Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GGAAUGU
Z-value: 6.99
Motif logo
miRNA associated with seed GGAAUGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-1-3p
|
MIMAT0000416 |
|
hsa-miR-206
|
MIMAT0000462 |
|
hsa-miR-613
|
MIMAT0003281 |
Activity profile of GGAAUGU motif
Sorted Z-values of GGAAUGU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GGAAUGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.6 | 77.8 | GO:0019322 | pentose biosynthetic process(GO:0019322) |
| 8.4 | 25.3 | GO:1902269 | positive regulation of polyamine transmembrane transport(GO:1902269) |
| 6.5 | 32.5 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 6.2 | 18.6 | GO:0002368 | B cell cytokine production(GO:0002368) |
| 5.4 | 21.6 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 5.1 | 25.4 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 5.0 | 15.1 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 4.6 | 18.4 | GO:0072526 | pyridine-containing compound catabolic process(GO:0072526) |
| 4.4 | 26.6 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 4.2 | 16.6 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) negative regulation of glial cell migration(GO:1903976) |
| 4.0 | 16.1 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 3.9 | 15.4 | GO:0097327 | response to antineoplastic agent(GO:0097327) |
| 3.7 | 14.8 | GO:0072369 | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) |
| 3.5 | 10.6 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 3.5 | 24.8 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 3.4 | 10.3 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
| 3.4 | 13.4 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) asymmetric Golgi ribbon formation(GO:0090164) |
| 3.3 | 43.2 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 3.2 | 42.1 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 3.1 | 12.6 | GO:0016333 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 3.1 | 12.5 | GO:1901873 | regulation of post-translational protein modification(GO:1901873) |
| 3.0 | 15.0 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 3.0 | 3.0 | GO:0072190 | ureter urothelium development(GO:0072190) ureter morphogenesis(GO:0072197) |
| 2.9 | 11.6 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 2.7 | 19.1 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 2.6 | 15.8 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 2.4 | 16.8 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 2.2 | 13.5 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 2.2 | 8.8 | GO:0030047 | actin modification(GO:0030047) |
| 2.2 | 6.6 | GO:0034729 | histone H3-K79 methylation(GO:0034729) |
| 2.2 | 12.9 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 2.1 | 6.3 | GO:1901804 | beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457) |
| 2.1 | 14.7 | GO:0032328 | alanine transport(GO:0032328) |
| 2.1 | 16.7 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 2.0 | 6.1 | GO:2000687 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 2.0 | 28.0 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 2.0 | 5.9 | GO:0060382 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 1.9 | 5.7 | GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity(GO:0090176) |
| 1.9 | 7.5 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
| 1.9 | 5.6 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
| 1.7 | 12.1 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 1.6 | 4.8 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 1.6 | 28.3 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 1.5 | 24.8 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 1.5 | 6.1 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 1.5 | 16.7 | GO:0051451 | myoblast migration(GO:0051451) |
| 1.5 | 13.5 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 1.5 | 28.4 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 1.5 | 11.8 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 1.4 | 11.2 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 1.4 | 1.4 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 1.4 | 10.9 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 1.4 | 12.3 | GO:1904798 | positive regulation of core promoter binding(GO:1904798) |
| 1.3 | 7.9 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 1.3 | 18.2 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 1.3 | 6.4 | GO:0097501 | detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501) |
| 1.3 | 12.5 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 1.2 | 13.7 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 1.2 | 12.1 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 1.2 | 9.6 | GO:0045176 | apical protein localization(GO:0045176) |
| 1.2 | 3.6 | GO:1990519 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 1.2 | 7.0 | GO:0097052 | L-kynurenine metabolic process(GO:0097052) |
| 1.2 | 5.8 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 1.1 | 3.4 | GO:0021897 | forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897) |
| 1.1 | 13.5 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 1.1 | 13.4 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 1.1 | 14.9 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 1.0 | 6.3 | GO:0098795 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795) |
| 1.0 | 20.8 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 1.0 | 3.1 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 1.0 | 9.1 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 1.0 | 8.9 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
| 1.0 | 14.6 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.9 | 7.1 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.9 | 2.7 | GO:0010752 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752) |
| 0.9 | 3.5 | GO:0018201 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201) |
| 0.8 | 23.6 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.8 | 3.3 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.8 | 10.8 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.8 | 5.6 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.8 | 7.9 | GO:0035437 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.8 | 4.7 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.8 | 10.9 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.8 | 25.5 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.8 | 5.3 | GO:0015677 | copper ion import(GO:0015677) cellular response to cisplatin(GO:0072719) |
| 0.8 | 2.3 | GO:1900110 | negative regulation of histone H3-K9 dimethylation(GO:1900110) |
| 0.7 | 5.9 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.7 | 8.1 | GO:0033327 | Leydig cell differentiation(GO:0033327) response to UV-A(GO:0070141) |
| 0.7 | 2.2 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
| 0.7 | 22.6 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.7 | 4.2 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669) |
| 0.7 | 12.6 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.7 | 4.2 | GO:0051036 | regulation of endosome size(GO:0051036) |
| 0.7 | 26.9 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 0.7 | 21.1 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.7 | 10.0 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.6 | 15.4 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.6 | 3.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.6 | 2.9 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.6 | 5.7 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.5 | 6.0 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.5 | 13.8 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.5 | 3.7 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
| 0.5 | 6.8 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.5 | 4.0 | GO:1901299 | negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299) |
| 0.5 | 6.5 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
| 0.5 | 12.6 | GO:1903432 | regulation of TORC1 signaling(GO:1903432) |
| 0.5 | 1.4 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.5 | 1.0 | GO:2001166 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.5 | 21.8 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.5 | 3.2 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.4 | 1.3 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) |
| 0.4 | 16.0 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.4 | 5.1 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.4 | 3.9 | GO:0015886 | heme transport(GO:0015886) |
| 0.4 | 10.6 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.4 | 2.1 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.4 | 3.7 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.4 | 1.2 | GO:0038190 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
| 0.4 | 8.6 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.4 | 3.5 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.4 | 2.3 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.4 | 8.1 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.4 | 19.0 | GO:0007566 | embryo implantation(GO:0007566) |
| 0.3 | 2.4 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.3 | 3.4 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.3 | 9.3 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.3 | 10.6 | GO:0006337 | nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) |
| 0.3 | 5.4 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.3 | 1.0 | GO:0060335 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.3 | 19.2 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.3 | 17.0 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.3 | 2.2 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.3 | 23.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.3 | 1.2 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
| 0.3 | 14.4 | GO:0043486 | histone exchange(GO:0043486) |
| 0.3 | 18.4 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.3 | 1.6 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.2 | 0.7 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.2 | 18.4 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.2 | 1.7 | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport(GO:0090481) |
| 0.2 | 20.2 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.2 | 0.7 | GO:0036446 | myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760) negative regulation of vascular smooth muscle cell differentiation(GO:1905064) |
| 0.2 | 14.5 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.2 | 9.0 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.2 | 10.9 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.2 | 8.8 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.2 | 0.6 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.2 | 6.7 | GO:0042953 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.2 | 9.9 | GO:0019835 | cytolysis(GO:0019835) |
| 0.2 | 6.5 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.2 | 2.5 | GO:0043622 | cortical microtubule organization(GO:0043622) negative regulation of p38MAPK cascade(GO:1903753) |
| 0.2 | 3.0 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.2 | 16.3 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.2 | 1.4 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.2 | 7.6 | GO:0046949 | fatty-acyl-CoA biosynthetic process(GO:0046949) |
| 0.2 | 1.3 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.2 | 6.7 | GO:0032757 | positive regulation of interleukin-8 production(GO:0032757) |
| 0.2 | 3.0 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.1 | 0.6 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.1 | 2.3 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 0.1 | 6.9 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.1 | 5.1 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.1 | 4.7 | GO:0045920 | negative regulation of exocytosis(GO:0045920) |
| 0.1 | 6.0 | GO:0046326 | positive regulation of glucose import(GO:0046326) |
| 0.1 | 20.2 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.1 | 8.3 | GO:0071806 | protein transmembrane transport(GO:0071806) |
| 0.1 | 7.9 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.1 | 0.8 | GO:1900045 | negative regulation of histone ubiquitination(GO:0033183) histone H2A K63-linked ubiquitination(GO:0070535) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.1 | 4.9 | GO:0033260 | nuclear DNA replication(GO:0033260) |
| 0.1 | 14.4 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.1 | 3.5 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.1 | 6.8 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.1 | 6.9 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.1 | 0.9 | GO:0060033 | anatomical structure regression(GO:0060033) |
| 0.1 | 10.5 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.1 | 2.0 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 6.3 | GO:0008652 | cellular amino acid biosynthetic process(GO:0008652) |
| 0.0 | 9.5 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 0.6 | GO:0070828 | heterochromatin organization(GO:0070828) |
| 0.0 | 1.0 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 1.5 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 0.0 | 0.2 | GO:0006591 | ornithine metabolic process(GO:0006591) |
| 0.0 | 0.2 | GO:0061739 | protein lipidation involved in autophagosome assembly(GO:0061739) |
| 0.0 | 0.2 | GO:0044800 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.0 | 8.7 | GO:0009416 | response to light stimulus(GO:0009416) |
| 0.0 | 4.1 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.0 | 7.5 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.0 | 0.8 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 1.3 | GO:0051289 | protein homotetramerization(GO:0051289) |
| 0.0 | 0.4 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.6 | GO:0014037 | Schwann cell differentiation(GO:0014037) |
| 0.0 | 1.0 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.0 | 1.5 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 0.0 | 0.3 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 2.4 | GO:0006413 | translational initiation(GO:0006413) |
| 0.0 | 0.8 | GO:0021766 | hippocampus development(GO:0021766) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 25.4 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 2.7 | 13.6 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 2.6 | 18.2 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 2.5 | 12.6 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 2.5 | 37.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 2.4 | 26.0 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 2.2 | 6.6 | GO:0055087 | Ski complex(GO:0055087) |
| 2.2 | 21.6 | GO:0071439 | clathrin complex(GO:0071439) |
| 2.1 | 12.6 | GO:1990131 | EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 2.1 | 25.0 | GO:0071203 | WASH complex(GO:0071203) |
| 2.1 | 18.6 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) lipopolysaccharide receptor complex(GO:0046696) |
| 2.0 | 11.8 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 1.9 | 9.6 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 1.7 | 28.0 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 1.7 | 17.4 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 1.7 | 12.1 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 1.6 | 26.2 | GO:0016600 | flotillin complex(GO:0016600) |
| 1.6 | 14.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 1.6 | 10.9 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 1.2 | 6.1 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 1.1 | 10.2 | GO:0097443 | sorting endosome(GO:0097443) |
| 1.1 | 15.9 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 1.1 | 2.1 | GO:1903349 | omegasome membrane(GO:1903349) |
| 1.0 | 3.1 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 1.0 | 7.9 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 1.0 | 8.6 | GO:0001739 | sex chromatin(GO:0001739) |
| 1.0 | 5.7 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.9 | 16.9 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.9 | 16.8 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.9 | 4.6 | GO:0033503 | HULC complex(GO:0033503) |
| 0.9 | 17.9 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.8 | 6.5 | GO:0030891 | VCB complex(GO:0030891) |
| 0.8 | 12.5 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.8 | 14.4 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.7 | 5.8 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.7 | 15.1 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.7 | 15.5 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.6 | 7.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.6 | 42.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.6 | 5.7 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.6 | 19.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.5 | 26.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.5 | 19.1 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.5 | 4.2 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.5 | 28.7 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.5 | 8.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.5 | 9.6 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.5 | 9.1 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.5 | 33.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.4 | 32.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.4 | 3.6 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.4 | 12.9 | GO:0016514 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.4 | 4.9 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.4 | 11.6 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.3 | 56.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 2.2 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.3 | 4.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.3 | 4.2 | GO:0033643 | host cell part(GO:0033643) |
| 0.3 | 107.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.3 | 3.0 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.3 | 14.0 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.3 | 1.4 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.3 | 24.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.2 | 26.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 2.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 5.9 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.2 | 10.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.2 | 6.7 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.2 | 3.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 10.0 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.2 | 7.3 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.2 | 5.8 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.2 | 17.9 | GO:0005903 | brush border(GO:0005903) |
| 0.2 | 4.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.2 | 2.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.2 | 3.0 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.2 | 2.5 | GO:0043219 | lateral loop(GO:0043219) |
| 0.2 | 97.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 13.2 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 6.4 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 30.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 4.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 12.4 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 10.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 16.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 22.8 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.1 | 14.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 2.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 3.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 8.2 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 6.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 4.7 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.1 | 6.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 7.9 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 6.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
| 0.0 | 7.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.0 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 76.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 3.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 11.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 0.2 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.6 | 25.8 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 6.4 | 25.8 | GO:0004802 | transketolase activity(GO:0004802) |
| 6.2 | 18.7 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 5.3 | 15.8 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 5.1 | 25.4 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 4.6 | 18.4 | GO:0002060 | purine nucleobase binding(GO:0002060) |
| 3.6 | 18.2 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 3.6 | 25.3 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 3.5 | 24.8 | GO:0102345 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 3.4 | 10.1 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 3.2 | 19.4 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 3.2 | 9.6 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 3.1 | 9.3 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 3.0 | 12.1 | GO:0004420 | hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282) |
| 3.0 | 9.1 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 2.8 | 11.2 | GO:0043273 | CTPase activity(GO:0043273) |
| 2.7 | 13.5 | GO:0004082 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 2.6 | 7.9 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 2.5 | 14.9 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 2.4 | 16.6 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 2.3 | 7.0 | GO:0047315 | kynurenine-glyoxylate transaminase activity(GO:0047315) |
| 2.2 | 10.9 | GO:0047280 | nicotinamide phosphoribosyltransferase activity(GO:0047280) |
| 2.1 | 6.3 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 2.0 | 27.8 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 2.0 | 21.6 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 1.9 | 7.6 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 1.8 | 12.5 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 1.8 | 7.1 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 1.7 | 26.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 1.7 | 23.2 | GO:0046790 | virion binding(GO:0046790) |
| 1.6 | 6.3 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 1.5 | 11.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 1.5 | 16.1 | GO:0004673 | protein histidine kinase activity(GO:0004673) |
| 1.5 | 4.4 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 1.5 | 20.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 1.4 | 5.6 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 1.4 | 8.3 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 1.4 | 20.6 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 1.4 | 10.9 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 1.2 | 3.6 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 1.1 | 16.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 1.0 | 12.6 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 1.0 | 3.0 | GO:0050146 | nucleoside phosphotransferase activity(GO:0050146) |
| 1.0 | 13.1 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.9 | 36.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.9 | 20.2 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.9 | 3.5 | GO:0019107 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 0.9 | 18.8 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.8 | 22.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.8 | 3.3 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.8 | 21.1 | GO:0046961 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.8 | 4.7 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.7 | 24.9 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.7 | 5.6 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.7 | 16.1 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.6 | 17.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.6 | 8.1 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.6 | 5.8 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.6 | 6.2 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.5 | 35.5 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.5 | 2.7 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.5 | 1.6 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.5 | 11.0 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.5 | 43.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.5 | 23.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.5 | 3.1 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.5 | 21.9 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 0.5 | 19.7 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.5 | 11.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.5 | 3.9 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.5 | 1.4 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.5 | 5.4 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.4 | 19.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.4 | 5.3 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.4 | 7.9 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.4 | 13.5 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.4 | 22.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.4 | 6.1 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.4 | 15.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.4 | 16.3 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.4 | 8.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.4 | 1.6 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.4 | 4.2 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.4 | 5.0 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.4 | 7.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.4 | 5.7 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.4 | 23.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.4 | 6.5 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.4 | 1.4 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.4 | 6.4 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.3 | 5.8 | GO:0005522 | profilin binding(GO:0005522) |
| 0.3 | 6.0 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.3 | 12.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.3 | 2.4 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.3 | 9.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.3 | 4.7 | GO:0019966 | interleukin-1 binding(GO:0019966) |
| 0.3 | 9.5 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.3 | 4.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.3 | 14.4 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.3 | 25.0 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.2 | 3.0 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.2 | 3.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 10.4 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.2 | 1.3 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.2 | 3.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 4.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 1.7 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.2 | 12.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 9.3 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.2 | 36.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 2.2 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.2 | 2.9 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.2 | 14.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 16.7 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.2 | 3.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 4.8 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.2 | 4.6 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.1 | 11.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 3.7 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.1 | 49.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 17.0 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.1 | 10.6 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 23.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 11.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 5.1 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 2.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 14.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.7 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 8.3 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.1 | 10.4 | GO:0020037 | heme binding(GO:0020037) |
| 0.1 | 0.4 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 1.5 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 1.1 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 8.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 5.3 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 12.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 5.5 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.7 | GO:0031702 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 2.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.6 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 2.8 | GO:0008375 | acetylglucosaminyltransferase activity(GO:0008375) |
| 0.0 | 4.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 2.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.2 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 1.1 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 26.5 | GO:0003723 | RNA binding(GO:0003723) |
| 0.0 | 0.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 34.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 1.0 | 40.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.8 | 39.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.8 | 15.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.7 | 32.1 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.5 | 18.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.5 | 28.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.5 | 27.1 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.4 | 5.8 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.4 | 26.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 18.2 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.4 | 13.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 24.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 24.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 10.0 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.3 | 36.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 3.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 10.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 42.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 4.2 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 4.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 3.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 19.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 17.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 7.5 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 6.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 9.3 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 9.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 17.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 4.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 4.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 2.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.2 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.0 | 0.3 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 24.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 1.7 | 67.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.4 | 21.4 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 1.4 | 27.0 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 1.4 | 18.3 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 1.1 | 23.0 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 1.1 | 28.4 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.9 | 19.6 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.9 | 26.0 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.7 | 1.5 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.7 | 7.5 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.7 | 21.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.6 | 29.4 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.5 | 11.4 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.5 | 16.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.5 | 3.5 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.5 | 17.4 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.5 | 6.8 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.5 | 11.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.5 | 10.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.4 | 17.0 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.4 | 3.4 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.4 | 24.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.4 | 20.9 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.4 | 15.0 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.4 | 11.6 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.4 | 11.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.4 | 8.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.4 | 10.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.4 | 5.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.3 | 25.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.3 | 16.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.3 | 34.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 12.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 14.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.3 | 9.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 13.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 11.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 14.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 54.4 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.2 | 4.6 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 4.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 2.8 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 18.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 11.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 6.3 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.1 | 29.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 24.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.0 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.4 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 4.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 7.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 10.6 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 12.7 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 4.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 5.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 0.2 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 0.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.7 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 4.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.4 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |