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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GATA6

Z-value: 0.35

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.11 GATA6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg38_v1_chr18_+_22169580_221695960.036.9e-01Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_49764123 15.96 ENST00000240364.7
ENST00000506156.1
FAM117A
family with sequence similarity 117 member A
chr11_+_119087979 15.02 ENST00000535253.5
ENST00000392841.1
ENST00000648374.1
HMBS
hydroxymethylbilane synthase
chr12_-_54295748 14.79 ENST00000540264.2
ENST00000312156.8
NFE2
nuclear factor, erythroid 2
chr1_-_158686700 12.46 ENST00000643759.2
SPTA1
spectrin alpha, erythrocytic 1
chr16_+_31527876 11.61 ENST00000302312.9
ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr7_-_142962206 10.97 ENST00000460479.2
ENST00000476829.5
ENST00000355265.7
KEL
Kell metallo-endopeptidase (Kell blood group)
chr19_-_13102848 10.46 ENST00000264824.5
LYL1
LYL1 basic helix-loop-helix family member
chr15_-_43220989 9.82 ENST00000540029.5
ENST00000441366.7
ENST00000648595.1
EPB42
erythrocyte membrane protein band 4.2
chr7_-_100641507 9.59 ENST00000431692.5
ENST00000223051.8
TFR2
transferrin receptor 2
chr1_+_25272439 9.55 ENST00000648012.1
RHD
Rh blood group D antigen
chr1_-_206023889 9.06 ENST00000358184.7
ENST00000360218.3
ENST00000678712.1
ENST00000678498.1
CTSE
cathepsin E
chr7_+_142760398 7.46 ENST00000632998.1
PRSS2
serine protease 2
chr1_+_25272492 6.91 ENST00000454452.6
RHD
Rh blood group D antigen
chr8_-_41797589 6.46 ENST00000347528.8
ENST00000289734.13
ANK1
ankyrin 1
chr13_-_46142834 6.34 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr1_+_25272502 5.97 ENST00000328664.9
RHD
Rh blood group D antigen
chr7_+_130380339 5.95 ENST00000481342.5
ENST00000604896.5
ENST00000011292.8
CPA1
carboxypeptidase A1
chr19_+_10286944 5.68 ENST00000380770.5
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10286971 5.57 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr1_+_25272479 5.51 ENST00000622561.4
RHD
Rh blood group D antigen
chr1_+_25272527 5.49 ENST00000342055.9
ENST00000357542.8
ENST00000417538.6
ENST00000423810.6
ENST00000568195.5
RHD
Rh blood group D antigen
chr10_+_116545907 5.41 ENST00000369221.2
PNLIP
pancreatic lipase
chr8_+_21966215 5.38 ENST00000433566.8
XPO7
exportin 7
chr17_-_64006880 5.14 ENST00000449662.6
ICAM2
intercellular adhesion molecule 2
chr1_+_161166390 5.08 ENST00000352210.9
ENST00000367999.9
ENST00000497522.5
ENST00000652182.1
ENST00000544598.5
ENST00000535223.5
PPOX
protoporphyrinogen oxidase
chr7_+_142749465 5.07 ENST00000486171.5
ENST00000619214.4
ENST00000311737.12
PRSS1
serine protease 1
chr13_-_40982880 5.06 ENST00000635415.1
ELF1
E74 like ETS transcription factor 1
chr6_-_30160880 4.57 ENST00000376704.3
TRIM10
tripartite motif containing 10
chr6_-_30161200 4.11 ENST00000449742.7
TRIM10
tripartite motif containing 10
chr11_-_57390636 3.75 ENST00000525955.1
ENST00000533605.5
ENST00000311862.10
PRG2
proteoglycan 2, pro eosinophil major basic protein
chr22_-_19881369 3.73 ENST00000462330.5
TXNRD2
thioredoxin reductase 2
chr3_+_152268920 3.48 ENST00000495875.6
ENST00000324210.10
ENST00000493459.5
MBNL1
muscleblind like splicing regulator 1
chr19_-_11384299 3.46 ENST00000592375.6
ENST00000222139.11
EPOR
erythropoietin receptor
chr22_-_19881163 3.45 ENST00000485358.5
TXNRD2
thioredoxin reductase 2
chr10_+_116590956 3.14 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr8_-_94436926 3.02 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr10_+_116591010 2.87 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr10_-_97771954 2.85 ENST00000266066.4
SFRP5
secreted frizzled related protein 5
chr9_+_33795551 2.79 ENST00000379405.4
PRSS3
serine protease 3
chr4_-_102345196 2.55 ENST00000683412.1
ENST00000682227.1
SLC39A8
solute carrier family 39 member 8
chr12_+_111405861 2.38 ENST00000341259.7
SH2B3
SH2B adaptor protein 3
chr8_-_144792380 2.22 ENST00000532702.1
ENST00000394920.6
ENST00000528957.6
ENST00000527914.5
RPL8
ribosomal protein L8
chr14_-_22815421 1.81 ENST00000674313.1
ENST00000555959.1
SLC7A7
solute carrier family 7 member 7
chr17_+_58755821 1.80 ENST00000308249.4
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent 1E
chr10_-_125816510 1.79 ENST00000650587.1
UROS
uroporphyrinogen III synthase
chr1_-_26913964 1.77 ENST00000254227.4
NR0B2
nuclear receptor subfamily 0 group B member 2
chr8_-_20183127 1.68 ENST00000276373.10
ENST00000519026.5
ENST00000440926.3
ENST00000437980.3
SLC18A1
solute carrier family 18 member A1
chr4_+_99574812 1.67 ENST00000422897.6
ENST00000265517.10
MTTP
microsomal triglyceride transfer protein
chr3_+_69763726 1.63 ENST00000448226.9
MITF
melanocyte inducing transcription factor
chr8_-_20183090 1.62 ENST00000265808.11
ENST00000522513.5
SLC18A1
solute carrier family 18 member A1
chr20_-_56392131 1.48 ENST00000422322.5
ENST00000371356.6
ENST00000451915.1
ENST00000347343.6
ENST00000395911.5
ENST00000395915.8
ENST00000395907.5
ENST00000441357.5
ENST00000456249.5
ENST00000420474.5
ENST00000395914.5
ENST00000312783.10
ENST00000395913.7
AURKA
aurora kinase A
chr14_+_75522427 1.47 ENST00000286639.8
BATF
basic leucine zipper ATF-like transcription factor
chr1_+_171248471 1.42 ENST00000402921.6
ENST00000617670.6
ENST00000367750.7
FMO1
flavin containing dimethylaniline monoxygenase 1
chr16_+_283157 1.31 ENST00000219406.11
ENST00000404312.5
ENST00000456379.1
PDIA2
protein disulfide isomerase family A member 2
chr6_+_31706866 1.21 ENST00000375832.5
ENST00000503322.1
LY6G6F
LY6G6F-LY6G6D
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr12_+_6310669 1.18 ENST00000684764.1
PLEKHG6
pleckstrin homology and RhoGEF domain containing G6
chr11_-_116837586 1.12 ENST00000375320.5
ENST00000359492.6
ENST00000375329.6
ENST00000375323.5
ENST00000236850.5
APOA1
apolipoprotein A1
chr22_-_29388530 1.11 ENST00000357586.7
ENST00000432560.6
ENST00000405198.6
ENST00000317368.11
AP1B1
adaptor related protein complex 1 subunit beta 1
chr2_-_68871382 1.07 ENST00000295379.2
BMP10
bone morphogenetic protein 10
chr2_+_86441341 1.02 ENST00000312912.10
ENST00000409064.5
KDM3A
lysine demethylase 3A
chr12_+_53425070 1.01 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor type 2
chr14_+_75522531 1.01 ENST00000555504.1
BATF
basic leucine zipper ATF-like transcription factor
chr4_-_102345061 1.00 ENST00000394833.6
SLC39A8
solute carrier family 39 member 8
chr2_-_213150236 0.99 ENST00000442445.1
ENST00000342002.6
IKZF2
IKAROS family zinc finger 2
chr18_-_31162849 0.97 ENST00000257197.7
ENST00000257198.6
DSC1
desmocollin 1
chr19_-_38812936 0.97 ENST00000307751.9
ENST00000594209.1
LGALS4
galectin 4
chr3_+_137998735 0.94 ENST00000343735.8
CLDN18
claudin 18
chr5_-_33984636 0.92 ENST00000382102.7
ENST00000509381.1
SLC45A2
solute carrier family 45 member 2
chr5_-_33984681 0.91 ENST00000296589.9
SLC45A2
solute carrier family 45 member 2
chr14_-_22815801 0.90 ENST00000397532.9
SLC7A7
solute carrier family 7 member 7
chr1_+_12464912 0.87 ENST00000543766.2
VPS13D
vacuolar protein sorting 13 homolog D
chr1_-_24143112 0.85 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chr18_+_22169580 0.84 ENST00000269216.10
GATA6
GATA binding protein 6
chr14_-_22815856 0.83 ENST00000554758.1
ENST00000397528.8
SLC7A7
solute carrier family 7 member 7
chr18_+_45724172 0.76 ENST00000321925.9
ENST00000415427.7
ENST00000589322.7
ENST00000586951.6
ENST00000535474.5
ENST00000402943.6
SLC14A1
solute carrier family 14 member 1 (Kidd blood group)
chr5_-_135954962 0.76 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
LECT2
leukocyte cell derived chemotaxin 2
chr19_+_14028148 0.75 ENST00000431365.3
ENST00000585987.1
RLN3
relaxin 3
chr5_+_132556911 0.73 ENST00000651541.1
ENST00000378823.8
ENST00000652485.1
RAD50
RAD50 double strand break repair protein
chr2_+_108621260 0.73 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chr17_+_4932248 0.70 ENST00000329125.6
GP1BA
glycoprotein Ib platelet subunit alpha
chr18_+_45724127 0.68 ENST00000619403.4
ENST00000587601.5
SLC14A1
solute carrier family 14 member 1 (Kidd blood group)
chr1_-_167518583 0.67 ENST00000392122.3
CD247
CD247 molecule
chr15_+_49423233 0.67 ENST00000560270.1
ENST00000267843.9
ENST00000560979.1
FGF7
fibroblast growth factor 7
chr3_-_119660580 0.63 ENST00000493094.6
ENST00000264231.7
ENST00000468801.1
POPDC2
popeye domain containing 2
chr8_-_71361860 0.63 ENST00000303824.11
ENST00000645451.1
EYA1
EYA transcriptional coactivator and phosphatase 1
chr18_-_48137295 0.61 ENST00000535628.6
ZBTB7C
zinc finger and BTB domain containing 7C
chr11_-_66438788 0.58 ENST00000329819.4
ENST00000310999.11
ENST00000430466.6
MRPL11
mitochondrial ribosomal protein L11
chr8_-_38150943 0.53 ENST00000276449.9
STAR
steroidogenic acute regulatory protein
chr2_+_168901290 0.52 ENST00000429379.2
ENST00000375363.8
ENST00000421979.1
G6PC2
glucose-6-phosphatase catalytic subunit 2
chr19_-_51019699 0.51 ENST00000358789.8
KLK10
kallikrein related peptidase 10
chr19_-_55038256 0.49 ENST00000417454.5
ENST00000310373.7
ENST00000333884.2
GP6
glycoprotein VI platelet
chr4_+_165873231 0.46 ENST00000061240.7
TLL1
tolloid like 1
chr21_-_38498415 0.44 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ERG
ETS transcription factor ERG
chr10_-_125816596 0.43 ENST00000368786.5
UROS
uroporphyrinogen III synthase
chr17_+_4932285 0.43 ENST00000611961.1
GP1BA
glycoprotein Ib platelet subunit alpha
chr10_+_69315760 0.41 ENST00000298649.8
HK1
hexokinase 1
chr2_+_219572304 0.40 ENST00000243786.3
INHA
inhibin subunit alpha
chr2_-_40512423 0.38 ENST00000402441.5
ENST00000448531.1
SLC8A1
solute carrier family 8 member A1
chr2_-_40512361 0.32 ENST00000403092.5
SLC8A1
solute carrier family 8 member A1
chr12_-_21775581 0.29 ENST00000537950.1
ENST00000665145.1
KCNJ8
potassium inwardly rectifying channel subfamily J member 8
chr14_+_21477177 0.25 ENST00000448790.7
ENST00000673643.1
ENST00000457430.2
ENST00000673911.1
TOX4
TOX high mobility group box family member 4
chr8_+_69466617 0.24 ENST00000525061.5
ENST00000260128.8
ENST00000458141.6
SULF1
sulfatase 1
chr6_+_117675448 0.16 ENST00000368494.4
NUS1
NUS1 dehydrodolichyl diphosphate synthase subunit
chr19_+_35358821 0.14 ENST00000594310.1
FFAR3
free fatty acid receptor 3
chr18_+_3447562 0.11 ENST00000618001.4
TGIF1
TGFB induced factor homeobox 1
chr9_-_114930508 0.09 ENST00000223795.3
ENST00000618336.4
TNFSF8
TNF superfamily member 8
chr1_-_167518521 0.09 ENST00000362089.10
CD247
CD247 molecule
chr12_-_9999176 0.04 ENST00000298527.10
ENST00000348658.4
CLEC1B
C-type lectin domain family 1 member B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.0 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
1.6 9.6 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
1.6 11.0 GO:0010961 cellular magnesium ion homeostasis(GO:0010961) regulation of axon diameter(GO:0031133)
1.2 3.5 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
1.1 21.8 GO:0020027 hemoglobin metabolic process(GO:0020027)
1.0 33.4 GO:0015695 organic cation transport(GO:0015695)
0.9 3.8 GO:0002215 defense response to nematode(GO:0002215)
0.9 10.5 GO:0001955 blood vessel maturation(GO:0001955)
0.7 2.9 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.7 3.5 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.6 2.2 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.6 3.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.5 17.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.5 3.5 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.5 9.1 GO:0016540 protein autoprocessing(GO:0016540)
0.5 1.5 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.5 14.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.4 6.5 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.4 6.5 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.4 1.4 GO:0071918 urea transmembrane transport(GO:0071918)
0.3 1.0 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.3 6.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 8.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.3 7.9 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 0.8 GO:0032912 negative regulation of transforming growth factor beta2 production(GO:0032912)
0.3 0.5 GO:0018963 phthalate metabolic process(GO:0018963)
0.2 1.0 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.2 1.4 GO:0070995 NADPH oxidation(GO:0070995)
0.2 1.6 GO:0034378 chylomicron assembly(GO:0034378)
0.2 5.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 0.7 GO:0060437 lung growth(GO:0060437)
0.2 2.5 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 1.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 7.2 GO:0000305 response to oxygen radical(GO:0000305)
0.1 1.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.9 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 1.1 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.1 0.7 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.1 7.5 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.4 GO:2000504 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.1 2.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 5.4 GO:0006611 protein export from nucleus(GO:0006611)
0.1 0.4 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.1 0.6 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 1.8 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 1.1 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.6 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 1.9 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 15.4 GO:0030198 extracellular matrix organization(GO:0030198)
0.0 1.5 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.1 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 3.5 GO:0045445 myoblast differentiation(GO:0045445)
0.0 0.7 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of adherens junction organization(GO:1903393)
0.0 2.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 1.8 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 12.5 GO:0032437 cuticular plate(GO:0032437)
0.8 11.6 GO:0005833 hemoglobin complex(GO:0005833)
0.7 9.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 3.3 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.3 6.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 1.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.2 5.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 6.3 GO:0001891 phagocytic cup(GO:0001891)
0.2 0.7 GO:0030870 Mre11 complex(GO:0030870)
0.2 5.1 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 1.5 GO:0032133 chromosome passenger complex(GO:0032133) meiotic spindle(GO:0072687)
0.1 0.4 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 1.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 11.8 GO:0016605 PML body(GO:0016605)
0.1 0.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 9.8 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 7.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.5 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 5.4 GO:0005643 nuclear pore(GO:0005643)
0.0 3.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 2.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.0 GO:0005921 gap junction(GO:0005921)
0.0 1.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.8 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 5.1 GO:0072562 blood microparticle(GO:0072562)
0.0 57.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.2 GO:0005902 microvillus(GO:0005902)
0.0 2.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 7.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 15.6 GO:0005615 extracellular space(GO:0005615)
0.0 8.5 GO:0005768 endosome(GO:0005768)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.0 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
3.2 9.6 GO:0004998 transferrin receptor activity(GO:0004998)
1.7 11.6 GO:0030492 hemoglobin binding(GO:0030492)
1.4 9.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
1.2 3.5 GO:0001069 regulatory region RNA binding(GO:0001069)
1.0 36.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.7 7.2 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.6 2.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.5 1.4 GO:0015265 urea channel activity(GO:0015265)
0.4 11.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 5.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.4 5.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 1.0 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.3 9.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 14.8 GO:0050699 WW domain binding(GO:0050699)
0.3 3.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 1.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.2 0.9 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 1.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 1.0 GO:0016936 galactoside binding(GO:0016936)
0.2 1.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.2 0.7 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2 0.5 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.2 3.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 1.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 4.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 18.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 4.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 2.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.8 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.1 1.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 1.1 GO:0031433 telethonin binding(GO:0031433)
0.1 15.4 GO:0005178 integrin binding(GO:0005178)
0.1 0.7 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 12.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.4 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.4 GO:0034711 inhibin binding(GO:0034711)
0.0 2.8 GO:0019843 rRNA binding(GO:0019843)
0.0 7.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 4.4 GO:0008201 heparin binding(GO:0008201)
0.0 1.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 7.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 7.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 2.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.5 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 17.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 5.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 24.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.8 PID EPO PATHWAY EPO signaling pathway
0.1 1.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 3.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.5 PID AURORA A PATHWAY Aurora A signaling
0.0 0.7 PID ATM PATHWAY ATM pathway
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 4.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 22.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.4 18.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 7.5 REACTOME DEFENSINS Genes involved in Defensins
0.2 3.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 17.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 5.9 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 5.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 4.7 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 18.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 1.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen