Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GAAAUGU
Z-value: 3.37
Motif logo
miRNA associated with seed GAAAUGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-203a-3p.1
|
Activity profile of GAAAUGU motif
Sorted Z-values of GAAAUGU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GAAAUGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 1.3 | 5.3 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 1.1 | 4.2 | GO:0009956 | radial pattern formation(GO:0009956) |
| 1.0 | 4.0 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.9 | 3.7 | GO:0006169 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) |
| 0.9 | 2.8 | GO:0060278 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.9 | 3.5 | GO:0050923 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.8 | 2.5 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.7 | 5.1 | GO:0033591 | response to L-ascorbic acid(GO:0033591) |
| 0.7 | 8.5 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.5 | 3.8 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.5 | 3.8 | GO:0060702 | negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) |
| 0.5 | 3.2 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.5 | 4.2 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.5 | 3.4 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.5 | 2.4 | GO:0006167 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) AMP biosynthetic process(GO:0006167) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 0.5 | 1.4 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149) |
| 0.5 | 4.2 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.5 | 0.9 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
| 0.5 | 1.8 | GO:0030047 | actin modification(GO:0030047) |
| 0.4 | 1.3 | GO:2000298 | regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.4 | 2.1 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.4 | 1.7 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.4 | 1.1 | GO:0043321 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 0.4 | 5.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.4 | 3.4 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.4 | 4.0 | GO:0035437 | maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.4 | 2.5 | GO:0061198 | fungiform papilla formation(GO:0061198) |
| 0.4 | 7.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.3 | 5.5 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.3 | 3.1 | GO:0010040 | response to iron(II) ion(GO:0010040) |
| 0.3 | 1.7 | GO:0010868 | negative regulation of triglyceride biosynthetic process(GO:0010868) negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.3 | 2.0 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.3 | 2.2 | GO:0052564 | response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572) |
| 0.3 | 1.3 | GO:0034670 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.3 | 3.7 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.3 | 3.7 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.3 | 4.6 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.3 | 1.8 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.3 | 2.1 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
| 0.3 | 0.9 | GO:0002513 | tolerance induction to self antigen(GO:0002513) bronchus morphogenesis(GO:0060434) |
| 0.3 | 4.4 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.3 | 0.6 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
| 0.3 | 2.5 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 0.3 | 2.7 | GO:0034350 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.3 | 0.5 | GO:0051771 | nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.3 | 3.0 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.3 | 2.1 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.3 | 0.5 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
| 0.2 | 1.0 | GO:0097327 | response to antineoplastic agent(GO:0097327) |
| 0.2 | 1.0 | GO:1900020 | regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.2 | 1.0 | GO:0016334 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 0.2 | 3.6 | GO:0046628 | positive regulation of insulin receptor signaling pathway(GO:0046628) |
| 0.2 | 0.7 | GO:0060577 | subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578) |
| 0.2 | 0.6 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.2 | 1.1 | GO:0015862 | uridine transport(GO:0015862) |
| 0.2 | 0.8 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) regulation of genetic imprinting(GO:2000653) |
| 0.2 | 3.1 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.2 | 1.4 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.2 | 1.6 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.2 | 3.2 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.2 | 2.0 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.2 | 0.6 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 0.2 | 2.0 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 0.7 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 0.2 | 0.7 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.2 | 2.4 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) |
| 0.2 | 1.6 | GO:0010994 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.2 | 0.9 | GO:0009082 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.2 | 1.0 | GO:0002943 | tRNA dihydrouridine synthesis(GO:0002943) |
| 0.2 | 2.6 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.2 | 1.0 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.2 | 2.2 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 0.2 | 0.8 | GO:0061083 | regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084) |
| 0.2 | 1.1 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.2 | 1.3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.2 | 1.8 | GO:1904424 | regulation of GTP binding(GO:1904424) |
| 0.2 | 1.0 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.2 | 1.6 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.2 | 4.6 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.2 | 0.6 | GO:0046833 | positive regulation of RNA export from nucleus(GO:0046833) |
| 0.1 | 0.4 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.1 | 1.1 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 1.6 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.1 | 8.1 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
| 0.1 | 0.5 | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 0.1 | 0.8 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.1 | 0.9 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.1 | 1.0 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.1 | 1.7 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.1 | 5.7 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.1 | 0.2 | GO:0060842 | blood vessel endothelial cell differentiation(GO:0060837) arterial endothelial cell differentiation(GO:0060842) |
| 0.1 | 1.3 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.1 | 1.1 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 1.3 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.1 | 0.6 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.1 | 2.9 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 1.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 0.8 | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport(GO:0090481) |
| 0.1 | 0.9 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.1 | 0.8 | GO:0071694 | sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) |
| 0.1 | 0.7 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.1 | 2.5 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 5.7 | GO:0043486 | histone exchange(GO:0043486) |
| 0.1 | 0.7 | GO:0008050 | negative regulation of female receptivity(GO:0007621) female courtship behavior(GO:0008050) |
| 0.1 | 0.3 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.1 | 0.8 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.1 | 1.0 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.1 | 0.7 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.1 | 0.4 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.1 | 0.8 | GO:0009048 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.1 | 0.5 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.1 | 2.7 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 1.6 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 2.4 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.1 | 0.5 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.1 | 0.5 | GO:0061314 | Notch signaling involved in heart development(GO:0061314) |
| 0.1 | 0.8 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 0.7 | GO:0090179 | establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.1 | 0.9 | GO:0007379 | segment specification(GO:0007379) |
| 0.1 | 1.5 | GO:0043586 | tongue development(GO:0043586) |
| 0.1 | 0.2 | GO:0001927 | exocyst assembly(GO:0001927) |
| 0.1 | 1.0 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 0.2 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.1 | 1.9 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 1.7 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.1 | 0.5 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.1 | 4.5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 0.6 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.1 | 3.2 | GO:0006378 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 0.1 | 0.7 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 0.7 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 0.1 | 1.5 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.1 | 0.5 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 1.3 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.1 | 0.8 | GO:0002070 | epithelial cell maturation(GO:0002070) |
| 0.1 | 0.3 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 0.3 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.1 | 1.6 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.2 | GO:0034091 | regulation of maintenance of sister chromatid cohesion(GO:0034091) regulation of maintenance of mitotic sister chromatid cohesion(GO:0034182) |
| 0.0 | 0.7 | GO:0002158 | osteoclast proliferation(GO:0002158) |
| 0.0 | 2.8 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.0 | 0.5 | GO:0070933 | histone H4 deacetylation(GO:0070933) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 1.5 | GO:0060999 | positive regulation of dendritic spine development(GO:0060999) |
| 0.0 | 0.2 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 1.8 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 0.0 | 0.2 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 0.0 | 1.7 | GO:0017145 | stem cell division(GO:0017145) |
| 0.0 | 0.2 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.0 | 2.4 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.0 | 0.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 2.5 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.0 | 1.0 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 2.4 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 3.0 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.0 | 1.2 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.0 | 0.8 | GO:0090005 | negative regulation of establishment of protein localization to plasma membrane(GO:0090005) |
| 0.0 | 0.3 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.0 | 1.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 0.2 | GO:0035965 | cardiolipin acyl-chain remodeling(GO:0035965) |
| 0.0 | 0.7 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 2.9 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 3.2 | GO:1902036 | regulation of hematopoietic stem cell differentiation(GO:1902036) |
| 0.0 | 1.1 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 2.3 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 0.2 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.4 | GO:0000479 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) |
| 0.0 | 0.9 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 1.2 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 1.6 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
| 0.0 | 1.2 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.0 | 2.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.0 | 0.2 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.0 | 0.2 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.0 | 0.4 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 0.2 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.0 | 1.0 | GO:0034067 | protein localization to Golgi apparatus(GO:0034067) |
| 0.0 | 1.3 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.2 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.5 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.0 | 3.1 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
| 0.0 | 0.9 | GO:0090175 | Wnt signaling pathway, planar cell polarity pathway(GO:0060071) regulation of establishment of planar polarity(GO:0090175) |
| 0.0 | 0.0 | GO:0061582 | intestinal epithelial cell migration(GO:0061582) |
| 0.0 | 0.1 | GO:0006344 | optic cup formation involved in camera-type eye development(GO:0003408) maintenance of chromatin silencing(GO:0006344) |
| 0.0 | 0.1 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.0 | 0.8 | GO:0090003 | regulation of establishment of protein localization to plasma membrane(GO:0090003) |
| 0.0 | 4.2 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
| 0.0 | 1.6 | GO:0051289 | protein homotetramerization(GO:0051289) |
| 0.0 | 0.4 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 0.7 | GO:1990090 | cellular response to nerve growth factor stimulus(GO:1990090) |
| 0.0 | 4.0 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.0 | 0.2 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.0 | 1.0 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.3 | GO:0009081 | branched-chain amino acid metabolic process(GO:0009081) |
| 0.0 | 0.2 | GO:0097369 | sodium ion import(GO:0097369) |
| 0.0 | 0.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.9 | GO:0014902 | myotube differentiation(GO:0014902) |
| 0.0 | 0.2 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 0.1 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.0 | 0.1 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.0 | 1.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.3 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 0.7 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.4 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.9 | 3.8 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.9 | 2.8 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.8 | 2.5 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.7 | 2.1 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.6 | 2.4 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.6 | 4.2 | GO:0031415 | NatA complex(GO:0031415) |
| 0.6 | 5.2 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.6 | 1.1 | GO:0031414 | N-terminal protein acetyltransferase complex(GO:0031414) |
| 0.5 | 8.5 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.5 | 1.4 | GO:0000939 | condensed chromosome inner kinetochore(GO:0000939) |
| 0.4 | 1.1 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.4 | 4.0 | GO:0005638 | lamin filament(GO:0005638) |
| 0.3 | 5.7 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.3 | 4.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.3 | 2.9 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.3 | 3.1 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.3 | 1.7 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.3 | 1.4 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.3 | 2.5 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.3 | 4.9 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.3 | 1.3 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.2 | 2.0 | GO:0000796 | condensin complex(GO:0000796) |
| 0.2 | 2.2 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 0.9 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.2 | 3.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.2 | 0.9 | GO:0071920 | cleavage body(GO:0071920) |
| 0.2 | 1.7 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.2 | 0.8 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.2 | 1.4 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.2 | 1.0 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.2 | 0.6 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 0.2 | 2.9 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.2 | 0.5 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.2 | 1.2 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.2 | 0.8 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.2 | 3.6 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.2 | 2.2 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 2.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 2.7 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 1.6 | GO:0030681 | multimeric ribonuclease P complex(GO:0030681) |
| 0.1 | 1.5 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 3.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 2.5 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 1.8 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 1.3 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 0.8 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 0.7 | GO:0016589 | NURF complex(GO:0016589) |
| 0.1 | 3.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.5 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 2.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 1.8 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 3.1 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 1.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 5.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 1.0 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 0.9 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 0.1 | 0.2 | GO:1903349 | omegasome membrane(GO:1903349) |
| 0.1 | 0.3 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 6.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 1.1 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 1.3 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 0.2 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.1 | 0.9 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.1 | 4.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 5.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 0.9 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 1.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 5.2 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 1.1 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 0.4 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 0.4 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 1.6 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 0.2 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.0 | 4.0 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 0.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 1.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 1.1 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 9.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 11.1 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 3.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.8 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.0 | 2.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.5 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.0 | 0.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 2.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.3 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 0.9 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 3.8 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.8 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.1 | GO:0002945 | cyclin K-CDK13 complex(GO:0002945) |
| 0.0 | 0.5 | GO:1990752 | microtubule end(GO:1990752) |
| 0.0 | 4.3 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 1.0 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.2 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 1.0 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 8.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 2.4 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 4.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.0 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 6.6 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.4 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.0 | 3.1 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 1.0 | 3.0 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 1.0 | 2.9 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.9 | 3.7 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 0.9 | 2.7 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.8 | 2.4 | GO:0047012 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity(GO:0047012) |
| 0.7 | 2.1 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.6 | 2.4 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.6 | 1.7 | GO:0004874 | aryl hydrocarbon receptor activity(GO:0004874) |
| 0.5 | 1.6 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.5 | 3.8 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.5 | 3.2 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.5 | 2.5 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.5 | 8.7 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.4 | 2.2 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.4 | 3.5 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.4 | 1.3 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.4 | 4.2 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.4 | 2.4 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.4 | 5.4 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.3 | 2.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 1.3 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.3 | 8.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.3 | 0.9 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.3 | 0.8 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.3 | 1.9 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.3 | 1.6 | GO:0016435 | rRNA (guanine) methyltransferase activity(GO:0016435) |
| 0.3 | 4.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.3 | 1.3 | GO:0017018 | myosin phosphatase activity(GO:0017018) |
| 0.3 | 0.8 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.3 | 2.1 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.3 | 1.0 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.2 | 2.2 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.2 | 0.6 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 0.2 | 1.1 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.2 | 1.3 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 0.2 | 3.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 1.0 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.2 | 3.1 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.2 | 0.6 | GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567) |
| 0.2 | 3.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.2 | 3.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 1.6 | GO:0018812 | 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) |
| 0.2 | 1.4 | GO:0098639 | collagen receptor activity(GO:0038064) collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.2 | 0.5 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.2 | 0.9 | GO:0052656 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.2 | 0.5 | GO:0031403 | lithium ion binding(GO:0031403) |
| 0.2 | 2.8 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.2 | 3.8 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.2 | 1.0 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.2 | 0.8 | GO:0032564 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 0.2 | 1.2 | GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929) |
| 0.2 | 2.5 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.2 | 13.4 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 1.0 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.2 | 1.1 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.2 | 0.8 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 5.8 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 0.7 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.1 | 0.7 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.1 | 0.7 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.1 | 0.4 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.1 | 0.5 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 0.1 | 1.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 1.0 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 1.7 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 1.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 0.7 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.1 | 2.7 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 4.4 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 4.2 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 0.8 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 0.1 | 1.3 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 4.2 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 4.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 1.1 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 4.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.5 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 3.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 7.7 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 0.8 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.1 | 1.4 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 2.5 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.1 | 2.1 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.1 | 1.8 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 0.6 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.5 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 1.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 1.6 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.1 | 1.3 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.8 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.1 | 0.5 | GO:0038049 | transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) |
| 0.1 | 0.6 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 2.6 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 0.6 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.1 | 0.8 | GO:0019966 | interleukin-1 binding(GO:0019966) |
| 0.1 | 1.2 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 0.2 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.1 | 3.8 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.1 | 4.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 1.8 | GO:0015301 | anion:anion antiporter activity(GO:0015301) |
| 0.1 | 1.0 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.1 | 0.7 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 1.1 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.1 | 0.2 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 0.1 | 0.6 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 0.4 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 0.5 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.1 | 4.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 2.7 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 1.0 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.3 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.0 | 0.5 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.4 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
| 0.0 | 0.7 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 0.0 | 0.4 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 1.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.6 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.7 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 3.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 0.7 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 2.3 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 1.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.1 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 0.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.0 | 2.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.2 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.0 | 2.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.0 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 1.3 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 0.7 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.1 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.0 | 0.5 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 2.2 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 1.9 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.7 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.3 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.2 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.0 | 0.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 0.2 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.0 | 3.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 3.1 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.3 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 0.2 | GO:0015386 | sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 2.1 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.0 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.0 | 0.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.3 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 8.0 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 2.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 2.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 5.1 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 4.8 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 3.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 6.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 2.0 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 2.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 5.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.0 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 2.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 2.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 4.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 0.7 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 3.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.4 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 6.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 1.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 1.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.7 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 2.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 7.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.9 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.4 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.7 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 1.6 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 1.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.5 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 0.2 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.2 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.3 | 2.2 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.3 | 11.9 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.2 | 3.3 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.2 | 3.0 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.2 | 2.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 7.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 7.6 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.2 | 3.9 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.2 | 1.9 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.2 | 3.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 2.9 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 3.5 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 2.1 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 2.1 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.5 | REACTOME SIGNALING BY NOTCH2 | Genes involved in Signaling by NOTCH2 |
| 0.1 | 3.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 5.9 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 0.1 | 0.9 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 2.6 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 4.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 1.5 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.1 | 2.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.0 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.1 | 2.5 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 1.3 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.0 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 0.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 2.2 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.8 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 2.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.2 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 2.0 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 1.2 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 1.3 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.8 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 2.2 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 1.1 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.7 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 0.7 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 2.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.2 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.6 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 1.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.5 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.6 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.7 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.2 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.0 | 0.4 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 0.2 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.2 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 2.0 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 0.2 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.3 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 0.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.3 | REACTOME KINESINS | Genes involved in Kinesins |