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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GATA5

Z-value: 4.20

Motif logo

Transcription factors associated with GATA5

Gene Symbol Gene ID Gene Info
ENSG00000130700.7 GATA5

Activity profile of GATA5 motif

Sorted Z-values of GATA5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr12_-_110445540 16.46 ENST00000547365.1
actin related protein 2/3 complex subunit 3
chr3_-_185923893 16.17 ENST00000259043.11
transformer 2 beta homolog
chr1_+_236394268 15.29 ENST00000334232.9
EDAR associated death domain
chr14_+_20455968 9.97 ENST00000438886.1
apurinic/apyrimidinic endodeoxyribonuclease 1
chr14_+_61697622 9.19 ENST00000539097.2
hypoxia inducible factor 1 subunit alpha
chr4_-_71784046 8.49 ENST00000513476.5
ENST00000273951.13
GC vitamin D binding protein
chr6_-_31540536 8.02 ENST00000376177.6
DExD-box helicase 39B
chr11_+_114439424 8.01 ENST00000544196.5
ENST00000265881.10
ENST00000539754.5
ENST00000539275.5
RNA exonuclease 2
chr22_-_28711931 7.99 ENST00000434810.5
ENST00000456369.5
checkpoint kinase 2
chr1_-_150697128 7.83 ENST00000427665.1
ENST00000271732.8
golgi phosphoprotein 3 like
chr22_-_28712136 7.75 ENST00000464581.6
checkpoint kinase 2
chr2_-_105396943 7.42 ENST00000409807.5
four and a half LIM domains 2
chr6_+_85449584 7.21 ENST00000369651.7
5'-nucleotidase ecto
chr3_-_108058361 7.07 ENST00000398258.7
CD47 molecule
chr3_+_184362599 6.76 ENST00000455712.5
RNA polymerase II, I and III subunit H
chr2_+_201132769 6.74 ENST00000494258.5
CASP8 and FADD like apoptosis regulator
chr3_-_146528750 6.61 ENST00000483300.5
phospholipid scramblase 1
chr3_+_172039556 6.56 ENST00000415807.7
ENST00000421757.5
fibronectin type III domain containing 3B
chr1_+_78649818 6.31 ENST00000370747.9
ENST00000438486.1
interferon induced protein 44
chr17_-_59707404 6.27 ENST00000393038.3
peptidyl-tRNA hydrolase 2
chr1_-_88891496 6.27 ENST00000448623.5
ENST00000370500.10
ENST00000418217.1
general transcription factor IIB
chr4_+_73740541 5.92 ENST00000401931.1
ENST00000307407.8
C-X-C motif chemokine ligand 8
chr20_-_50958520 5.88 ENST00000371588.10
ENST00000371584.9
ENST00000413082.1
ENST00000371582.8
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
chr17_-_42018488 5.69 ENST00000589773.5
ENST00000674214.1
DnaJ heat shock protein family (Hsp40) member C7
chrX_+_101390824 5.54 ENST00000427805.6
ENST00000614077.4
ribosomal protein L36a
chr1_+_75786246 5.49 ENST00000319942.8
Rab geranylgeranyltransferase subunit beta
chr3_+_138621225 5.47 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr7_-_30550761 5.31 ENST00000598361.4
ENST00000440438.6
novel protein
GARS1 divergent transcript
chr17_+_38752731 5.25 ENST00000619426.5
ENST00000610434.4
proteasome 20S subunit beta 3
chr2_-_46916020 5.24 ENST00000409800.5
ENST00000409218.5
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr2_+_201132872 5.21 ENST00000470178.6
CASP8 and FADD like apoptosis regulator
chr5_+_163503075 5.20 ENST00000280969.9
methionine adenosyltransferase 2B
chr1_+_174875505 5.17 ENST00000486220.5
RAB GTPase activating protein 1 like
chr9_+_104094557 5.01 ENST00000374787.7
structural maintenance of chromosomes 2
chr6_-_170553216 5.00 ENST00000262193.7
proteasome 20S subunit beta 1
chr8_-_140800535 4.93 ENST00000521986.5
ENST00000523539.5
protein tyrosine kinase 2
chr9_-_41189310 4.91 ENST00000456520.5
ENST00000377391.8
ENST00000613716.4
ENST00000617933.1
COBW domain containing 6
chr17_+_47522931 4.90 ENST00000525007.5
ENST00000530173.6
aminopeptidase puromycin sensitive
chr14_-_35121950 4.59 ENST00000554361.5
ENST00000261475.10
protein phosphatase 2 regulatory subunit B''gamma
chr4_-_82844418 4.39 ENST00000503937.5
SEC31 homolog A, COPII coat complex component
chr8_+_131939865 4.36 ENST00000520362.5
ENST00000519656.1
EFR3 homolog A
chr9_+_68241854 4.35 ENST00000616550.4
ENST00000618217.4
ENST00000377342.9
ENST00000478048.5
ENST00000360171.11
COBW domain containing 3
chr2_+_201132928 4.33 ENST00000462763.5
CASP8 and FADD like apoptosis regulator
chr7_+_134646798 4.21 ENST00000418040.5
ENST00000393132.2
bisphosphoglycerate mutase
chr3_+_138621207 4.20 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr7_+_134646845 4.18 ENST00000344924.8
bisphosphoglycerate mutase
chr12_+_57488059 4.13 ENST00000628866.2
ENST00000262027.10
methionyl-tRNA synthetase 1
chr10_+_5048748 4.02 ENST00000602997.5
ENST00000439082.7
aldo-keto reductase family 1 member C3
chr15_+_49621004 3.83 ENST00000403028.8
ENST00000558653.5
ENST00000559164.5
ENST00000560632.5
ENST00000559405.5
ENST00000251250.7
DTW domain containing 1
chr6_-_130956371 3.80 ENST00000639623.1
ENST00000525193.5
ENST00000527659.5
erythrocyte membrane protein band 4.1 like 2
chr7_+_142760398 3.80 ENST00000632998.1
serine protease 2
chr5_+_141223332 3.62 ENST00000239449.7
ENST00000624896.1
ENST00000624396.1
protocadherin beta 14
novel protein
chr7_+_77840122 3.58 ENST00000450574.5
ENST00000248550.7
putative homeodomain transcription factor 2
chr11_-_27700447 3.53 ENST00000356660.9
brain derived neurotrophic factor
chr2_-_178451094 3.48 ENST00000677981.1
ENST00000678845.1
ENST00000677689.1
ENST00000325748.9
ENST00000678775.1
protein activator of interferon induced protein kinase EIF2AK2
chr16_-_69339493 3.47 ENST00000562595.5
ENST00000615447.1
ENST00000306875.10
ENST00000562081.2
component of oligomeric golgi complex 8
chr15_+_88635626 3.35 ENST00000379224.10
interferon stimulated exonuclease gene 20
chr11_-_27700472 3.33 ENST00000418212.5
ENST00000533246.5
brain derived neurotrophic factor
chr12_-_8650529 3.23 ENST00000543467.5
microfibril associated protein 5
chr7_-_123557679 3.15 ENST00000677264.1
ENST00000471770.5
ENST00000676730.1
ENST00000677391.1
ENST00000677251.1
ENST00000470123.2
ENST00000679163.1
ENST00000676614.1
ENST00000378795.9
ENST00000676516.1
ENST00000355749.7
ENST00000678090.1
NADH:ubiquinone oxidoreductase subunit A5
chrX_-_71255060 3.03 ENST00000373988.5
ENST00000373998.5
zinc finger MYM-type containing 3
chr12_+_20815672 2.98 ENST00000261196.6
ENST00000381541.7
ENST00000540229.1
solute carrier organic anion transporter family member 1B3
SLCO1B3-SLCO1B7 readthrough
chr6_-_53545091 2.97 ENST00000650454.1
glutamate-cysteine ligase catalytic subunit
chr3_+_141426108 2.96 ENST00000441582.2
ENST00000510726.1
zinc finger and BTB domain containing 38
chr7_+_142749465 2.92 ENST00000486171.5
ENST00000619214.4
ENST00000311737.12
serine protease 1
chr2_+_101998955 2.54 ENST00000393414.6
interleukin 1 receptor type 2
chr11_+_112086853 2.53 ENST00000528182.5
ENST00000528048.5
ENST00000375549.8
ENST00000528021.6
ENST00000526592.5
ENST00000525291.5
succinate dehydrogenase complex subunit D
chr8_+_85187650 2.48 ENST00000517476.5
ENST00000521429.5
E2F transcription factor 5
chr8_-_23854796 2.44 ENST00000290271.7
stanniocalcin 1
chr16_+_31527876 2.44 ENST00000302312.9
ENST00000564707.1
alpha hemoglobin stabilizing protein
chr19_+_926001 2.41 ENST00000263620.8
AT-rich interaction domain 3A
chr12_+_53097656 2.40 ENST00000301464.4
insulin like growth factor binding protein 6
chr15_-_63381835 2.36 ENST00000344366.7
ENST00000178638.8
ENST00000422263.2
carbonic anhydrase 12
chr4_-_109801978 2.34 ENST00000510800.1
ENST00000512148.5
ENST00000394634.7
ENST00000394635.8
ENST00000645635.1
complement factor I
novel protein
chr10_-_61001430 2.29 ENST00000357917.4
Rho related BTB domain containing 1
chrX_+_46912276 2.27 ENST00000424392.5
ENST00000611250.4
jade family PHD finger 3
chr10_-_112446932 2.25 ENST00000682195.1
ENST00000683505.1
ENST00000683895.1
ENST00000682839.1
ENST00000682055.1
zinc finger DHHC-type palmitoyltransferase 6
chr11_+_57761787 2.21 ENST00000358694.10
ENST00000361332.8
ENST00000361391.10
ENST00000361796.9
ENST00000415361.6
ENST00000426142.6
ENST00000428599.6
ENST00000525902.5
ENST00000526357.5
ENST00000526772.5
ENST00000527467.5
ENST00000528232.5
ENST00000528621.5
ENST00000529526.5
ENST00000529873.5
ENST00000529986.5
ENST00000530094.5
ENST00000530748.5
ENST00000531014.5
ENST00000532245.5
ENST00000532463.5
ENST00000532649.5
ENST00000532787.5
ENST00000532844.5
ENST00000533667.5
ENST00000534579.5
ENST00000399050.10
ENST00000526938.5
ENST00000674015.1
ENST00000531007.2
ENST00000673826.1
catenin delta 1
chr1_+_224183197 2.13 ENST00000323699.9
delta 4-desaturase, sphingolipid 1
chr4_+_68815991 1.88 ENST00000265403.12
ENST00000458688.2
UDP glucuronosyltransferase family 2 member B10
chr11_-_4697831 1.86 ENST00000641159.1
ENST00000396950.4
ENST00000532598.1
olfactory receptor family 51 subfamily C member 1 pseudogene
olfactory receptor family 51 subfamily E member 2
chr2_+_201132958 1.80 ENST00000479953.6
ENST00000340870.6
CASP8 and FADD like apoptosis regulator
chrX_+_153179276 1.75 ENST00000356661.7
MAGE family member A1
chrX_-_77895546 1.72 ENST00000358075.11
magnesium transporter 1
chr4_+_154563003 1.69 ENST00000302068.9
ENST00000509493.1
fibrinogen beta chain
chr10_-_112446891 1.66 ENST00000369404.3
ENST00000369405.7
ENST00000626395.2
zinc finger DHHC-type palmitoyltransferase 6
chrX_-_77895414 1.64 ENST00000618282.5
ENST00000373336.3
magnesium transporter 1
chr12_-_102061946 1.62 ENST00000240079.11
WASH complex subunit 3
chr13_+_30735523 1.57 ENST00000380490.5
arachidonate 5-lipoxygenase activating protein
chr12_-_68225806 1.49 ENST00000229134.5
interleukin 26
chr3_+_190615308 1.47 ENST00000412080.1
interleukin 1 receptor accessory protein
chr6_+_26500296 1.46 ENST00000684113.1
butyrophilin subfamily 1 member A1
chr17_+_64449037 1.45 ENST00000615220.4
ENST00000619286.5
ENST00000612535.4
ENST00000616498.4
mast cell immunoglobulin like receptor 1
chr1_+_56854764 1.40 ENST00000361249.4
complement C8 alpha chain
chr22_+_20859483 1.38 ENST00000439214.1
synaptosome associated protein 29
chr8_+_40153475 1.35 ENST00000315792.5
transcriptional and immune response regulator
chr4_+_47485268 1.35 ENST00000273859.8
ENST00000504445.1
ATPase phospholipid transporting 10D (putative)
chr2_-_49154433 1.33 ENST00000454032.5
ENST00000304421.8
follicle stimulating hormone receptor
chr17_-_43125450 1.33 ENST00000494123.5
ENST00000468300.5
ENST00000471181.7
ENST00000652672.1
BRCA1 DNA repair associated
chr10_+_35195124 1.32 ENST00000487763.5
ENST00000473940.5
ENST00000488328.5
ENST00000356917.9
cAMP responsive element modulator
chr10_-_112446734 1.31 ENST00000684507.1
zinc finger DHHC-type palmitoyltransferase 6
chr16_+_56451513 1.30 ENST00000562150.5
ENST00000561646.5
ENST00000566157.6
ENST00000568397.1
2-oxoglutarate and iron dependent oxygenase domain containing 1
chr15_+_58138368 1.29 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr4_+_87608529 1.27 ENST00000651931.1
dentin sialophosphoprotein
chr12_-_102062079 1.24 ENST00000545679.5
WASH complex subunit 3
chr2_-_49154507 1.22 ENST00000406846.7
follicle stimulating hormone receptor
chr1_-_26900437 1.15 ENST00000361720.10
G-patch domain containing 3
chr17_+_43170452 1.14 ENST00000341165.10
ENST00000586650.5
NBR1 autophagy cargo receptor
chr9_-_120477354 1.10 ENST00000416449.5
CDK5 regulatory subunit associated protein 2
chr7_+_136868622 1.07 ENST00000680005.1
ENST00000445907.6
cholinergic receptor muscarinic 2
chr14_-_24084625 1.04 ENST00000397002.6
neural retina leucine zipper
chr12_-_30735014 1.02 ENST00000433722.6
caprin family member 2
chr4_-_48780242 0.97 ENST00000507711.5
ENST00000358350.9
FRY like transcription coactivator
chr1_+_171485520 0.96 ENST00000647382.2
ENST00000392078.7
ENST00000367742.7
ENST00000338920.8
proline rich coiled-coil 2C
chr2_-_217842154 0.94 ENST00000446688.5
tensin 1
chr18_+_63775395 0.90 ENST00000398019.7
serpin family B member 7
chr13_-_46182136 0.80 ENST00000323076.7
lymphocyte cytosolic protein 1
chr3_-_197573323 0.80 ENST00000358186.6
ENST00000431056.5
3-hydroxybutyrate dehydrogenase 1
chr8_-_78805515 0.77 ENST00000379113.6
ENST00000541183.2
interleukin 7
chr9_-_92482350 0.74 ENST00000375543.2
asporin
chr6_-_132757883 0.70 ENST00000525289.5
ENST00000326499.11
vanin 2
chr12_-_130839230 0.69 ENST00000392373.7
ENST00000261653.10
syntaxin 2
chr3_+_108822778 0.67 ENST00000295756.11
T cell receptor associated transmembrane adaptor 1
chr3_+_108822759 0.66 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr5_+_93583212 0.66 ENST00000327111.8
nuclear receptor subfamily 2 group F member 1
chr4_-_69653223 0.63 ENST00000286604.8
ENST00000505512.1
ENST00000514019.1
UDP glucuronosyltransferase family 2 member A1 complex locus
chr6_+_29111560 0.59 ENST00000377169.2
olfactory receptor family 2 subfamily J member 3
chr11_-_61967127 0.56 ENST00000532601.1
ferritin heavy chain 1
chr11_+_122862303 0.55 ENST00000533709.1
cytotoxic and regulatory T cell molecule
chr6_+_46793379 0.44 ENST00000230588.9
ENST00000611727.2
meprin A subunit alpha
chr8_-_78805306 0.37 ENST00000639719.1
ENST00000263851.9
interleukin 7
chrX_-_140784366 0.33 ENST00000674533.1
cerebellar degeneration related protein 1
chrX_+_78945332 0.32 ENST00000544091.1
ENST00000171757.3
P2Y receptor family member 10
chr11_+_30231000 0.23 ENST00000254122.8
ENST00000533718.2
ENST00000417547.1
follicle stimulating hormone subunit beta
chr16_+_25216943 0.18 ENST00000219660.6
aquaporin 8
chr3_-_179251615 0.15 ENST00000314235.9
ENST00000392685.6
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr1_+_202462730 0.14 ENST00000290419.9
ENST00000491336.5
protein phosphatase 1 regulatory subunit 12B
chr9_-_6645712 0.13 ENST00000321612.8
glycine decarboxylase
chr1_+_115029823 0.11 ENST00000256592.3
thyroid stimulating hormone subunit beta
chr16_+_33827140 0.10 ENST00000562905.2
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr2_+_190927649 0.10 ENST00000409428.5
ENST00000409215.5
glutaminase
chrX_+_1615049 0.09 ENST00000381241.9
acetylserotonin O-methyltransferase
chr6_-_24935942 0.08 ENST00000645100.1
ENST00000643898.2
ENST00000613507.4
RHO family interacting cell polarization regulator 2
chr15_+_99565921 0.08 ENST00000558812.5
ENST00000338042.10
myocyte enhancer factor 2A
chr15_+_99566066 0.05 ENST00000557942.5
myocyte enhancer factor 2A
chr8_-_90082871 0.04 ENST00000265431.7
calbindin 1
chrX_+_11759604 0.03 ENST00000649602.1
ENST00000650215.1
ENST00000649685.1
ENST00000649649.1
ENST00000380693.8
ENST00000380692.7
ENST00000650628.1
ENST00000649851.1
ENST00000421368.3
MSL complex subunit 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.7 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
3.3 10.0 GO:0097698 telomere maintenance via base-excision repair(GO:0097698)
2.3 6.9 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
1.9 7.4 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
1.6 18.1 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.5 9.2 GO:0070101 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
1.4 8.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
1.3 4.0 GO:0016488 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
1.3 5.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
1.3 6.3 GO:2000210 positive regulation of anoikis(GO:2000210)
1.2 16.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
1.2 7.2 GO:0046086 AMP catabolic process(GO:0006196) adenosine biosynthetic process(GO:0046086)
1.2 5.9 GO:0019348 dolichol metabolic process(GO:0019348)
1.1 8.0 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
1.1 3.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.0 3.0 GO:0044752 response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.9 2.6 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.8 2.5 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.8 5.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.8 6.6 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.7 7.8 GO:0048194 Golgi vesicle budding(GO:0048194)
0.7 6.3 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.6 2.5 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.6 5.5 GO:0018344 protein geranylgeranylation(GO:0018344)
0.6 5.9 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.4 1.3 GO:0070510 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.4 1.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.4 3.4 GO:0015693 magnesium ion transport(GO:0015693)
0.4 6.7 GO:0008228 opsonization(GO:0008228)
0.4 1.9 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.4 2.9 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.4 16.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.4 4.9 GO:0051964 netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964)
0.3 2.4 GO:0055064 chloride ion homeostasis(GO:0055064)
0.3 5.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.3 8.5 GO:0042359 vitamin D metabolic process(GO:0042359)
0.3 1.4 GO:0016240 autophagosome docking(GO:0016240)
0.3 4.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 1.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.3 5.2 GO:0018345 protein palmitoylation(GO:0018345)
0.2 3.5 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.2 1.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.2 1.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.0 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.2 8.0 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.2 3.8 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.2 2.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 0.9 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.2 2.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 6.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 2.4 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.1 0.8 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 1.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 1.6 GO:2001300 lipoxin metabolic process(GO:2001300)
0.1 1.5 GO:0072602 interleukin-4 secretion(GO:0072602)
0.1 2.9 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 1.4 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.1 1.3 GO:0006449 regulation of translational termination(GO:0006449)
0.1 10.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 5.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 3.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 3.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 2.2 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.1 0.6 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 3.6 GO:0043171 peptide catabolic process(GO:0043171)
0.1 12.3 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 3.0 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 2.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 5.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 1.4 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.0 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.5 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 3.7 GO:0030574 collagen catabolic process(GO:0030574)
0.0 2.1 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.7 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 2.4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 1.1 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 4.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.6 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 1.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 2.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.4 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 1.0 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.9 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 1.5 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.1 GO:1990868 negative regulation of establishment of T cell polarity(GO:1903904) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.0 GO:0072025 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.0 0.5 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
1.7 5.2 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
1.4 5.5 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.0 3.0 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.9 18.1 GO:0097342 ripoptosome(GO:0097342)
0.8 16.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.7 10.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.6 6.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.6 5.0 GO:0000796 condensin complex(GO:0000796)
0.6 8.0 GO:0005688 U6 snRNP(GO:0005688)
0.5 2.5 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.4 6.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 3.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 3.5 GO:0017119 Golgi transport complex(GO:0017119)
0.3 1.3 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.2 4.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 2.9 GO:0071203 WASH complex(GO:0071203)
0.2 1.4 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.2 3.5 GO:0070578 RISC-loading complex(GO:0070578)
0.2 2.4 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.2 16.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.1 GO:0032279 asymmetric synapse(GO:0032279)
0.2 1.4 GO:0005579 membrane attack complex(GO:0005579)
0.2 2.2 GO:0005915 zonula adherens(GO:0005915)
0.2 2.4 GO:0005833 hemoglobin complex(GO:0005833)
0.2 3.2 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 9.2 GO:1904115 axon cytoplasm(GO:1904115)
0.1 1.7 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.6 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.1 2.3 GO:0008091 spectrin(GO:0008091)
0.1 23.6 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 5.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 5.0 GO:0031430 M band(GO:0031430)
0.1 7.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 8.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 8.6 GO:0035579 specific granule membrane(GO:0035579)
0.1 1.1 GO:0000242 pericentriolar material(GO:0000242) mitotic spindle pole(GO:0097431)
0.1 0.8 GO:0098576 lumenal side of membrane(GO:0098576)
0.1 8.5 GO:0043202 lysosomal lumen(GO:0043202)
0.1 5.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 5.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.4 GO:0042629 mast cell granule(GO:0042629)
0.0 2.5 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 4.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.3 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 7.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.5 GO:0001650 fibrillar center(GO:0001650)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.0 4.6 GO:0005819 spindle(GO:0005819)
0.0 5.5 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.5 GO:1902271 D3 vitamins binding(GO:1902271)
2.5 10.0 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
2.0 5.9 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
1.7 6.9 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
1.7 8.4 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
1.3 4.0 GO:0047787 geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
1.3 6.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
1.1 3.4 GO:0008859 exoribonuclease II activity(GO:0008859)
1.1 5.5 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
1.0 3.0 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.9 8.0 GO:0030621 U4 snRNA binding(GO:0030621)
0.9 2.6 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.6 2.5 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.6 18.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.6 7.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.5 7.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.5 2.5 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.4 1.3 GO:0015265 urea channel activity(GO:0015265)
0.4 6.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 6.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 5.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.4 3.8 GO:0042731 PH domain binding(GO:0042731)
0.4 10.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 7.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 2.4 GO:0030492 hemoglobin binding(GO:0030492)
0.3 3.5 GO:0070883 pre-miRNA binding(GO:0070883)
0.3 16.2 GO:0070717 poly-purine tract binding(GO:0070717)
0.3 3.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 1.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.3 5.2 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 0.8 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.3 1.3 GO:0031544 peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.3 4.9 GO:0008432 JUN kinase binding(GO:0008432)
0.2 8.0 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.2 1.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 2.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 4.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 3.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.2 9.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 5.7 GO:0001671 ATPase activator activity(GO:0001671)
0.2 6.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 3.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 15.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 4.7 GO:0050681 androgen receptor binding(GO:0050681)
0.1 4.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.4 GO:0001848 complement binding(GO:0001848)
0.0 4.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 15.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 5.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.3 GO:0009055 electron carrier activity(GO:0009055)
0.0 1.7 GO:0051087 chaperone binding(GO:0051087)
0.0 1.5 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0005372 water transmembrane transporter activity(GO:0005372) water channel activity(GO:0015250)
0.0 2.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 1.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.0 GO:0005499 vitamin D binding(GO:0005499)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 18.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3 17.1 PID ATM PATHWAY ATM pathway
0.3 9.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 10.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 7.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 16.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 4.9 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 16.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 5.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 8.8 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 2.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 4.0 PID IL1 PATHWAY IL1-mediated signaling events
0.1 5.0 PID AURORA B PATHWAY Aurora B signaling
0.1 7.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 3.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 2.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.9 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 15.7 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.6 18.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.5 7.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.4 12.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.4 7.9 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.4 5.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.3 6.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.3 8.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 9.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 8.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 2.9 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 3.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 9.6 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 6.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 10.2 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1 6.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 2.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 2.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 4.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 7.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 3.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.3 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 5.5 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 3.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 4.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport