070295 transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295)
2.3 16.3 GO:0032218 riboflavin transport(GO:0032218)
2.2 6.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.9 11.2 GO:0003164 His-Purkinje system development(GO:0003164)
1.8 5.4 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
1.8 8.8 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
1.7 5.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) neuron projection maintenance(GO:1990535)
1.7 22.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.7 6.6 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
1.6 4.7 GO:0097698 telomere maintenance via base-excision repair(GO:0097698)
1.5 6.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
1.5 16.9 GO:0048194 Golgi vesicle budding(GO:0048194)
1.3 6.6 GO:0019348 dolichol metabolic process(GO:0019348)
1.3 11.6 GO:0075525 viral translational termination-reinitiation(GO:0075525)
1.2 5.0 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
1.2 3.7 GO:1901420 negative regulation of response to alcohol(GO:1901420)
1.2 15.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.2 3.6 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
1.1 5.7 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
1.1 46.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
1.0 11.5 GO:0009414 response to water deprivation(GO:0009414)
0.9 2.8 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.9 10.0 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.9 6.4 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.9 6.3 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.9 2.7 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.9 3.5 GO:0003409 optic cup structural organization(GO:0003409)
0.8 2.4 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.8 4.0 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.7 6.0 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.7 8.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.7 2.8 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.7 48.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6 3.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.6 5.1 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) regulation of lung blood pressure(GO:0014916) tetrahydrobiopterin metabolic process(GO:0046146)
0.6 3.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.6 3.6 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.6 2.3 GO:0048539 bone marrow development(GO:0048539)
0.5 7.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.5 3.2 GO:0048254 snoRNA localization(GO:0048254)
0.5 6.5 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.5 6.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.5 1.4 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.5 6.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 18.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.4 2.6 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.4 6.6 GO:0003334 keratinocyte development(GO:0003334)
0.4 9.2 GO:0097062 dendritic spine maintenance(GO:0097062)
0.4 3.8 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.4 6.4 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.4 2.5 GO:0016584 nucleosome positioning(GO:0016584)
0.4 1.4 GO:0043387 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.3 15.1 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.3 6.8 GO:0031167 rRNA methylation(GO:0031167)
0.3 8.0 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.2 3.2 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.2 3.2 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.2 3.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 5.5 GO:0007398 ectoderm development(GO:0007398)
0.2 2.7 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.2 6.9 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2 5.9 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.2 2.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 25.2 GO:0031424 keratinization(GO:0031424)
0.2 1.1 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.2 2.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 2.2 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.2 13.5 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2 4.5 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.2 0.7 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.2 14.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 0.8 GO:0001575 globoside metabolic process(GO:0001575)
0.2 1.3 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.2 2.1 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 1.8 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 31.3 GO:0008203 cholesterol metabolic process(GO:0008203)
0.2 2.3 GO:1990573 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) potassium ion import across plasma membrane(GO:1990573)
0.2 1.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.2 3.5 GO:0008210 estrogen metabolic process(GO:0008210)
0.1 5.8 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 2.1 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.5 GO:0070673 response to interleukin-18(GO:0070673)
0.1 1.6 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.1 2.5 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1 0.5 GO:0060023 soft palate development(GO:0060023)
0.1 2.3 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 4.4 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 5.9 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 1.3 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 0.6 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.1 2.7 GO:0051639 actin filament network formation(GO:0051639)
0.1 2.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 1.3 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 2.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 1.0 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 1.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 2.1 GO:0005513 detection of calcium ion(GO:0005513)
0.1 2.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.4 GO:0019323 pentose catabolic process(GO:0019323)
0.1 2.1 GO:0030261 chromosome condensation(GO:0030261)
0.1 0.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 2.3 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.7 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 7.8 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 1.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 5.3 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 2.5 GO:0006308 DNA catabolic process(GO:0006308)
0.1 2.0 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 0.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 2.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 1.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 1.0 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.9 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 2.0 GO:0048747 muscle fiber development(GO:0048747)
0.0 3.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 7.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 5.9 GO:0002576 platelet degranulation(GO:0002576)
0.0 1.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 1.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.3 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 2.2 GO:0042100 B cell proliferation(GO:0042100)
0.0 3.4 GO:0042594 response to starvation(GO:0042594)
0.0 2.2 GO:0002377 immunoglobulin production(GO:0002377)
0.0 2.3 GO:0001889 liver development(GO:0001889)
0.0 0.4 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.9 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.3 GO:0042462 eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0018444 translation release factor complex(GO:0018444)
3.9 31.3 GO:0061689 tricellular tight junction(GO:0061689)
3.2 12.7 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
3.2 15.9 GO:0097149 centralspindlin complex(GO:0097149)
2.7 10.8 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
2.7 10.6 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
2.2 64.6 GO:0005680 anaphase-promoting complex(GO:0005680)
2.0 6.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
1.9 5.8 GO:1990393 3M complex(GO:1990393)
1.9 5.8 GO:0035370 UBC13-UEV1A complex(GO:0035370)
1.8 5.4 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
1.7 22.1 GO:0042555 MCM complex(GO:0042555)
1.5 6.0 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
1.3 5.3 GO:0008537 proteasome activator complex(GO:0008537)
0.9 6.4 GO:0030905 retromer, tubulation complex(GO:0030905)
0.8 7.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.7 9.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 11.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.6 2.3 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.5 2.7 GO:0032044 DSIF complex(GO:0032044)
0.5 4.0 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.5 11.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.5 21.8 GO:0045095 keratin filament(GO:0045095)
0.5 14.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 4.4 GO:0061574 ASAP complex(GO:0061574)
0.4 3.2 GO:0070761 pre-snoRNP complex(GO:0070761)
0.4 17.3 GO:0032420 stereocilium(GO:0032420)
0.4 5.0 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.4 11.5 GO:0030057 desmosome(GO:0030057)
0.4 6.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.3 6.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.3 9.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 7.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 6.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 8.8 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.3 24.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 16.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 2.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 2.9 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 19.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 18.5 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 4.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 2.6 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 0.5 GO:0005592 collagen type XI trimer(GO:0005592)
0.2 5.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 2.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 2.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 6.6 GO:0002102 podosome(GO:0002102)
0.1 2.1 GO:0097225 sperm midpiece(GO:0097225)
0.1 3.5 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.1 GO:0070552 BRISC complex(GO:0070552)
0.1 9.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.9 GO:0043256 laminin complex(GO:0043256)
0.1 2.3 GO:0001533 cornified envelope(GO:0001533)
0.1 7.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 2.4 GO:0031143 pseudopodium(GO:0031143)
0.1 29.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 5.3 GO:0035580 specific granule lumen(GO:0035580)
0.1 11.0 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.6 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 2.3 GO:0016459 myosin complex(GO:0016459)
0.1 28.9 GO:0010008 endosome membrane(GO:0010008)
0.1 5.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 6.5 GO:0016605 PML body(GO:0016605)
0.0 7.7 GO:0005938 cell cortex(GO:0005938)
0.0 6.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 61.9 GO:0005615 extracellular space(GO:0005615)
0.0 5.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 28.3 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 17.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 24.8 GO:0005730 nucleolus(GO:0005730)
0.0 5.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.3 GO:0044853 plasma membrane raft(GO:0044853)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.5 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.3 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 4.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 4.3 GO:0005925 focal adhesion(GO:0005925)
0.0 8.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.9 GO:0019866 organelle inner membrane(GO:0019866)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 53.6 GO:0016403 dimethylargininase activity(GO:0016403)
4.6 18.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
4.4 13.1 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
3.6 10.8 GO:0035730 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
2.5 17.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
2.4 11.8 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
2.3 16.3 GO:0032217 riboflavin transporter activity(GO:0032217)
2.3 6.8 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
2.2 6.5 GO:0008859 exoribonuclease II activity(GO:0008859)
2.1 12.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
2.1 6.3 GO:0004766 spermidine synthase activity(GO:0004766)
1.8 84.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.7 6.6 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
1.5 6.0 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
1.4 11.5 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
1.3 4.0 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.3 6.6 GO:0004771 sterol esterase activity(GO:0004771)
1.3 6.4 GO:1990460 leptin receptor binding(GO:1990460)
1.2 4.7 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
1.1 8.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.1 11.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.9 3.7 GO:0070404 NADH binding(GO:0070404)
0.9 5.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.8 5.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.8 6.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.8 16.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.8 2.3 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.8 5.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 20.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 12.9 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.6 2.5 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.6 14.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.5 8.7 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.5 3.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 15.1 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.4 22.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.4 22.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 2.4 GO:0015057 thrombin receptor activity(GO:0015057)
0.4 2.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.4 6.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.4 6.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.4 11.5 GO:0001968 fibronectin binding(GO:0001968)
0.3 7.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.3 5.6 GO:0030297 ErbB-2 class receptor binding(GO:0005176) transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.3 3.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 19.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 1.3 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
0.3 2.8 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 5.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 8.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 6.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 2.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 12.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.2 8.0 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 5.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 2.1 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 1.8 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 1.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 1.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.8 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 3.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 12.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 36.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 7.4 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 17.3 GO:0005179 hormone activity(GO:0005179)
0.1 3.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 5.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 2.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 12.9 GO:0005178 integrin binding(GO:0005178)
0.1 5.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 2.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 2.7 GO:0003785 actin monomer binding(GO:0003785)
0.1 7.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.7 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.6 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 28.2 GO:0005525 GTP binding(GO:0005525)
0.1 0.8 GO:0015643 toxic substance binding(GO:0015643)
0.1 5.5 GO:0019905 syntaxin binding(GO:0019905)
0.1 0.5 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 3.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 4.5 GO:0005518 collagen binding(GO:0005518)
0.0 5.4 GO:0051087 chaperone binding(GO:0051087)
0.0 2.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.6 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 1.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 4.4 GO:0008201 heparin binding(GO:0008201)
0.0 0.6 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 8.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 34.4 PID BARD1 PATHWAY BARD1 signaling events
0.4 16.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.4 28.6 PID PLK1 PATHWAY PLK1 signaling events
0.3 14.9 PID ATR PATHWAY ATR signaling pathway
0.3 72.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 10.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 13.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 11.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 9.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.2 5.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 5.8 PID IL1 PATHWAY IL1-mediated signaling events
0.1 2.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 6.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 3.3 PID MYC PATHWAY C-MYC pathway
0.1 5.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 6.4 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 2.7 ST GA12 PATHWAY G alpha 12 Pathway
0.1 6.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 6.6 PID NOTCH PATHWAY Notch signaling pathway
0.1 8.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 3.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 2.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 3.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 7.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 4.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.9 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 77.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
1.5 22.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.2 18.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.0 19.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.9 36.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.6 12.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.5 11.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 13.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.4 16.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 4.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 7.2 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.3 5.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.3 10.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 6.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.3 12.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.3 6.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 22.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 19.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 12.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 5.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 4.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.2 9.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 16.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 6.0 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 6.0 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.2 5.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 6.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 9.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 15.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.7 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1 5.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 4.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 13.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 7.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 6.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.1 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 3.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 5.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.6 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.7 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.0 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes