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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FOXO4

Z-value: 6.28

Motif logo

Transcription factors associated with FOXO4

Gene Symbol Gene ID Gene Info
ENSG00000184481.17 FOXO4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXO4hg38_v1_chrX_+_71095838_710958600.606.2e-23Click!

Activity profile of FOXO4 motif

Sorted Z-values of FOXO4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_+_127611760 30.57 ENST00000625363.2
ENST00000626539.3
syntaxin binding protein 1
chr5_-_42811884 30.21 ENST00000514985.6
ENST00000511224.5
ENST00000507920.5
ENST00000510965.1
selenoprotein P
chr5_-_131796921 29.27 ENST00000307968.11
ENST00000307954.12
folliculin interacting protein 1
chr5_-_131797030 26.52 ENST00000615660.4
folliculin interacting protein 1
chr14_-_59630582 26.39 ENST00000395090.5
reticulon 1
chr16_+_6019585 25.58 ENST00000547372.5
RNA binding fox-1 homolog 1
chr1_-_182391783 25.25 ENST00000331872.11
ENST00000339526.8
glutamate-ammonia ligase
chr1_-_182391323 24.31 ENST00000642379.1
glutamate-ammonia ligase
chr2_-_71227055 23.65 ENST00000244221.9
poly(A) binding protein interacting protein 2B
chr1_+_92080305 23.17 ENST00000342818.4
ENST00000636805.2
BTB domain containing 8
chr11_-_62709493 23.08 ENST00000405837.5
ENST00000531524.5
ENST00000524862.6
ENST00000679883.1
BSCL2 lipid droplet biogenesis associated, seipin
chr1_-_182391363 22.93 ENST00000417584.6
glutamate-ammonia ligase
chr1_-_56579555 22.61 ENST00000371250.4
phospholipid phosphatase 3
chr14_-_103521342 21.79 ENST00000553610.5
creatine kinase B
chr20_+_45406560 20.53 ENST00000372717.5
ENST00000360981.8
dysbindin domain containing 2
chr16_+_6019016 20.41 ENST00000550418.6
RNA binding fox-1 homolog 1
chr19_-_36032799 19.98 ENST00000592017.5
ENST00000360535.9
CAP-Gly domain containing linker protein 3
chr16_+_6019071 18.70 ENST00000547605.5
ENST00000553186.5
RNA binding fox-1 homolog 1
chr11_+_114060204 18.68 ENST00000683318.1
zinc finger and BTB domain containing 16
chr20_+_45407207 18.12 ENST00000372712.6
dysbindin domain containing 2
chr2_-_2326210 18.12 ENST00000647755.1
myelin transcription factor 1 like
chr14_-_21025490 18.09 ENST00000553442.5
ENST00000555869.5
ENST00000556457.5
ENST00000397844.6
ENST00000554415.5
ENST00000556974.5
ENST00000554419.5
ENST00000298687.9
ENST00000397858.5
ENST00000360463.7
ENST00000350792.7
ENST00000397847.6
NDRG family member 2
chr19_-_12610799 17.93 ENST00000311437.11
zinc finger protein 490
chr17_-_17972374 16.10 ENST00000318094.14
ENST00000540946.5
ENST00000379504.8
ENST00000542206.5
ENST00000395739.8
ENST00000581396.5
ENST00000535933.5
ENST00000579586.1
target of myb1 like 2 membrane trafficking protein
chr2_+_232662733 15.99 ENST00000410095.5
ENST00000611312.1
EF-hand domain family member D1
chr16_+_56191476 15.66 ENST00000262493.12
G protein subunit alpha o1
chr17_-_44324770 15.39 ENST00000592857.5
ENST00000586016.5
ENST00000590194.5
ENST00000588049.5
ENST00000586633.5
ENST00000377095.10
ENST00000537904.6
ENST00000585636.5
ENST00000585523.1
ENST00000225308.12
solute carrier family 25 member 39
chr17_+_17972813 14.86 ENST00000582416.5
ENST00000313838.12
ENST00000399187.6
ENST00000581264.5
ENST00000479684.2
ENST00000584166.5
ENST00000585108.5
ENST00000399182.5
ENST00000579977.1
dynein regulatory complex subunit 3
chr8_-_133297092 14.66 ENST00000522890.5
ENST00000675983.1
ENST00000518176.5
ENST00000323851.13
ENST00000522476.5
ENST00000518066.5
ENST00000521544.5
ENST00000674605.1
ENST00000518480.5
ENST00000523892.5
N-myc downstream regulated 1
chr6_-_152168291 14.19 ENST00000354674.5
spectrin repeat containing nuclear envelope protein 1
chr19_-_36528232 14.04 ENST00000592282.1
ENST00000523638.6
zinc finger protein 260
chr6_-_152168349 14.01 ENST00000539504.5
spectrin repeat containing nuclear envelope protein 1
chr19_+_12610912 13.98 ENST00000446165.2
ENST00000343325.9
zinc finger protein 791
chr12_+_79045625 13.37 ENST00000552744.5
synaptotagmin 1
chr2_-_2326378 13.16 ENST00000647618.1
myelin transcription factor 1 like
chr19_+_49877425 13.13 ENST00000622860.4
TBC1 domain family member 17
chr3_-_28348805 12.64 ENST00000457172.5
ENST00000479665.6
5-azacytidine induced 2
chr1_+_162069768 12.17 ENST00000530878.5
nitric oxide synthase 1 adaptor protein
chr5_-_65624288 11.93 ENST00000381018.7
ENST00000274327.11
ENST00000231524.14
tripartite motif containing 23
chr6_+_101398788 11.85 ENST00000369138.5
ENST00000413795.5
ENST00000358361.7
glutamate ionotropic receptor kainate type subunit 2
chr19_+_49877660 11.61 ENST00000535102.6
TBC1 domain family member 17
chr18_-_24272179 11.42 ENST00000399443.7
oxysterol binding protein like 1A
chr2_-_36966471 11.41 ENST00000379213.3
striatin
chr3_+_124384513 11.03 ENST00000682540.1
ENST00000522553.6
ENST00000682695.1
ENST00000682674.1
ENST00000684382.1
kalirin RhoGEF kinase
chr12_+_12725897 10.85 ENST00000326765.10
apolipoprotein L domain containing 1
chr11_-_114595777 10.65 ENST00000375478.4
neurexophilin and PC-esterase domain family member 4
chr11_-_114595750 10.42 ENST00000424261.6
neurexophilin and PC-esterase domain family member 4
chr19_+_49877694 10.05 ENST00000221543.10
TBC1 domain family member 17
chr5_-_116536458 9.74 ENST00000510263.5
semaphorin 6A
chr15_-_29822418 9.73 ENST00000614355.5
ENST00000495972.6
ENST00000346128.10
tight junction protein 1
chr15_+_43692886 9.63 ENST00000434505.5
ENST00000411750.5
creatine kinase, mitochondrial 1A
chr1_+_43389889 9.61 ENST00000562955.2
ENST00000634258.3
SZT2 subunit of KICSTOR complex
chr4_-_86358487 9.54 ENST00000641066.1
ENST00000512689.6
ENST00000641803.1
ENST00000640970.1
ENST00000641983.1
mitogen-activated protein kinase 10
chr1_+_150257247 9.30 ENST00000647854.1
carbonic anhydrase 14
chr18_-_55635948 9.24 ENST00000565124.4
ENST00000398339.5
transcription factor 4
chr5_-_108367860 9.19 ENST00000496714.2
F-box and leucine rich repeat protein 17
chr1_+_162069674 9.09 ENST00000361897.10
nitric oxide synthase 1 adaptor protein
chr11_-_56292254 8.95 ENST00000641600.1
olfactory receptor family 8 subfamily H member 1
chr17_+_79778135 8.92 ENST00000310942.9
ENST00000269399.5
chromobox 2
chr21_-_31558977 8.85 ENST00000286827.7
ENST00000541036.5
TIAM Rac1 associated GEF 1
chr7_+_20615653 8.76 ENST00000404938.7
ATP binding cassette subfamily B member 5
chr10_+_110225955 8.72 ENST00000239007.11
MAX interactor 1, dimerization protein
chr21_-_31160904 8.70 ENST00000636887.1
TIAM Rac1 associated GEF 1
chr15_+_43593054 8.60 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
creatine kinase, mitochondrial 1B
chr14_+_94110728 8.56 ENST00000616764.4
ENST00000618863.1
ENST00000611954.4
ENST00000618200.4
ENST00000621160.4
ENST00000555819.5
ENST00000620396.4
ENST00000612813.4
ENST00000620066.1
interferon alpha inducible protein 27
chr19_-_40226682 8.41 ENST00000430325.7
ENST00000599263.6
cyclin P
chr2_-_112255015 8.31 ENST00000615791.1
ENST00000409573.7
ENST00000272570.9
zinc finger CCCH-type containing 8
chr12_-_12338674 8.22 ENST00000545735.1
MANSC domain containing 1
chr7_+_134866831 8.21 ENST00000435928.1
caldesmon 1
chr14_+_70452161 8.11 ENST00000603540.2
ADAM metallopeptidase domain 21
chr6_-_46921926 8.08 ENST00000283296.12
adhesion G protein-coupled receptor F5
chr4_-_185775271 8.04 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
sorbin and SH3 domain containing 2
chr11_+_46617521 8.02 ENST00000580238.5
ENST00000581416.5
ENST00000529655.5
ENST00000533325.5
ENST00000683050.1
ENST00000581438.5
ENST00000583249.5
ENST00000530500.5
ENST00000526508.5
ENST00000578626.5
ENST00000577256.5
ENST00000524625.5
ENST00000582547.5
ENST00000359513.8
ENST00000528494.5
autophagy related 13
chr4_-_89836213 7.91 ENST00000618500.4
ENST00000508895.5
synuclein alpha
chr2_+_235494024 7.90 ENST00000304032.13
ENST00000409457.5
ENST00000336665.9
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr10_+_91220603 7.86 ENST00000336126.6
polycomb group ring finger 5
chr3_+_159852933 7.57 ENST00000482804.1
schwannomin interacting protein 1
chr3_-_139539577 7.52 ENST00000619087.4
retinol binding protein 1
chr2_-_165204042 7.50 ENST00000283254.12
ENST00000453007.1
sodium voltage-gated channel alpha subunit 3
chr8_-_42843201 7.40 ENST00000529779.1
ENST00000345117.2
ENST00000254250.7
THAP domain containing 1
chr17_+_3475959 7.38 ENST00000263080.3
aspartoacylase
chr2_-_2331225 7.22 ENST00000648627.1
ENST00000649663.1
ENST00000650560.1
ENST00000428368.7
ENST00000648316.1
ENST00000648665.1
ENST00000649313.1
ENST00000399161.7
ENST00000647738.2
myelin transcription factor 1 like
chr6_-_167157980 7.14 ENST00000366834.2
G protein-coupled receptor 31
chr5_-_218136 7.10 ENST00000296824.4
coiled-coil domain containing 127
chr3_+_138348823 7.07 ENST00000475711.5
ENST00000464896.5
muscle RAS oncogene homolog
chr2_+_32277883 6.93 ENST00000238831.9
Yip1 domain family member 4
chr3_+_138349209 6.92 ENST00000474559.1
muscle RAS oncogene homolog
chr10_-_60141004 6.79 ENST00000355288.6
ankyrin 3
chr6_+_32154131 6.78 ENST00000375143.6
ENST00000324816.11
ENST00000424499.1
palmitoyl-protein thioesterase 2
chr4_+_123399488 6.74 ENST00000394339.2
sprouty RTK signaling antagonist 1
chr5_-_134371004 6.74 ENST00000521755.1
ENST00000523054.5
ENST00000518409.1
cyclin dependent kinase like 3
novel transcript
chr2_-_165203870 6.71 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
sodium voltage-gated channel alpha subunit 3
chr12_-_10098977 6.70 ENST00000315330.8
ENST00000457018.6
C-type lectin domain family 1 member A
chr19_+_41262656 6.68 ENST00000599719.5
ENST00000601309.5
heterogeneous nuclear ribonucleoprotein U like 1
chr9_+_27109200 6.59 ENST00000380036.10
TEK receptor tyrosine kinase
chr10_-_50885619 6.49 ENST00000373997.8
APOBEC1 complementation factor
chr14_-_75051426 6.46 ENST00000556257.5
ENST00000355774.7
ENST00000557648.1
ENST00000553263.1
ENST00000380968.6
mutL homolog 3
chr4_+_87832917 6.32 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr4_-_185775890 6.18 ENST00000437304.6
sorbin and SH3 domain containing 2
chr11_-_66907891 6.14 ENST00000393955.6
pyruvate carboxylase
chr17_-_8118489 6.13 ENST00000380149.6
ENST00000448843.7
arachidonate lipoxygenase 3
chr19_-_58150772 6.09 ENST00000597186.5
ENST00000598312.6
zinc finger protein 329
chr8_-_71547626 6.07 ENST00000647540.1
ENST00000644229.1
EYA transcriptional coactivator and phosphatase 1
chr9_+_27109135 6.06 ENST00000519097.5
ENST00000615002.4
TEK receptor tyrosine kinase
chr7_-_712437 6.04 ENST00000360274.8
protein kinase cAMP-dependent type I regulatory subunit beta
chr6_+_122789197 6.01 ENST00000368440.5
sphingomyelin phosphodiesterase acid like 3A
chr19_+_15049469 5.99 ENST00000427043.4
caspase 14
chr11_+_57598184 5.98 ENST00000677625.1
ENST00000676670.1
serpin family G member 1
chr1_-_2003780 5.89 ENST00000682832.1
cilia and flagella associated protein 74
chr18_+_34493428 5.86 ENST00000682483.1
dystrobrevin alpha
chr9_+_27109393 5.83 ENST00000406359.8
TEK receptor tyrosine kinase
chr11_+_57597563 5.81 ENST00000619430.2
ENST00000457869.1
ENST00000340687.10
ENST00000278407.9
ENST00000378323.8
ENST00000378324.6
ENST00000403558.1
serpin family G member 1
chr1_+_151766655 5.78 ENST00000400999.7
ornithine decarboxylase antizyme 3
chr3_+_148730100 5.77 ENST00000474935.5
ENST00000475347.5
ENST00000461609.1
angiotensin II receptor type 1
chr10_-_50885656 5.70 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
APOBEC1 complementation factor
chr16_-_4273014 5.68 ENST00000204517.11
transcription factor AP-4
chr2_+_174395721 5.63 ENST00000272732.11
ENST00000458563.5
ENST00000409673.7
ENST00000435964.1
ENST00000424069.5
ENST00000427038.5
secernin 3
chr2_+_65056382 5.54 ENST00000377990.7
ENST00000537589.1
ENST00000260569.4
centrosomal protein 68
chr15_-_55365231 5.54 ENST00000568543.1
cell cycle progression 1
chr2_+_227616998 5.44 ENST00000641801.1
small cysteine and glycine repeat containing 4
chr10_-_60572599 5.34 ENST00000503366.5
ankyrin 3
chr6_+_32154010 5.32 ENST00000375137.6
palmitoyl-protein thioesterase 2
chr19_+_1205761 5.30 ENST00000326873.12
ENST00000586243.5
serine/threonine kinase 11
chr11_+_112961247 5.25 ENST00000621518.4
ENST00000618266.4
ENST00000615112.4
ENST00000615285.4
ENST00000619839.4
ENST00000401611.6
ENST00000621128.4
neural cell adhesion molecule 1
chr9_-_15472732 5.20 ENST00000481862.1
PC4 and SFRS1 interacting protein 1
chr5_-_10307821 5.20 ENST00000296658.4
carboxymethylenebutenolidase homolog
chr16_+_1680337 5.17 ENST00000566691.5
ENST00000382710.8
Jupiter microtubule associated homolog 2
chr10_+_80413817 5.11 ENST00000372187.9
peroxiredoxin like 2A
chr3_-_186109067 5.09 ENST00000306376.10
ETS variant transcription factor 5
chr10_+_122163590 5.08 ENST00000368999.5
transforming acidic coiled-coil containing protein 2
chr1_+_110210272 5.04 ENST00000438661.3
potassium voltage-gated channel subfamily C member 4
chr13_-_98977975 4.99 ENST00000376460.5
dedicator of cytokinesis 9
chr7_+_106865263 4.87 ENST00000440650.6
ENST00000496166.6
ENST00000473541.5
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr15_-_58279245 4.87 ENST00000558231.5
aldehyde dehydrogenase 1 family member A2
chr18_+_34493386 4.85 ENST00000679936.1
dystrobrevin alpha
chr4_+_95051671 4.70 ENST00000440890.7
bone morphogenetic protein receptor type 1B
chr2_-_182866627 4.69 ENST00000295113.5
frizzled related protein
chr11_-_94493798 4.67 ENST00000538923.1
ENST00000540013.5
ENST00000407439.7
ENST00000323929.8
ENST00000393241.8
MRE11 homolog, double strand break repair nuclease
chr3_-_45884685 4.63 ENST00000684620.1
leucine zipper transcription factor like 1
chr13_-_98978022 4.59 ENST00000682017.1
ENST00000442173.5
ENST00000627024.2
dedicator of cytokinesis 9
chr11_+_77821105 4.43 ENST00000532481.5
adipogenesis associated Mth938 domain containing
chr4_-_89835617 4.40 ENST00000611107.1
ENST00000345009.8
ENST00000505199.5
ENST00000502987.5
synuclein alpha
chr8_-_42768781 4.33 ENST00000276410.7
cholinergic receptor nicotinic alpha 6 subunit
chr5_-_131796965 4.32 ENST00000514667.1
ENST00000511848.1
ENST00000510461.6
novel protein
folliculin interacting protein 1
chr5_+_80407994 4.28 ENST00000338008.9
ENST00000510158.5
zinc finger FYVE-type containing 16
chr17_-_42745025 4.24 ENST00000592492.5
ENST00000585893.5
ENST00000593214.5
ENST00000590078.5
ENST00000428826.7
ENST00000586382.5
ENST00000415827.6
ENST00000592743.5
ENST00000586089.5
enhancer of zeste 1 polycomb repressive complex 2 subunit
chr18_+_62715526 4.23 ENST00000262719.10
PH domain and leucine rich repeat protein phosphatase 1
chr1_-_153541765 4.22 ENST00000368718.5
S100 calcium binding protein A5
chr7_-_13988863 4.22 ENST00000405358.8
ETS variant transcription factor 1
chr1_-_56966006 4.19 ENST00000371237.9
complement C8 beta chain
chr5_+_80408031 4.15 ENST00000505560.5
ENST00000509562.2
zinc finger FYVE-type containing 16
chr4_-_152411734 3.99 ENST00000603841.1
F-box and WD repeat domain containing 7
chr2_+_156436345 3.96 ENST00000438166.7
glycerol-3-phosphate dehydrogenase 2
chr7_-_95596507 3.88 ENST00000005178.6
pyruvate dehydrogenase kinase 4
chr4_-_69961007 3.84 ENST00000353151.3
casein beta
chr14_-_99272184 3.78 ENST00000357195.8
BAF chromatin remodeling complex subunit BCL11B
chr14_-_70809494 3.77 ENST00000381250.8
ENST00000554752.7
ENST00000555993.6
mitogen-activated protein kinase kinase kinase 9
chr3_-_46566276 3.77 ENST00000395905.8
leucine rich repeat containing 2
chr20_-_46364385 3.71 ENST00000243896.6
ENST00000543605.5
ENST00000372230.10
ENST00000317734.12
solute carrier family 35 member C2
chr2_+_172556039 3.70 ENST00000410055.5
ENST00000282077.8
pyruvate dehydrogenase kinase 1
chr13_+_97434154 3.68 ENST00000245304.5
RAP2A, member of RAS oncogene family
chr3_+_108296489 3.68 ENST00000619531.4
HERV-H LTR-associating 2
chr1_+_96722628 3.61 ENST00000675401.1
polypyrimidine tract binding protein 2
chr10_+_97640686 3.60 ENST00000370631.3
phosphatidylinositol 4-kinase type 2 alpha
chr17_+_74431338 3.60 ENST00000342648.9
ENST00000652232.1
ENST00000481232.2
G protein-coupled receptor class C group 5 member C
chr5_-_126595185 3.59 ENST00000510111.6
ENST00000635851.1
ENST00000637964.1
ENST00000413020.6
ENST00000637782.1
ENST00000409134.8
ENST00000637272.1
ENST00000636879.1
ENST00000636743.1
ENST00000636886.1
ENST00000509270.2
aldehyde dehydrogenase 7 family member A1
chr1_-_168137430 3.50 ENST00000546300.5
ENST00000271357.9
ENST00000367835.1
ENST00000537209.5
G protein-coupled receptor 161
chr2_-_36966503 3.48 ENST00000263918.9
striatin
chr8_-_42768602 3.45 ENST00000534622.5
cholinergic receptor nicotinic alpha 6 subunit
chr7_-_38349972 3.39 ENST00000390344.2
T cell receptor gamma variable 5
chr10_+_122163672 3.33 ENST00000369004.7
ENST00000260733.7
transforming acidic coiled-coil containing protein 2
chr12_-_70637405 3.29 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
protein tyrosine phosphatase receptor type B
chr11_-_5269933 3.29 ENST00000396895.3
hemoglobin subunit epsilon 1
chr7_+_135148041 3.21 ENST00000275767.3
transmembrane protein 140
chr7_+_106865474 3.18 ENST00000359195.3
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr8_-_40897814 3.11 ENST00000297737.11
ENST00000315769.11
zinc finger matrin-type 4
chr17_-_69141878 3.09 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr18_-_55402187 3.09 ENST00000630268.2
ENST00000570177.6
transcription factor 4
chr7_+_99828010 2.96 ENST00000631161.2
ENST00000354829.7
ENST00000342499.8
ENST00000417625.5
ENST00000415413.5
ENST00000444905.5
ENST00000222382.5
ENST00000312017.9
cytochrome P450 family 3 subfamily A member 43
chr10_+_122163426 2.88 ENST00000360561.7
transforming acidic coiled-coil containing protein 2
chr9_+_706841 2.88 ENST00000382293.7
KN motif and ankyrin repeat domains 1
chr8_-_53843228 2.83 ENST00000359530.7
ATPase H+ transporting V1 subunit H
chr6_-_117425855 2.81 ENST00000368508.7
ROS proto-oncogene 1, receptor tyrosine kinase
chr15_-_30991415 2.76 ENST00000563714.5
myotubularin related protein 10
chrX_-_149595314 2.74 ENST00000598963.3
heat shock transcription factor family, X-linked 2
chr16_+_28846674 2.74 ENST00000322610.12
SH2B adaptor protein 1
chr4_-_108166715 2.69 ENST00000510624.5
lymphoid enhancer binding factor 1
chr9_+_5510492 2.67 ENST00000397747.5
programmed cell death 1 ligand 2
chr1_-_227318125 2.66 ENST00000366764.7
CDC42 binding protein kinase alpha
chr8_+_119067239 2.64 ENST00000332843.3
collectin subfamily member 10
chr1_+_160796157 2.64 ENST00000263285.11
ENST00000368039.2
lymphocyte antigen 9
chr10_+_110207587 2.62 ENST00000332674.9
ENST00000453116.5
MAX interactor 1, dimerization protein
chr10_-_1200360 2.59 ENST00000381310.7
ENST00000381305.1
adenosine deaminase RNA specific B2 (inactive)
chr11_-_123741614 2.57 ENST00000526252.5
ENST00000530393.6
ENST00000533463.5
ENST00000336139.8
ENST00000529691.1
ENST00000528306.5
zinc finger protein 202
chr1_-_56966133 2.54 ENST00000535057.5
ENST00000543257.5
complement C8 beta chain
chr8_-_86743626 2.54 ENST00000320005.6
cyclic nucleotide gated channel subunit beta 3
chr20_-_44521989 2.53 ENST00000342374.5
ENST00000255175.5
serine incorporator 3
chr12_-_102478539 2.53 ENST00000424202.6
insulin like growth factor 1
chr14_-_92106535 2.53 ENST00000526872.3
ENST00000532032.5
ENST00000506466.5
ENST00000554592.5
ENST00000555381.5
ENST00000553491.5
ENST00000556220.5
ENST00000557311.6
ENST00000617719.4
ENST00000554672.6
ENST00000644486.2
ENST00000502250.5
ENST00000503767.5
ataxin 3
chr16_+_77199408 2.51 ENST00000378644.5
synaptonemal complex central element protein 1 like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
18.1 72.5 GO:0006542 glutamine biosynthetic process(GO:0006542)
12.0 60.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
7.7 31.0 GO:1903294 regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
5.3 21.3 GO:1903116 positive regulation of actin filament-based movement(GO:1903116) positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
5.0 20.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
4.5 13.4 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
4.4 17.5 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
4.2 12.6 GO:0044565 dendritic cell proliferation(GO:0044565)
3.9 11.8 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
3.8 30.2 GO:0001887 selenium compound metabolic process(GO:0001887)
3.6 21.8 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
3.4 23.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
3.0 12.1 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.8 28.2 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
2.5 7.4 GO:0006533 aspartate catabolic process(GO:0006533)
2.1 12.3 GO:0051945 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
2.0 12.2 GO:0016554 cytidine to uridine editing(GO:0016554)
1.9 9.7 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
1.9 5.8 GO:0015847 putrescine transport(GO:0015847)
1.9 22.6 GO:0008354 germ cell migration(GO:0008354)
1.8 14.5 GO:0048014 Tie signaling pathway(GO:0048014)
1.8 5.3 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
1.7 6.7 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
1.7 8.3 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
1.5 4.6 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
1.5 6.1 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
1.4 5.8 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
1.4 10.8 GO:0042118 endothelial cell activation(GO:0042118)
1.4 14.9 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
1.3 8.0 GO:0032252 negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252)
1.3 14.7 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
1.3 23.1 GO:0034389 lipid particle organization(GO:0034389)
1.3 3.8 GO:1903487 regulation of lactation(GO:1903487)
1.2 11.0 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
1.2 3.6 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
1.2 5.8 GO:0006127 glycerophosphate shuttle(GO:0006127)
1.1 12.1 GO:0098734 macromolecule depalmitoylation(GO:0098734)
1.1 18.1 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.0 4.0 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
1.0 4.0 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.9 12.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.9 33.4 GO:0048665 neuron fate specification(GO:0048665)
0.8 11.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.8 64.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.8 4.7 GO:0010966 regulation of phosphate transport(GO:0010966)
0.8 4.7 GO:0060029 convergent extension involved in organogenesis(GO:0060029)
0.8 6.1 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.8 2.3 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.7 9.6 GO:0006600 creatine metabolic process(GO:0006600)
0.7 3.7 GO:0071895 odontoblast differentiation(GO:0071895)
0.7 8.1 GO:0043129 surfactant homeostasis(GO:0043129) positive regulation of phospholipid biosynthetic process(GO:0071073)
0.7 18.1 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.7 2.9 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.7 8.8 GO:0042908 xenobiotic transport(GO:0042908)
0.7 4.7 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.7 2.0 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.7 5.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.6 9.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.6 1.8 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.6 9.0 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.6 1.7 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.6 5.5 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.5 6.0 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.5 4.2 GO:0002249 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.5 9.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.5 2.5 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.5 1.4 GO:0072709 cellular response to sorbitol(GO:0072709)
0.5 3.8 GO:0007256 activation of JNKK activity(GO:0007256)
0.5 3.7 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.4 5.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.4 4.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.4 14.2 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 15.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.4 3.7 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.4 17.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.4 6.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.4 34.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.3 11.3 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.3 15.7 GO:0014072 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.3 2.3 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.3 2.5 GO:0009597 detection of virus(GO:0009597)
0.3 5.7 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.3 1.6 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 0.9 GO:1902617 response to fluoride(GO:1902617)
0.3 6.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 2.7 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.3 16.1 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.3 4.7 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.3 3.9 GO:0050812 regulation of acyl-CoA biosynthetic process(GO:0050812)
0.2 6.5 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.2 11.4 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.2 12.7 GO:0019228 neuronal action potential(GO:0019228)
0.2 3.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 0.7 GO:0071486 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) retinal cell apoptotic process(GO:1990009)
0.2 8.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.2 2.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 8.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.2 0.6 GO:0097114 NMDA glutamate receptor clustering(GO:0097114)
0.2 1.8 GO:1904424 regulation of GTP binding(GO:1904424)
0.2 1.2 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.2 4.2 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 14.9 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.2 8.6 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.2 4.2 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.2 3.3 GO:0015671 oxygen transport(GO:0015671)
0.2 9.3 GO:0015701 bicarbonate transport(GO:0015701)
0.2 5.9 GO:0035082 axoneme assembly(GO:0035082)
0.1 5.2 GO:0030517 negative regulation of axon extension(GO:0030517)
0.1 0.4 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 3.6 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.1 7.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 3.7 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.1 0.3 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.1 1.8 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 0.9 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.8 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 2.8 GO:0007035 vacuolar acidification(GO:0007035) energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) phagosome acidification(GO:0090383)
0.1 9.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 11.3 GO:0021987 cerebral cortex development(GO:0021987)
0.1 5.0 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 0.6 GO:0060044 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.1 0.4 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.1 1.9 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 9.3 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 0.7 GO:1903944 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 15.8 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 1.0 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.4 GO:0046850 regulation of bone remodeling(GO:0046850)
0.1 0.8 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.4 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.9 GO:0097264 self proteolysis(GO:0097264)
0.0 11.8 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 1.6 GO:0035456 response to interferon-beta(GO:0035456)
0.0 5.3 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 4.3 GO:0001935 endothelial cell proliferation(GO:0001935)
0.0 2.1 GO:0007632 visual behavior(GO:0007632)
0.0 0.2 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.8 GO:0007635 chemosensory behavior(GO:0007635)
0.0 1.1 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 3.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 1.7 GO:0016486 peptide hormone processing(GO:0016486)
0.0 3.6 GO:0070268 cornification(GO:0070268)
0.0 0.7 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.7 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 1.2 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.2 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 2.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 4.5 GO:0009615 response to virus(GO:0009615)
0.0 0.9 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 2.5 GO:0007601 visual perception(GO:0007601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 30.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
4.3 21.3 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
3.0 12.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
2.7 8.0 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
2.7 13.4 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
2.6 72.5 GO:0097386 glial cell projection(GO:0097386)
2.2 28.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
2.1 8.3 GO:0035363 histone locus body(GO:0035363)
1.8 5.3 GO:0036398 TCR signalosome(GO:0036398)
1.5 30.2 GO:0031089 platelet dense granule lumen(GO:0031089)
1.4 9.6 GO:1990130 Iml1 complex(GO:1990130)
1.3 8.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
1.3 6.5 GO:0005712 chiasma(GO:0005712)
1.0 5.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.8 6.7 GO:0005579 membrane attack complex(GO:0005579)
0.7 3.6 GO:0035838 growing cell tip(GO:0035838)
0.7 2.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.7 17.5 GO:0044295 axonal growth cone(GO:0044295)
0.7 12.1 GO:0043194 axon initial segment(GO:0043194)
0.6 3.7 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.6 14.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.6 4.0 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.6 8.9 GO:0035102 PRC1 complex(GO:0035102)
0.5 8.2 GO:0030478 actin cap(GO:0030478)
0.5 38.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.5 38.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4 12.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 4.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 15.5 GO:0009925 basal plasma membrane(GO:0009925)
0.4 32.9 GO:0005776 autophagosome(GO:0005776)
0.3 9.7 GO:0005921 gap junction(GO:0005921)
0.3 11.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 22.9 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.3 6.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 7.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.3 3.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.3 43.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 2.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 5.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 1.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 11.9 GO:0031519 PcG protein complex(GO:0031519)
0.2 15.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 4.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 48.2 GO:0005802 trans-Golgi network(GO:0005802)
0.2 3.3 GO:0005833 hemoglobin complex(GO:0005833)
0.2 3.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 0.8 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 2.3 GO:0030870 Mre11 complex(GO:0030870)
0.2 24.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.4 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 1.5 GO:0016013 syntrophin complex(GO:0016013)
0.1 21.7 GO:0030426 growth cone(GO:0030426)
0.1 18.4 GO:0032993 protein-DNA complex(GO:0032993)
0.1 16.3 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.7 GO:0005801 cis-Golgi network(GO:0005801)
0.1 14.5 GO:0030018 Z disc(GO:0030018)
0.1 1.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 13.1 GO:0043209 myelin sheath(GO:0043209)
0.1 2.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 9.8 GO:0042383 sarcolemma(GO:0042383)
0.1 2.5 GO:0000795 synaptonemal complex(GO:0000795)
0.1 4.4 GO:0055037 recycling endosome(GO:0055037)
0.1 7.3 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 8.9 GO:0043202 lysosomal lumen(GO:0043202)
0.0 3.3 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 5.0 GO:0043679 axon terminus(GO:0043679)
0.0 1.9 GO:0045095 keratin filament(GO:0045095)
0.0 19.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 7.4 GO:0001650 fibrillar center(GO:0001650)
0.0 8.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0097342 ripoptosome(GO:0097342)
0.0 1.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.6 GO:0005581 collagen trimer(GO:0005581)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)
0.0 1.1 GO:0016592 mediator complex(GO:0016592)
0.0 6.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.2 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 6.0 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 4.1 GO:0030424 axon(GO:0030424)
0.0 3.1 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 5.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 17.4 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
18.1 72.5 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
15.0 60.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
5.0 20.0 GO:0097001 ceramide binding(GO:0097001)
3.9 31.4 GO:0004111 creatine kinase activity(GO:0004111)
3.8 22.6 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
2.7 13.4 GO:0030348 syntaxin-3 binding(GO:0030348)
2.5 30.2 GO:0008430 selenium binding(GO:0008430)
2.1 12.3 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
1.9 5.8 GO:0015489 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
1.9 5.8 GO:0001596 angiotensin type I receptor activity(GO:0001596)
1.8 8.8 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
1.6 6.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.6 18.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
1.5 30.6 GO:0043274 phospholipase binding(GO:0043274)
1.4 5.8 GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
1.3 11.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
1.3 7.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.2 7.4 GO:0004046 aminoacylase activity(GO:0004046)
1.2 6.1 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
1.2 36.8 GO:0005521 lamin binding(GO:0005521)
1.2 3.6 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
1.1 23.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
1.1 12.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
1.0 15.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.9 3.8 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.9 28.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.9 8.7 GO:0005549 odorant binding(GO:0005549)
0.8 8.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.8 6.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.8 18.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.8 12.4 GO:0016918 retinal binding(GO:0016918)
0.8 21.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.7 9.5 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.7 6.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.6 6.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.6 12.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5 9.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.5 6.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.5 14.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.5 4.0 GO:0050816 phosphothreonine binding(GO:0050816)
0.5 3.3 GO:0030492 hemoglobin binding(GO:0030492)
0.4 14.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.4 2.5 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.4 5.2 GO:0097100 supercoiled DNA binding(GO:0097100)
0.4 14.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.4 4.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.4 14.0 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.4 2.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 6.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3 8.2 GO:0005523 tropomyosin binding(GO:0005523)
0.3 1.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 4.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 7.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 51.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 5.6 GO:0016805 dipeptidase activity(GO:0016805)
0.2 16.1 GO:0030276 clathrin binding(GO:0030276)
0.2 5.3 GO:0030275 LRR domain binding(GO:0030275)
0.2 1.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 2.5 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 12.1 GO:0030507 spectrin binding(GO:0030507)
0.2 69.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 4.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 8.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 17.4 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 2.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 2.6 GO:0004000 adenosine deaminase activity(GO:0004000)
0.2 2.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 5.7 GO:0070888 E-box binding(GO:0070888)
0.1 3.0 GO:0070330 aromatase activity(GO:0070330)
0.1 2.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.7 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 2.6 GO:0005537 mannose binding(GO:0005537)
0.1 2.8 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 8.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 12.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 18.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 12.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 3.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 8.7 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 4.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 3.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.2 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 8.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.8 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 11.3 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.1 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 3.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 4.2 GO:0005507 copper ion binding(GO:0005507)
0.1 2.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 5.3 GO:0001618 virus receptor activity(GO:0001618)
0.0 3.1 GO:0019003 GDP binding(GO:0019003)
0.0 22.7 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 9.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.8 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 1.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 3.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 1.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.0 GO:0043531 ADP binding(GO:0043531)
0.0 2.8 GO:0005179 hormone activity(GO:0005179)
0.0 2.7 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.7 GO:0005123 death receptor binding(GO:0005123)
0.0 3.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 28.6 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.7 15.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.5 3.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.3 20.9 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.3 12.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 9.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.2 8.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 7.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.2 8.0 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.2 8.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.2 9.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 1.4 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.1 10.0 PID SHP2 PATHWAY SHP2 signaling
0.1 3.3 PID CONE PATHWAY Visual signal transduction: Cones
0.1 4.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 10.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 5.8 PID ARF6 PATHWAY Arf6 signaling events
0.1 8.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 14.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 6.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 5.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 6.4 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 3.8 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.1 8.8 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 5.3 PID FGF PATHWAY FGF signaling pathway
0.1 17.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 0.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.1 1.6 PID IL27 PATHWAY IL27-mediated signaling events
0.1 10.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 0.9 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 2.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 2.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 9.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 3.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 72.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
2.0 43.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.3 8.0 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.6 9.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.6 28.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.5 11.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.5 5.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.4 7.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.4 12.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.4 4.9 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 28.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.4 9.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.4 15.7 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4 9.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 7.8 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.4 9.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.3 11.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 2.4 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.3 12.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 11.9 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 6.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.2 9.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 9.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 13.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 6.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 6.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 6.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.2 3.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 8.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 5.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 2.8 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 11.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.7 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 9.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 10.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 8.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 0.8 REACTOME OPSINS Genes involved in Opsins
0.1 3.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.2 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 3.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 23.5 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 2.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 2.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 3.0 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 10.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 7.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling