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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GCCUGUC

Z-value: 0.09

Motif logo

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miRNA associated with seed GCCUGUC

NamemiRBASE accession
hsa-miR-214-5p
MIMAT0004564

Activity profile of GCCUGUC motif

Sorted Z-values of GCCUGUC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GCCUGUC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_+_113584683 0.59 ENST00000375370.10
TFDP1
transcription factor Dp-1
chr13_-_74133892 0.56 ENST00000377669.7
KLF12
Kruppel like factor 12
chr11_+_76783349 0.46 ENST00000333090.5
TSKU
tsukushi, small leucine rich proteoglycan
chr13_+_73058993 0.38 ENST00000377687.6
KLF5
Kruppel like factor 5
chr22_-_50307598 0.37 ENST00000425954.1
ENST00000449103.5
ENST00000359337.9
PLXNB2
plexin B2
chr2_-_216695540 0.33 ENST00000233813.5
IGFBP5
insulin like growth factor binding protein 5
chr7_-_19117625 0.33 ENST00000242261.6
TWIST1
twist family bHLH transcription factor 1
chrX_+_53048781 0.32 ENST00000332582.5
GPR173
G protein-coupled receptor 173
chr6_-_39229465 0.31 ENST00000359534.4
KCNK5
potassium two pore domain channel subfamily K member 5
chr11_-_57515686 0.28 ENST00000533263.1
ENST00000278426.8
SLC43A1
solute carrier family 43 member 1
chr3_-_50611767 0.28 ENST00000443053.6
ENST00000348721.4
CISH
cytokine inducible SH2 containing protein
chr8_-_102655707 0.28 ENST00000285407.11
KLF10
Kruppel like factor 10
chr9_-_124771304 0.27 ENST00000416460.6
ENST00000487099.7
NR6A1
nuclear receptor subfamily 6 group A member 1
chrX_-_108736556 0.27 ENST00000372129.4
IRS4
insulin receptor substrate 4
chr4_+_86934976 0.26 ENST00000507468.5
ENST00000395146.9
AFF1
AF4/FMR2 family member 1
chr6_+_21593742 0.25 ENST00000244745.4
SOX4
SRY-box transcription factor 4
chr2_+_190408324 0.24 ENST00000417958.5
ENST00000432036.5
ENST00000392328.6
MFSD6
major facilitator superfamily domain containing 6
chr2_+_24793394 0.24 ENST00000380834.7
ENST00000260662.2
CENPO
centromere protein O
chr20_-_10673987 0.23 ENST00000254958.10
JAG1
jagged canonical Notch ligand 1
chr15_+_92393841 0.22 ENST00000268164.8
ENST00000539113.5
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr20_-_23049659 0.22 ENST00000377103.3
THBD
thrombomodulin
chr16_-_85688912 0.22 ENST00000253462.8
GINS2
GINS complex subunit 2
chr6_+_44219595 0.22 ENST00000393844.7
ENST00000652680.1
ENST00000643028.2
ENST00000371713.6
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr3_-_115071333 0.21 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_54930827 0.20 ENST00000394636.9
IRX5
iroquois homeobox 5
chr1_+_244969869 0.20 ENST00000366523.5
EFCAB2
EF-hand calcium binding domain 2
chr7_-_123748902 0.19 ENST00000223023.5
WASL
WASP like actin nucleation promoting factor
chr11_-_83071819 0.19 ENST00000524635.1
ENST00000526205.5
ENST00000533486.5
ENST00000533276.6
ENST00000527633.6
RAB30
RAB30, member RAS oncogene family
chr11_+_118883884 0.19 ENST00000292174.5
CXCR5
C-X-C motif chemokine receptor 5
chr1_+_39491618 0.19 ENST00000331593.6
BMP8A
bone morphogenetic protein 8a
chr1_+_117060309 0.18 ENST00000369466.9
TTF2
transcription termination factor 2
chr14_-_77320855 0.18 ENST00000556394.2
ENST00000261534.9
POMT2
protein O-mannosyltransferase 2
chr19_+_1753499 0.17 ENST00000382349.5
ONECUT3
one cut homeobox 3
chrX_+_100584928 0.17 ENST00000373031.5
TNMD
tenomodulin
chr11_+_14643782 0.17 ENST00000282096.9
PDE3B
phosphodiesterase 3B
chr10_-_116273009 0.16 ENST00000439649.8
ENST00000369234.5
ENST00000682194.1
ENST00000355422.11
GFRA1
GDNF family receptor alpha 1
chr1_+_54053573 0.16 ENST00000234827.6
TCEANC2
transcription elongation factor A N-terminal and central domain containing 2
chr12_-_120904337 0.15 ENST00000353487.7
SPPL3
signal peptide peptidase like 3
chr19_+_29942205 0.15 ENST00000392271.6
URI1
URI1 prefoldin like chaperone
chr19_+_39125769 0.14 ENST00000602004.1
ENST00000599470.5
ENST00000321944.8
ENST00000593480.5
ENST00000358301.7
ENST00000593690.5
ENST00000599386.5
PAK4
p21 (RAC1) activated kinase 4
chr9_+_74497308 0.14 ENST00000376896.8
RORB
RAR related orphan receptor B
chr14_+_60249191 0.14 ENST00000395076.9
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent 1A
chr12_-_42238203 0.14 ENST00000327791.8
ENST00000534854.7
YAF2
YY1 associated factor 2
chr17_-_47189176 0.13 ENST00000531206.5
ENST00000527547.5
ENST00000575483.5
ENST00000066544.8
CDC27
cell division cycle 27
chr22_+_29883158 0.13 ENST00000333027.7
ENST00000401950.7
ENST00000445401.5
ENST00000323630.9
ENST00000351488.7
MTMR3
myotubularin related protein 3
chr4_+_127782270 0.13 ENST00000508549.5
ENST00000296464.9
HSPA4L
heat shock protein family A (Hsp70) member 4 like
chr2_-_210171402 0.13 ENST00000281772.14
KANSL1L
KAT8 regulatory NSL complex subunit 1 like
chr14_+_74881887 0.12 ENST00000334220.9
ENST00000626051.1
ENST00000554806.5
DLST
dihydrolipoamide S-succinyltransferase
chr10_-_43407769 0.12 ENST00000357065.8
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr11_-_6683282 0.12 ENST00000532203.1
ENST00000288937.7
MRPL17
mitochondrial ribosomal protein L17
chrX_-_18984090 0.11 ENST00000379942.5
PHKA2
phosphorylase kinase regulatory subunit alpha 2
chr1_-_23531206 0.10 ENST00000361729.3
E2F2
E2F transcription factor 2
chr3_-_197959977 0.10 ENST00000265239.11
IQCG
IQ motif containing G
chr1_+_35883189 0.10 ENST00000674304.1
ENST00000373204.6
ENST00000674426.1
AGO1
argonaute RISC component 1
chr2_-_113278898 0.09 ENST00000554830.2
ENST00000263335.11
ENST00000348715.9
ENST00000397647.7
ENST00000681162.1
ENST00000263334.9
ENST00000429538.8
PAX8
paired box 8
chr2_+_26848093 0.09 ENST00000288699.11
DPYSL5
dihydropyrimidinase like 5
chr17_-_41734641 0.09 ENST00000347901.9
ENST00000393939.6
ENST00000341193.9
ENST00000310778.5
HAP1
huntingtin associated protein 1
chr11_-_6603571 0.09 ENST00000534343.1
ENST00000254605.11
RRP8
ribosomal RNA processing 8
chr2_-_219160781 0.09 ENST00000356853.10
NHEJ1
non-homologous end joining factor 1
chr1_+_26826682 0.09 ENST00000374142.9
ZDHHC18
zinc finger DHHC-type palmitoyltransferase 18
chr7_-_130440848 0.09 ENST00000675803.1
ENST00000223208.10
ENST00000343969.10
ENST00000471201.6
ENST00000675649.1
ENST00000675168.1
ENST00000469826.2
ENST00000334451.6
ENST00000675962.1
ENST00000675563.1
ENST00000480206.2
ENST00000489512.5
ENST00000676243.1
ENST00000674539.1
ENST00000675935.1
CEP41
centrosomal protein 41
chr3_+_37452121 0.09 ENST00000264741.10
ITGA9
integrin subunit alpha 9
chr16_+_29778252 0.08 ENST00000400752.6
ZG16
zymogen granule protein 16
chr1_-_203086001 0.08 ENST00000241651.5
MYOG
myogenin
chr4_+_54229261 0.08 ENST00000508170.5
ENST00000512143.1
ENST00000257290.10
PDGFRA
platelet derived growth factor receptor alpha
chr17_-_714709 0.08 ENST00000401468.7
ENST00000575100.2
ENST00000680069.1
ENST00000681902.1
ENST00000576019.6
ENST00000571456.2
ENST00000679361.1
ENST00000680241.1
ENST00000681917.1
ENST00000681133.1
ENST00000437048.7
ENST00000680128.1
ENST00000681154.1
ENST00000679961.1
ENST00000680970.1
ENST00000681295.1
ENST00000574029.6
ENST00000681317.1
ENST00000571805.6
ENST00000291074.10
VPS53
VPS53 subunit of GARP complex
chr7_-_128343823 0.07 ENST00000415472.6
ENST00000478061.5
ENST00000223073.6
ENST00000459726.1
RBM28
RNA binding motif protein 28
chr11_-_6612141 0.07 ENST00000527248.2
ENST00000299424.9
TAF10
TATA-box binding protein associated factor 10
chr17_-_63446168 0.07 ENST00000584031.5
ENST00000392976.5
CYB561
cytochrome b561
chr19_+_40717091 0.07 ENST00000263370.3
ITPKC
inositol-trisphosphate 3-kinase C
chr3_+_114056728 0.07 ENST00000485050.5
ENST00000281273.8
ENST00000479882.5
ENST00000493014.1
QTRT2
queuine tRNA-ribosyltransferase accessory subunit 2
chr1_+_110211471 0.07 ENST00000369787.7
ENST00000413138.7
KCNC4
potassium voltage-gated channel subfamily C member 4
chr5_+_168291599 0.07 ENST00000265293.9
WWC1
WW and C2 domain containing 1
chr14_-_75660816 0.06 ENST00000256319.7
ERG28
ergosterol biosynthesis 28 homolog
chr5_-_67196791 0.05 ENST00000256447.5
CD180
CD180 molecule
chr17_+_48107549 0.05 ENST00000580219.5
ENST00000452859.6
ENST00000393405.6
SNX11
sorting nexin 11
chr13_-_98577131 0.04 ENST00000397517.6
STK24
serine/threonine kinase 24
chr3_-_196432397 0.04 ENST00000381887.7
ENST00000296328.9
ENST00000428095.1
UBXN7
UBX domain protein 7
chr11_+_47980538 0.04 ENST00000613246.4
ENST00000418331.7
ENST00000615445.4
ENST00000440289.6
PTPRJ
protein tyrosine phosphatase receptor type J
chr3_-_197029775 0.03 ENST00000439320.1
ENST00000296351.8
ENST00000296350.10
MELTF
melanotransferrin
chr20_-_32207708 0.03 ENST00000246229.5
PLAGL2
PLAG1 like zinc finger 2
chr5_-_137754327 0.03 ENST00000314940.7
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chrX_-_53422644 0.02 ENST00000322213.9
ENST00000375340.10
ENST00000674590.1
SMC1A
structural maintenance of chromosomes 1A
chr11_+_67119245 0.02 ENST00000529006.7
ENST00000398645.6
KDM2A
lysine demethylase 2A
chr3_+_138187248 0.01 ENST00000538260.5
ENST00000481646.5
ENST00000491704.5
ENST00000469044.6
ENST00000461600.5
ENST00000466749.5
ENST00000358441.6
ENST00000489213.5
ARMC8
armadillo repeat containing 8
chr4_-_39458900 0.01 ENST00000503040.5
ENST00000508595.6
ENST00000295955.14
ENST00000645496.2
RPL9
ribosomal protein L9
chr4_+_705748 0.01 ENST00000419774.5
ENST00000362003.9
ENST00000400151.6
ENST00000427463.5
ENST00000470161.6
PCGF3
polycomb group ring finger 3
chr9_-_114806031 0.01 ENST00000374045.5
TNFSF15
TNF superfamily member 15
chr15_-_50265666 0.00 ENST00000543581.5
ENST00000267845.8
HDC
histidine decarboxylase
chr5_+_133051983 0.00 ENST00000304858.7
ENST00000617074.4
ENST00000615899.1
HSPA4
heat shock protein family A (Hsp70) member 4
chr20_+_36306325 0.00 ENST00000373913.7
ENST00000339266.10
DLGAP4
DLG associated protein 4
chr3_-_171460368 0.00 ENST00000436636.7
ENST00000465393.1
ENST00000341852.10
TNIK
TRAF2 and NCK interacting kinase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.3 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.3 GO:2000793 negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) cell proliferation involved in heart valve development(GO:2000793)
0.1 0.3 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 0.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.2 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.1 0.3 GO:0035910 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 0.1 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0 0.1 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.0 0.1 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.1 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.1 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.1 GO:0072049 thyroid-stimulating hormone secretion(GO:0070460) comma-shaped body morphogenesis(GO:0072049) metanephric comma-shaped body morphogenesis(GO:0072278) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.2 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.2 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.2 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.1 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.1 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.1 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.2 GO:0048535 lymph node development(GO:0048535)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.0 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere