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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GGAGUGU

Z-value: 1.59

Motif logo

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miRNA associated with seed GGAGUGU

NamemiRBASE accession
hsa-miR-122-5p
MIMAT0000421

Activity profile of GGAGUGU motif

Sorted Z-values of GGAGUGU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GGAGUGU

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_163437569 3.03 ENST00000512163.5
ENST00000393929.5
ENST00000510097.5
ENST00000340828.7
ENST00000511490.4
ENST00000510664.5
CCNG1
cyclin G1
chr19_-_2456924 2.62 ENST00000325327.4
LMNB2
lamin B2
chr10_-_73096850 2.29 ENST00000307116.6
ENST00000373008.6
ENST00000394890.7
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr17_+_47531052 1.79 ENST00000532729.6
ENST00000322157.9
NPEPPS
aminopeptidase puromycin sensitive
chr8_-_29350666 1.65 ENST00000240100.7
DUSP4
dual specificity phosphatase 4
chr7_+_94656325 1.55 ENST00000482108.1
ENST00000488574.5
ENST00000612748.1
ENST00000613043.1
PEG10
paternally expressed 10
chr1_-_244864560 1.42 ENST00000444376.7
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr12_-_56300358 1.40 ENST00000550655.5
ENST00000548567.5
ENST00000551430.6
CS
citrate synthase
chr5_+_179698906 1.27 ENST00000452673.6
ENST00000680614.1
ENST00000680812.1
ENST00000681265.1
ENST00000680894.1
ENST00000681894.1
ENST00000679642.1
ENST00000680827.1
ENST00000680984.1
ENST00000680042.1
ENST00000681476.1
ENST00000681072.1
ENST00000247461.9
ENST00000502673.6
ENST00000513246.6
ENST00000680618.1
ENST00000680092.1
ENST00000506654.6
CANX
calnexin
chr14_+_22871732 1.15 ENST00000359591.9
LRP10
LDL receptor related protein 10
chr11_+_112025367 1.04 ENST00000679614.1
ENST00000679878.1
ENST00000280346.11
ENST00000681339.1
ENST00000681328.1
ENST00000681316.1
ENST00000531306.2
ENST00000680331.1
ENST00000393051.5
DLAT
dihydrolipoamide S-acetyltransferase
chr20_+_33993646 0.90 ENST00000375114.7
ENST00000448364.5
RALY
RALY heterogeneous nuclear ribonucleoprotein
chr13_-_98577131 0.84 ENST00000397517.6
STK24
serine/threonine kinase 24
chr4_-_75673112 0.81 ENST00000395719.7
ENST00000677489.1
G3BP2
G3BP stress granule assembly factor 2
chr19_-_8308287 0.78 ENST00000537716.6
ENST00000301458.10
CD320
CD320 molecule
chr8_+_144358557 0.73 ENST00000530047.5
ENST00000527078.6
ENST00000674870.1
ENST00000526338.7
ENST00000402965.5
ENST00000329994.7
ENST00000526752.3
ENST00000533662.2
ENST00000534725.6
ENST00000674929.1
ENST00000675597.1
ENST00000643944.2
ENST00000675121.1
SLC52A2
solute carrier family 52 member 2
chr1_+_24745396 0.67 ENST00000374379.9
CLIC4
chloride intracellular channel 4
chr1_+_35883189 0.66 ENST00000674304.1
ENST00000373204.6
ENST00000674426.1
AGO1
argonaute RISC component 1
chr1_-_244451896 0.66 ENST00000366535.4
ADSS2
adenylosuccinate synthase 2
chr2_-_86563382 0.65 ENST00000263856.9
CHMP3
charged multivesicular body protein 3
chr8_-_116874746 0.55 ENST00000297338.7
RAD21
RAD21 cohesin complex component
chr14_-_103057509 0.50 ENST00000361246.7
CDC42BPB
CDC42 binding protein kinase beta
chr17_-_4366616 0.50 ENST00000572484.5
ENST00000396981.7
UBE2G1
ubiquitin conjugating enzyme E2 G1
chr16_+_30065753 0.48 ENST00000642816.3
ENST00000643777.4
ENST00000569798.5
ALDOA
aldolase, fructose-bisphosphate A
chr19_-_46788586 0.43 ENST00000542575.6
SLC1A5
solute carrier family 1 member 5
chr10_-_22714531 0.42 ENST00000376573.9
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
chr22_+_37805218 0.40 ENST00000340857.4
H1-0
H1.0 linker histone
chr12_+_50085325 0.36 ENST00000551966.5
ENST00000550477.5
ENST00000394963.9
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr5_-_142012973 0.35 ENST00000503794.5
ENST00000510194.5
ENST00000504424.1
ENST00000513454.5
ENST00000311337.11
ENST00000503229.5
ENST00000500692.6
ENST00000504139.5
ENST00000505689.5
GNPDA1
glucosamine-6-phosphate deaminase 1
chr10_-_32056376 0.28 ENST00000302418.5
KIF5B
kinesin family member 5B
chr8_-_56211257 0.24 ENST00000316981.8
ENST00000423799.6
ENST00000429357.2
PLAG1
PLAG1 zinc finger
chr6_+_151690492 0.16 ENST00000404742.5
ENST00000440973.5
ESR1
estrogen receptor 1
chr6_-_46015812 0.14 ENST00000544153.3
ENST00000339561.12
CLIC5
chloride intracellular channel 5
chr1_-_208244375 0.12 ENST00000367033.4
PLXNA2
plexin A2
chr19_-_48811012 0.12 ENST00000545387.6
ENST00000402551.5
ENST00000598162.5
ENST00000316273.11
ENST00000599246.5
BCAT2
branched chain amino acid transaminase 2
chr16_+_69565958 0.11 ENST00000349945.7
ENST00000354436.6
NFAT5
nuclear factor of activated T cells 5
chr10_-_59906509 0.11 ENST00000263102.7
CCDC6
coiled-coil domain containing 6
chr3_-_187291680 0.09 ENST00000425937.1
ENST00000337774.10
ENST00000296280.11
MASP1
mannan binding lectin serine peptidase 1
chr16_-_30370396 0.08 ENST00000409939.8
TBC1D10B
TBC1 domain family member 10B
chr16_-_31065011 0.05 ENST00000539836.3
ENST00000535577.5
ENST00000442862.2
ZNF668
zinc finger protein 668
chr8_-_67343768 0.05 ENST00000262215.8
ARFGEF1
ADP ribosylation factor guanine nucleotide exchange factor 1
chr19_+_46601296 0.02 ENST00000598871.5
ENST00000291295.14
ENST00000594523.5
CALM3
calmodulin 3
chr5_+_126423363 0.01 ENST00000285689.8
GRAMD2B
GRAM domain containing 2B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.7 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 1.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.4 GO:1903803 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1 0.7 GO:0032218 riboflavin transport(GO:0032218)
0.1 1.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.5 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.1 0.4 GO:0006041 glucosamine metabolic process(GO:0006041)
0.1 1.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.6 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.1 1.0 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.7 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.8 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.8 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.3 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.4 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 1.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.9 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 1.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0006550 isoleucine catabolic process(GO:0006550)
0.0 3.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.4 GO:0060736 prostate gland growth(GO:0060736)
0.0 1.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.0 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.0 0.5 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.1 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 2.6 GO:0005638 lamin filament(GO:0005638)
0.2 1.0 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.5 GO:0000798 nuclear cohesin complex(GO:0000798)
0.1 1.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.7 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.6 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.4 1.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.3 1.0 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.2 1.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.7 GO:0032217 riboflavin transporter activity(GO:0032217)
0.1 0.8 GO:0015235 cobalamin transporter activity(GO:0015235)
0.1 0.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 1.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.4 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.6 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.7 GO:0035198 miRNA binding(GO:0035198)
0.0 0.8 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.7 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis