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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GFI1

Z-value: 5.24

Motif logo

Transcription factors associated with GFI1

Gene Symbol Gene ID Gene Info
ENSG00000162676.12 GFI1

Activity-expression correlation:

Activity profile of GFI1 motif

Sorted Z-values of GFI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GFI1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_-_88857582 12.33 ENST00000390237.2
immunoglobulin kappa constant
chr17_-_28368012 12.08 ENST00000555059.2
novel protein, readthrough between VTN and SEBOX
chr11_+_72080313 12.05 ENST00000307198.11
ENST00000538413.6
ENST00000642648.1
ENST00000289488.7
leucine rich transmembrane and O-methyltransferase domain containing
leucine rich transmembrane and O-methyltransferase domain containing
chr17_-_69150062 10.72 ENST00000522787.5
ENST00000521538.5
ATP binding cassette subfamily A member 10
chr11_+_72080803 10.30 ENST00000423494.6
ENST00000539587.6
ENST00000536917.2
ENST00000538478.5
ENST00000324866.11
ENST00000643715.1
ENST00000439209.5
leucine rich transmembrane and O-methyltransferase domain containing
leucine rich transmembrane and O-methyltransferase domain containing
chr11_+_72080595 9.72 ENST00000647530.1
ENST00000539271.6
ENST00000642510.1
leucine rich transmembrane and O-methyltransferase domain containing
chr6_+_6588708 9.53 ENST00000230568.5
lymphocyte antigen 86
chr6_+_31982057 9.03 ENST00000428956.7
ENST00000498271.1
complement C4A (Rodgers blood group)
chr6_+_32014795 8.96 ENST00000435363.7
ENST00000425700.3
complement C4B (Chido blood group)
chr11_-_117877463 8.89 ENST00000527717.5
FXYD domain containing ion transport regulator 6
chr6_-_28587250 8.41 ENST00000452236.3
zinc finger BED-type containing 9
chr11_+_57741451 8.17 ENST00000534355.6
selenoprotein H
chr1_-_153375591 7.82 ENST00000368737.5
S100 calcium binding protein A12
chr2_+_17540670 7.76 ENST00000451533.5
ENST00000295156.9
visinin like 1
chr13_+_30617902 6.91 ENST00000255304.9
ENST00000614860.1
ubiquitin specific peptidase like 1
chr14_-_21537206 6.89 ENST00000614342.1
spalt like transcription factor 2
chr1_+_163069353 6.86 ENST00000531057.5
ENST00000527809.5
ENST00000367908.8
ENST00000367909.11
regulator of G protein signaling 4
chr1_-_173824322 6.80 ENST00000356198.6
centromere protein L
chr2_+_17539964 6.72 ENST00000457525.5
visinin like 1
chrX_+_37780049 6.53 ENST00000378588.5
cytochrome b-245 beta chain
chr6_+_31586859 6.41 ENST00000433492.5
leukocyte specific transcript 1
chr5_-_35230332 6.38 ENST00000504500.5
prolactin receptor
chr19_+_47309853 6.33 ENST00000355085.4
complement C5a receptor 1
chr17_+_1762052 6.21 ENST00000254722.9
ENST00000576406.5
ENST00000571149.5
serpin family F member 1
chr14_-_22815856 6.10 ENST00000554758.1
ENST00000397528.8
solute carrier family 7 member 7
chr1_-_2391535 6.07 ENST00000378531.8
MORN repeat containing 1
chr6_+_31827730 6.07 ENST00000375650.5
heat shock protein family A (Hsp70) member 1B
chr19_-_19192122 5.91 ENST00000444486.7
ENST00000514819.7
ENST00000585679.1
ENST00000462790.8
myocyte enhancer factor 2B
BORCS8-MEF2B readthrough
BLOC-1 related complex subunit 8
chrX_+_134373297 5.84 ENST00000332070.7
ENST00000370803.8
ENST00000625464.2
ENST00000370799.5
PHD finger protein 6
chr1_+_164559173 5.82 ENST00000420696.7
PBX homeobox 1
chr1_-_173824856 5.65 ENST00000682279.1
centromere protein L
chr6_+_31586124 5.64 ENST00000418507.6
ENST00000376096.5
ENST00000376099.5
ENST00000376110.7
leukocyte specific transcript 1
chr5_+_66958870 5.63 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
microtubule associated serine/threonine kinase family member 4
chr14_-_22815801 5.57 ENST00000397532.9
solute carrier family 7 member 7
chr6_+_45328203 5.53 ENST00000371432.7
ENST00000647337.2
ENST00000371438.5
RUNX family transcription factor 2
chr1_-_173824107 5.50 ENST00000345664.10
ENST00000367710.7
centromere protein L
chr8_-_27258414 5.48 ENST00000523048.5
stathmin 4
chr18_-_55589795 5.40 ENST00000568740.5
ENST00000629387.2
transcription factor 4
chr2_+_183078736 5.34 ENST00000354221.5
dual specificity phosphatase 19
chr6_+_31586269 5.30 ENST00000438075.7
leukocyte specific transcript 1
chr6_+_41072939 5.26 ENST00000341376.11
ENST00000353205.5
nuclear transcription factor Y subunit alpha
chr11_-_104164126 5.25 ENST00000393158.7
platelet derived growth factor D
chr5_-_88883701 5.24 ENST00000636998.1
myocyte enhancer factor 2C
chr19_+_54630497 5.18 ENST00000396332.8
ENST00000427581.6
leukocyte immunoglobulin like receptor B1
chr18_-_55589836 5.12 ENST00000537578.5
ENST00000564403.6
transcription factor 4
chr14_+_103529208 5.07 ENST00000299202.4
tRNA methyltransferase 61A
chr2_+_147844601 5.06 ENST00000404590.1
activin A receptor type 2A
chr6_+_31587002 5.05 ENST00000376090.6
leukocyte specific transcript 1
chr14_-_22815421 4.96 ENST00000674313.1
ENST00000555959.1
solute carrier family 7 member 7
chr11_+_6259806 4.96 ENST00000532715.5
ENST00000334619.7
ENST00000525014.1
ENST00000531712.5
ENST00000525462.1
cholecystokinin B receptor
chr8_-_118951876 4.90 ENST00000297350.9
TNF receptor superfamily member 11b
chr12_+_8123899 4.89 ENST00000641376.1
C-type lectin domain family 4 member A
chr2_-_151973991 4.80 ENST00000534999.6
ENST00000637217.1
ENST00000360283.11
calcium voltage-gated channel auxiliary subunit beta 4
chr14_-_69797232 4.79 ENST00000216540.5
solute carrier family 10 member 1
chr19_+_54630410 4.76 ENST00000396327.7
ENST00000324602.12
leukocyte immunoglobulin like receptor B1
chr6_+_28141830 4.71 ENST00000330236.7
zinc finger with KRAB and SCAN domains 8
chr8_-_27258386 4.71 ENST00000350889.8
ENST00000519997.5
ENST00000519614.5
ENST00000522908.1
ENST00000265770.11
stathmin 4
chr2_-_88992903 4.68 ENST00000495489.1
immunoglobulin kappa variable 1-8
chrX_-_14029877 4.58 ENST00000680255.1
ENST00000380523.8
ENST00000398355.7
gem nuclear organelle associated protein 8
chr17_-_58529344 4.56 ENST00000317268.7
septin 4
chr18_-_55589770 4.53 ENST00000565018.6
ENST00000636400.2
transcription factor 4
chr11_-_4608226 4.48 ENST00000300747.10
ENST00000526337.5
tripartite motif containing 68
chr2_+_147844488 4.46 ENST00000535787.5
activin A receptor type 2A
chr6_+_31587049 4.45 ENST00000376089.6
ENST00000396112.6
leukocyte specific transcript 1
chr5_+_178941186 4.45 ENST00000320129.7
ENST00000519564.2
zinc finger protein 454
chr11_-_65780917 4.43 ENST00000532090.3
adaptor related protein complex 5 subunit beta 1
chr17_-_58529303 4.42 ENST00000580844.5
septin 4
chr18_-_55423757 4.39 ENST00000675707.1
transcription factor 4
chr5_+_36608146 4.37 ENST00000381918.4
ENST00000513646.1
solute carrier family 1 member 3
chr14_-_21536928 4.37 ENST00000613414.4
spalt like transcription factor 2
chr7_+_98617275 4.37 ENST00000265634.4
neuronal pentraxin 2
chr2_-_2326210 4.36 ENST00000647755.1
myelin transcription factor 1 like
chr5_-_141958174 4.35 ENST00000231484.4
protocadherin 12
chr17_-_58529277 4.34 ENST00000579371.5
septin 4
chr19_-_48637338 4.34 ENST00000601104.1
ENST00000222122.10
D-box binding PAR bZIP transcription factor
chr11_+_2302119 4.29 ENST00000381121.7
tetraspanin 32
chr2_-_99141169 4.25 ENST00000674128.1
testis specific 10
chr4_-_88823165 4.21 ENST00000508369.5
family with sequence similarity 13 member A
chr7_-_116030735 4.17 ENST00000393485.5
transcription factor EC
chr6_-_46325641 4.17 ENST00000330430.10
ENST00000405162.2
regulator of calcineurin 2
chr11_+_72189528 4.17 ENST00000312293.9
folate receptor alpha
chr5_-_88883420 4.14 ENST00000437473.6
myocyte enhancer factor 2C
chr2_-_2326378 4.09 ENST00000647618.1
myelin transcription factor 1 like
chr11_+_49028823 4.04 ENST00000332682.9
tripartite motif containing 49B
chr1_-_109619605 4.04 ENST00000679935.1
G protein subunit alpha transducin 2
chr19_+_54965252 4.04 ENST00000543010.5
ENST00000391721.8
ENST00000339757.11
NLR family pyrin domain containing 2
chr11_+_72189659 3.99 ENST00000393681.6
folate receptor alpha
chr19_-_43619591 3.98 ENST00000598676.1
ENST00000300811.8
zinc finger protein 428
chr5_-_11904417 3.97 ENST00000304623.13
catenin delta 2
chr17_+_19378476 3.94 ENST00000395604.8
ENST00000482850.1
mitogen-activated protein kinase 7
chr1_+_173824626 3.91 ENST00000648960.1
ENST00000648807.1
ENST00000649067.1
ENST00000649689.2
aspartyl-tRNA synthetase 2, mitochondrial
chr4_+_55948871 3.88 ENST00000422247.6
ENST00000257287.5
centrosomal protein 135
chrX_+_85244075 3.86 ENST00000276123.7
zinc finger protein 711
chr6_+_31586835 3.85 ENST00000211921.11
leukocyte specific transcript 1
chr17_+_19377721 3.85 ENST00000308406.9
ENST00000299612.11
mitogen-activated protein kinase 7
chr3_-_187670385 3.84 ENST00000287641.4
somatostatin
chr19_+_40597168 3.82 ENST00000308370.11
latent transforming growth factor beta binding protein 4
chr1_+_156369202 3.82 ENST00000537040.6
Rh family B glycoprotein
chr22_-_17219424 3.81 ENST00000649540.1
ENST00000399837.8
ENST00000543038.1
adenosine deaminase 2
chr1_+_150364136 3.79 ENST00000369068.5
regulation of nuclear pre-mRNA domain containing 2
chr9_-_21368962 3.75 ENST00000610660.1
interferon alpha 13
chr3_+_1092654 3.73 ENST00000350110.2
contactin 6
chr15_+_91853819 3.73 ENST00000424469.2
solute carrier organic anion transporter family member 3A1
chr12_+_80707625 3.71 ENST00000228641.4
myogenic factor 6
chr12_+_54280663 3.70 ENST00000677375.1
ENST00000677210.1
ENST00000677385.1
ENST00000677249.1
ENST00000550482.2
ENST00000679101.1
ENST00000340913.11
ENST00000547708.5
ENST00000551702.5
ENST00000676794.1
ENST00000330752.12
ENST00000678690.1
ENST00000678919.1
ENST00000547276.5
heterogeneous nuclear ribonucleoprotein A1
chr3_+_46370854 3.67 ENST00000292303.4
C-C motif chemokine receptor 5
chrX_-_130385656 3.66 ENST00000276218.4
ENST00000682440.1
G protein-coupled receptor 119
chrX_-_48196763 3.64 ENST00000311798.5
ENST00000347757.6
SSX family member 5
chr18_+_44700796 3.64 ENST00000677130.1
SET binding protein 1
chr4_-_144140683 3.63 ENST00000324022.14
glycophorin A (MNS blood group)
chr12_+_8123609 3.63 ENST00000229332.12
C-type lectin domain family 4 member A
chr14_-_92748570 3.62 ENST00000553918.1
ENST00000555699.5
ENST00000334869.9
ENST00000553802.5
ENST00000554397.5
ENST00000554919.5
ENST00000554080.5
ENST00000553371.1
ENST00000557434.5
ENST00000393218.6
legumain
chr6_-_134950081 3.60 ENST00000367847.2
ENST00000265605.7
ENST00000367845.6
aldehyde dehydrogenase 8 family member A1
chr3_-_114624193 3.60 ENST00000481632.5
zinc finger and BTB domain containing 20
chr2_+_66435558 3.58 ENST00000488550.5
Meis homeobox 1
chr6_-_52994248 3.58 ENST00000457564.1
ENST00000370960.5
glutathione S-transferase alpha 4
chr2_-_151973780 3.57 ENST00000637514.1
ENST00000636350.1
ENST00000434468.2
ENST00000637762.1
ENST00000637779.1
ENST00000637547.1
ENST00000636901.1
ENST00000397327.7
ENST00000636721.1
ENST00000636380.1
ENST00000637284.1
ENST00000636617.1
ENST00000636947.1
ENST00000638091.1
ENST00000636108.1
ENST00000638040.1
ENST00000636773.1
ENST00000637418.1
ENST00000637216.1
calcium voltage-gated channel auxiliary subunit beta 4
chr10_-_74150781 3.56 ENST00000355264.9
ENST00000372745.1
adaptor related protein complex 3 subunit mu 1
chr7_-_4862015 3.55 ENST00000404991.2
poly(A) polymerase beta
chr10_-_118595637 3.54 ENST00000239032.4
prolactin releasing hormone receptor
chrX_+_139530730 3.54 ENST00000218099.7
coagulation factor IX
chr6_-_145735964 3.54 ENST00000640980.1
ENST00000639423.1
ENST00000611340.5
EPM2A glucan phosphatase, laforin
chr11_-_83035545 3.52 ENST00000528379.1
ENST00000534103.5
RAB30, member RAS oncogene family
chr1_+_173824694 3.50 ENST00000647645.1
aspartyl-tRNA synthetase 2, mitochondrial
chr15_+_83447411 3.50 ENST00000324537.5
SH3 domain containing GRB2 like 3, endophilin A3
chr8_+_27311471 3.49 ENST00000397501.5
protein tyrosine kinase 2 beta
chrX_+_85244032 3.49 ENST00000373165.7
zinc finger protein 711
chr2_+_238426920 3.49 ENST00000264607.9
ankyrin repeat and SOCS box containing 1
chr4_-_88823214 3.47 ENST00000513837.5
ENST00000503556.5
family with sequence similarity 13 member A
chr7_-_126533850 3.47 ENST00000444921.3
glutamate metabotropic receptor 8
chr8_+_132919403 3.45 ENST00000519178.5
thyroglobulin
chr7_+_90709816 3.42 ENST00000436577.3
cyclin dependent kinase 14
chr15_+_83447328 3.41 ENST00000427482.7
SH3 domain containing GRB2 like 3, endophilin A3
chr3_-_66038537 3.41 ENST00000483466.5
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr6_+_6588082 3.41 ENST00000379953.6
lymphocyte antigen 86
chr7_-_116030750 3.39 ENST00000265440.12
ENST00000320239.11
transcription factor EC
chr6_+_80106655 3.36 ENST00000320393.9
branched chain keto acid dehydrogenase E1 subunit beta
chr4_+_105710809 3.36 ENST00000360505.9
ENST00000510865.5
ENST00000509336.5
glutathione S-transferase C-terminal domain containing
chr6_-_32953017 3.35 ENST00000395305.7
ENST00000374843.9
ENST00000395303.7
ENST00000429234.1
major histocompatibility complex, class II, DM alpha
novel protein
chr2_+_79185231 3.34 ENST00000466387.5
catenin alpha 2
chr17_-_19377876 3.34 ENST00000674596.1
ENST00000642870.2
B9 domain containing 1
chr12_+_51912329 3.34 ENST00000547400.5
ENST00000550683.5
ENST00000419526.6
activin A receptor like type 1
chr9_+_65736555 3.32 ENST00000377413.2
forkhead box D4 like 4
chr12_+_116738308 3.31 ENST00000257575.9
ring finger protein, transmembrane 2
chr1_-_119768892 3.31 ENST00000369406.8
ENST00000544913.2
3-hydroxy-3-methylglutaryl-CoA synthase 2
chr19_-_17377334 3.30 ENST00000252590.9
ENST00000599426.1
plasmalemma vesicle associated protein
chrX_-_54994022 3.30 ENST00000614686.1
ENST00000374992.6
ENST00000375006.8
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr12_+_56338873 3.30 ENST00000228534.6
interleukin 23 subunit alpha
chr5_-_19988179 3.30 ENST00000502796.5
ENST00000382275.6
ENST00000511273.1
cadherin 18
chr5_+_148383976 3.29 ENST00000394370.7
F-box protein 38
chr3_+_1093002 3.18 ENST00000446702.7
contactin 6
chr4_-_154612635 3.15 ENST00000407946.5
ENST00000405164.5
ENST00000336098.8
ENST00000393846.6
ENST00000404648.7
ENST00000443553.5
fibrinogen gamma chain
chr6_-_41734160 3.15 ENST00000424495.2
ENST00000420312.6
transcription factor EB
chr6_+_31586680 3.12 ENST00000339530.8
leukocyte specific transcript 1
chr19_-_15418979 3.11 ENST00000397410.10
ENST00000596195.5
ENST00000595067.1
ENST00000595465.6
ENST00000680649.1
ENST00000679638.1
ENST00000600247.5
A-kinase anchoring protein 8 like
chr10_-_99235783 3.11 ENST00000370546.5
ENST00000614306.1
heparanase 2 (inactive)
chr17_+_70075317 3.10 ENST00000589377.1
potassium inwardly rectifying channel subfamily J member 16
chr11_+_112167366 3.07 ENST00000530752.5
ENST00000280358.5
testis expressed 12
chr11_-_60952559 3.03 ENST00000538739.2
solute carrier family 15 member 3
chr5_+_148383935 3.03 ENST00000296701.10
ENST00000340253.10
F-box protein 38
chr2_+_156436345 3.01 ENST00000438166.7
glycerol-3-phosphate dehydrogenase 2
chr1_-_48776811 3.01 ENST00000371833.4
BEN domain containing 5
chr8_+_69466617 3.01 ENST00000525061.5
ENST00000260128.8
ENST00000458141.6
sulfatase 1
chr19_-_43082692 3.00 ENST00000406487.6
pregnancy specific beta-1-glycoprotein 2
chr10_-_89535575 2.98 ENST00000371790.5
solute carrier family 16 member 12
chr10_-_99235846 2.97 ENST00000370552.8
ENST00000370549.5
ENST00000628193.2
heparanase 2 (inactive)
chr4_-_144140635 2.94 ENST00000512064.5
ENST00000512789.5
ENST00000504786.5
ENST00000503627.2
ENST00000642713.1
ENST00000643148.1
ENST00000642738.1
ENST00000642295.1
ENST00000646447.1
ENST00000535709.6
glycophorin A (MNS blood group)
chrX_+_85243983 2.92 ENST00000674551.1
zinc finger protein 711
chr17_+_63477052 2.91 ENST00000290866.10
ENST00000428043.5
angiotensin I converting enzyme
chr3_+_186717348 2.91 ENST00000447445.1
ENST00000287611.8
ENST00000644859.2
kininogen 1
chr3_-_38794042 2.91 ENST00000643924.1
sodium voltage-gated channel alpha subunit 10
chr20_-_23086316 2.90 ENST00000246006.5
CD93 molecule
chr9_+_35605234 2.89 ENST00000336395.6
testis associated actin remodelling kinase 1
chr1_+_92299023 2.87 ENST00000610020.2
RNA polymerase II associated protein 2
chr9_+_34989641 2.86 ENST00000453597.8
ENST00000312316.9
ENST00000458263.6
ENST00000537321.5
ENST00000682809.1
ENST00000684748.1
DnaJ heat shock protein family (Hsp40) member B5
chr20_+_16748358 2.84 ENST00000246081.3
otoraplin
chr15_-_23687290 2.84 ENST00000649030.2
necdin, MAGE family member
chr5_+_140875299 2.83 ENST00000613593.1
ENST00000398631.3
protocadherin alpha 12
chr7_-_27147774 2.82 ENST00000222728.3
homeobox A6
chr10_-_80289647 2.82 ENST00000372213.8
methionine adenosyltransferase 1A
chr6_+_98834560 2.77 ENST00000328345.8
POU class 3 homeobox 2
chr12_+_109573757 2.76 ENST00000228510.8
ENST00000539696.5
ENST00000392727.7
mevalonate kinase
chr5_-_35230467 2.74 ENST00000515839.1
ENST00000618457.5
prolactin receptor
chr4_-_69760610 2.74 ENST00000310613.8
sulfotransferase family 1B member 1
chr1_+_164559739 2.72 ENST00000627490.2
PBX homeobox 1
chr13_+_46553157 2.72 ENST00000311191.10
ENST00000389797.8
ENST00000389798.7
leucine rich repeats and calponin homology domain containing 1
chr12_+_8123837 2.71 ENST00000345999.9
ENST00000352620.9
ENST00000360500.5
C-type lectin domain family 4 member A
chr17_+_70075215 2.70 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
potassium inwardly rectifying channel subfamily J member 16
chrX_-_48411910 2.66 ENST00000619890.1
ENST00000595235.6
SSX family member 4B
chr11_+_5624987 2.65 ENST00000429814.3
tripartite motif containing 34
chr19_+_54906140 2.65 ENST00000291890.9
ENST00000598576.5
ENST00000594765.5
ENST00000350790.9
ENST00000338835.9
ENST00000357397.5
natural cytotoxicity triggering receptor 1
chr11_-_72080472 2.64 ENST00000537217.5
ENST00000366394.7
ENST00000358965.10
ENST00000546131.1
ENST00000393695.8
ENST00000543937.5
ENST00000368959.9
ENST00000541641.5
nuclear mitotic apparatus protein 1
chr2_-_127220293 2.64 ENST00000664447.2
ENST00000409327.2
cytochrome P450 family 27 subfamily C member 1
chr7_-_120858066 2.64 ENST00000222747.8
tetraspanin 12
chr17_+_4771878 2.63 ENST00000270560.4
transmembrane 4 L six family member 5
chr5_-_134371004 2.63 ENST00000521755.1
ENST00000523054.5
ENST00000518409.1
cyclin dependent kinase like 3
novel transcript
chr12_+_116738285 2.63 ENST00000392549.7
ENST00000407967.7
ring finger protein, transmembrane 2
chr4_+_94974984 2.61 ENST00000672698.1
bone morphogenetic protein receptor type 1B
chr12_+_113221429 2.60 ENST00000551096.5
ENST00000551099.5
ENST00000552897.5
ENST00000550785.5
ENST00000549279.1
ENST00000335509.11
two pore segment channel 1
chr19_+_3880647 2.58 ENST00000450849.7
ATCAY kinesin light chain interacting caytaxin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
2.5 9.9 GO:0035548 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
2.5 7.4 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
2.4 16.6 GO:1990822 basic amino acid transmembrane transport(GO:1990822)
2.2 6.5 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
2.1 6.3 GO:0038178 complement component C5a signaling pathway(GO:0038178)
1.9 7.8 GO:0030821 negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821)
1.8 9.1 GO:0038161 prolactin signaling pathway(GO:0038161)
1.8 5.4 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.8 5.3 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
1.7 32.1 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
1.7 6.6 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
1.6 18.0 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
1.6 11.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
1.6 3.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
1.6 4.7 GO:0071988 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
1.5 6.1 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
1.4 12.9 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
1.3 3.8 GO:0070634 transepithelial ammonium transport(GO:0070634)
1.2 10.0 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
1.2 3.5 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
1.2 6.9 GO:0016926 protein desumoylation(GO:0016926)
1.0 4.1 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
1.0 2.9 GO:0061011 hepatic duct development(GO:0061011)
0.9 6.5 GO:0002051 osteoblast fate commitment(GO:0002051)
0.9 2.8 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.9 3.6 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.9 6.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279)
0.9 6.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.9 1.7 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.8 4.2 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.8 3.3 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.8 4.9 GO:0015811 L-cystine transport(GO:0015811)
0.8 4.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.8 2.4 GO:0002125 maternal aggressive behavior(GO:0002125)
0.8 3.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.8 3.2 GO:0002384 hepatic immune response(GO:0002384)
0.8 2.3 GO:0061074 regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
0.8 3.8 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.8 3.8 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.7 3.7 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.7 2.9 GO:0002019 regulation of renal output by angiotensin(GO:0002019) positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.7 2.9 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.7 2.8 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.7 2.1 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.7 3.3 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.7 2.0 GO:0070845 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.6 3.2 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.6 2.5 GO:1903238 positive regulation of leukocyte tethering or rolling(GO:1903238)
0.6 2.4 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.6 2.4 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.6 8.4 GO:0015074 DNA integration(GO:0015074)
0.6 4.2 GO:0034201 response to oleic acid(GO:0034201)
0.6 2.9 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.5 1.6 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.5 1.6 GO:1904692 positive regulation of type B pancreatic cell proliferation(GO:1904692)
0.5 3.1 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.5 6.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.5 2.5 GO:0035106 negative regulation of luteinizing hormone secretion(GO:0033685) operant conditioning(GO:0035106)
0.5 1.5 GO:0071461 cellular response to redox state(GO:0071461)
0.5 4.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.5 1.9 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.4 4.0 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.4 4.4 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.4 3.5 GO:0015705 iodide transport(GO:0015705)
0.4 2.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.4 1.7 GO:0045356 toll-like receptor 7 signaling pathway(GO:0034154) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.4 3.7 GO:0086043 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.4 6.2 GO:0042574 retinal metabolic process(GO:0042574)
0.4 2.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 3.5 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.4 3.9 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.4 2.2 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.4 1.9 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.4 2.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.4 3.7 GO:0090500 endocardial cushion to mesenchymal transition(GO:0090500)
0.4 3.7 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.4 0.4 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.4 5.4 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.3 14.0 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.3 10.8 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.3 13.0 GO:0048665 neuron fate specification(GO:0048665)
0.3 3.0 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.3 5.7 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.3 3.3 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.3 0.7 GO:0048865 stem cell fate commitment(GO:0048865)
0.3 2.0 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.3 2.3 GO:0061085 regulation of histone H3-K27 methylation(GO:0061085) positive regulation of histone H3-K27 methylation(GO:0061087)
0.3 6.0 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.3 5.6 GO:0015732 prostaglandin transport(GO:0015732)
0.3 2.1 GO:0001714 endodermal cell fate specification(GO:0001714)
0.3 2.1 GO:0072104 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.3 0.8 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.3 4.3 GO:0021670 lateral ventricle development(GO:0021670) nose development(GO:0043584)
0.3 1.3 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.3 2.0 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.3 10.4 GO:0007019 microtubule depolymerization(GO:0007019)
0.3 1.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.3 1.8 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.2 1.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 1.7 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 1.2 GO:0060746 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.2 3.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.2 2.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 4.8 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 1.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 3.3 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.2 4.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 3.9 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 8.2 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2 1.8 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 1.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 1.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 2.2 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.2 1.3 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.2 3.5 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.2 6.1 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.2 5.0 GO:0001696 gastric acid secretion(GO:0001696)
0.2 1.6 GO:0072719 cellular response to cisplatin(GO:0072719)
0.2 1.0 GO:0070474 tachykinin receptor signaling pathway(GO:0007217) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.2 0.8 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 7.8 GO:0050832 defense response to fungus(GO:0050832)
0.2 2.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.2 1.1 GO:0048539 bone marrow development(GO:0048539)
0.2 8.8 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.2 7.6 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 4.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.2 3.1 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.2 17.3 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.2 7.2 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 1.6 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 1.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.2 4.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 1.7 GO:0032264 IMP salvage(GO:0032264)
0.2 3.3 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.2 12.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 2.0 GO:0071313 cellular response to caffeine(GO:0071313)
0.2 0.5 GO:0035963 cellular response to interleukin-13(GO:0035963)
0.2 3.4 GO:0009812 flavonoid metabolic process(GO:0009812)
0.2 8.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.2 8.0 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.1 8.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 5.8 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 2.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 3.5 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.1 5.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 3.6 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 5.8 GO:0010107 potassium ion import(GO:0010107)
0.1 2.5 GO:0050718 positive regulation of interleukin-1 beta secretion(GO:0050718)
0.1 2.8 GO:0001502 cartilage condensation(GO:0001502)
0.1 3.7 GO:0030252 growth hormone secretion(GO:0030252)
0.1 4.5 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.1 3.0 GO:0072337 modified amino acid transport(GO:0072337)
0.1 16.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.2 GO:0042269 regulation of natural killer cell mediated cytotoxicity(GO:0042269)
0.1 1.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 2.8 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.1 0.6 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.1 1.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 1.8 GO:0044458 motile cilium assembly(GO:0044458)
0.1 2.9 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 2.5 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 3.2 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 1.5 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 1.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.6 GO:0034389 lipid particle organization(GO:0034389)
0.1 3.1 GO:0097484 dendrite extension(GO:0097484)
0.1 1.2 GO:0006004 fucose metabolic process(GO:0006004)
0.1 6.9 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 0.6 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 3.5 GO:0007631 feeding behavior(GO:0007631)
0.1 9.7 GO:0046718 viral entry into host cell(GO:0046718)
0.1 0.3 GO:0072278 thyroid-stimulating hormone secretion(GO:0070460) comma-shaped body morphogenesis(GO:0072049) metanephric comma-shaped body morphogenesis(GO:0072278) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.1 0.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.9 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 1.4 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.1 3.2 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 2.7 GO:0070206 protein trimerization(GO:0070206)
0.1 3.3 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.1 1.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 1.2 GO:0030728 ovulation(GO:0030728)
0.1 0.9 GO:0006833 water transport(GO:0006833)
0.1 4.0 GO:0008306 associative learning(GO:0008306)
0.1 3.1 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 14.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 2.9 GO:0042116 macrophage activation(GO:0042116)
0.1 3.9 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.1 0.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.2 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 2.1 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 1.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 3.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 4.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 15.9 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.8 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 1.5 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 1.5 GO:0061053 somite development(GO:0061053)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 1.4 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 7.7 GO:0048511 rhythmic process(GO:0048511)
0.0 1.2 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 3.0 GO:0007030 Golgi organization(GO:0007030)
0.0 1.6 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 5.3 GO:0006869 lipid transport(GO:0006869)
0.0 0.5 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.9 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 2.9 GO:0010976 positive regulation of neuron projection development(GO:0010976)
0.0 0.7 GO:0007612 learning(GO:0007612)
0.0 2.2 GO:0007163 establishment or maintenance of cell polarity(GO:0007163)
0.0 0.8 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.0 0.0 GO:0071073 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) positive regulation of phospholipid biosynthetic process(GO:0071073)
0.0 0.5 GO:0050909 sensory perception of taste(GO:0050909)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
1.7 10.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
1.6 4.7 GO:0055028 cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
1.5 5.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
1.1 4.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.0 5.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.8 3.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.8 3.1 GO:0000801 central element(GO:0000801)
0.7 4.3 GO:0005879 axonemal microtubule(GO:0005879)
0.7 2.1 GO:0070701 mucus layer(GO:0070701)
0.7 4.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.6 3.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.6 1.8 GO:0097224 sperm connecting piece(GO:0097224)
0.6 4.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.6 4.6 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.6 6.2 GO:0043203 axon hillock(GO:0043203)
0.5 3.6 GO:0036021 endolysosome lumen(GO:0036021)
0.5 1.8 GO:1990246 uniplex complex(GO:1990246)
0.5 8.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.4 5.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 6.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.4 1.7 GO:0033186 CAF-1 complex(GO:0033186)
0.4 9.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.4 2.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 1.7 GO:0045160 myosin I complex(GO:0045160)
0.3 8.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.3 2.5 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.3 3.1 GO:0005577 fibrinogen complex(GO:0005577)
0.3 2.3 GO:0001739 sex chromatin(GO:0001739)
0.2 3.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 3.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 2.1 GO:0033391 chromatoid body(GO:0033391)
0.2 12.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 3.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 4.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 2.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 2.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 3.2 GO:0005922 connexon complex(GO:0005922)
0.2 9.7 GO:0031904 endosome lumen(GO:0031904)
0.2 3.3 GO:0036038 MKS complex(GO:0036038)
0.2 12.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 9.5 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.2 1.7 GO:0032009 early phagosome(GO:0032009)
0.2 5.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 1.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 20.9 GO:0032993 protein-DNA complex(GO:0032993)
0.1 0.5 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 6.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 4.9 GO:0016235 aggresome(GO:0016235)
0.1 34.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 4.8 GO:1904115 axon cytoplasm(GO:1904115)
0.1 3.0 GO:0005795 Golgi stack(GO:0005795)
0.1 5.8 GO:0015030 Cajal body(GO:0015030)
0.1 3.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 10.6 GO:0016605 PML body(GO:0016605)
0.1 4.3 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.1 1.3 GO:0000145 exocyst(GO:0000145)
0.1 17.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 10.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 8.0 GO:0072562 blood microparticle(GO:0072562)
0.1 1.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 14.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 2.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.3 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.0 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.4 GO:0005610 laminin-5 complex(GO:0005610)
0.1 1.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 5.0 GO:0005811 lipid particle(GO:0005811)
0.0 18.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 4.0 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 8.6 GO:0030426 growth cone(GO:0030426)
0.0 4.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.3 GO:0043204 perikaryon(GO:0043204)
0.0 1.0 GO:0030057 desmosome(GO:0030057)
0.0 2.9 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 4.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.7 GO:0005901 caveola(GO:0005901)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.0 119.9 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.0 GO:1990909 Wnt signalosome(GO:1990909)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.7 GO:0043195 terminal bouton(GO:0043195)
0.0 12.6 GO:0005615 extracellular space(GO:0005615)
0.0 4.7 GO:0031966 mitochondrial membrane(GO:0031966)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 32.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
2.5 9.9 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
2.3 9.1 GO:0004925 prolactin receptor activity(GO:0004925)
2.1 6.3 GO:0004878 complement component C5a receptor activity(GO:0004878)
2.0 8.2 GO:0061714 folic acid receptor activity(GO:0061714)
2.0 6.1 GO:0030305 heparanase activity(GO:0030305)
1.7 5.1 GO:0003863 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
1.7 11.9 GO:0001849 complement component C1q binding(GO:0001849)
1.7 5.1 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
1.7 13.4 GO:0098821 BMP receptor activity(GO:0098821)
1.4 4.3 GO:0031862 prostanoid receptor binding(GO:0031862)
1.4 16.6 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.3 4.0 GO:0032090 Pyrin domain binding(GO:0032090)
1.3 3.9 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
1.2 4.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.2 6.9 GO:0016929 SUMO-specific protease activity(GO:0016929)
1.1 3.3 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
1.1 3.2 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
1.1 4.2 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.9 19.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.9 3.7 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.9 2.6 GO:0005502 11-cis retinal binding(GO:0005502)
0.8 2.5 GO:0016497 substance K receptor activity(GO:0016497)
0.8 3.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.8 4.9 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.8 3.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.7 2.2 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.6 1.9 GO:0015265 urea channel activity(GO:0015265)
0.6 2.5 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.6 10.0 GO:0003680 AT DNA binding(GO:0003680)
0.6 2.9 GO:0070573 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
0.6 6.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.6 5.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.5 1.6 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.5 6.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.5 3.6 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.5 3.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.5 3.0 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.5 2.4 GO:0031893 vasopressin receptor binding(GO:0031893)
0.5 1.5 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.5 1.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.5 2.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.5 4.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.5 4.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.5 1.4 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.5 4.1 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.4 2.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.4 1.3 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.4 3.8 GO:0031685 adenosine receptor binding(GO:0031685)
0.4 2.5 GO:0004359 glutaminase activity(GO:0004359)
0.4 1.3 GO:0005042 netrin receptor activity(GO:0005042)
0.4 3.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.4 1.2 GO:0004967 glucagon receptor activity(GO:0004967)
0.4 2.0 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.4 1.6 GO:0035473 lipase binding(GO:0035473)
0.4 5.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 7.8 GO:0050786 RAGE receptor binding(GO:0050786)
0.4 9.0 GO:0001848 complement binding(GO:0001848)
0.3 3.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.3 11.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 7.2 GO:0005112 Notch binding(GO:0005112)
0.3 8.6 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 4.0 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.3 7.4 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.3 4.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 5.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 3.6 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.3 3.0 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.3 5.0 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.3 3.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.3 8.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 9.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.3 5.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.3 1.3 GO:0004370 glycerol kinase activity(GO:0004370)
0.3 2.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 0.8 GO:0017129 triglyceride binding(GO:0017129)
0.3 5.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 7.8 GO:0004707 MAP kinase activity(GO:0004707)
0.2 1.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 3.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.2 1.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 0.7 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 1.8 GO:0032027 myosin light chain binding(GO:0032027)
0.2 1.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 0.9 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 2.6 GO:0050700 CARD domain binding(GO:0050700)
0.2 0.8 GO:0086077 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2 1.9 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 12.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 2.4 GO:0004075 biotin carboxylase activity(GO:0004075)
0.2 2.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 1.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.2 4.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 1.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 3.6 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.2 0.6 GO:0070052 collagen V binding(GO:0070052)
0.2 1.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 0.4 GO:0004945 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.2 1.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 4.6 GO:0002162 dystroglycan binding(GO:0002162)
0.2 4.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 2.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 4.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 2.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 5.8 GO:0030332 cyclin binding(GO:0030332)
0.1 4.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 1.7 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 8.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 3.1 GO:0044548 S100 protein binding(GO:0044548)
0.1 2.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.7 GO:0004630 heme oxygenase (decyclizing) activity(GO:0004392) phospholipase D activity(GO:0004630)
0.1 12.9 GO:0001618 virus receptor activity(GO:0001618)
0.1 3.7 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 6.2 GO:0070888 E-box binding(GO:0070888)
0.1 3.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 6.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 1.7 GO:0035197 siRNA binding(GO:0035197)
0.1 2.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 3.5 GO:0008066 glutamate receptor activity(GO:0008066)
0.1 1.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.8 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.3 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 1.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 1.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 2.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 4.1 GO:0005504 fatty acid binding(GO:0005504)
0.1 9.5 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.1 GO:0015250 water transmembrane transporter activity(GO:0005372) water channel activity(GO:0015250)
0.1 0.8 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 7.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 2.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.8 GO:0005243 gap junction channel activity(GO:0005243)
0.1 3.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 6.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 7.0 GO:0005179 hormone activity(GO:0005179)
0.1 2.6 GO:0019894 kinesin binding(GO:0019894)
0.0 2.9 GO:0051018 protein kinase A binding(GO:0051018)
0.0 4.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 8.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 5.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 22.0 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 1.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 4.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 33.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.9 GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 2.1 GO:0002039 p53 binding(GO:0002039)
0.0 2.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.4 GO:0015485 cholesterol binding(GO:0015485)
0.0 8.0 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 1.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0008061 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.0 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 15.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 3.0 GO:0003823 antigen binding(GO:0003823)
0.0 5.4 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.0 GO:0051087 chaperone binding(GO:0051087)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 17.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 10.9 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 3.2 ST STAT3 PATHWAY STAT3 Pathway
0.2 3.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 3.9 PID CONE PATHWAY Visual signal transduction: Cones
0.1 20.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 5.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 2.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 5.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 5.1 NABA COLLAGENS Genes encoding collagen proteins
0.1 6.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 8.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 3.3 PID ALK1 PATHWAY ALK1 signaling events
0.1 2.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 7.7 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 2.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 2.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.3 PID IL23 PATHWAY IL23-mediated signaling events
0.1 6.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 3.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 4.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.6 PID LKB1 PATHWAY LKB1 signaling events
0.1 17.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.6 PID TNF PATHWAY TNF receptor signaling pathway
0.1 1.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 2.6 PID BMP PATHWAY BMP receptor signaling
0.1 10.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 16.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 5.3 NABA MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins
0.0 0.9 PID ATR PATHWAY ATR signaling pathway
0.0 0.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.7 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.5 3.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.5 4.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.5 9.0 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.5 7.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.4 5.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.4 7.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.4 28.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.4 7.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.4 5.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.4 7.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 16.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 8.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.3 9.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.3 12.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.3 0.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 6.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 4.0 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.2 4.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 7.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 5.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 2.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 4.1 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 6.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 7.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 3.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 3.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 5.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.1 REACTOME OPSINS Genes involved in Opsins
0.2 1.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 13.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 5.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 3.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 5.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 1.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 4.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 14.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 8.8 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 5.0 REACTOME GRB2 EVENTS IN ERBB2 SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.1 6.1 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 5.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 22.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.0 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 2.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 3.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 2.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.2 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 2.5 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 0.9 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 5.2 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 1.0 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 3.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 2.2 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.1 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 4.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 5.3 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 8.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 8.3 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 3.3 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 1.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.2 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.0 0.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades