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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GAUAUGU

Z-value: 1.17

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miRNA associated with seed GAUAUGU

NamemiRBASE accession
hsa-miR-190a-5p
MIMAT0000458
hsa-miR-190b
MIMAT0004929

Activity profile of GAUAUGU motif

Sorted Z-values of GAUAUGU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GAUAUGU

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_227472132 1.27 ENST00000409979.6
ENST00000310078.13
AGFG1
ArfGAP with FG repeats 1
chr7_+_24573415 1.27 ENST00000409761.5
ENST00000222644.10
ENST00000396475.6
MPP6
membrane palmitoylated protein 6
chr8_+_60678705 1.26 ENST00000423902.7
CHD7
chromodomain helicase DNA binding protein 7
chr5_+_62306228 1.24 ENST00000381103.7
KIF2A
kinesin family member 2A
chr2_+_113890039 1.07 ENST00000443297.5
ENST00000263238.7
ENST00000415792.5
ACTR3
actin related protein 3
chr3_-_160565560 0.96 ENST00000334256.9
ENST00000676866.1
ENST00000469804.1
KPNA4
karyopherin subunit alpha 4
chr11_-_31811314 0.78 ENST00000640368.2
ENST00000379123.10
ENST00000379115.9
ENST00000419022.6
ENST00000643871.1
ENST00000640610.1
ENST00000639034.2
PAX6
paired box 6
chr8_-_121641424 0.76 ENST00000303924.5
HAS2
hyaluronan synthase 2
chr13_-_102401599 0.65 ENST00000376131.8
FGF14
fibroblast growth factor 14
chr12_-_118359639 0.60 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr1_-_32817311 0.56 ENST00000373477.9
ENST00000675785.1
YARS1
tyrosyl-tRNA synthetase 1
chr1_-_211830748 0.56 ENST00000366997.9
LPGAT1
lysophosphatidylglycerol acyltransferase 1
chr14_+_54567612 0.52 ENST00000251091.9
ENST00000392067.7
ENST00000631086.2
SAMD4A
sterile alpha motif domain containing 4A
chr7_+_5045821 0.50 ENST00000353796.7
ENST00000396912.2
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr18_-_28177102 0.47 ENST00000413878.2
ENST00000269141.8
CDH2
cadherin 2
chr4_+_127782270 0.45 ENST00000508549.5
ENST00000296464.9
HSPA4L
heat shock protein family A (Hsp70) member 4 like
chr2_+_207529892 0.44 ENST00000432329.6
ENST00000445803.5
CREB1
cAMP responsive element binding protein 1
chr3_+_173398438 0.40 ENST00000457714.5
NLGN1
neuroligin 1
chr8_-_23854796 0.39 ENST00000290271.7
STC1
stanniocalcin 1
chr2_-_61538313 0.32 ENST00000677803.1
ENST00000677239.1
ENST00000401558.7
XPO1
exportin 1
chr4_+_98995709 0.28 ENST00000296411.11
ENST00000625963.1
METAP1
methionyl aminopeptidase 1
chrX_-_110318062 0.26 ENST00000372059.6
ENST00000262844.10
AMMECR1
AMMECR nuclear protein 1
chr5_-_44389407 0.22 ENST00000264664.5
FGF10
fibroblast growth factor 10
chr7_-_26200734 0.22 ENST00000354667.8
ENST00000618183.5
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr21_-_38498415 0.22 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ERG
ETS transcription factor ERG
chr11_-_70661762 0.17 ENST00000357171.7
ENST00000412252.5
ENST00000449833.6
ENST00000338508.8
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr14_+_66508127 0.14 ENST00000459628.5
ENST00000478722.6
GPHN
gephyrin
chr22_+_40177917 0.13 ENST00000454349.7
ENST00000335727.13
TNRC6B
trinucleotide repeat containing adaptor 6B
chr14_+_79279403 0.11 ENST00000281127.11
NRXN3
neurexin 3
chr3_+_11272413 0.11 ENST00000446450.6
ENST00000354956.9
ENST00000354449.7
ENST00000419112.5
ATG7
autophagy related 7
chr8_+_63168597 0.11 ENST00000539294.6
ENST00000621957.4
ENST00000517371.5
ENST00000621413.4
ENST00000612880.4
YTHDF3
YTH N6-methyladenosine RNA binding protein 3
chr19_-_1652576 0.11 ENST00000453954.6
ENST00000395423.7
ENST00000262965.12
ENST00000588136.7
TCF3
transcription factor 3
chr6_-_90296824 0.10 ENST00000257749.9
BACH2
BTB domain and CNC homolog 2
chr2_-_181680490 0.09 ENST00000684145.1
ENST00000295108.4
ENST00000684079.1
ENST00000683430.1
CERKL
NEUROD1
ceramide kinase like
neuronal differentiation 1
chr15_-_52529050 0.04 ENST00000399231.7
MYO5A
myosin VA
chr12_-_31591129 0.03 ENST00000389082.10
DENND5B
DENN domain containing 5B
chr8_-_92103217 0.03 ENST00000615601.4
ENST00000523629.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr12_-_27971970 0.02 ENST00000395872.5
ENST00000201015.8
PTHLH
parathyroid hormone like hormone

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.4 1.1 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.2 0.8 GO:1900127 renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.4 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 1.3 GO:0001675 acrosome assembly(GO:0001675)
0.1 0.4 GO:0099543 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.1 0.2 GO:0060435 male genitalia morphogenesis(GO:0048808) bronchiole development(GO:0060435) submandibular salivary gland formation(GO:0060661) white fat cell proliferation(GO:0070343) positive regulation of fat cell proliferation(GO:0070346) regulation of white fat cell proliferation(GO:0070350) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) male anatomical structure morphogenesis(GO:0090598)
0.1 0.7 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 0.1 GO:1901859 negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.1 0.5 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.1 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.2 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.6 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 0.2 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 1.2 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 0.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.2 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 2.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.4 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 0.6 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.1 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 1.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.8 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition