Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for FLI1
Z-value: 7.05
Motif logo
Transcription factors associated with FLI1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FLI1
|
ENSG00000151702.17 | FLI1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FLI1 | hg38_v1_chr11_+_128693887_128693931, hg38_v1_chr11_+_128694052_128694108 | 0.67 | 2.7e-29 | Click! |
Activity profile of FLI1 motif
Sorted Z-values of FLI1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of FLI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.4 | 57.4 | GO:0002357 | defense response to tumor cell(GO:0002357) |
| 10.2 | 30.7 | GO:0032887 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 8.7 | 26.1 | GO:0071139 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 6.9 | 27.4 | GO:0052053 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 5.4 | 21.7 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 5.1 | 30.6 | GO:0038016 | insulin receptor internalization(GO:0038016) |
| 4.6 | 13.8 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 4.5 | 18.2 | GO:0002881 | negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881) |
| 4.5 | 13.4 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 4.0 | 16.1 | GO:0045626 | negative regulation of T-helper 1 cell differentiation(GO:0045626) |
| 4.0 | 15.9 | GO:0003366 | cell-matrix adhesion involved in ameboidal cell migration(GO:0003366) |
| 3.9 | 15.5 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 3.9 | 11.6 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 3.8 | 11.3 | GO:2000439 | positive regulation of monocyte extravasation(GO:2000439) |
| 3.7 | 14.8 | GO:0090299 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 3.2 | 3.2 | GO:0002589 | negative regulation of antigen processing and presentation of peptide antigen(GO:0002584) regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) |
| 3.1 | 59.4 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 3.1 | 15.6 | GO:0046103 | adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103) |
| 3.0 | 21.0 | GO:0045079 | negative regulation of chemokine biosynthetic process(GO:0045079) |
| 3.0 | 11.9 | GO:1905224 | clathrin-coated pit assembly(GO:1905224) |
| 2.9 | 2.9 | GO:0019336 | phenol-containing compound catabolic process(GO:0019336) |
| 2.8 | 11.4 | GO:0052251 | induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) |
| 2.6 | 7.7 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) |
| 2.5 | 14.9 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 2.5 | 7.4 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 2.5 | 7.4 | GO:1903248 | regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283) |
| 2.4 | 7.3 | GO:0050904 | diapedesis(GO:0050904) |
| 2.4 | 7.2 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 2.4 | 7.1 | GO:0098759 | response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) |
| 2.4 | 2.4 | GO:0099403 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 2.3 | 20.9 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 2.3 | 4.5 | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) |
| 2.2 | 11.2 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 2.2 | 46.7 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 2.2 | 32.3 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 2.2 | 15.1 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 2.1 | 4.2 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 2.0 | 6.1 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678) |
| 2.0 | 6.1 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 2.0 | 6.0 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 2.0 | 6.0 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 2.0 | 11.9 | GO:1903936 | cellular response to sodium arsenite(GO:1903936) |
| 1.9 | 5.8 | GO:2000537 | regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 1.9 | 26.9 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 1.8 | 5.5 | GO:0002884 | negative regulation of hypersensitivity(GO:0002884) |
| 1.8 | 7.3 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 1.8 | 7.3 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 1.8 | 3.5 | GO:1905237 | response to cyclosporin A(GO:1905237) |
| 1.7 | 7.0 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 1.7 | 6.8 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) |
| 1.7 | 25.3 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) |
| 1.7 | 5.1 | GO:0045897 | positive regulation of transcription during mitosis(GO:0045897) |
| 1.7 | 5.0 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.7 | 6.6 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 1.6 | 4.9 | GO:0002625 | regulation of T cell antigen processing and presentation(GO:0002625) |
| 1.6 | 26.2 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 1.6 | 6.3 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 1.6 | 4.7 | GO:0018307 | tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307) |
| 1.6 | 6.3 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 1.5 | 4.6 | GO:0018395 | peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine(GO:0018395) histone arginine demethylation(GO:0070077) histone H3-R2 demethylation(GO:0070078) histone H4-R3 demethylation(GO:0070079) |
| 1.5 | 10.7 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 1.5 | 19.2 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 1.4 | 12.8 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 1.4 | 31.1 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 1.3 | 5.3 | GO:0032290 | peripheral nervous system myelin formation(GO:0032290) |
| 1.3 | 9.2 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
| 1.3 | 11.9 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 1.3 | 7.9 | GO:1904685 | positive regulation of metalloendopeptidase activity(GO:1904685) |
| 1.3 | 3.9 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 1.3 | 3.8 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 1.2 | 13.6 | GO:0015074 | DNA integration(GO:0015074) |
| 1.2 | 2.5 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 1.2 | 3.7 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 1.2 | 3.7 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 1.2 | 1.2 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 1.2 | 3.6 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 1.2 | 6.0 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 1.2 | 7.1 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.2 | 5.9 | GO:1903906 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 1.2 | 4.6 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 1.2 | 13.9 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 1.2 | 8.1 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 1.1 | 4.6 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 1.1 | 2.3 | GO:0002351 | serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554) |
| 1.1 | 9.1 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 1.1 | 3.4 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 1.1 | 11.2 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 1.1 | 8.9 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
| 1.1 | 6.6 | GO:0048619 | embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619) |
| 1.1 | 5.4 | GO:0030242 | pexophagy(GO:0030242) |
| 1.1 | 29.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 1.1 | 18.2 | GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103) |
| 1.0 | 4.2 | GO:0097676 | histone H3-K36 dimethylation(GO:0097676) |
| 1.0 | 6.2 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 1.0 | 3.1 | GO:0072276 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 1.0 | 2.1 | GO:0033025 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
| 1.0 | 10.2 | GO:0044800 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 1.0 | 4.1 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 1.0 | 3.0 | GO:0038178 | complement component C5a signaling pathway(GO:0038178) |
| 1.0 | 3.0 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 1.0 | 2.9 | GO:0036079 | GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079) |
| 1.0 | 2.9 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.9 | 2.8 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.9 | 7.4 | GO:0046146 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.9 | 4.6 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.9 | 3.7 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.9 | 3.6 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.9 | 13.6 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 0.9 | 3.6 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.9 | 7.2 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.9 | 2.7 | GO:1990168 | protein K33-linked deubiquitination(GO:1990168) |
| 0.9 | 4.4 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.9 | 2.6 | GO:0036245 | cellular response to menadione(GO:0036245) |
| 0.9 | 15.5 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) |
| 0.9 | 4.3 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.9 | 4.3 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.9 | 7.7 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.9 | 8.6 | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.9 | 7.7 | GO:0017062 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 0.9 | 3.4 | GO:1903347 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.8 | 5.1 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.8 | 5.9 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
| 0.8 | 15.1 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.8 | 8.2 | GO:1901978 | positive regulation of cell cycle checkpoint(GO:1901978) |
| 0.8 | 2.4 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 0.8 | 5.6 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.8 | 7.2 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.8 | 6.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.8 | 3.1 | GO:0019086 | late viral transcription(GO:0019086) |
| 0.8 | 12.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.8 | 1.5 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 0.8 | 3.0 | GO:0060335 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.8 | 37.0 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.8 | 17.3 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.8 | 3.0 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.7 | 2.2 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) |
| 0.7 | 1.5 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 0.7 | 2.2 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 0.7 | 2.9 | GO:0046968 | peptide antigen transport(GO:0046968) |
| 0.7 | 2.2 | GO:0061011 | hepatic duct development(GO:0061011) |
| 0.7 | 4.4 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.7 | 3.6 | GO:2000870 | oocyte growth(GO:0001555) regulation of progesterone secretion(GO:2000870) |
| 0.7 | 4.3 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.7 | 2.8 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.7 | 6.4 | GO:0097012 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 0.7 | 2.1 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.7 | 4.9 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.7 | 4.9 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.7 | 8.3 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.7 | 2.0 | GO:0051182 | coenzyme transport(GO:0051182) |
| 0.7 | 3.4 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
| 0.7 | 8.1 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.7 | 3.3 | GO:0001957 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.7 | 7.3 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.7 | 3.3 | GO:0002681 | somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) |
| 0.7 | 33.9 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.6 | 4.5 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.6 | 9.0 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.6 | 1.3 | GO:0070346 | positive regulation of fat cell proliferation(GO:0070346) |
| 0.6 | 3.2 | GO:0045023 | G0 to G1 transition(GO:0045023) |
| 0.6 | 3.8 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.6 | 1.9 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.6 | 3.7 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.6 | 3.7 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.6 | 9.1 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.6 | 11.5 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.6 | 12.6 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.6 | 4.2 | GO:0051344 | negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
| 0.6 | 5.4 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.6 | 42.0 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.6 | 1.7 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.6 | 3.4 | GO:0035385 | Roundabout signaling pathway(GO:0035385) |
| 0.6 | 21.4 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.6 | 4.5 | GO:1901529 | positive regulation of anion channel activity(GO:1901529) |
| 0.6 | 1.7 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.6 | 7.2 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 0.5 | 6.5 | GO:0048535 | lymph node development(GO:0048535) |
| 0.5 | 5.4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.5 | 4.8 | GO:0021888 | hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) fat pad development(GO:0060613) |
| 0.5 | 5.9 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.5 | 17.6 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.5 | 44.5 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.5 | 1.6 | GO:1903568 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 0.5 | 4.7 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.5 | 3.1 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 0.5 | 14.5 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.5 | 4.6 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.5 | 3.1 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.5 | 4.1 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.5 | 1.5 | GO:0051142 | regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142) |
| 0.5 | 3.0 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.5 | 5.5 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.5 | 1.5 | GO:0072102 | glomerulus morphogenesis(GO:0072102) |
| 0.5 | 3.4 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.5 | 3.9 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.5 | 1.9 | GO:0071639 | positive regulation of microtubule depolymerization(GO:0031117) cortical microtubule organization(GO:0043622) positive regulation of monocyte chemotactic protein-1 production(GO:0071639) |
| 0.5 | 6.7 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.5 | 9.1 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.5 | 8.1 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.5 | 26.2 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.5 | 1.4 | GO:0048213 | Golgi vesicle prefusion complex stabilization(GO:0048213) |
| 0.5 | 1.0 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
| 0.5 | 0.9 | GO:1901204 | regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) negative regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901205) |
| 0.5 | 4.2 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.5 | 2.3 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
| 0.5 | 6.0 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.5 | 8.3 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
| 0.5 | 3.7 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.5 | 2.3 | GO:0000730 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
| 0.4 | 2.7 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.4 | 3.6 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.4 | 2.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.4 | 4.5 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.4 | 4.0 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.4 | 4.4 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.4 | 7.3 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.4 | 1.3 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.4 | 1.6 | GO:1904304 | regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306) |
| 0.4 | 6.4 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.4 | 2.0 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.4 | 13.2 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.4 | 2.4 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.4 | 9.1 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.4 | 14.1 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.4 | 2.3 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.4 | 2.7 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.4 | 1.9 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.4 | 56.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.4 | 3.0 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
| 0.4 | 4.6 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.4 | 2.6 | GO:1902731 | ovarian cumulus expansion(GO:0001550) oogenesis stage(GO:0022605) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731) |
| 0.4 | 2.6 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.4 | 1.5 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.4 | 0.7 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.4 | 4.8 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.4 | 6.6 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.4 | 1.1 | GO:0099557 | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission(GO:0099557) |
| 0.4 | 9.3 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.4 | 1.4 | GO:2000346 | negative regulation of hepatocyte proliferation(GO:2000346) |
| 0.4 | 1.4 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.3 | 3.1 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.3 | 1.0 | GO:0032700 | negative regulation of interleukin-17 production(GO:0032700) |
| 0.3 | 3.8 | GO:2001204 | regulation of osteoclast development(GO:2001204) |
| 0.3 | 1.7 | GO:2001295 | negative regulation of fatty acid beta-oxidation(GO:0031999) malonyl-CoA biosynthetic process(GO:2001295) |
| 0.3 | 1.0 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 0.3 | 9.9 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.3 | 1.4 | GO:0019072 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.3 | 3.7 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.3 | 5.7 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.3 | 8.7 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 0.3 | 2.7 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.3 | 2.3 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.3 | 2.3 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.3 | 2.2 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.3 | 1.9 | GO:0045779 | negative regulation of bone resorption(GO:0045779) |
| 0.3 | 1.3 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.3 | 0.9 | GO:0039022 | pronephric nephron morphogenesis(GO:0039007) pronephric nephron tubule morphogenesis(GO:0039008) pronephric duct development(GO:0039022) pronephric duct morphogenesis(GO:0039023) Kupffer's vesicle development(GO:0070121) |
| 0.3 | 0.6 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.3 | 1.2 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.3 | 4.7 | GO:0030220 | platelet formation(GO:0030220) |
| 0.3 | 0.9 | GO:0022007 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.3 | 3.1 | GO:1901623 | regulation of lymphocyte chemotaxis(GO:1901623) |
| 0.3 | 3.1 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.3 | 7.9 | GO:0050651 | dermatan sulfate proteoglycan biosynthetic process(GO:0050651) |
| 0.3 | 2.4 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.3 | 8.8 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.3 | 1.2 | GO:0072574 | hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575) |
| 0.3 | 1.8 | GO:2000773 | negative regulation of cellular senescence(GO:2000773) |
| 0.3 | 5.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.3 | 3.0 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.3 | 0.3 | GO:1900104 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.3 | 5.2 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.3 | 2.0 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.3 | 0.9 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) |
| 0.3 | 4.0 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.3 | 3.6 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.3 | 11.9 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.3 | 1.7 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.3 | 2.4 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.3 | 10.2 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.3 | 0.8 | GO:0060352 | cell adhesion molecule production(GO:0060352) |
| 0.3 | 0.8 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.3 | 2.0 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.3 | 2.8 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
| 0.2 | 4.7 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.2 | 6.4 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.2 | 3.0 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.2 | 3.2 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.2 | 3.1 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.2 | 4.4 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.2 | 3.5 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.2 | 0.5 | GO:0023035 | CD40 signaling pathway(GO:0023035) |
| 0.2 | 3.7 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.2 | 1.4 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.2 | 1.8 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.2 | 1.1 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.2 | 7.2 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.2 | 1.9 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.2 | 1.5 | GO:0006702 | androgen biosynthetic process(GO:0006702) |
| 0.2 | 0.8 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949) |
| 0.2 | 4.1 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.2 | 4.6 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.2 | 3.7 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.2 | 1.2 | GO:0060252 | positive regulation of glial cell proliferation(GO:0060252) |
| 0.2 | 0.8 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.2 | 0.4 | GO:0032823 | regulation of natural killer cell differentiation(GO:0032823) |
| 0.2 | 4.0 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 0.2 | 0.6 | GO:0071934 | thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934) |
| 0.2 | 1.6 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.2 | 2.4 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.2 | 1.6 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.2 | 6.0 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.2 | 0.8 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919) |
| 0.2 | 2.9 | GO:0007099 | centriole replication(GO:0007099) |
| 0.2 | 4.4 | GO:0001945 | lymph vessel development(GO:0001945) |
| 0.2 | 0.4 | GO:0010159 | specification of organ position(GO:0010159) |
| 0.2 | 1.9 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.2 | 1.5 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.2 | 0.8 | GO:0050927 | positive regulation of positive chemotaxis(GO:0050927) |
| 0.2 | 1.1 | GO:0009629 | response to gravity(GO:0009629) |
| 0.2 | 15.0 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.2 | 9.0 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.2 | 5.8 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.2 | 2.7 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 0.2 | 5.4 | GO:0006706 | steroid catabolic process(GO:0006706) |
| 0.2 | 1.1 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.2 | 2.7 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.2 | 12.0 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.2 | 4.1 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 0.2 | 1.6 | GO:0032695 | negative regulation of interleukin-12 production(GO:0032695) |
| 0.2 | 1.6 | GO:0008298 | intracellular mRNA localization(GO:0008298) |
| 0.2 | 0.3 | GO:0051459 | regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.2 | 1.7 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.2 | 2.1 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.2 | 1.0 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.2 | 0.8 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.2 | 3.0 | GO:0001935 | endothelial cell proliferation(GO:0001935) |
| 0.2 | 1.0 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.2 | 0.8 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.2 | 3.7 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.2 | 1.8 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.2 | 1.2 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.2 | 1.5 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.2 | 1.5 | GO:0045986 | negative regulation of smooth muscle contraction(GO:0045986) |
| 0.2 | 1.4 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.2 | 9.6 | GO:0002819 | regulation of adaptive immune response(GO:0002819) |
| 0.2 | 0.8 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.2 | 12.8 | GO:0070301 | cellular response to hydrogen peroxide(GO:0070301) |
| 0.2 | 0.9 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.2 | 17.2 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.2 | 2.2 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.2 | 1.7 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.2 | 12.3 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.2 | 2.0 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.2 | 1.1 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.2 | 5.0 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.2 | 3.2 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.2 | 14.0 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 3.9 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 1.9 | GO:0001569 | patterning of blood vessels(GO:0001569) |
| 0.1 | 3.3 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.1 | 2.6 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.1 | 12.0 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.1 | 1.4 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.1 | 3.5 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.1 | 0.3 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.1 | 2.4 | GO:0006506 | GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506) |
| 0.1 | 1.6 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.1 | 1.5 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.1 | 0.7 | GO:2000465 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) regulation of glycogen (starch) synthase activity(GO:2000465) positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.1 | 0.4 | GO:0046015 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) regulation of transcription by glucose(GO:0046015) |
| 0.1 | 2.7 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 9.1 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.1 | 1.8 | GO:0007184 | SMAD protein import into nucleus(GO:0007184) |
| 0.1 | 7.2 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.1 | 1.5 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.1 | 2.8 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 2.9 | GO:0016577 | histone demethylation(GO:0016577) |
| 0.1 | 1.4 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.1 | 0.8 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.1 | 3.6 | GO:0042116 | macrophage activation(GO:0042116) |
| 0.1 | 3.4 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 1.1 | GO:0009642 | response to light intensity(GO:0009642) |
| 0.1 | 0.5 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.1 | 1.6 | GO:0042554 | superoxide anion generation(GO:0042554) |
| 0.1 | 3.4 | GO:0001938 | positive regulation of endothelial cell proliferation(GO:0001938) |
| 0.1 | 0.4 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.1 | 1.5 | GO:0060484 | lung-associated mesenchyme development(GO:0060484) |
| 0.1 | 3.0 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.1 | 14.3 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 0.6 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 0.1 | 5.1 | GO:2000181 | negative regulation of angiogenesis(GO:0016525) negative regulation of vasculature development(GO:1901343) negative regulation of blood vessel morphogenesis(GO:2000181) |
| 0.1 | 0.4 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 0.6 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 0.9 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.1 | 3.8 | GO:0050771 | negative regulation of axonogenesis(GO:0050771) |
| 0.1 | 0.6 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.1 | 3.0 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
| 0.1 | 0.9 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.1 | 0.6 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 0.1 | 0.6 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.1 | 6.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 0.8 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 0.1 | 1.0 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 7.3 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.1 | 0.3 | GO:0045554 | TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759) TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556) |
| 0.1 | 2.4 | GO:0048265 | response to pain(GO:0048265) |
| 0.1 | 1.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 2.2 | GO:0006356 | regulation of transcription from RNA polymerase I promoter(GO:0006356) |
| 0.1 | 0.2 | GO:0030157 | pancreatic juice secretion(GO:0030157) |
| 0.1 | 1.8 | GO:0071850 | mitotic cell cycle arrest(GO:0071850) |
| 0.1 | 1.4 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
| 0.1 | 1.5 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 1.1 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 0.1 | 0.9 | GO:0043507 | positive regulation of JUN kinase activity(GO:0043507) |
| 0.1 | 1.5 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 2.5 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.1 | 1.0 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.1 | 0.5 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.1 | 0.7 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
| 0.1 | 0.6 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.1 | 1.2 | GO:0033006 | regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304) |
| 0.1 | 1.2 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 2.2 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.1 | 0.6 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.1 | 1.0 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.1 | 2.7 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 0.6 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.1 | 3.2 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.1 | 1.9 | GO:0009083 | branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083) |
| 0.1 | 0.4 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.1 | 0.8 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.1 | 0.8 | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314) |
| 0.1 | 2.8 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.1 | 2.3 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 3.9 | GO:0003014 | renal system process(GO:0003014) |
| 0.1 | 0.4 | GO:0031069 | hair follicle morphogenesis(GO:0031069) |
| 0.1 | 1.7 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.1 | 2.8 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 0.0 | 13.3 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 1.8 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 4.5 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade(GO:0070374) |
| 0.0 | 0.7 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 2.7 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 0.0 | 0.4 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 2.2 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 2.8 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.0 | 0.2 | GO:1904293 | negative regulation of ERAD pathway(GO:1904293) |
| 0.0 | 1.7 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 0.8 | GO:0042136 | neurotransmitter biosynthetic process(GO:0042136) |
| 0.0 | 0.4 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.0 | 2.1 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.4 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.0 | 1.2 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.4 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
| 0.0 | 0.8 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.0 | 0.7 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.0 | 0.4 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.0 | 0.4 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 0.3 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 0.0 | 0.2 | GO:0045601 | regulation of endothelial cell differentiation(GO:0045601) |
| 0.0 | 1.8 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.0 | 1.0 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.0 | 0.2 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 1.2 | GO:0000045 | autophagosome assembly(GO:0000045) |
| 0.0 | 0.8 | GO:0046835 | carbohydrate phosphorylation(GO:0046835) |
| 0.0 | 1.4 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 0.6 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.0 | 0.3 | GO:0035588 | G-protein coupled purinergic receptor signaling pathway(GO:0035588) G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.2 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.7 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 0.0 | 0.4 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.0 | 0.0 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.0 | 0.3 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.0 | 0.2 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.0 | 0.7 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.0 | 0.3 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
| 0.0 | 0.3 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.0 | 0.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.2 | 30.7 | GO:0055028 | cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673) |
| 8.8 | 52.7 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 5.7 | 57.4 | GO:0044194 | cytolytic granule(GO:0044194) |
| 5.3 | 32.0 | GO:0070545 | PeBoW complex(GO:0070545) |
| 4.0 | 16.1 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 4.0 | 15.9 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 3.9 | 30.9 | GO:0072487 | MSL complex(GO:0072487) |
| 2.7 | 8.2 | GO:0044609 | DBIRD complex(GO:0044609) |
| 2.3 | 50.2 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 2.1 | 6.4 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 2.0 | 6.0 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 2.0 | 21.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 2.0 | 17.6 | GO:0097427 | microtubule bundle(GO:0097427) |
| 1.9 | 7.7 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 1.9 | 15.2 | GO:0032010 | phagolysosome(GO:0032010) |
| 1.8 | 3.7 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 1.5 | 7.7 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 1.3 | 28.2 | GO:0000242 | pericentriolar material(GO:0000242) |
| 1.3 | 27.9 | GO:0097342 | ripoptosome(GO:0097342) |
| 1.3 | 16.4 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.2 | 6.2 | GO:0070847 | core mediator complex(GO:0070847) |
| 1.2 | 46.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 1.2 | 6.1 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 1.2 | 4.7 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 1.2 | 5.9 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 1.1 | 10.3 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 1.1 | 9.7 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
| 1.0 | 3.1 | GO:0005760 | gamma DNA polymerase complex(GO:0005760) |
| 1.0 | 7.2 | GO:1990745 | EARP complex(GO:1990745) |
| 1.0 | 5.1 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 1.0 | 3.0 | GO:0005953 | CAAX-protein geranylgeranyltransferase complex(GO:0005953) |
| 1.0 | 7.0 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 1.0 | 5.9 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.9 | 4.7 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.9 | 14.2 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.9 | 11.4 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.9 | 3.4 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.8 | 21.2 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.8 | 15.1 | GO:0036038 | MKS complex(GO:0036038) |
| 0.8 | 3.9 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.7 | 4.4 | GO:0033063 | DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.7 | 4.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.7 | 11.6 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.7 | 4.3 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.7 | 4.2 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.7 | 5.6 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
| 0.7 | 3.4 | GO:0045293 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.7 | 4.6 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.7 | 22.2 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.6 | 7.0 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.6 | 1.9 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.6 | 21.4 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.6 | 6.2 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.6 | 6.6 | GO:0032039 | integrator complex(GO:0032039) |
| 0.6 | 3.0 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.6 | 2.9 | GO:0031523 | Myb complex(GO:0031523) |
| 0.6 | 11.2 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.5 | 5.4 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.5 | 4.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.5 | 14.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.4 | 2.6 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.4 | 0.4 | GO:0098536 | deuterosome(GO:0098536) |
| 0.4 | 4.3 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.4 | 3.8 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.4 | 24.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.4 | 11.8 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.4 | 22.2 | GO:0019814 | immunoglobulin complex(GO:0019814) |
| 0.4 | 5.8 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.4 | 7.0 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.4 | 4.0 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.4 | 4.8 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.4 | 5.8 | GO:0030478 | actin cap(GO:0030478) |
| 0.4 | 4.2 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.4 | 6.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.4 | 1.9 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.4 | 9.4 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.4 | 3.0 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.4 | 2.2 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.4 | 2.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.4 | 7.2 | GO:0046930 | pore complex(GO:0046930) |
| 0.4 | 3.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.3 | 5.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.3 | 3.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.3 | 1.7 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
| 0.3 | 24.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 5.6 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.3 | 1.0 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.3 | 3.5 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.3 | 6.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 3.4 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.3 | 1.5 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.3 | 1.5 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.3 | 2.0 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.3 | 1.7 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.3 | 1.4 | GO:0034448 | EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.3 | 6.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.3 | 2.6 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.3 | 4.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.3 | 4.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 1.0 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.2 | 0.7 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.2 | 1.5 | GO:0097425 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.2 | 22.3 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 74.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 3.7 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.2 | 3.7 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.2 | 10.4 | GO:0002102 | podosome(GO:0002102) |
| 0.2 | 1.6 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 0.6 | GO:0032009 | early phagosome(GO:0032009) |
| 0.2 | 6.5 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.2 | 3.6 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.2 | 2.6 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.2 | 2.4 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.2 | 26.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 14.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.2 | 0.5 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 2.2 | GO:0097433 | dense body(GO:0097433) |
| 0.2 | 2.0 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.2 | 2.2 | GO:0031045 | dense core granule(GO:0031045) |
| 0.2 | 13.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 0.8 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.2 | 4.8 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.2 | 1.7 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.2 | 1.8 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.2 | 5.5 | GO:0016592 | mediator complex(GO:0016592) |
| 0.2 | 20.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 1.4 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.2 | 1.8 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.2 | 1.4 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.2 | 3.9 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 5.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 6.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 3.0 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.4 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 0.1 | 0.8 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 3.2 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 0.8 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.1 | 0.5 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.1 | 1.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 15.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 4.1 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 1.8 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 5.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 12.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 9.4 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 0.7 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 2.0 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 6.3 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.1 | 1.5 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 1.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 0.4 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 5.5 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 1.4 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.1 | 23.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 0.3 | GO:0051286 | cell tip(GO:0051286) |
| 0.1 | 0.4 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.1 | 0.3 | GO:0089701 | U2AF(GO:0089701) |
| 0.1 | 1.0 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 1.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 0.8 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 1.8 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.1 | 0.7 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.1 | 3.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 7.1 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 0.7 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.1 | 0.6 | GO:0030904 | retromer complex(GO:0030904) |
| 0.1 | 2.1 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 4.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 205.3 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 1.2 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.2 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 16.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.7 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.0 | GO:0032589 | neuron projection membrane(GO:0032589) |
| 0.0 | 0.1 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.0 | 0.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.0 | GO:0072379 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 38.3 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 7.5 | 52.7 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 6.6 | 59.4 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 5.2 | 20.9 | GO:0004911 | interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976) |
| 4.7 | 28.3 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 4.5 | 18.2 | GO:0016495 | C-X3-C chemokine receptor activity(GO:0016495) |
| 4.2 | 21.2 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 3.9 | 15.5 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 3.8 | 30.6 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 3.7 | 25.6 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 2.9 | 8.8 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 2.9 | 29.2 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 2.8 | 11.4 | GO:0005471 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 2.7 | 21.7 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 2.5 | 7.4 | GO:0036487 | nitric-oxide synthase inhibitor activity(GO:0036487) |
| 2.3 | 20.8 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 2.2 | 8.8 | GO:0004773 | steryl-sulfatase activity(GO:0004773) |
| 2.1 | 34.9 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 2.0 | 8.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 2.0 | 7.9 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 2.0 | 5.9 | GO:0032089 | NACHT domain binding(GO:0032089) |
| 1.9 | 15.2 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 1.9 | 7.4 | GO:0004505 | phenylalanine 4-monooxygenase activity(GO:0004505) |
| 1.8 | 36.6 | GO:0005522 | profilin binding(GO:0005522) |
| 1.8 | 46.9 | GO:0022829 | wide pore channel activity(GO:0022829) |
| 1.7 | 7.0 | GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) |
| 1.7 | 5.2 | GO:0004144 | diacylglycerol O-acyltransferase activity(GO:0004144) |
| 1.7 | 15.6 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 1.7 | 35.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 1.7 | 5.0 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 1.7 | 6.6 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 1.5 | 4.6 | GO:0033746 | histone demethylase activity (H3-R2 specific)(GO:0033746) histone demethylase activity (H4-R3 specific)(GO:0033749) |
| 1.5 | 6.1 | GO:0032810 | sterol response element binding(GO:0032810) |
| 1.5 | 4.5 | GO:0090555 | phosphatidylethanolamine-translocating ATPase activity(GO:0090555) |
| 1.5 | 7.3 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 1.4 | 11.6 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 1.4 | 9.5 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 1.3 | 4.0 | GO:0015226 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
| 1.3 | 6.6 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 1.2 | 7.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 1.2 | 6.0 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 1.2 | 22.2 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 1.2 | 4.6 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
| 1.2 | 3.5 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 1.1 | 3.4 | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422) |
| 1.1 | 12.3 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 1.1 | 12.0 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 1.0 | 3.1 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 1.0 | 3.0 | GO:0004662 | CAAX-protein geranylgeranyltransferase activity(GO:0004662) |
| 1.0 | 3.0 | GO:0004878 | complement component C5a receptor activity(GO:0004878) |
| 1.0 | 15.5 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 1.0 | 5.8 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 1.0 | 2.9 | GO:0036080 | GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080) |
| 1.0 | 3.8 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.9 | 4.7 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.9 | 2.7 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.9 | 13.4 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.9 | 3.5 | GO:0090554 | phosphatidylcholine-translocating ATPase activity(GO:0090554) |
| 0.9 | 10.6 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.9 | 6.9 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.9 | 20.6 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.9 | 2.6 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.8 | 4.9 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.8 | 9.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.8 | 6.3 | GO:0008430 | selenium binding(GO:0008430) |
| 0.8 | 7.1 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.8 | 84.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.8 | 1.6 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.8 | 19.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.8 | 2.3 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.8 | 3.8 | GO:0047238 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238) |
| 0.8 | 3.0 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.8 | 10.5 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.7 | 3.7 | GO:0032558 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 0.7 | 4.5 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.7 | 3.0 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.7 | 2.2 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.7 | 2.9 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.7 | 17.7 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.7 | 5.6 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.7 | 16.5 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.7 | 4.6 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.7 | 4.6 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.7 | 11.2 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.7 | 2.6 | GO:0001588 | dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588) |
| 0.7 | 2.6 | GO:0030107 | HLA-A specific inhibitory MHC class I receptor activity(GO:0030107) |
| 0.6 | 7.1 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.6 | 1.9 | GO:0015275 | stretch-activated, cation-selective, calcium channel activity(GO:0015275) |
| 0.6 | 4.4 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.6 | 1.9 | GO:0016429 | tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
| 0.6 | 1.9 | GO:0003826 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
| 0.6 | 4.4 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.6 | 3.6 | GO:0070004 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.6 | 1.8 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 0.6 | 2.4 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.6 | 8.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.6 | 3.5 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.6 | 4.7 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.6 | 5.8 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.6 | 13.2 | GO:0031005 | filamin binding(GO:0031005) |
| 0.6 | 2.9 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.6 | 2.9 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.6 | 10.2 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.6 | 1.7 | GO:0004320 | oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) |
| 0.6 | 7.9 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.6 | 5.0 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.5 | 4.9 | GO:0043426 | MRF binding(GO:0043426) |
| 0.5 | 3.2 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.5 | 1.6 | GO:0032090 | Pyrin domain binding(GO:0032090) |
| 0.5 | 10.8 | GO:0005112 | Notch binding(GO:0005112) |
| 0.5 | 2.0 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.5 | 14.6 | GO:0071949 | FAD binding(GO:0071949) |
| 0.5 | 15.0 | GO:0015149 | hexose transmembrane transporter activity(GO:0015149) |
| 0.5 | 8.9 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.5 | 3.9 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.5 | 3.4 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.5 | 2.8 | GO:0070513 | death domain binding(GO:0070513) |
| 0.5 | 30.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.5 | 6.8 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.4 | 1.3 | GO:0061752 | telomeric repeat-containing RNA binding(GO:0061752) |
| 0.4 | 3.5 | GO:0003958 | NADPH-hemoprotein reductase activity(GO:0003958) |
| 0.4 | 6.3 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.4 | 5.9 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.4 | 1.2 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.4 | 5.8 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.4 | 31.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.4 | 2.5 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.4 | 22.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 1.6 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.4 | 4.0 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
| 0.4 | 7.0 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.4 | 3.4 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.4 | 4.5 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.4 | 2.3 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.4 | 1.5 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.4 | 8.1 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.4 | 1.5 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
| 0.4 | 47.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.4 | 1.5 | GO:0000995 | transcription factor activity, core RNA polymerase III binding(GO:0000995) |
| 0.4 | 14.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.4 | 58.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 0.7 | GO:0042806 | fucose binding(GO:0042806) |
| 0.4 | 10.2 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.3 | 4.2 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.3 | 4.2 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.3 | 5.2 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.3 | 3.5 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.3 | 4.5 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.3 | 1.7 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.3 | 1.7 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.3 | 2.4 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.3 | 5.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.3 | 2.4 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.3 | 2.0 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.3 | 1.0 | GO:0001596 | angiotensin type I receptor activity(GO:0001596) |
| 0.3 | 8.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.3 | 23.2 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.3 | 1.3 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.3 | 9.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 1.2 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.3 | 11.9 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.3 | 2.4 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.3 | 9.9 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.3 | 7.1 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.3 | 2.0 | GO:0004459 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 0.3 | 2.8 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.3 | 7.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.3 | 1.1 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.3 | 7.9 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.3 | 4.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.3 | 4.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.3 | 1.1 | GO:0005334 | norepinephrine:sodium symporter activity(GO:0005334) |
| 0.3 | 0.8 | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829) |
| 0.3 | 2.6 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.3 | 5.5 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.3 | 1.6 | GO:0019826 | NAD(P)H oxidase activity(GO:0016174) oxygen sensor activity(GO:0019826) |
| 0.3 | 9.3 | GO:0043394 | proteoglycan binding(GO:0043394) |
| 0.3 | 3.8 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.2 | 1.2 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.2 | 2.7 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.2 | 4.4 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.2 | 2.2 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.2 | 2.7 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 0.7 | GO:0004040 | amidase activity(GO:0004040) |
| 0.2 | 4.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.2 | 1.6 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 0.2 | 1.2 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.2 | 1.2 | GO:0010340 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.2 | 1.2 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.2 | 1.8 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.2 | 3.0 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 8.6 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.2 | 12.6 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.2 | 7.2 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.2 | 1.7 | GO:0089720 | caspase binding(GO:0089720) |
| 0.2 | 0.9 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.2 | 3.4 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.2 | 5.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.2 | 5.8 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.2 | 1.0 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.2 | 0.8 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.2 | 4.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 0.6 | GO:0015403 | thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403) |
| 0.2 | 2.6 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 1.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 2.7 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.2 | 1.1 | GO:0022821 | potassium ion antiporter activity(GO:0022821) |
| 0.2 | 0.8 | GO:0004102 | choline O-acetyltransferase activity(GO:0004102) |
| 0.2 | 3.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.2 | 1.8 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.2 | 0.9 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 0.2 | 1.4 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.2 | 18.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 2.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.2 | 2.3 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.2 | 5.2 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
| 0.2 | 5.3 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.2 | 4.9 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.2 | 1.2 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.2 | 2.1 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
| 0.2 | 1.1 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.2 | 6.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.2 | 2.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.2 | 2.9 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 0.6 | GO:0070404 | NADH binding(GO:0070404) |
| 0.1 | 2.2 | GO:0001164 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.1 | 6.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.6 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 3.0 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 1.5 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 0.8 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.1 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 0.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 10.8 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 0.5 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
| 0.1 | 0.4 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.1 | 1.4 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.1 | 4.9 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 1.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 8.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 2.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 0.8 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.1 | 10.6 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 0.5 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.1 | 0.7 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 1.5 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.1 | 10.7 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 1.9 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 11.7 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 2.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 0.6 | GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060) |
| 0.1 | 0.3 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 1.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 1.5 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 0.7 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.1 | 8.5 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 1.2 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.1 | 1.0 | GO:0035197 | siRNA binding(GO:0035197) |
| 0.1 | 1.0 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 2.1 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.1 | 1.6 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.1 | 2.5 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 6.2 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 2.0 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.1 | 0.8 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 6.6 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 0.1 | 1.2 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 23.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 0.3 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.1 | 1.1 | GO:0004955 | prostaglandin receptor activity(GO:0004955) |
| 0.1 | 0.4 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.1 | 0.4 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.1 | 3.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 5.1 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 1.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 0.7 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.1 | 1.7 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.1 | 1.6 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 0.4 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.1 | 2.6 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 0.6 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.1 | 2.0 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 0.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 0.7 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 1.7 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.1 | 1.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.2 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.1 | 1.0 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.1 | 1.3 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 0.4 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 0.6 | GO:0015101 | organic cation transmembrane transporter activity(GO:0015101) |
| 0.1 | 2.5 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.1 | 8.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 0.2 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 1.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.2 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.1 | 0.3 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.1 | 0.3 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.1 | 1.7 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.1 | 0.8 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.7 | GO:1901476 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
| 0.0 | 63.3 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.4 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.0 | 1.3 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.8 | GO:0015278 | calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604) |
| 0.0 | 27.9 | GO:0004888 | transmembrane signaling receptor activity(GO:0004888) |
| 0.0 | 11.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 0.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 4.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.5 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.0 | 0.3 | GO:0031404 | chloride ion binding(GO:0031404) |
| 0.0 | 0.8 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.4 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.8 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 0.2 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.4 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.0 | 0.3 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 1.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 1.6 | GO:0015081 | sodium ion transmembrane transporter activity(GO:0015081) |
| 0.0 | 0.3 | GO:0004707 | MAP kinase activity(GO:0004707) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 59.1 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 2.2 | 85.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 2.0 | 10.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 1.8 | 89.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.3 | 98.4 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.3 | 110.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.3 | 14.6 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 1.1 | 80.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.9 | 17.3 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.7 | 15.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.7 | 34.5 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.6 | 12.0 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.5 | 10.2 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.5 | 13.4 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.5 | 2.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.4 | 2.8 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.4 | 5.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.4 | 6.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.4 | 25.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.3 | 16.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 7.1 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.3 | 9.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.3 | 10.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 4.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.3 | 6.1 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.3 | 13.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 6.5 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.3 | 4.7 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.3 | 15.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.3 | 16.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.3 | 14.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 5.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.3 | 5.2 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.3 | 1.6 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.3 | 3.0 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.2 | 1.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.2 | 3.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.2 | 5.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 3.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 12.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 81.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 3.1 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.2 | 2.4 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.2 | 2.0 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.2 | 8.1 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.2 | 6.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.2 | 10.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 9.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 2.6 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.2 | 6.5 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.2 | 1.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 0.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.2 | 0.8 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.2 | 4.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 3.5 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.2 | 4.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 1.2 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 8.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 23.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 1.6 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 1.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 1.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 1.3 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 3.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 1.5 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 3.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 2.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 13.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 1.6 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 0.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 0.8 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 6.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 1.0 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 1.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 0.9 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 1.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 1.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.1 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 7.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 53.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 2.4 | 30.7 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 2.2 | 54.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 1.8 | 38.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 1.5 | 50.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 1.4 | 134.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.3 | 49.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.0 | 13.0 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.9 | 3.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.9 | 4.4 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.9 | 7.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.9 | 11.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.8 | 8.1 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.8 | 21.0 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.7 | 9.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.7 | 17.7 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.6 | 10.2 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |
| 0.6 | 2.5 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.5 | 32.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.5 | 3.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.5 | 2.3 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.4 | 5.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.4 | 4.3 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.4 | 14.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.4 | 4.9 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.4 | 5.2 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.4 | 14.0 | REACTOME IL 2 SIGNALING | Genes involved in Interleukin-2 signaling |
| 0.4 | 4.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.4 | 4.2 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.3 | 5.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 4.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.3 | 18.4 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 13.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.3 | 6.7 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.3 | 24.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.3 | 6.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.3 | 3.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.3 | 3.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 3.4 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.3 | 25.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 6.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.3 | 7.3 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.3 | 8.4 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.2 | 4.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 1.2 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.2 | 17.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 4.2 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.2 | 97.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 5.6 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.2 | 39.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 54.5 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.2 | 5.0 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 1.0 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.2 | 7.5 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 7.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.2 | 6.5 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.2 | 1.5 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.2 | 3.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 2.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 7.1 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 3.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 11.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 2.7 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 3.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 3.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 5.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 5.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 4.0 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.1 | 9.8 | REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | Genes involved in MyD88:Mal cascade initiated on plasma membrane |
| 0.1 | 2.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 0.2 | REACTOME SHC MEDIATED SIGNALLING | Genes involved in SHC-mediated signalling |
| 0.1 | 2.7 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 1.6 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.5 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.1 | 4.7 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 4.1 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 1.2 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 1.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.3 | REACTOME SIGNALING BY SCF KIT | Genes involved in Signaling by SCF-KIT |
| 0.1 | 1.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 0.5 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 5.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 1.1 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 8.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.7 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 2.4 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 0.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.3 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.0 | 0.4 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.2 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |