Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GGCAGUG
Z-value: 5.25
Motif logo
miRNA associated with seed GGCAGUG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-34a-5p
|
MIMAT0000255 |
|
hsa-miR-34c-5p
|
MIMAT0000686 |
|
hsa-miR-449a
|
MIMAT0001541 |
|
hsa-miR-449b-5p
|
MIMAT0003327 |
Activity profile of GGCAGUG motif
Sorted Z-values of GGCAGUG motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GGCAGUG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.4 | 25.3 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 5.6 | 28.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 4.6 | 13.7 | GO:0051946 | regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920) |
| 4.3 | 13.0 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 3.2 | 13.0 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 2.8 | 8.5 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 2.7 | 13.3 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 2.6 | 10.5 | GO:0072660 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 2.6 | 7.9 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
| 2.3 | 7.0 | GO:0071206 | establishment of protein localization to juxtaparanode region of axon(GO:0071206) |
| 2.3 | 6.8 | GO:0097534 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 2.2 | 8.8 | GO:1903116 | positive regulation of actin filament-based movement(GO:1903116) positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
| 2.2 | 8.6 | GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 1.8 | 7.0 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 1.7 | 10.1 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 1.7 | 6.6 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 1.7 | 19.9 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 1.4 | 4.3 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) |
| 1.2 | 3.7 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 1.2 | 3.7 | GO:0072023 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
| 1.2 | 13.4 | GO:0071205 | protein localization to juxtaparanode region of axon(GO:0071205) |
| 1.1 | 3.3 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 1.0 | 8.3 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 1.0 | 2.9 | GO:2001151 | regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153) |
| 1.0 | 7.6 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.9 | 7.0 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.9 | 3.5 | GO:1904980 | positive regulation of endosome organization(GO:1904980) |
| 0.8 | 6.7 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.8 | 8.0 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.8 | 5.5 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.7 | 2.2 | GO:0051939 | gamma-aminobutyric acid import(GO:0051939) |
| 0.7 | 5.7 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.7 | 2.8 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.7 | 7.6 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.7 | 3.5 | GO:0046167 | glycerol-3-phosphate biosynthetic process(GO:0046167) |
| 0.7 | 2.0 | GO:0034499 | late endosome to Golgi transport(GO:0034499) |
| 0.7 | 1.3 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.6 | 31.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.6 | 3.2 | GO:0032849 | positive regulation of cellular pH reduction(GO:0032849) |
| 0.6 | 3.0 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.6 | 3.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.6 | 8.7 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.5 | 4.0 | GO:0070054 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054) mRNA endonucleolytic cleavage involved in unfolded protein response(GO:0070055) |
| 0.5 | 10.1 | GO:0021978 | telencephalon regionalization(GO:0021978) |
| 0.5 | 3.8 | GO:0045023 | G0 to G1 transition(GO:0045023) |
| 0.5 | 9.0 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.5 | 2.4 | GO:0001555 | oocyte growth(GO:0001555) |
| 0.5 | 2.8 | GO:2000980 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.5 | 6.5 | GO:0021794 | thalamus development(GO:0021794) |
| 0.5 | 3.2 | GO:0045217 | cell-cell junction maintenance(GO:0045217) |
| 0.5 | 5.9 | GO:0042355 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.4 | 4.8 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.4 | 2.1 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 0.4 | 2.1 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 0.4 | 5.4 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.4 | 6.2 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.4 | 21.8 | GO:0043278 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.4 | 1.2 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.4 | 3.7 | GO:0048680 | positive regulation of axon regeneration(GO:0048680) |
| 0.4 | 3.8 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.4 | 4.1 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.4 | 4.9 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.4 | 1.1 | GO:1904017 | cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.4 | 1.8 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) sensory perception of sour taste(GO:0050915) |
| 0.4 | 6.3 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.3 | 6.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.3 | 2.3 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.3 | 3.3 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.3 | 3.8 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.3 | 5.0 | GO:0042711 | maternal behavior(GO:0042711) parental behavior(GO:0060746) |
| 0.3 | 1.6 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.3 | 3.1 | GO:0002934 | desmosome organization(GO:0002934) enamel mineralization(GO:0070166) |
| 0.3 | 4.0 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.3 | 4.2 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.3 | 12.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.3 | 4.5 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.3 | 0.8 | GO:1900114 | positive regulation of histone H3-K9 trimethylation(GO:1900114) |
| 0.3 | 6.3 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.3 | 4.3 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.2 | 6.9 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.2 | 2.2 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.2 | 0.7 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.2 | 7.6 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.2 | 1.5 | GO:0002371 | dendritic cell cytokine production(GO:0002371) |
| 0.2 | 4.3 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.2 | 6.4 | GO:0022011 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.2 | 7.6 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.2 | 4.2 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.2 | 1.0 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.2 | 9.0 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.2 | 2.6 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.2 | 0.6 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.2 | 7.5 | GO:0042036 | negative regulation of cytokine biosynthetic process(GO:0042036) |
| 0.2 | 2.6 | GO:0060836 | lymphatic endothelial cell differentiation(GO:0060836) |
| 0.2 | 2.2 | GO:0007379 | segment specification(GO:0007379) |
| 0.2 | 0.7 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.2 | 1.6 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.2 | 0.9 | GO:0097021 | positive regulation of neuron maturation(GO:0014042) Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.2 | 1.5 | GO:0044860 | protein localization to plasma membrane raft(GO:0044860) |
| 0.2 | 12.4 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.2 | 2.0 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 6.4 | GO:0046710 | GDP metabolic process(GO:0046710) |
| 0.1 | 2.8 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.1 | 10.1 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.1 | 1.6 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 1.1 | GO:0098903 | regulation of membrane repolarization during action potential(GO:0098903) |
| 0.1 | 0.7 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.1 | 0.4 | GO:0072276 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 0.1 | 1.1 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.1 | 7.1 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.1 | 0.5 | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 0.1 | 2.0 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 2.7 | GO:0035640 | exploration behavior(GO:0035640) |
| 0.1 | 0.7 | GO:0014050 | negative regulation of glutamate secretion(GO:0014050) |
| 0.1 | 0.6 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 2.2 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.1 | 0.8 | GO:0072656 | maintenance of protein location in mitochondrion(GO:0072656) |
| 0.1 | 3.3 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 0.3 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.1 | 1.0 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.1 | 1.3 | GO:0021873 | forebrain neuroblast division(GO:0021873) |
| 0.1 | 1.3 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 0.1 | 2.8 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.1 | 2.6 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.1 | 1.8 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.1 | 0.7 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.1 | 11.7 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.1 | 1.5 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.1 | 0.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 5.7 | GO:0006306 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.1 | 2.5 | GO:0070536 | response to ischemia(GO:0002931) protein K63-linked deubiquitination(GO:0070536) |
| 0.1 | 3.6 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 1.5 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
| 0.1 | 1.6 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 1.8 | GO:0043536 | positive regulation of blood vessel endothelial cell migration(GO:0043536) |
| 0.1 | 7.5 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 0.1 | 1.2 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 2.0 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.1 | 0.7 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) potassium ion import across plasma membrane(GO:1990573) |
| 0.1 | 10.2 | GO:0006661 | phosphatidylinositol biosynthetic process(GO:0006661) |
| 0.1 | 2.4 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.1 | 3.1 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.1 | 3.6 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 2.8 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 1.1 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 3.3 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.0 | 5.4 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 3.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.7 | GO:0099514 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 3.0 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.0 | 4.0 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.5 | GO:0050951 | sensory perception of temperature stimulus(GO:0050951) |
| 0.0 | 2.0 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 3.7 | GO:0007173 | epidermal growth factor receptor signaling pathway(GO:0007173) |
| 0.0 | 1.3 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.0 | 1.6 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.7 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 0.3 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.0 | 2.3 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 1.1 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 1.5 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.4 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 1.0 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 0.6 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 0.0 | 1.2 | GO:0098869 | cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748) |
| 0.0 | 0.0 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.0 | 3.0 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 1.5 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
| 0.0 | 0.2 | GO:1900078 | positive regulation of cellular response to insulin stimulus(GO:1900078) |
| 0.0 | 1.8 | GO:0016579 | protein deubiquitination(GO:0016579) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.1 | 36.6 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 5.1 | 25.3 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 3.4 | 13.7 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 2.5 | 10.1 | GO:0070695 | FHF complex(GO:0070695) |
| 2.2 | 13.3 | GO:0045298 | tubulin complex(GO:0045298) |
| 1.8 | 8.8 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 1.3 | 4.0 | GO:1990597 | AIP1-IRE1 complex(GO:1990597) |
| 1.2 | 19.9 | GO:0005883 | neurofilament(GO:0005883) |
| 1.1 | 8.6 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.9 | 4.3 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.8 | 14.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.8 | 13.4 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.7 | 4.3 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.7 | 15.0 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.6 | 3.7 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.6 | 2.8 | GO:0044308 | axonal spine(GO:0044308) |
| 0.5 | 2.7 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.5 | 3.2 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.5 | 3.1 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.5 | 1.5 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.4 | 2.6 | GO:0030430 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
| 0.4 | 2.2 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.4 | 5.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.4 | 6.4 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.4 | 7.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.4 | 7.0 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.3 | 5.6 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.3 | 4.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.3 | 10.8 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.3 | 2.5 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.2 | 2.4 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.2 | 15.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 2.4 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.2 | 11.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 12.3 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 9.5 | GO:0097546 | ciliary base(GO:0097546) |
| 0.2 | 2.0 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.2 | 7.3 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.2 | 3.8 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.2 | 8.6 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 5.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 1.5 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 1.6 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 3.5 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.1 | 6.6 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.1 | 6.8 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.1 | 1.8 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 2.1 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 1.3 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 2.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 0.7 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.1 | 7.3 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 2.0 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 3.8 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.7 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.1 | 8.4 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.1 | 13.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 16.3 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.1 | 1.3 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 7.6 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.1 | 3.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 0.7 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 2.0 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 9.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 0.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 1.5 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 25.2 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 1.1 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 3.4 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 3.0 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 6.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 0.8 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 4.6 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 0.6 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.6 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 2.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 3.8 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 1.5 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 25.3 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 3.4 | 13.7 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 3.3 | 13.3 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 2.1 | 8.5 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 2.0 | 8.1 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 1.9 | 5.8 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 1.3 | 38.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 1.1 | 14.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 1.1 | 7.6 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 1.1 | 3.2 | GO:0005011 | macrophage colony-stimulating factor receptor activity(GO:0005011) |
| 1.0 | 3.0 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.9 | 7.0 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.9 | 13.7 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.8 | 8.6 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.7 | 15.4 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.7 | 3.5 | GO:0004370 | glycerol kinase activity(GO:0004370) |
| 0.7 | 8.7 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.7 | 2.0 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.7 | 5.9 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.6 | 1.8 | GO:0052810 | 1-phosphatidylinositol-5-kinase activity(GO:0052810) |
| 0.6 | 3.7 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.5 | 3.3 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.5 | 7.9 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.5 | 3.6 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.5 | 6.5 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.5 | 4.2 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.5 | 1.8 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.4 | 7.6 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.4 | 3.8 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.4 | 4.3 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.4 | 23.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.4 | 1.5 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.4 | 1.1 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.4 | 2.9 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
| 0.4 | 6.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.3 | 8.8 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.3 | 8.1 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.3 | 6.2 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.3 | 0.8 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.3 | 12.9 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.3 | 2.2 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.3 | 7.6 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.3 | 5.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.3 | 4.1 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.3 | 1.5 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.3 | 1.0 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.3 | 1.3 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
| 0.2 | 26.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.2 | 1.6 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.2 | 2.0 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.2 | 1.1 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.2 | 3.1 | GO:0046790 | virion binding(GO:0046790) |
| 0.2 | 1.1 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.2 | 3.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 2.8 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.2 | 6.7 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 4.3 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.2 | 6.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 1.8 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.2 | 7.2 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.2 | 0.6 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.2 | 0.7 | GO:0070905 | serine binding(GO:0070905) |
| 0.2 | 3.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 12.3 | GO:0043621 | protein self-association(GO:0043621) |
| 0.2 | 2.1 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.2 | 2.0 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 4.8 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.2 | 2.1 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.2 | 5.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.2 | 4.4 | GO:0070001 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.2 | 1.6 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 6.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 0.7 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 5.7 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 2.6 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 2.4 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 1.6 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.1 | 19.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 2.9 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 2.7 | GO:0099604 | calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604) |
| 0.1 | 4.9 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.1 | 2.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 2.0 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.1 | 0.3 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 0.1 | 0.3 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.1 | 0.7 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 0.4 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.1 | 1.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 35.3 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.1 | 1.3 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 0.8 | GO:0019158 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.1 | 0.5 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 1.5 | GO:0010857 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857) |
| 0.1 | 2.3 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 2.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 12.3 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.1 | 0.7 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.1 | 2.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 0.6 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 4.0 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 2.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 11.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 18.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 2.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 4.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 1.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 2.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.3 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.0 | 4.5 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 5.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 3.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.7 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.6 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.0 | 0.5 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 3.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 3.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 1.4 | GO:0008565 | protein transporter activity(GO:0008565) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 17.6 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.5 | 8.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.5 | 10.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.4 | 25.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 8.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 9.2 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 9.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 6.7 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 7.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 3.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 3.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 3.7 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 2.8 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 3.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 3.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 1.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 3.2 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 0.7 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 3.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.9 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.7 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 0.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.4 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 2.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.0 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 0.3 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 2.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.1 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 61.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.7 | 14.4 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.6 | 21.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.5 | 22.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.4 | 17.2 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.3 | 5.7 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.3 | 11.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 14.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 3.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.2 | 1.6 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.2 | 3.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.2 | 8.1 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 7.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 4.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.2 | 4.6 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.2 | 3.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 4.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 6.3 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 2.9 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.1 | REACTOME ION CHANNEL TRANSPORT | Genes involved in Ion channel transport |
| 0.1 | 6.6 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 1.6 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 13.3 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 5.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.2 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 6.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 8.6 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 4.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 4.6 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 1.5 | REACTOME DAG AND IP3 SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.1 | 0.5 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.1 | 2.3 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 9.0 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 2.0 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 0.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 0.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.5 | REACTOME GAB1 SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.0 | 0.5 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 3.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 4.7 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 1.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.3 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.4 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 1.5 | REACTOME UNFOLDED PROTEIN RESPONSE | Genes involved in Unfolded Protein Response |