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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FOSB

Z-value: 4.87

Motif logo

Transcription factors associated with FOSB

Gene Symbol Gene ID Gene Info
ENSG00000125740.14 FOSB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOSBhg38_v1_chr19_+_45467988_45468007-0.144.5e-02Click!

Activity profile of FOSB motif

Sorted Z-values of FOSB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSB

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_-_31736504 23.50 ENST00000616760.1
ENST00000375784.7
ENST00000375779.6
chloride intracellular channel 1
chr17_-_75154534 20.27 ENST00000356033.8
Jupiter microtubule associated homolog 1
chr1_+_26280117 18.79 ENST00000319041.6
SH3 domain binding glutamate rich protein like 3
chr1_+_223712491 18.04 ENST00000295006.6
calpain 2
chr1_+_223701582 17.94 ENST00000433674.6
calpain 2
chr1_-_23799533 16.05 ENST00000429356.5
UDP-galactose-4-epimerase
chrX_+_49171918 14.45 ENST00000376322.7
proteolipid protein 2
chr11_-_64245816 13.29 ENST00000542235.1
protein phosphatase 1 regulatory inhibitor subunit 14B
chr11_-_67356970 12.72 ENST00000532830.5
DNA polymerase delta 4, accessory subunit
chr11_-_65900375 12.45 ENST00000312562.7
FOS like 1, AP-1 transcription factor subunit
chr11_-_11353241 12.27 ENST00000528848.3
casein kinase 2 alpha 3
chr11_-_64246190 12.00 ENST00000392210.6
protein phosphatase 1 regulatory inhibitor subunit 14B
chr11_-_65900413 11.64 ENST00000448083.6
ENST00000531493.5
ENST00000532401.1
FOS like 1, AP-1 transcription factor subunit
chr15_-_60397964 11.63 ENST00000558998.5
ENST00000560165.5
ENST00000557986.5
ENST00000559467.5
ENST00000677968.1
ENST00000678450.1
ENST00000332680.8
ENST00000396024.7
ENST00000557906.6
ENST00000558558.6
ENST00000559113.6
ENST00000559780.6
ENST00000559956.6
ENST00000560468.6
ENST00000678870.1
ENST00000678061.1
ENST00000451270.7
ENST00000421017.6
ENST00000560466.5
ENST00000558132.5
ENST00000559370.5
ENST00000559725.5
ENST00000558985.6
ENST00000679109.1
annexin A2
chr5_+_136059151 11.60 ENST00000503087.1
transforming growth factor beta induced
chrX_+_49171889 11.33 ENST00000376327.6
proteolipid protein 2
chr14_+_34993240 11.33 ENST00000677647.1
signal recognition particle 54
chr10_+_17228215 11.15 ENST00000544301.7
vimentin
chr3_+_184176949 10.93 ENST00000432591.5
ENST00000431779.5
ENST00000621863.4
adaptor related protein complex 2 subunit mu 1
chr1_-_112704921 10.75 ENST00000414971.1
ENST00000534717.5
ras homolog family member C
chr6_+_44227025 9.88 ENST00000371708.1
solute carrier family 29 member 1 (Augustine blood group)
chr17_+_37491464 9.84 ENST00000613659.1
dual specificity phosphatase 14
chr8_+_26293112 9.43 ENST00000523925.5
ENST00000315985.7
protein phosphatase 2 regulatory subunit Balpha
chr14_+_103334803 9.37 ENST00000561325.5
ENST00000392715.6
ENST00000559130.5
ENST00000559532.5
ENST00000558506.1
eukaryotic translation initiation factor 5
chr3_+_184176778 9.11 ENST00000439647.5
adaptor related protein complex 2 subunit mu 1
chr11_+_102112445 9.08 ENST00000524575.5
Yes1 associated transcriptional regulator
chr14_-_22957128 8.96 ENST00000342454.12
ENST00000555986.5
ENST00000554516.5
ENST00000347758.6
ENST00000206474.11
ENST00000555040.5
HAUS augmin like complex subunit 4
chr3_-_142028597 8.48 ENST00000467667.5
transcription factor Dp-2
chr14_-_22957061 8.25 ENST00000557591.5
ENST00000541587.6
ENST00000490506.5
ENST00000554406.1
HAUS augmin like complex subunit 4
chr14_-_22957100 8.03 ENST00000555367.5
HAUS augmin like complex subunit 4
chr19_+_19405655 7.39 ENST00000683918.1
GATA zinc finger domain containing 2A
chr15_-_22980334 7.32 ENST00000610365.4
ENST00000617928.5
ENST00000611832.4
cytoplasmic FMR1 interacting protein 1
chr1_-_153985366 7.22 ENST00000614713.4
RAB13, member RAS oncogene family
chr16_+_89921851 7.19 ENST00000554444.5
ENST00000556565.5
tubulin beta 3 class III
chr19_+_48874318 6.94 ENST00000600406.1
protein phosphatase 1 regulatory subunit 15A
chr22_-_31662180 6.94 ENST00000435900.5
phosphatidylserine decarboxylase
chr1_+_156126160 6.87 ENST00000448611.6
ENST00000368297.5
lamin A/C
chr6_-_38703066 6.51 ENST00000373365.5
glyoxalase I
chr12_+_53299682 6.46 ENST00000267103.10
ENST00000548632.5
MYG1 exonuclease
chr6_+_30717433 6.45 ENST00000681435.1
tubulin beta class I
chr1_+_26543106 6.28 ENST00000530003.5
ribosomal protein S6 kinase A1
chr6_-_35921079 6.24 ENST00000507909.1
ENST00000373825.7
SRSF protein kinase 1
chr3_-_142029108 6.21 ENST00000497579.5
transcription factor Dp-2
chr6_-_158818225 6.07 ENST00000337147.11
ezrin
chr5_+_160009113 6.04 ENST00000522793.5
ENST00000682719.1
ENST00000684137.1
ENST00000683219.1
ENST00000684018.1
ENST00000231238.10
ENST00000682131.1
tetratricopeptide repeat domain 1
chr6_-_35921128 6.02 ENST00000510290.5
ENST00000423325.6
SRSF protein kinase 1
chr7_-_103344588 5.99 ENST00000426036.6
ENST00000249270.11
ENST00000379263.8
ENST00000454277.5
ENST00000412522.1
DnaJ heat shock protein family (Hsp40) member C2
chr1_+_26863140 5.91 ENST00000339276.6
stratifin
chr3_-_149576203 5.91 ENST00000472417.1
WW domain containing transcription regulator 1
chr19_-_43670153 5.83 ENST00000601723.5
ENST00000339082.7
ENST00000340093.8
plasminogen activator, urokinase receptor
chr7_+_39623547 5.66 ENST00000005257.7
RAS like proto-oncogene A
chr6_-_35921047 5.60 ENST00000361690.7
ENST00000512445.5
SRSF protein kinase 1
chr18_+_23873000 5.41 ENST00000269217.11
ENST00000587184.5
laminin subunit alpha 3
chr6_+_2988606 5.40 ENST00000380472.7
ENST00000605901.1
ENST00000454015.1
N-ribosyldihydronicotinamide:quinone reductase 2
long intergenic non-protein coding RNA 1011
chr7_+_112423137 5.25 ENST00000005558.8
ENST00000621379.4
interferon related developmental regulator 1
chr3_-_31981228 5.11 ENST00000396556.7
ENST00000438237.6
oxysterol binding protein like 10
chr1_+_36155930 4.93 ENST00000316156.8
MAP7 domain containing 1
chr17_+_77450737 4.91 ENST00000541152.6
ENST00000591704.5
septin 9
chr17_+_81683963 4.88 ENST00000676462.1
ENST00000679336.1
ENST00000678196.1
ENST00000677243.1
ENST00000677044.1
ENST00000677109.1
ENST00000677484.1
ENST00000678105.1
ENST00000677209.1
ENST00000329138.9
ENST00000677225.1
ENST00000678866.1
ENST00000676729.1
ENST00000572392.2
ENST00000577012.1
hepatocyte growth factor-regulated tyrosine kinase substrate
chr11_+_706117 4.83 ENST00000533256.5
ENST00000614442.4
EPS8 like 2
chr11_-_102798148 4.81 ENST00000315274.7
matrix metallopeptidase 1
chr6_+_63571702 4.74 ENST00000672924.1
protein tyrosine phosphatase 4A1
chr7_+_143381286 4.69 ENST00000449630.5
ENST00000322764.10
ENST00000457235.5
zyxin
chr3_+_158110363 4.65 ENST00000683137.1
arginine and serine rich coiled-coil 1
chr11_+_706196 4.58 ENST00000534755.5
ENST00000650127.1
EPS8 like 2
chr1_+_36156096 4.52 ENST00000474796.2
ENST00000373150.8
ENST00000373151.6
MAP7 domain containing 1
chr14_+_73058521 4.50 ENST00000527432.5
ENST00000531500.5
ENST00000261973.12
ENST00000525321.5
ENST00000526754.5
RNA binding motif protein 25
chr17_+_21288029 4.34 ENST00000526076.6
ENST00000361818.9
ENST00000316920.10
mitogen-activated protein kinase kinase 3
chr3_-_49358320 4.28 ENST00000643797.1
ENST00000646881.2
ENST00000496791.2
glutathione peroxidase 1
chr12_-_118190510 4.26 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr14_-_75069478 4.23 ENST00000555463.1
acylphosphatase 1
chr19_+_36140059 4.16 ENST00000246533.8
ENST00000587718.5
ENST00000592483.5
ENST00000590874.5
ENST00000588815.5
calpain small subunit 1
chr11_-_65662780 4.16 ENST00000534283.1
ENST00000527749.5
ENST00000533187.5
ENST00000525693.5
ENST00000534558.5
ENST00000532879.5
ENST00000406246.8
ENST00000532999.5
RELA proto-oncogene, NF-kB subunit
chr6_-_43629222 4.10 ENST00000307126.10
GTP binding protein 2
chr2_-_135876382 4.10 ENST00000264156.3
minichromosome maintenance complex component 6
chr3_-_49358272 4.05 ENST00000419349.2
glutathione peroxidase 1
chr10_-_86521737 4.00 ENST00000298767.10
WAPL cohesin release factor
chr5_-_177496802 3.99 ENST00000506161.5
PDZ and LIM domain 7
chr8_-_30727777 3.93 ENST00000537535.5
ENST00000541648.5
ENST00000546342.5
ENST00000221130.11
glutathione-disulfide reductase
chr6_-_24877262 3.91 ENST00000378023.8
ENST00000540914.5
RHO family interacting cell polarization regulator 2
chr15_+_75043263 3.86 ENST00000563393.1
phosphopantothenoylcysteine decarboxylase
chr17_-_18258556 3.85 ENST00000579294.5
ENST00000628188.1
ENST00000545457.6
ENST00000578558.5
ENST00000327031.9
FLII actin remodeling protein
chr19_-_55370455 3.84 ENST00000264563.7
ENST00000585513.1
ENST00000590625.5
interleukin 11
chr9_+_69205141 3.84 ENST00000649134.1
ENST00000539225.2
ENST00000650084.1
ENST00000648402.1
tight junction protein 2
chr17_+_77319465 3.81 ENST00000329047.13
septin 9
chr11_+_706222 3.75 ENST00000318562.13
ENST00000533500.5
EPS8 like 2
chr22_+_31082860 3.67 ENST00000619644.4
smoothelin
chr3_+_105366877 3.65 ENST00000306107.9
activated leukocyte cell adhesion molecule
chr17_+_32444379 3.63 ENST00000578213.5
ENST00000649012.1
ENST00000457654.6
ENST00000579451.1
ENST00000261712.8
proteasome 26S subunit, non-ATPase 11
chr6_+_125219804 3.57 ENST00000524679.1
TPD52 like 1
chr13_+_75760659 3.54 ENST00000526202.5
ENST00000465261.6
LIM domain 7
chr1_+_174875505 3.52 ENST00000486220.5
RAB GTPase activating protein 1 like
chr11_+_67583803 3.52 ENST00000398606.10
glutathione S-transferase pi 1
chr5_-_177496845 3.49 ENST00000506537.1
PDZ and LIM domain 7
chr19_+_926001 3.42 ENST00000263620.8
AT-rich interaction domain 3A
chr7_+_150368189 3.40 ENST00000519397.1
ENST00000479668.5
replication initiator 1
chr13_+_75760431 3.37 ENST00000321797.12
LIM domain 7
chr17_-_74868616 3.35 ENST00000579893.1
ENST00000544854.5
ferredoxin reductase
chr3_+_141368497 3.28 ENST00000321464.7
zinc finger and BTB domain containing 38
chr15_+_67166019 3.26 ENST00000537194.6
SMAD family member 3
chr6_-_138107412 3.24 ENST00000421351.4
p53 apoptosis effector related to PMP22
chr4_+_73740541 3.15 ENST00000401931.1
ENST00000307407.8
C-X-C motif chemokine ligand 8
chr1_+_156114700 3.14 ENST00000677389.1
ENST00000368300.9
ENST00000368299.7
lamin A/C
chr21_+_31659666 3.13 ENST00000389995.4
ENST00000270142.11
superoxide dismutase 1
chr3_-_142028617 3.12 ENST00000477292.5
ENST00000478006.5
ENST00000495310.5
ENST00000486111.5
transcription factor Dp-2
chr13_-_40982880 3.02 ENST00000635415.1
E74 like ETS transcription factor 1
chr9_-_127874964 2.99 ENST00000373156.5
adenylate kinase 1
chr1_+_156126525 2.93 ENST00000504687.6
ENST00000473598.6
lamin A/C
chr7_+_32979445 2.87 ENST00000418354.5
ENST00000490776.3
FKBP prolyl isomerase 9
chr4_+_169660062 2.85 ENST00000507875.5
ENST00000613795.4
chloride voltage-gated channel 3
chr3_-_125055987 2.84 ENST00000311127.9
heart development protein with EGF like domains 1
chr3_-_11568764 2.82 ENST00000424529.6
vestigial like family member 4
chrX_+_123960519 2.81 ENST00000455404.5
ENST00000218089.13
stromal antigen 2
chr8_-_8893548 2.80 ENST00000276282.7
malignant fibrous histiocytoma amplified sequence 1
chr19_+_1407517 2.75 ENST00000336761.10
ENST00000233078.9
ENST00000592522.5
DAZ associated protein 1
chr3_+_100709424 2.73 ENST00000675246.1
ENST00000675692.1
ENST00000675890.1
ENST00000675586.1
ENST00000674645.1
ENST00000675958.1
ENST00000479672.6
ENST00000675420.1
ENST00000674615.1
ENST00000676431.1
ENST00000674758.1
trafficking from ER to golgi regulator
chr12_+_57455266 2.73 ENST00000266646.3
inhibin subunit beta E
chr17_-_29078857 2.65 ENST00000359450.6
TGFB1-induced anti-apoptotic factor 1
chr1_-_92792396 2.65 ENST00000370331.5
ENST00000540033.2
ecotropic viral integration site 5
chr16_+_30740621 2.53 ENST00000615541.3
ENST00000483578.1
transmembrane protein 265
novel transcript
chr11_+_67583742 2.46 ENST00000398603.6
glutathione S-transferase pi 1
chr7_-_78771108 2.40 ENST00000626691.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr7_-_20217342 2.35 ENST00000400331.10
ENST00000332878.8
MET transcriptional regulator MACC1
chr17_-_81923532 2.33 ENST00000392366.7
MAF bZIP transcription factor G
chr4_-_145098541 2.28 ENST00000613466.4
ENST00000514390.5
anaphase promoting complex subunit 10
chr17_-_40565459 2.27 ENST00000578085.1
ENST00000246657.2
C-C motif chemokine receptor 7
chr19_+_46601296 2.20 ENST00000598871.5
ENST00000291295.14
ENST00000594523.5
calmodulin 3
chr17_+_7219857 2.19 ENST00000583312.5
ENST00000350303.9
ENST00000584103.5
ENST00000356839.10
ENST00000579886.2
acyl-CoA dehydrogenase very long chain
chr12_-_54419259 2.15 ENST00000293379.9
integrin subunit alpha 5
chr19_-_45424364 2.06 ENST00000589165.5
ERCC excision repair 1, endonuclease non-catalytic subunit
chr11_-_65662931 2.03 ENST00000615805.4
ENST00000612991.4
RELA proto-oncogene, NF-kB subunit
chr6_-_41705813 2.02 ENST00000419574.6
ENST00000445214.2
transcription factor EB
chr1_-_153094521 1.96 ENST00000368750.8
small proline rich protein 2E
chr11_-_66336396 1.89 ENST00000627248.1
ENST00000311320.9
Ras and Rab interactor 1
chr8_-_142742398 1.87 ENST00000246515.2
secreted LY6/PLAUR domain containing 1
chr15_+_67125707 1.85 ENST00000540846.6
SMAD family member 3
chr12_-_14961559 1.84 ENST00000228945.9
ENST00000541546.5
Rho GDP dissociation inhibitor beta
chr17_+_48892761 1.79 ENST00000355938.9
ENST00000393366.7
ENST00000503641.5
ENST00000514808.5
ENST00000506855.1
ATP synthase membrane subunit c locus 1
chr18_+_34710307 1.72 ENST00000679796.1
dystrobrevin alpha
chr2_+_102001966 1.66 ENST00000457817.5
interleukin 1 receptor type 2
chr18_+_63476927 1.66 ENST00000489441.5
ENST00000382771.9
ENST00000424602.1
serpin family B member 5
chr11_-_102843597 1.65 ENST00000299855.10
matrix metallopeptidase 3
chr7_+_101085464 1.59 ENST00000306085.11
ENST00000412507.1
tripartite motif containing 56
chr1_-_12616762 1.58 ENST00000464917.5
dehydrogenase/reductase 3
chr1_+_247416149 1.53 ENST00000366497.6
ENST00000391828.8
NLR family pyrin domain containing 3
chr17_-_41786688 1.52 ENST00000310706.9
ENST00000393931.8
ENST00000424457.5
ENST00000591690.5
junction plakoglobin
chr3_+_113747022 1.50 ENST00000273398.8
ENST00000496747.5
ENST00000475322.1
ATPase H+ transporting V1 subunit A
chr1_-_6602885 1.49 ENST00000377663.3
kelch like family member 21
chr16_+_57628684 1.43 ENST00000567397.5
ENST00000568979.5
ENST00000672974.1
adhesion G protein-coupled receptor G1
chr1_-_153549120 1.42 ENST00000368712.1
S100 calcium binding protein A3
chr16_-_28482634 1.35 ENST00000637378.1
novel protein
chr15_-_82952683 1.32 ENST00000450735.7
ENST00000304231.12
homer scaffold protein 2
chr1_+_156114251 1.31 ENST00000361308.9
lamin A/C
chr10_-_29634964 1.30 ENST00000375398.6
ENST00000355867.8
supervillin
chr22_-_19881163 1.29 ENST00000485358.5
thioredoxin reductase 2
chr2_+_28392802 1.28 ENST00000379619.5
ENST00000264716.9
FOS like 2, AP-1 transcription factor subunit
chr3_-_48595267 1.28 ENST00000328333.12
ENST00000681320.1
collagen type VII alpha 1 chain
chr18_+_58196736 1.26 ENST00000675221.1
NEDD4 like E3 ubiquitin protein ligase
chr14_+_73058591 1.26 ENST00000525161.5
RNA binding motif protein 25
chr1_+_247416166 1.26 ENST00000391827.3
ENST00000336119.8
NLR family pyrin domain containing 3
chr12_-_51009264 1.21 ENST00000545993.7
solute carrier family 11 member 2
chr19_-_38773432 1.17 ENST00000599035.1
ENST00000378626.5
galectin 7
chr5_+_43602648 1.13 ENST00000505678.6
ENST00000512422.5
ENST00000264663.9
ENST00000670904.1
ENST00000653251.1
nicotinamide nucleotide transhydrogenase
chr3_-_151316795 1.11 ENST00000260843.5
G protein-coupled receptor 87
chr12_-_48957445 1.11 ENST00000541959.5
ENST00000447318.6
ENST00000256682.9
ADP ribosylation factor 3
chr1_-_6602859 1.09 ENST00000377658.8
kelch like family member 21
chr11_-_2171805 1.06 ENST00000381178.5
ENST00000381175.5
ENST00000333684.9
ENST00000352909.8
tyrosine hydroxylase
chr2_+_151357583 1.04 ENST00000243347.5
TNF alpha induced protein 6
chr1_-_153549238 1.03 ENST00000368713.8
S100 calcium binding protein A3
chr4_-_99435134 1.01 ENST00000476959.5
ENST00000482593.5
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr5_-_16916400 1.00 ENST00000513882.5
myosin X
chr3_+_48466222 0.96 ENST00000625293.3
ENST00000492235.2
ENST00000635452.2
ENST00000456089.1
three prime repair exonuclease 1
chr5_-_79514127 0.90 ENST00000334082.11
homer scaffold protein 1
chrX_-_20141810 0.83 ENST00000379593.1
ENST00000379607.10
eukaryotic translation initiation factor 1A X-linked
chr8_-_107497909 0.82 ENST00000517746.6
angiopoietin 1
chr15_+_86079863 0.81 ENST00000614907.3
ENST00000441037.7
ATP/GTP binding protein like 1
chr2_+_171687501 0.81 ENST00000508530.5
dynein cytoplasmic 1 intermediate chain 2
chr18_+_63775369 0.80 ENST00000540675.5
serpin family B member 7
chr2_+_190343561 0.79 ENST00000322522.8
ENST00000392329.7
ENST00000430311.5
inositol polyphosphate-1-phosphatase
chr1_+_100538131 0.78 ENST00000315033.5
G protein-coupled receptor 88
chr12_-_48957365 0.77 ENST00000398092.4
ENST00000539611.1
novel protein
ADP ribosylation factor 3
chr12_-_8612850 0.72 ENST00000229335.11
ENST00000537228.5
activation induced cytidine deaminase
chr15_-_77071032 0.68 ENST00000559494.1
tetraspanin 3
chr9_-_114078293 0.67 ENST00000265132.8
alpha-1-microglobulin/bikunin precursor
chr7_+_74209989 0.64 ENST00000361082.7
ENST00000275635.11
ENST00000460943.6
ENST00000470709.1
linker for activation of T cells family member 2
chr12_+_120534697 0.64 ENST00000675818.1
ENST00000413266.6
novel protein
ring finger protein 10
chr11_-_2903490 0.63 ENST00000455942.3
ENST00000625099.4
solute carrier family 22 member 18 antisense
chr3_+_9917185 0.63 ENST00000413608.2
ENST00000451165.6
interleukin 17 receptor C
chr5_+_143812161 0.59 ENST00000289448.4
histocompatibility minor HB-1
chr15_-_77071099 0.57 ENST00000267970.9
ENST00000346495.6
ENST00000424443.7
ENST00000561277.5
tetraspanin 3
chr12_-_95996302 0.54 ENST00000261208.8
ENST00000538703.5
ENST00000541929.5
histidine ammonia-lyase
chr5_-_170297746 0.52 ENST00000046794.10
lymphocyte cytosolic protein 2
chr17_-_29176752 0.49 ENST00000533112.5
myosin XVIIIA
chr11_-_118342645 0.46 ENST00000529594.5
CD3d molecule
chr2_-_65366650 0.46 ENST00000443619.6
sprouty related EVH1 domain containing 2
chr11_-_102874974 0.44 ENST00000571244.3
matrix metallopeptidase 12
chr5_-_88731827 0.40 ENST00000627170.2
myocyte enhancer factor 2C
chr17_+_76385256 0.39 ENST00000392496.3
sphingosine kinase 1
chr3_+_9917074 0.39 ENST00000416074.6
ENST00000383812.9
ENST00000438091.5
ENST00000295981.7
ENST00000403601.8
ENST00000436503.5
ENST00000455057.5
interleukin 17 receptor C
chr15_+_75206398 0.39 ENST00000565074.1
chromosome 15 open reading frame 39

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 24.1 GO:0007296 vitellogenesis(GO:0007296)
2.8 11.3 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
2.8 8.3 GO:1902905 positive regulation of fibril organization(GO:1902905)
2.6 7.7 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
2.4 7.3 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
2.4 14.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
2.3 11.6 GO:0044111 development involved in symbiotic interaction(GO:0044111)
2.3 6.9 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
2.2 10.8 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
2.1 6.2 GO:0006117 acetaldehyde metabolic process(GO:0006117)
2.0 36.0 GO:0016540 protein autoprocessing(GO:0016540)
2.0 6.0 GO:0035732 nitric oxide storage(GO:0035732)
2.0 9.9 GO:0015862 uridine transport(GO:0015862)
1.8 9.1 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
1.8 7.2 GO:1902463 protein localization to cell leading edge(GO:1902463)
1.8 5.3 GO:0007518 myoblast fate determination(GO:0007518)
1.6 17.9 GO:0035092 sperm chromatin condensation(GO:0035092)
1.3 4.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) regulation of chromosome condensation(GO:0060623) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.2 16.0 GO:0019388 galactose catabolic process(GO:0019388)
1.2 6.1 GO:1902896 terminal web assembly(GO:1902896)
1.2 5.9 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
1.1 13.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
1.1 6.5 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.9 6.3 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.9 11.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.9 5.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.8 20.0 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.8 3.9 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.8 2.3 GO:0097026 dendritic cell dendrite assembly(GO:0097026) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.7 2.9 GO:0048388 endosomal lumen acidification(GO:0048388)
0.7 5.9 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.6 3.1 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.6 4.3 GO:0035897 proteolysis in other organism(GO:0035897)
0.6 1.8 GO:0071461 cellular response to redox state(GO:0071461)
0.6 9.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.6 1.1 GO:0006740 NADPH regeneration(GO:0006740)
0.6 2.8 GO:0032621 interleukin-18 production(GO:0032621)
0.5 4.8 GO:0002934 desmosome organization(GO:0002934)
0.5 5.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.5 3.8 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.5 3.8 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.5 5.7 GO:0051665 membrane raft localization(GO:0051665)
0.4 1.7 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.4 2.8 GO:0090269 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.4 15.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.4 12.7 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.4 3.8 GO:0051014 actin filament severing(GO:0051014)
0.4 1.1 GO:0052314 phthalate metabolic process(GO:0018963) epinephrine biosynthetic process(GO:0042418) phytoalexin metabolic process(GO:0052314)
0.3 4.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 3.1 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.3 1.2 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 2.1 GO:1904431 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431)
0.3 1.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.3 18.8 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.3 0.8 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.3 2.4 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.3 22.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.3 1.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 4.9 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
0.2 2.2 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.2 5.1 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.2 1.2 GO:0015692 lead ion transport(GO:0015692)
0.2 2.8 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.2 3.6 GO:0043248 proteasome assembly(GO:0043248)
0.2 0.9 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 31.7 GO:0051225 spindle assembly(GO:0051225)
0.2 0.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.2 5.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 0.5 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.2 3.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 6.5 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.2 0.5 GO:1903028 positive regulation of opsonization(GO:1903028)
0.2 4.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 3.9 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.3 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.1 1.0 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1 2.6 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313)
0.1 5.0 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 1.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 3.0 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 3.6 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.1 10.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 3.7 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 6.0 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.1 7.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 2.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 1.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.7 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.1 0.6 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.1 0.8 GO:2000580 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 1.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 7.4 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 6.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 2.6 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 0.6 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.1 8.7 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 3.0 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.1 1.7 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.1 1.1 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 2.4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 2.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.7 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 2.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 4.3 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 1.6 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 2.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 3.4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 1.0 GO:0030728 ovulation(GO:0030728)
0.0 11.2 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 4.6 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 2.0 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 1.5 GO:0000305 response to oxygen radical(GO:0000305)
0.0 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 3.6 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 4.1 GO:0002576 platelet degranulation(GO:0002576)
0.0 8.8 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 7.5 GO:0007411 axon guidance(GO:0007411)
0.0 2.0 GO:0098773 skin epidermis development(GO:0098773)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.8 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
2.8 25.2 GO:0070652 HAUS complex(GO:0070652)
2.5 12.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
2.1 6.2 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
2.0 32.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
2.0 6.1 GO:0044393 microspike(GO:0044393)
1.7 11.6 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
1.6 4.9 GO:0033565 ESCRT-0 complex(GO:0033565)
1.5 6.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
1.3 14.3 GO:0005638 lamin filament(GO:0005638)
1.3 11.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.9 20.0 GO:0036020 endolysosome membrane(GO:0036020)
0.8 7.3 GO:0044294 dendritic growth cone(GO:0044294)
0.8 5.4 GO:0005610 laminin-5 complex(GO:0005610)
0.7 2.2 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.7 7.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.6 5.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 1.3 GO:0032426 stereocilium tip(GO:0032426)
0.4 6.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 5.3 GO:0097413 Lewy body(GO:0097413)
0.4 4.0 GO:0008278 cohesin complex(GO:0008278)
0.4 5.7 GO:0071438 invadopodium membrane(GO:0071438)
0.4 3.9 GO:0060171 stereocilium membrane(GO:0060171)
0.3 3.4 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 6.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 3.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 2.6 GO:0005827 polar microtubule(GO:0005827)
0.3 4.1 GO:0042555 MCM complex(GO:0042555)
0.3 2.8 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.3 2.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.3 17.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.2 GO:0070826 paraferritin complex(GO:0070826)
0.2 9.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 7.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 1.4 GO:0097451 glial limiting end-foot(GO:0097451)
0.2 16.4 GO:0034707 chloride channel complex(GO:0034707)
0.2 2.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.5 GO:0036398 TCR signalosome(GO:0036398)
0.2 3.1 GO:0031045 dense core granule(GO:0031045)
0.2 22.0 GO:0042734 presynaptic membrane(GO:0042734)
0.2 4.8 GO:0030057 desmosome(GO:0030057)
0.1 1.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 3.0 GO:0042101 T cell receptor complex(GO:0042101)
0.1 17.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 8.0 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.0 GO:0032433 filopodium tip(GO:0032433)
0.1 2.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 11.4 GO:0016363 nuclear matrix(GO:0016363)
0.1 13.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 6.0 GO:0005604 basement membrane(GO:0005604)
0.0 17.3 GO:0005819 spindle(GO:0005819)
0.0 0.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 4.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 14.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 4.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 6.6 GO:0030027 lamellipodium(GO:0030027)
0.0 0.5 GO:0042641 actomyosin(GO:0042641)
0.0 4.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 9.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.8 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.7 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 1.3 GO:0005771 multivesicular body(GO:0005771)
0.0 2.8 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 12.1 GO:0070161 anchoring junction(GO:0070161)
0.0 0.8 GO:0005902 microvillus(GO:0005902)
0.0 5.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 8.1 GO:0019866 organelle inner membrane(GO:0019866)
0.0 4.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 16.0 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
2.3 11.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
2.2 11.1 GO:1990254 keratin filament binding(GO:1990254)
2.0 6.0 GO:0035730 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
2.0 5.9 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
1.9 11.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
1.9 5.7 GO:0031755 endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755)
1.7 6.9 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
1.4 5.4 GO:0001512 dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
1.2 6.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.0 6.2 GO:0071532 ankyrin repeat binding(GO:0071532)
1.0 40.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
1.0 15.9 GO:0030215 semaphorin receptor binding(GO:0030215)
1.0 3.9 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.9 20.0 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.9 5.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.8 5.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.7 7.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.7 2.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.7 4.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.7 9.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.7 28.0 GO:0019956 chemokine binding(GO:0019956)
0.6 6.9 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.6 1.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.5 2.2 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.5 25.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.5 9.9 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.5 8.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.5 13.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.5 6.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.4 18.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 12.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 13.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 9.4 GO:0048156 tau protein binding(GO:0048156)
0.3 1.7 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.3 9.1 GO:0070064 proline-rich region binding(GO:0070064)
0.3 3.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 1.2 GO:0004031 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.3 2.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 6.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.3 2.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.2 1.2 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 2.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.2 1.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 1.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 3.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 3.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 1.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.5 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.2 2.8 GO:0042834 peptidoglycan binding(GO:0042834)
0.2 0.7 GO:0019862 IgA binding(GO:0019862)
0.2 2.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 6.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 3.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 0.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) tetrahydrobiopterin binding(GO:0034617)
0.1 1.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.5 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 2.8 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.0 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 9.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 4.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 4.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 5.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.5 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 3.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.7 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.8 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 1.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 3.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 2.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.5 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 14.1 GO:0000287 magnesium ion binding(GO:0000287)
0.1 19.0 GO:0003924 GTPase activity(GO:0003924)
0.1 0.2 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.1 0.9 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 34.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 4.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 6.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 7.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.8 GO:0005525 GTP binding(GO:0005525)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 3.0 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 5.8 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 3.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.5 GO:0043531 ADP binding(GO:0043531)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 20.0 PID ARF 3PATHWAY Arf1 pathway
0.5 33.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 38.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.4 30.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.4 6.3 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.4 15.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 31.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.3 10.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 6.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.3 11.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 7.5 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 6.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 22.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 7.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 4.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 1.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 9.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 10.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 15.5 PID E2F PATHWAY E2F transcription factor network
0.1 1.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 4.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 3.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 7.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 12.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.9 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.7 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 1.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 2.8 PID PLK1 PATHWAY PLK1 signaling events
0.0 3.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.3 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 20.0 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.8 12.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.7 18.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.6 8.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.4 6.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.3 11.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 12.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.3 4.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 5.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.3 12.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 13.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 4.3 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.3 10.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 7.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 3.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 5.7 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.2 9.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 6.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 2.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 5.8 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.2 6.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 2.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 9.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 2.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 5.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 4.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 7.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 3.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.1 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 1.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 17.2 REACTOME TRANSLATION Genes involved in Translation
0.1 2.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 7.0 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 3.6 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 2.2 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 1.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 3.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 3.7 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 1.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 3.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 6.0 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 0.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade