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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GCM2

Z-value: 0.35

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Transcription factors associated with GCM2

Gene Symbol Gene ID Gene Info
GCM2
ENSG00000124827.7 GCM2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCM2hg38_v1_chr6_-_10882037_108820480.194.9e-03Click!

Activity profile of GCM2 motif

Sorted Z-values of GCM2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_127612222 19.13 ENST00000637953.1
ENST00000636962.2
STXBP1
syntaxin binding protein 1
chr14_-_59630806 19.07 ENST00000342503.8
RTN1
reticulon 1
chr11_-_12008584 17.98 ENST00000534511.5
ENST00000683431.1
DKK3
dickkopf WNT signaling pathway inhibitor 3
chr9_+_127612257 17.62 ENST00000637173.2
ENST00000630492.2
ENST00000627871.2
ENST00000373302.8
ENST00000373299.5
ENST00000650920.1
ENST00000476182.3
STXBP1
syntaxin binding protein 1
chr11_-_12009082 17.06 ENST00000396505.7
DKK3
dickkopf WNT signaling pathway inhibitor 3
chr14_-_59630582 16.67 ENST00000395090.5
RTN1
reticulon 1
chr3_+_50674896 13.73 ENST00000266037.10
DOCK3
dedicator of cytokinesis 3
chr7_-_44325421 12.92 ENST00000395747.6
ENST00000347193.8
ENST00000346990.8
ENST00000258682.10
ENST00000353625.8
ENST00000421607.1
ENST00000424197.5
CAMK2B
calcium/calmodulin dependent protein kinase II beta
chr13_-_36131286 11.68 ENST00000255448.8
ENST00000379892.4
DCLK1
doublecortin like kinase 1
chr1_-_54887161 11.30 ENST00000535035.6
ENST00000371269.9
ENST00000436604.2
DHCR24
24-dehydrocholesterol reductase
chr7_-_44325653 11.07 ENST00000440254.6
CAMK2B
calcium/calmodulin dependent protein kinase II beta
chr19_+_46602050 10.98 ENST00000599839.5
ENST00000596362.1
CALM3
calmodulin 3
chr7_-_44325490 10.38 ENST00000350811.7
CAMK2B
calcium/calmodulin dependent protein kinase II beta
chr11_+_63681444 9.88 ENST00000341307.6
ENST00000356000.7
ENST00000542238.5
RTN3
reticulon 3
chr11_+_63681483 9.77 ENST00000339997.8
ENST00000540798.5
ENST00000545432.5
ENST00000543552.5
ENST00000377819.10
ENST00000537981.5
RTN3
reticulon 3
chr1_+_14924100 8.21 ENST00000361144.9
KAZN
kazrin, periplakin interacting protein
chr3_+_35639589 7.86 ENST00000428373.5
ARPP21
cAMP regulated phosphoprotein 21
chr12_-_16606102 7.73 ENST00000537304.6
LMO3
LIM domain only 3
chr6_-_110179623 7.51 ENST00000265601.7
ENST00000447287.5
ENST00000392589.6
ENST00000444391.5
WASF1
WASP family member 1
chr17_-_10114546 7.40 ENST00000323816.8
GAS7
growth arrest specific 7
chr15_-_29968864 7.39 ENST00000356107.11
TJP1
tight junction protein 1
chr19_+_35292125 7.39 ENST00000600291.5
ENST00000361922.8
MAG
myelin associated glycoprotein
chr12_-_16605939 7.38 ENST00000541295.5
ENST00000535535.5
LMO3
LIM domain only 3
chr6_-_110179702 7.23 ENST00000392587.6
WASF1
WASP family member 1
chr6_-_6007511 7.21 ENST00000616243.1
NRN1
neuritin 1
chr1_+_2050387 6.86 ENST00000378567.8
PRKCZ
protein kinase C zeta
chr19_+_35292145 6.78 ENST00000595791.5
ENST00000597035.5
ENST00000537831.2
ENST00000392213.8
MAG
myelin associated glycoprotein
chr2_-_44361485 6.63 ENST00000438314.1
ENST00000409411.6
ENST00000409936.5
PREPL
prolyl endopeptidase like
chr2_-_44361555 6.58 ENST00000409957.5
PREPL
prolyl endopeptidase like
chr13_-_36131352 6.55 ENST00000360631.8
DCLK1
doublecortin like kinase 1
chr22_+_19718390 6.18 ENST00000383045.7
ENST00000438754.6
SEPTIN5
septin 5
chr16_+_71358713 6.15 ENST00000349553.9
ENST00000302628.9
ENST00000562305.5
CALB2
calbindin 2
chr22_-_29315656 5.94 ENST00000401450.3
ENST00000216101.7
RASL10A
RAS like family 10 member A
chr3_-_51968387 5.77 ENST00000490063.5
ENST00000468324.5
ENST00000497653.5
ENST00000484633.5
PCBP4
poly(rC) binding protein 4
chr7_-_94655993 5.65 ENST00000647110.1
ENST00000647048.1
ENST00000643020.1
ENST00000644682.1
ENST00000646119.1
ENST00000646265.1
ENST00000645445.1
ENST00000647334.1
ENST00000645262.1
ENST00000428696.7
ENST00000647096.1
ENST00000642394.1
ENST00000645725.1
ENST00000647351.1
ENST00000646943.1
ENST00000648936.2
ENST00000642707.1
ENST00000645109.1
ENST00000646489.1
ENST00000642933.1
ENST00000643128.1
ENST00000445866.7
ENST00000645101.1
ENST00000644116.1
ENST00000642441.1
ENST00000646879.1
ENST00000647018.1
SGCE
sarcoglycan epsilon
chr9_-_127873462 5.61 ENST00000223836.10
AK1
adenylate kinase 1
chr5_+_83471668 5.47 ENST00000342785.8
ENST00000343200.9
VCAN
versican
chr22_+_19723525 5.34 ENST00000366425.4
GP1BB
glycoprotein Ib platelet subunit beta
chr7_-_94656197 5.20 ENST00000643903.1
ENST00000644122.1
ENST00000447873.6
ENST00000644816.1
ENST00000644375.1
SGCE
sarcoglycan epsilon
chr3_-_138834867 5.18 ENST00000674063.1
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
chr9_-_96655280 5.16 ENST00000446045.1
ENST00000375234.8
PRXL2C
peroxiredoxin like 2C
chr5_+_83471764 5.08 ENST00000512590.6
ENST00000513960.5
ENST00000513984.5
VCAN
versican
chr5_+_83471736 5.05 ENST00000265077.8
VCAN
versican
chr7_-_94656160 4.97 ENST00000644609.1
ENST00000643272.1
ENST00000646137.1
ENST00000646098.1
ENST00000643193.1
ENST00000437425.7
ENST00000644551.1
ENST00000415788.3
SGCE
sarcoglycan epsilon
chr15_+_43517590 4.49 ENST00000300231.6
MAP1A
microtubule associated protein 1A
chr7_-_151057848 4.25 ENST00000297518.4
CDK5
cyclin dependent kinase 5
chr2_-_33599269 4.16 ENST00000431950.1
ENST00000403368.1
ENST00000238823.13
FAM98A
family with sequence similarity 98 member A
chr22_-_20320009 4.13 ENST00000405465.3
ENST00000248879.8
DGCR6L
DiGeorge syndrome critical region gene 6 like
chr16_+_2514253 3.98 ENST00000565223.1
ATP6V0C
ATPase H+ transporting V0 subunit c
chr7_-_151057880 3.98 ENST00000485972.6
CDK5
cyclin dependent kinase 5
chr9_+_78297117 3.93 ENST00000376588.4
PSAT1
phosphoserine aminotransferase 1
chr3_+_156291020 3.87 ENST00000302490.12
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr10_+_101031223 3.86 ENST00000393459.5
ENST00000224807.9
SFXN3
sideroflexin 3
chr12_-_49188811 3.76 ENST00000295766.9
TUBA1A
tubulin alpha 1a
chr19_+_18612848 3.74 ENST00000262817.8
TMEM59L
transmembrane protein 59 like
chr3_-_79019444 3.72 ENST00000618833.4
ENST00000436010.6
ENST00000618846.4
ROBO1
roundabout guidance receptor 1
chrX_-_72572794 3.69 ENST00000421523.6
ENST00000648036.1
ENST00000373559.8
ENST00000648139.1
ENST00000650636.1
ENST00000648962.1
ENST00000373560.7
ENST00000373568.7
ENST00000373573.9
ENST00000647654.1
ENST00000647859.1
ENST00000415409.6
ENST00000648298.1
ENST00000649752.1
ENST00000373571.6
ENST00000647980.1
ENST00000650126.1
ENST00000373554.6
ENST00000648870.1
ENST00000373556.8
ENST00000647886.1
ENST00000648452.1
ENST00000647594.1
ENST00000373583.6
ENST00000648922.1
HDAC8
ENSG00000285547.1
histone deacetylase 8
novel protein
chr11_-_6320494 3.64 ENST00000303927.4
ENST00000530979.1
CAVIN3
caveolae associated protein 3
chr10_-_101031095 3.59 ENST00000645349.1
ENST00000619208.6
ENST00000644782.1
ENST00000370215.7
ENST00000646029.1
PDZD7
PDZ domain containing 7
chr16_+_22814154 3.58 ENST00000261374.4
HS3ST2
heparan sulfate-glucosamine 3-sulfotransferase 2
chr18_+_58341038 3.42 ENST00000679791.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr1_-_243850216 3.30 ENST00000673466.1
AKT3
AKT serine/threonine kinase 3
chr17_-_78903193 3.26 ENST00000322630.3
ENST00000586713.5
CEP295NL
CEP295 N-terminal like
chr1_+_14945775 3.20 ENST00000400797.3
KAZN
kazrin, periplakin interacting protein
chr19_-_38869921 3.17 ENST00000593809.1
ENST00000593424.5
RINL
Ras and Rab interactor like
chr1_+_156728916 3.10 ENST00000519086.5
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr5_+_83471925 2.97 ENST00000502527.2
VCAN
versican
chr5_+_138439020 2.89 ENST00000378339.7
ENST00000254901.9
ENST00000506158.5
REEP2
receptor accessory protein 2
chr11_-_61429934 2.87 ENST00000541963.5
ENST00000477890.6
ENST00000439958.8
CPSF7
cleavage and polyadenylation specific factor 7
chr2_+_188292771 2.87 ENST00000359135.7
GULP1
GULP PTB domain containing engulfment adaptor 1
chr3_-_138834752 2.78 ENST00000477593.5
ENST00000483968.5
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
chr2_+_188292814 2.74 ENST00000409580.5
ENST00000409637.7
GULP1
GULP PTB domain containing engulfment adaptor 1
chr1_+_109910840 2.73 ENST00000329608.11
ENST00000488198.5
CSF1
colony stimulating factor 1
chr3_+_130931893 2.72 ENST00000504612.5
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr1_+_27773189 2.70 ENST00000373943.9
ENST00000440806.2
STX12
syntaxin 12
chr12_+_56224318 2.68 ENST00000267023.9
ENST00000380198.6
ENST00000341463.5
NABP2
nucleic acid binding protein 2
chr18_-_14132423 2.68 ENST00000589498.5
ENST00000590202.3
ZNF519
zinc finger protein 519
chr1_-_243850070 2.59 ENST00000366539.6
ENST00000672578.1
AKT3
AKT serine/threonine kinase 3
chr14_+_75069577 2.58 ENST00000238686.8
ZC2HC1C
zinc finger C2HC-type containing 1C
chr9_+_4490388 2.56 ENST00000262352.8
SLC1A1
solute carrier family 1 member 1
chr3_+_155080088 2.53 ENST00000462745.5
MME
membrane metalloendopeptidase
chr4_-_52038260 2.51 ENST00000381431.10
SGCB
sarcoglycan beta
chr20_+_43514492 2.49 ENST00000373135.8
ENST00000373134.5
L3MBTL1
L3MBTL histone methyl-lysine binding protein 1
chr22_+_50600783 2.41 ENST00000329492.6
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr10_-_68332878 2.41 ENST00000309049.8
PBLD
phenazine biosynthesis like protein domain containing
chr3_-_48556785 2.41 ENST00000232375.8
ENST00000383734.6
ENST00000416568.5
ENST00000412035.5
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr6_+_31666128 2.34 ENST00000375865.6
ENST00000375866.2
CSNK2B
casein kinase 2 beta
chr8_+_65644701 2.29 ENST00000262146.9
MTFR1
mitochondrial fission regulator 1
chrX_+_47078434 2.28 ENST00000397180.6
RGN
regucalcin
chrX_+_47078380 2.25 ENST00000352078.8
RGN
regucalcin
chr2_+_72887368 2.25 ENST00000234454.6
SPR
sepiapterin reductase
chr11_-_61430008 2.25 ENST00000394888.8
CPSF7
cleavage and polyadenylation specific factor 7
chr14_+_75069632 2.24 ENST00000439583.2
ENST00000554763.2
ENST00000524913.3
ENST00000525046.2
ENST00000674086.1
ENST00000526130.2
ENST00000674094.1
ENST00000532198.2
ZC2HC1C
zinc finger C2HC-type containing 1C
chr1_+_109910986 2.20 ENST00000369801.1
CSF1
colony stimulating factor 1
chr20_+_43514426 2.17 ENST00000422861.3
L3MBTL1
L3MBTL histone methyl-lysine binding protein 1
chr11_-_61161414 2.09 ENST00000301765.10
VPS37C
VPS37C subunit of ESCRT-I
chr1_+_43979877 2.09 ENST00000356836.10
ENST00000309519.8
B4GALT2
beta-1,4-galactosyltransferase 2
chr8_+_133113483 2.08 ENST00000521107.1
TG
thyroglobulin
chr9_-_124500986 2.07 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5 group A member 1
chr20_+_347024 2.05 ENST00000382291.7
ENST00000609504.5
ENST00000382285.7
ENST00000608467.5
NRSN2
neurensin 2
chr15_+_84981981 2.05 ENST00000339708.9
PDE8A
phosphodiesterase 8A
chr7_-_27130182 2.05 ENST00000511914.1
HOXA4
homeobox A4
chr19_+_38390055 2.04 ENST00000587947.5
ENST00000338502.8
SPRED3
sprouty related EVH1 domain containing 3
chr6_+_31666056 2.04 ENST00000375882.7
ENST00000375880.6
CSNK2B
ENSG00000263020.6
casein kinase 2 beta
novel protein
chr1_+_156728442 2.04 ENST00000368218.8
ENST00000368216.9
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr15_+_78872809 2.01 ENST00000331268.9
MORF4L1
mortality factor 4 like 1
chr1_+_109910892 2.01 ENST00000369802.7
ENST00000420111.6
CSF1
colony stimulating factor 1
chr5_+_179699003 1.99 ENST00000681733.1
ENST00000680006.1
ENST00000680013.1
ENST00000681076.1
ENST00000681168.1
CANX
calnexin
chr15_+_84981834 1.98 ENST00000394553.6
PDE8A
phosphodiesterase 8A
chr1_-_223364059 1.96 ENST00000343846.7
ENST00000484758.6
ENST00000344029.6
ENST00000366878.9
ENST00000494793.6
ENST00000681285.1
ENST00000680429.1
ENST00000681669.1
ENST00000681305.1
SUSD4
sushi domain containing 4
chr5_+_134905100 1.95 ENST00000512783.5
ENST00000254908.11
PCBD2
pterin-4 alpha-carbinolamine dehydratase 2
chr19_+_40717091 1.94 ENST00000263370.3
ITPKC
inositol-trisphosphate 3-kinase C
chr19_-_14206168 1.93 ENST00000361434.7
ENST00000340736.10
ADGRL1
adhesion G protein-coupled receptor L1
chrX_-_63785149 1.88 ENST00000671741.2
ENST00000625116.3
ENST00000624355.1
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr2_-_219387881 1.85 ENST00000322176.11
ENST00000273075.9
DNPEP
aspartyl aminopeptidase
chr11_+_66857056 1.76 ENST00000309602.5
ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chrX_+_47078330 1.73 ENST00000457380.5
RGN
regucalcin
chr2_-_11344580 1.70 ENST00000616279.4
ENST00000315872.11
ROCK2
Rho associated coiled-coil containing protein kinase 2
chr15_+_78872881 1.65 ENST00000559930.5
ENST00000426013.7
MORF4L1
mortality factor 4 like 1
chr20_+_18288477 1.65 ENST00000377671.7
ENST00000360010.9
ENST00000628216.2
ENST00000425686.3
ENST00000434018.5
ENST00000630056.1
ZNF133
zinc finger protein 133
chr9_+_15422704 1.65 ENST00000380821.7
ENST00000610884.4
ENST00000421710.5
SNAPC3
small nuclear RNA activating complex polypeptide 3
chr19_+_42325550 1.63 ENST00000334370.8
ENST00000378073.5
MEGF8
multiple EGF like domains 8
chr5_+_114362043 1.63 ENST00000673685.1
KCNN2
potassium calcium-activated channel subfamily N member 2
chr1_-_16431371 1.62 ENST00000612240.1
SPATA21
spermatogenesis associated 21
chr3_-_50567711 1.61 ENST00000357203.8
C3orf18
chromosome 3 open reading frame 18
chr7_-_139777774 1.59 ENST00000428878.6
HIPK2
homeodomain interacting protein kinase 2
chr15_+_78872954 1.59 ENST00000558746.5
ENST00000558830.5
ENST00000559345.5
MORF4L1
mortality factor 4 like 1
chr13_-_46897021 1.53 ENST00000542664.4
ENST00000543956.5
HTR2A
5-hydroxytryptamine receptor 2A
chr17_-_7219813 1.49 ENST00000399510.8
ENST00000648172.8
DLG4
discs large MAGUK scaffold protein 4
chr1_+_43358968 1.48 ENST00000310955.11
CDC20
cell division cycle 20
chr3_+_19947316 1.47 ENST00000422242.1
RAB5A
RAB5A, member RAS oncogene family
chr2_-_72825982 1.46 ENST00000634650.1
ENST00000272427.11
ENST00000410104.1
EXOC6B
exocyst complex component 6B
chr15_+_78873030 1.45 ENST00000558502.5
MORF4L1
mortality factor 4 like 1
chrX_-_41923429 1.44 ENST00000378154.3
ENST00000643831.2
ENST00000378168.8
ENST00000675354.1
ENST00000645986.2
CASK
calcium/calmodulin dependent serine protein kinase
chr1_+_167936818 1.43 ENST00000367840.3
DCAF6
DDB1 and CUL4 associated factor 6
chr19_+_42325612 1.43 ENST00000251268.11
MEGF8
multiple EGF like domains 8
chr9_-_69014090 1.42 ENST00000377276.5
PRKACG
protein kinase cAMP-activated catalytic subunit gamma
chr5_-_73448769 1.36 ENST00000615637.3
FOXD1
forkhead box D1
chr5_+_179698906 1.33 ENST00000452673.6
ENST00000680614.1
ENST00000680812.1
ENST00000681265.1
ENST00000680894.1
ENST00000681894.1
ENST00000679642.1
ENST00000680827.1
ENST00000680984.1
ENST00000680042.1
ENST00000681476.1
ENST00000681072.1
ENST00000247461.9
ENST00000502673.6
ENST00000513246.6
ENST00000680618.1
ENST00000680092.1
ENST00000506654.6
CANX
calnexin
chr5_-_138543198 1.31 ENST00000507939.5
ENST00000572514.5
ENST00000499810.6
ENST00000360541.10
ETF1
eukaryotic translation termination factor 1
chr12_+_56996151 1.31 ENST00000556850.1
GPR182
G protein-coupled receptor 182
chr19_+_56595279 1.29 ENST00000328070.10
ENST00000599599.7
ENST00000650950.1
ZNF71
ZIM2-AS1
zinc finger protein 71
ZIM2 antisense RNA 1
chrX_-_41923547 1.27 ENST00000378163.7
CASK
calcium/calmodulin dependent serine protein kinase
chr6_-_138218491 1.27 ENST00000527246.3
PBOV1
prostate and breast cancer overexpressed 1
chr14_-_77271200 1.24 ENST00000298352.5
NGB
neuroglobin
chr9_-_21974821 1.24 ENST00000304494.10
ENST00000579122.1
ENST00000498124.1
CDKN2A
cyclin dependent kinase inhibitor 2A
chr22_-_29061831 1.24 ENST00000216071.5
C22orf31
chromosome 22 open reading frame 31
chr2_-_219543793 1.24 ENST00000243776.11
CHPF
chondroitin polymerizing factor
chr11_-_796185 1.23 ENST00000533385.5
ENST00000528936.5
ENST00000629634.2
ENST00000625752.2
ENST00000528606.5
ENST00000320230.9
SLC25A22
solute carrier family 25 member 22
chr1_+_43358998 1.21 ENST00000372462.1
CDC20
cell division cycle 20
chr3_+_155079911 1.20 ENST00000675418.2
MME
membrane metalloendopeptidase
chr5_-_150290093 1.20 ENST00000672479.1
CAMK2A
calcium/calmodulin dependent protein kinase II alpha
chr3_+_155079847 1.17 ENST00000615825.2
MME
membrane metalloendopeptidase
chr5_+_114362286 1.15 ENST00000610748.4
ENST00000264773.7
KCNN2
potassium calcium-activated channel subfamily N member 2
chr19_+_17871937 1.12 ENST00000222248.4
SLC5A5
solute carrier family 5 member 5
chr12_-_55728436 1.09 ENST00000552692.5
CD63
CD63 molecule
chr11_-_61429715 1.07 ENST00000449811.5
ENST00000413232.5
ENST00000340437.8
ENST00000539952.5
ENST00000544585.5
ENST00000450000.5
CPSF7
cleavage and polyadenylation specific factor 7
chr19_-_12775513 1.04 ENST00000397668.8
ENST00000587178.1
ENST00000264827.9
HOOK2
hook microtubule tethering protein 2
chrX_-_120629936 1.03 ENST00000371313.2
ENST00000304661.6
C1GALT1C1
C1GALT1 specific chaperone 1
chr16_-_10182394 1.00 ENST00000330684.4
GRIN2A
glutamate ionotropic receptor NMDA type subunit 2A
chr12_+_55997180 0.98 ENST00000356124.8
ENST00000266971.8
ENST00000394115.6
ENST00000547586.5
ENST00000552258.5
ENST00000548274.5
ENST00000546833.5
SUOX
sulfite oxidase
chr19_+_45039040 0.96 ENST00000221455.8
ENST00000391953.8
ENST00000588936.5
CLASRP
CLK4 associating serine/arginine rich protein
chr15_+_74615808 0.92 ENST00000395066.9
ENST00000568139.6
ENST00000563297.5
ENST00000568488.6
CLK3
CDC like kinase 3
chr10_-_48524236 0.91 ENST00000374170.5
ARHGAP22
Rho GTPase activating protein 22
chr9_-_35732122 0.91 ENST00000314888.10
TLN1
talin 1
chr5_-_173328407 0.89 ENST00000265087.9
STC2
stanniocalcin 2
chr17_-_44830242 0.89 ENST00000592524.6
GJC1
gap junction protein gamma 1
chr3_+_155079663 0.88 ENST00000460393.6
MME
membrane metalloendopeptidase
chr14_+_20891385 0.87 ENST00000304639.4
RNASE3
ribonuclease A family member 3
chr15_+_74174403 0.87 ENST00000560862.1
ENST00000395118.1
ISLR
immunoglobulin superfamily containing leucine rich repeat
chr7_+_155458129 0.86 ENST00000297375.4
EN2
engrailed homeobox 2
chrX_+_129540236 0.86 ENST00000371113.9
ENST00000357121.5
OCRL
OCRL inositol polyphosphate-5-phosphatase
chr21_+_37367097 0.85 ENST00000644942.1
DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A
chr7_-_101165114 0.84 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr7_-_101165558 0.83 ENST00000611537.1
ENST00000249330.3
VGF
VGF nerve growth factor inducible
chr13_+_31846713 0.83 ENST00000645780.1
FRY
FRY microtubule binding protein
chr15_+_78340344 0.82 ENST00000299529.7
CRABP1
cellular retinoic acid binding protein 1
chr17_-_44830774 0.82 ENST00000590758.3
ENST00000591424.5
GJC1
gap junction protein gamma 1
chr1_-_204190324 0.81 ENST00000638118.1
REN
renin
chrX_+_43654888 0.81 ENST00000542639.5
MAOA
monoamine oxidase A
chr6_+_46793379 0.80 ENST00000230588.9
ENST00000611727.2
MEP1A
meprin A subunit alpha
chr16_+_55479188 0.78 ENST00000219070.9
MMP2
matrix metallopeptidase 2
chr10_-_68332914 0.76 ENST00000358769.7
ENST00000495025.2
PBLD
phenazine biosynthesis like protein domain containing
chr4_-_152352800 0.67 ENST00000393956.9
FBXW7
F-box and WD repeat domain containing 7
chr15_-_92655712 0.67 ENST00000327355.6
FAM174B
family with sequence similarity 174 member B
chr20_-_32207708 0.65 ENST00000246229.5
PLAGL2
PLAG1 like zinc finger 2
chr12_+_4909895 0.65 ENST00000638821.1
ENST00000382545.5
ENSG00000256654.4
KCNA1
novel transcript, sense overlapping KCNA1
potassium voltage-gated channel subfamily A member 1
chrX_-_63785510 0.65 ENST00000437457.6
ENST00000374878.5
ENST00000623517.3
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr3_-_50567646 0.63 ENST00000426034.5
ENST00000441239.5
C3orf18
chromosome 3 open reading frame 18
chr1_+_17618310 0.62 ENST00000375408.7
ARHGEF10L
Rho guanine nucleotide exchange factor 10 like
chr9_+_134025455 0.60 ENST00000603928.3
ENST00000432807.1
BRD3OS
BRD3 opposite strand
chr7_+_121328991 0.59 ENST00000222462.3
WNT16
Wnt family member 16
chr15_-_74956758 0.57 ENST00000322177.6
RPP25
ribonuclease P and MRP subunit p25
chrX_+_121047601 0.56 ENST00000328078.3
GLUD2
glutamate dehydrogenase 2
chr20_+_1135217 0.52 ENST00000381898.5
PSMF1
proteasome inhibitor subunit 1
chr20_+_1135178 0.49 ENST00000435720.5
PSMF1
proteasome inhibitor subunit 1
chr17_-_8118489 0.49 ENST00000380149.6
ENST00000448843.7
ALOXE3
arachidonate lipoxygenase 3
chr17_+_7455571 0.47 ENST00000575379.1
CHRNB1
cholinergic receptor nicotinic beta 1 subunit
chr17_-_16569184 0.44 ENST00000448349.2
ENST00000395825.4
ZNF287
zinc finger protein 287
chr12_-_213338 0.42 ENST00000424061.6
SLC6A12
solute carrier family 6 member 12

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 36.7 GO:1903296 regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
7.0 35.0 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
2.2 15.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.1 14.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
2.0 19.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.9 11.3 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
1.7 34.8 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
1.7 6.9 GO:1902228 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
1.6 8.0 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
1.6 6.3 GO:1903610 regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634)
1.5 7.4 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
1.4 6.9 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
1.3 3.9 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
1.2 3.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.2 3.6 GO:0043465 fermentation(GO:0006113) regulation of fermentation(GO:0043465)
1.2 8.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
1.1 14.2 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
1.1 3.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.9 3.7 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.8 18.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.7 2.9 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.7 2.7 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.6 5.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.6 3.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.5 4.4 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.5 4.2 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.5 2.1 GO:0007538 primary sex determination(GO:0007538)
0.5 2.7 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.4 1.7 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.4 1.7 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.4 2.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.4 3.2 GO:0015705 iodide transport(GO:0015705)
0.4 4.0 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.4 18.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 3.6 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.4 14.9 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.3 5.9 GO:0045793 positive regulation of cell size(GO:0045793)
0.3 1.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 3.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.3 2.6 GO:0000101 sulfur amino acid transport(GO:0000101)
0.3 0.8 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.3 1.4 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.2 1.0 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.2 3.9 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 2.5 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.2 0.8 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.2 2.4 GO:0046958 nonassociative learning(GO:0046958)
0.2 1.0 GO:0033058 directional locomotion(GO:0033058)
0.2 1.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.2 2.8 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.2 5.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.2 5.1 GO:0031167 rRNA methylation(GO:0031167)
0.2 4.6 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.2 1.2 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.2 3.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 2.7 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 0.7 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.2 0.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.5 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 2.7 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 0.5 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.1 4.0 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.1 2.1 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.1 0.8 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.1 1.3 GO:0006449 regulation of translational termination(GO:0006449)
0.1 7.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.6 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 1.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 1.2 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.1 6.1 GO:0006342 chromatin silencing(GO:0006342)
0.1 0.7 GO:0034378 chylomicron assembly(GO:0034378)
0.1 0.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 1.1 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.1 1.7 GO:0002021 response to dietary excess(GO:0002021)
0.1 0.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 2.1 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.1 4.7 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.1 1.2 GO:0015671 oxygen transport(GO:0015671)
0.1 7.8 GO:0070268 cornification(GO:0070268)
0.1 1.4 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.1 2.7 GO:0033344 cholesterol efflux(GO:0033344)
0.1 0.5 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 0.6 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.1 0.9 GO:1990403 embryonic brain development(GO:1990403)
0.1 5.6 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.1 1.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.0 GO:0036344 platelet morphogenesis(GO:0036344)
0.1 4.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 0.8 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.4 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.1 0.3 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.0 2.3 GO:0000266 mitochondrial fission(GO:0000266)
0.0 13.4 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.5 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 6.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 1.0 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 1.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.6 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 3.4 GO:0051262 protein tetramerization(GO:0051262)
0.0 3.8 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.4 GO:2000505 regulation of energy homeostasis(GO:2000505)
0.0 0.2 GO:0019068 virion assembly(GO:0019068)
0.0 1.1 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 2.6 GO:0007050 cell cycle arrest(GO:0007050)
0.0 1.0 GO:1901799 negative regulation of proteasomal protein catabolic process(GO:1901799)
0.0 0.4 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 36.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
2.3 18.3 GO:0016012 sarcoglycan complex(GO:0016012)
1.6 8.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
1.2 6.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.1 14.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.9 12.0 GO:0031209 SCAR complex(GO:0031209)
0.9 3.6 GO:0002139 stereocilia coupling link(GO:0002139)
0.9 6.9 GO:0045179 apical cortex(GO:0045179)
0.7 4.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.7 2.7 GO:0070876 SOSS complex(GO:0070876)
0.6 4.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.6 34.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.6 3.9 GO:1990635 proximal dendrite(GO:1990635)
0.5 14.7 GO:0005921 gap junction(GO:0005921)
0.4 6.7 GO:0016580 Sin3 complex(GO:0016580)
0.4 4.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4 11.4 GO:0030057 desmosome(GO:0030057)
0.3 8.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.3 1.0 GO:0070695 FHF complex(GO:0070695)
0.3 6.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.2 2.1 GO:0000813 ESCRT I complex(GO:0000813)
0.2 3.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.2 1.7 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.2 35.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 1.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 2.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.2 1.5 GO:0070852 cell body fiber(GO:0070852)
0.1 18.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.7 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.5 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 0.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 2.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 6.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.5 GO:0000145 exocyst(GO:0000145)
0.1 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 11.8 GO:0000922 spindle pole(GO:0000922)
0.1 0.6 GO:0033270 paranode region of axon(GO:0033270)
0.1 18.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 6.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 38.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 5.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 4.5 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.4 GO:0097546 ciliary base(GO:0097546)
0.0 0.9 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 1.0 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 4.7 GO:0000793 condensed chromosome(GO:0000793)
0.0 2.1 GO:0031514 motile cilium(GO:0031514)
0.0 4.1 GO:0001726 ruffle(GO:0001726)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.2 GO:0043204 perikaryon(GO:0043204)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
1.6 43.6 GO:0043274 phospholipase binding(GO:0043274)
1.6 6.3 GO:0004341 gluconolactonase activity(GO:0004341)
1.6 4.7 GO:0032093 SAM domain binding(GO:0032093)
1.4 14.2 GO:0033691 sialic acid binding(GO:0033691)
1.4 6.9 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.0 4.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 3.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.9 5.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.8 8.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.7 35.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.5 2.1 GO:0004461 lactose synthase activity(GO:0004461)
0.5 13.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.5 18.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.5 1.9 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.5 1.9 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.5 3.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 1.7 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.4 1.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.4 1.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.4 2.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.4 2.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 11.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.3 1.9 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.3 1.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.3 2.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.3 2.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 3.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 1.0 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.2 5.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 6.1 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 3.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 1.5 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 15.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 2.7 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.2 2.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 2.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.7 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 1.5 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 1.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 3.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 1.6 GO:0046790 virion binding(GO:0046790)
0.1 1.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.9 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.5 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.1 4.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 13.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 1.8 GO:0008483 transaminase activity(GO:0008483)
0.1 7.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.0 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 1.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.1 0.8 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.1 1.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 8.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 4.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 1.0 GO:0070628 proteasome binding(GO:0070628)
0.0 9.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 6.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 4.4 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 1.0 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 1.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 3.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.9 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 1.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 7.9 GO:0003924 GTPase activity(GO:0003924)
0.0 2.1 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 2.9 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 2.7 GO:0016853 isomerase activity(GO:0016853)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 34.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.7 38.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.5 18.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 22.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.3 16.4 SIG CHEMOTAXIS Genes related to chemotaxis
0.2 8.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 6.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 4.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.2 14.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 2.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 6.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 5.6 PID ARF6 PATHWAY Arf6 signaling events
0.1 1.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 1.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 3.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.8 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.9 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 3.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID REELIN PATHWAY Reelin signaling pathway
0.0 4.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 37.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.4 47.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.7 18.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 8.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 5.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 6.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.3 14.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.3 11.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 8.0 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.3 7.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.3 3.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 3.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 3.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 2.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 2.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 2.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 3.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 0.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 4.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 3.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 3.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 2.7 REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.1 1.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 4.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 4.4 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 2.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 1.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 9.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 2.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 2.8 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 1.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 4.0 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 2.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.0 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)