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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GGAAGAC

Z-value: 0.29

Motif logo

miRNA associated with seed GGAAGAC

NamemiRBASE accession
MIMAT0000252

Activity profile of GGAAGAC motif

Sorted Z-values of GGAAGAC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GGAAGAC

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_-_111757704 6.14 ENST00000379671.7
neuronal regeneration related protein
chr3_-_12664101 5.17 ENST00000251849.9
ENST00000442415.7
Raf-1 proto-oncogene, serine/threonine kinase
chr7_-_10940123 4.99 ENST00000339600.6
NDUFA4 mitochondrial complex associated
chr12_-_106247950 4.60 ENST00000378026.5
cytoskeleton associated protein 4
chr3_-_18425295 4.53 ENST00000338745.11
ENST00000450898.1
SATB homeobox 1
chr2_-_160493799 4.44 ENST00000348849.8
RNA binding motif single stranded interacting protein 1
chr19_-_47113756 4.10 ENST00000253048.10
zinc finger CCCH-type containing 4
chr8_+_26577843 4.01 ENST00000311151.9
dihydropyrimidinase like 2
chr2_-_131093378 3.91 ENST00000409185.5
ENST00000389915.4
family with sequence similarity 168 member B
chr1_+_112619824 3.61 ENST00000263168.4
capping actin protein of muscle Z-line subunit alpha 1
chrX_+_49171889 3.37 ENST00000376327.6
proteolipid protein 2
chr8_-_28386417 3.36 ENST00000521185.5
ENST00000520290.5
ENST00000344423.10
zinc finger protein 395
chr13_-_109786567 3.33 ENST00000375856.5
insulin receptor substrate 2
chr4_-_89837106 3.33 ENST00000394986.5
ENST00000394991.8
ENST00000506244.5
ENST00000394989.6
ENST00000673902.1
ENST00000674129.1
synuclein alpha
chr6_-_16761447 3.17 ENST00000244769.8
ENST00000436367.6
ataxin 1
chr14_+_69611586 3.06 ENST00000342745.5
sushi domain containing 6
chr3_-_149971109 3.04 ENST00000239940.11
profilin 2
chr14_-_89619118 2.98 ENST00000345097.8
ENST00000555855.5
ENST00000555353.5
forkhead box N3
chr18_-_9614518 2.75 ENST00000400556.8
ENST00000400555.7
protein phosphatase 4 regulatory subunit 1
chr1_-_113812448 2.75 ENST00000612242.4
ENST00000261441.9
round spermatid basic protein 1
chr2_-_61888570 2.73 ENST00000394440.8
ENST00000544079.2
chaperonin containing TCP1 subunit 4
chr5_+_177592182 2.73 ENST00000332598.7
transmembrane p24 trafficking protein 9
chr3_+_141387801 2.69 ENST00000514251.5
zinc finger and BTB domain containing 38
chr15_+_56918612 2.68 ENST00000438423.6
ENST00000267811.9
ENST00000333725.10
ENST00000559609.5
transcription factor 12
chr5_+_31532277 2.62 ENST00000507818.6
ENST00000325366.14
chromosome 5 open reading frame 22
chr5_+_138352674 2.53 ENST00000314358.10
lysine demethylase 3B
chr14_+_22871732 2.43 ENST00000359591.9
LDL receptor related protein 10
chr10_+_69124152 2.39 ENST00000395098.5
ENST00000263559.11
VPS26, retromer complex component A
chr2_-_226799806 2.34 ENST00000305123.6
insulin receptor substrate 1
chr6_-_24719146 2.27 ENST00000378119.9
chromosome 6 open reading frame 62
chr12_-_46372763 2.27 ENST00000256689.10
solute carrier family 38 member 2
chr17_-_81927699 2.26 ENST00000574686.1
ENST00000357736.9
MAF bZIP transcription factor G
chr2_-_219176895 2.10 ENST00000451647.1
ENST00000360507.10
cyclin Pas1/PHO80 domain containing 1
chr17_+_40219276 2.04 ENST00000583268.1
ENST00000323571.9
WAS/WASL interacting protein family member 2
chr3_-_52278620 1.98 ENST00000296490.8
WD repeat domain 82
chr2_+_6917404 1.96 ENST00000320892.11
ring finger protein 144A
chr17_-_50397472 1.96 ENST00000576448.1
ENST00000225972.8
leucine rich repeat containing 59
chr1_-_109041986 1.92 ENST00000400794.7
ENST00000528747.1
ENST00000361054.7
WD repeat domain 47
chr20_+_36605734 1.79 ENST00000344795.8
ENST00000373852.9
RAB5 interacting factor
chr4_+_128809684 1.76 ENST00000226319.11
ENST00000511647.5
jade family PHD finger 1
chr5_+_138338256 1.71 ENST00000513056.5
ENST00000239906.10
ENST00000511276.1
family with sequence similarity 53 member C
chr3_+_196739839 1.67 ENST00000327134.7
p21 (RAC1) activated kinase 2
chr5_-_134004635 1.61 ENST00000425992.2
ENST00000395044.7
ENST00000395047.6
voltage dependent anion channel 1
chr8_+_78516329 1.49 ENST00000396418.7
ENST00000352966.9
cAMP-dependent protein kinase inhibitor alpha
chr8_+_106657836 1.48 ENST00000312046.10
oxidation resistance 1
chr12_-_57846686 1.48 ENST00000548823.1
ENST00000398073.7
CTD small phosphatase 2
chr1_-_205750167 1.48 ENST00000367142.5
nuclear casein kinase and cyclin dependent kinase substrate 1
chr2_+_177392734 1.42 ENST00000680770.1
ENST00000637633.2
ENST00000679459.1
ENST00000409888.1
ENST00000264167.11
ENST00000642466.2
alkylglycerone phosphate synthase
chr10_-_110304894 1.41 ENST00000369603.10
survival motor neuron domain containing 1
chr3_-_57597325 1.40 ENST00000496292.5
ENST00000489843.1
ENST00000303436.11
ADP ribosylation factor 4
chr11_-_70661762 1.28 ENST00000357171.7
ENST00000412252.5
ENST00000449833.6
ENST00000338508.8
SH3 and multiple ankyrin repeat domains 2
chr10_-_86521737 1.24 ENST00000298767.10
WAPL cohesin release factor
chr12_+_65169546 1.23 ENST00000308330.3
LEM domain containing 3
chr4_-_75673112 1.20 ENST00000395719.7
ENST00000677489.1
G3BP stress granule assembly factor 2
chr18_-_55588184 1.17 ENST00000354452.8
ENST00000565908.6
ENST00000635822.2
transcription factor 4
chr11_-_64878612 1.14 ENST00000320631.8
EH domain containing 1
chr7_-_32891744 1.14 ENST00000304056.9
kelch repeat and BTB domain containing 2
chr3_+_45594727 1.11 ENST00000273317.5
LIM domains containing 1
chr3_+_30606574 1.09 ENST00000295754.10
ENST00000359013.4
transforming growth factor beta receptor 2
chr20_+_36574535 1.09 ENST00000558530.1
ENST00000558028.5
ENST00000611732.4
ENST00000560025.1
TGIF2-RAB5IF readthrough
TGFB induced factor homeobox 2
chr8_+_58411333 1.08 ENST00000399598.7
UBX domain protein 2B
chr3_-_125375249 1.03 ENST00000484491.5
ENST00000492394.5
ENST00000471196.1
ENST00000468369.5
ENST00000485866.5
ENST00000360647.9
zinc finger protein 148
chr2_+_219178266 1.01 ENST00000430297.7
reticulophagy regulator family member 2
chrX_+_71533095 0.99 ENST00000373719.8
ENST00000373701.7
O-linked N-acetylglucosamine (GlcNAc) transferase
chr2_-_96870034 0.99 ENST00000305476.10
semaphorin 4C
chr3_-_125595488 0.96 ENST00000296220.6
oxysterol binding protein like 11
chr16_-_18801424 0.92 ENST00000546206.6
ENST00000562819.5
ENST00000304414.12
ENST00000562234.2
ENST00000567078.2
ADP ribosylation factor like GTPase 6 interacting protein 1
novel protein
chr1_+_66332004 0.92 ENST00000371045.9
ENST00000531025.5
ENST00000526197.5
phosphodiesterase 4B
chr11_+_9384621 0.88 ENST00000379719.8
ENST00000527431.1
ENST00000630083.1
importin 7
chrX_+_41085436 0.81 ENST00000324545.9
ENST00000378308.7
ubiquitin specific peptidase 9 X-linked
chr5_+_17217617 0.81 ENST00000322611.4
brain abundant membrane attached signal protein 1
chr4_-_102827494 0.80 ENST00000453744.7
ENST00000321805.11
ubiquitin conjugating enzyme E2 D3
chr9_-_120793377 0.77 ENST00000684001.1
ENST00000684405.1
ENST00000608872.6
F-box and WD repeat domain containing 2
chr1_-_94927079 0.76 ENST00000370206.9
ENST00000394202.8
calponin 3
chr8_-_143939543 0.74 ENST00000345136.8
plectin
chr12_+_59689337 0.73 ENST00000261187.8
solute carrier family 16 member 7
chr11_-_31811314 0.70 ENST00000640368.2
ENST00000379123.10
ENST00000379115.9
ENST00000419022.6
ENST00000643871.1
ENST00000640610.1
ENST00000639034.2
paired box 6
chr5_+_154858594 0.70 ENST00000519430.5
ENST00000520671.5
ENST00000521583.5
ENST00000285896.11
ENST00000518028.5
ENST00000519404.5
ENST00000519394.5
ENST00000518775.5
CCR4-NOT transcription complex subunit 8
chr10_+_79068955 0.67 ENST00000334512.10
zinc finger MIZ-type containing 1
chr16_-_11915878 0.66 ENST00000439887.6
ENST00000434724.7
G1 to S phase transition 1
chr9_+_125747345 0.64 ENST00000342287.9
ENST00000373489.10
ENST00000373487.8
PBX homeobox 3
chr3_+_112562030 0.62 ENST00000468642.5
ENST00000492406.6
solute carrier family 35 member A5
chr16_+_69311339 0.61 ENST00000254950.13
vacuolar protein sorting 4 homolog A
chr1_-_114511160 0.61 ENST00000369543.6
ENST00000358465.7
tripartite motif containing 33
chr10_+_72273914 0.58 ENST00000681898.1
ENST00000307365.4
DNA damage inducible transcript 4
chr3_-_72446623 0.57 ENST00000477973.4
RING1 and YY1 binding protein
chr15_-_65517244 0.57 ENST00000341861.9
dipeptidyl peptidase 8
chr6_+_110874775 0.55 ENST00000675380.1
ENST00000368882.8
ENST00000368877.9
ENST00000368885.8
ENST00000672937.2
adenosylmethionine decarboxylase 1
chr11_-_115504389 0.54 ENST00000545380.5
ENST00000452722.7
ENST00000331581.11
ENST00000537058.5
ENST00000536727.5
ENST00000542447.6
cell adhesion molecule 1
chr3_-_150546403 0.53 ENST00000239944.7
ENST00000491660.1
ENST00000487153.1
stress associated endoplasmic reticulum protein 1
chr1_-_44031446 0.52 ENST00000372310.8
ENST00000466926.1
solute carrier family 6 member 9
chr16_+_28950807 0.51 ENST00000564978.5
ENST00000320805.8
nuclear factor of activated T cells 2 interacting protein
chr1_+_35883189 0.50 ENST00000674304.1
ENST00000373204.6
ENST00000674426.1
argonaute RISC component 1
chr6_-_134318097 0.49 ENST00000367858.10
ENST00000533224.1
serum/glucocorticoid regulated kinase 1
chr10_+_42782769 0.49 ENST00000374518.6
BMS1 ribosome biogenesis factor
chr17_+_5486856 0.48 ENST00000381165.3
MIS12 kinetochore complex component
chr1_+_229271100 0.48 ENST00000366690.5
RAB4A, member RAS oncogene family
chr17_-_4366616 0.47 ENST00000572484.5
ENST00000396981.7
ubiquitin conjugating enzyme E2 G1
chr2_-_165794190 0.44 ENST00000392701.8
ENST00000422973.1
polypeptide N-acetylgalactosaminyltransferase 3
chr12_+_55973913 0.42 ENST00000553116.5
RAB5B, member RAS oncogene family
chr2_+_200811882 0.42 ENST00000409600.6
basic leucine zipper and W2 domains 1
chr4_+_39698109 0.42 ENST00000510934.5
ENST00000261427.10
ubiquitin conjugating enzyme E2 K
chr15_+_72474305 0.40 ENST00000379887.9
ariadne RBR E3 ubiquitin protein ligase 1
chr1_-_70205531 0.38 ENST00000370952.4
leucine rich repeat containing 40
chr1_-_46604283 0.38 ENST00000341183.9
ENST00000649800.1
ENST00000650026.1
ENST00000650508.1
ENST00000496619.6
MAPK interacting serine/threonine kinase 1
chr1_+_86704564 0.38 ENST00000616170.4
ENST00000535010.5
ENST00000370558.8
SH3 domain containing GRB2 like, endophilin B1
chr20_-_31722533 0.36 ENST00000677194.1
ENST00000434194.2
ENST00000376062.6
BCL2 like 1
chr3_-_121749704 0.35 ENST00000393667.7
ENST00000340645.9
ENST00000614479.4
golgin B1
chr8_+_42391840 0.35 ENST00000520115.5
ENST00000522069.5
ENST00000522572.5
ENST00000022615.9
voltage dependent anion channel 3
chr16_-_74607088 0.35 ENST00000565260.1
ENST00000447066.6
ENST00000205061.9
ENST00000422840.7
ENST00000627032.2
golgi glycoprotein 1
chr1_-_39691393 0.33 ENST00000372844.8
hippocalcin like 4
chr13_+_40789548 0.31 ENST00000338625.9
solute carrier family 25 member 15
chr7_+_128739292 0.31 ENST00000535011.6
ENST00000542996.6
ENST00000249364.9
ENST00000449187.6
calumenin
chr2_-_70768175 0.30 ENST00000355733.7
ENST00000447731.6
ENST00000430656.5
ENST00000264436.9
ENST00000413157.6
adducin 2
chr17_-_1562630 0.29 ENST00000573231.1
ENST00000576722.5
ENST00000576761.5
ENST00000576010.6
ENST00000539476.5
ENST00000313486.12
phosphatidylinositol transfer protein alpha
chr11_+_108008880 0.29 ENST00000393094.7
cullin 5
chr5_+_146447304 0.29 ENST00000296702.9
ENST00000394421.7
ENST00000679501.2
transcription elongation regulator 1
chr6_+_13615322 0.29 ENST00000451315.7
nucleolar protein 7
chr3_-_69386079 0.29 ENST00000398540.8
FERM domain containing 4B
chr7_+_139359846 0.28 ENST00000619796.4
ENST00000354926.9
LUC7 like 2, pre-mRNA splicing factor
chr7_-_75738930 0.27 ENST00000336926.11
ENST00000434438.6
huntingtin interacting protein 1
chr1_+_28668746 0.27 ENST00000361872.8
ENST00000294409.2
ENST00000373816.6
glucocorticoid modulatory element binding protein 1
chr16_+_85613252 0.26 ENST00000253458.12
ENST00000393243.5
Gse1 coiled-coil protein
chr17_+_30477362 0.26 ENST00000225724.9
ENST00000451249.7
ENST00000467337.6
ENST00000581721.5
ENST00000414833.2
golgi SNAP receptor complex member 1
chr15_+_77420880 0.26 ENST00000336216.9
ENST00000558176.1
high mobility group 20A
chr16_+_7332839 0.24 ENST00000355637.9
RNA binding fox-1 homolog 1
chr7_+_107168961 0.21 ENST00000468410.5
ENST00000478930.5
ENST00000464009.1
ENST00000222574.9
HMG-box transcription factor 1
chr2_+_233354474 0.21 ENST00000264057.7
ENST00000427930.5
ENST00000442524.4
diacylglycerol kinase delta
chr15_+_68054308 0.19 ENST00000249636.11
protein inhibitor of activated STAT 1
chrX_+_108091752 0.17 ENST00000457035.5
ENST00000372232.8
autophagy related 4A cysteine peptidase
chr11_-_75351609 0.16 ENST00000420843.7
arrestin beta 1
chr3_+_126983035 0.16 ENST00000393409.3
plexin A1
chr11_-_86069043 0.15 ENST00000532317.5
ENST00000528256.1
ENST00000393346.8
ENST00000526033.5
phosphatidylinositol binding clathrin assembly protein
chr22_+_23180365 0.15 ENST00000359540.7
ENST00000305877.13
BCR activator of RhoGEF and GTPase
chr7_+_149239641 0.15 ENST00000335870.7
zinc finger protein 212
chr6_+_37170133 0.13 ENST00000373509.6
Pim-1 proto-oncogene, serine/threonine kinase
chr1_+_193121950 0.13 ENST00000367435.5
cell division cycle 73
chr17_-_58328756 0.13 ENST00000268893.10
ENST00000343736.9
TSPO associated protein 1
chr9_-_14314067 0.13 ENST00000397575.7
nuclear factor I B
chr9_-_125707177 0.12 ENST00000427078.5
ENST00000373496.3
ENST00000433483.1
ENST00000350766.7
ENST00000265960.8
ENST00000373503.7
ENST00000373511.6
ENST00000394060.7
ENST00000394063.5
MAPK associated protein 1
chr14_-_70416994 0.12 ENST00000621525.4
ENST00000256366.6
SYNJ2BP-COX16 readthrough
synaptojanin 2 binding protein
chr6_+_53794948 0.12 ENST00000370888.6
leucine rich repeat containing 1
chr3_-_122514876 0.11 ENST00000493510.1
ENST00000476916.5
ENST00000344337.11
ENST00000465882.5
karyopherin subunit alpha 1
chr1_-_84690406 0.09 ENST00000605755.5
ENST00000342203.8
ENST00000437941.6
SSX family member 2 interacting protein
chr14_+_75002903 0.08 ENST00000266126.10
eukaryotic translation initiation factor 2B subunit beta
chr19_+_50376447 0.08 ENST00000253727.10
ENST00000598168.5
ENST00000411902.6
ENST00000597790.5
ENST00000597130.5
ENST00000599105.5
nuclear receptor subfamily 1 group H member 2
chr4_+_52862308 0.05 ENST00000248706.5
RAS like family 11 member B
chr16_+_15949549 0.05 ENST00000399408.7
ENST00000572882.3
ENST00000677164.1
ATP binding cassette subfamily C member 1
chr17_+_59893046 0.05 ENST00000393021.7
ENST00000225577.9
ENST00000443572.6
ENST00000406116.7
ribosomal protein S6 kinase B1
chr3_+_11272413 0.05 ENST00000446450.6
ENST00000354956.9
ENST00000354449.7
ENST00000419112.5
autophagy related 7
chr13_+_26557659 0.05 ENST00000335327.6
ENST00000361042.8
ENST00000671038.1
WASP family member 3
chr9_-_107489754 0.04 ENST00000610832.1
ENST00000374672.5
Kruppel like factor 4
chr8_+_23528947 0.03 ENST00000519973.6
solute carrier family 25 member 37
chr21_-_37916440 0.03 ENST00000609713.2
potassium inwardly rectifying channel subfamily J member 6
chr12_-_116277677 0.03 ENST00000281928.9
mediator complex subunit 13L
chr8_+_86342539 0.03 ENST00000517970.6
WW domain containing E3 ubiquitin protein ligase 1
chr12_+_57772648 0.01 ENST00000333012.5
EEF1A lysine methyltransferase 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.6 3.3 GO:0010748 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.6 3.3 GO:2000470 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.5 1.5 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.5 1.4 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.4 1.2 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.4 2.7 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.4 1.1 GO:0060434 bronchus morphogenesis(GO:0060434)
0.3 5.2 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.3 2.3 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.3 1.7 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3 2.3 GO:0032328 alanine transport(GO:0032328)
0.3 0.9 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.3 4.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3 2.8 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.3 2.5 GO:0072718 response to cisplatin(GO:0072718)
0.2 5.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 1.2 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.2 3.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 0.7 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 0.6 GO:0090611 mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.2 0.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 0.8 GO:2001074 regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.2 1.0 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.2 1.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 1.1 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 1.8 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.6 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.4 GO:1903778 protein localization to vacuolar membrane(GO:1903778)
0.1 2.4 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 3.9 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 0.7 GO:0007296 vitellogenesis(GO:0007296)
0.1 1.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.4 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 3.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.3 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1 1.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.7 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 0.5 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.5 GO:0008295 spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295)
0.1 1.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.5 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 1.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.5 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 1.6 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.1 0.4 GO:0039526 suppression by virus of host apoptotic process(GO:0019050) modulation by virus of host apoptotic process(GO:0039526)
0.1 0.3 GO:0015853 adenine transport(GO:0015853)
0.1 1.1 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.5 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.0 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.4 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.1 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.0 0.2 GO:0051697 protein delipidation(GO:0051697)
0.0 0.7 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.8 GO:0001780 neutrophil homeostasis(GO:0001780)
0.0 0.2 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.3 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
0.0 0.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of respiratory burst(GO:0060268)
0.0 1.0 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.5 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.6 GO:0045820 negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198)
0.0 1.1 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 4.1 GO:0030516 regulation of axon extension(GO:0030516)
0.0 0.5 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.0 2.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.0 0.6 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 1.3 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.0 GO:0021762 substantia nigra development(GO:0021762)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.7 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.7 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.1 GO:0034635 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.0 0.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 1.4 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 7.0 GO:0006260 DNA replication(GO:0006260)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 2.0 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.5 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 1.4 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.0 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.0 4.9 GO:0043687 post-translational protein modification(GO:0043687)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.8 2.4 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.8 3.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.6 2.3 GO:0005899 insulin receptor complex(GO:0005899)
0.4 5.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 3.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 0.7 GO:0018444 translation release factor complex(GO:0018444)
0.2 2.7 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 4.6 GO:0042599 lamellar body(GO:0042599)
0.2 1.1 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.2 1.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 2.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 5.3 GO:0031143 pseudopodium(GO:0031143)
0.2 0.9 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 1.2 GO:0008278 cohesin complex(GO:0008278)
0.1 0.5 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 0.5 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 3.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 2.0 GO:0046930 pore complex(GO:0046930)
0.1 1.3 GO:0005883 neurofilament(GO:0005883)
0.1 2.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 2.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.6 GO:0090543 Flemming body(GO:0090543)
0.1 1.2 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 0.7 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.5 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 2.0 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 3.0 GO:0043195 terminal bouton(GO:0043195)
0.0 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 2.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.5 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.4 GO:0032433 filopodium tip(GO:0032433)
0.0 1.4 GO:0015030 Cajal body(GO:0015030)
0.0 2.3 GO:0005903 brush border(GO:0005903)
0.0 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0030686 90S preribosome(GO:0030686)
0.0 1.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 1.0 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 2.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 5.7 GO:0005874 microtubule(GO:0005874)
0.0 0.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.6 3.3 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.5 3.2 GO:0034046 poly(G) binding(GO:0034046)
0.4 1.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.3 1.0 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 1.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 2.0 GO:0015288 porin activity(GO:0015288)
0.2 0.7 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 5.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.2 1.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 5.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 5.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 2.7 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 2.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 2.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.7 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 1.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 2.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 3.4 GO:0019956 chemokine binding(GO:0019956)
0.1 2.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 3.0 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.5 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.0 0.6 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0 1.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.5 GO:0031386 protein tag(GO:0031386)
0.0 0.5 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 3.2 GO:0019905 syntaxin binding(GO:0019905)
0.0 3.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 1.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 3.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 8.0 GO:0045296 cadherin binding(GO:0045296)
0.0 1.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.0 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 3.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0019992 diacylglycerol kinase activity(GO:0004143) diacylglycerol binding(GO:0019992)
0.0 0.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 5.2 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 4.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 4.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.6 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.5 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.8 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.2 3.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 4.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.7 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 3.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 2.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 3.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 5.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 3.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 5.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 2.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 3.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.0 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling