ISMARA results: GLIS2

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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GLIS2

Z-value: 3.65

Motif logo

Transcription factors associated with GLIS2

Gene Symbol	Gene ID	Gene Info
GLIS2 Ensembl NCBI GeneCards UniProt	ENSG00000126603.9	GLIS2

Activity profile of GLIS2 motif

Sorted Z-values of GLIS2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS2

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr5_-_132777215 Show fit	10.94	ENST00000458488.2	SEPTIN8 Ensembl NCBI GeneCards UniProt Show fit	septin 8
chr18_+_12948001 Show fit	10.73	ENST00000399892.7 ENST00000585730.5 ENST00000589446.5 ENST00000587761.1	SEH1L Ensembl NCBI GeneCards UniProt Show fit	SEH1 like nucleoporin
chrX_+_19355582 Show fit	10.58	ENST00000379804.1	PDHA1 Ensembl NCBI GeneCards UniProt Show fit	pyruvate dehydrogenase E1 subunit alpha 1
chr10_+_104254867 Show fit	10.50	ENST00000369713.10	GSTO1 Ensembl NCBI GeneCards UniProt Show fit	glutathione S-transferase omega 1
chrX_-_103064164 Show fit	10.48	ENST00000372728.4	BEX1 Ensembl NCBI GeneCards UniProt Show fit	brain expressed X-linked 1
chr14_+_99684283 Show fit	10.22	ENST00000261835.8	CYP46A1 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 46 subfamily A member 1
chr5_-_132777229 Show fit	10.20	ENST00000378721.8 ENST00000378719.7 ENST00000378701.5	SEPTIN8 Ensembl NCBI GeneCards UniProt Show fit	septin 8
chr7_-_73719629 Show fit	10.20	ENST00000395155.3 ENST00000395154.7 ENST00000395156.7 ENST00000222812.8	STX1A Ensembl NCBI GeneCards UniProt Show fit	syntaxin 1A
chr10_+_104254915 Show fit	10.15	ENST00000445155.5	GSTO1 Ensembl NCBI GeneCards UniProt Show fit	glutathione S-transferase omega 1
chr3_-_149086488 Show fit	9.92	ENST00000392912.6 ENST00000465259.5 ENST00000310053.10 ENST00000494055.5	HLTF Ensembl NCBI GeneCards UniProt Show fit	helicase like transcription factor
chr16_-_29899532 Show fit	9.77	ENST00000308713.9 ENST00000617533.5	SEZ6L2 Ensembl NCBI GeneCards UniProt Show fit	seizure related 6 homolog like 2
chr16_-_29899043 Show fit	9.62	ENST00000346932.9 ENST00000350527.7 ENST00000568380.1	SEZ6L2 Ensembl NCBI GeneCards UniProt Show fit	seizure related 6 homolog like 2
chr9_+_124869126 Show fit	9.26	ENST00000259477.6	ARPC5L Ensembl NCBI GeneCards UniProt Show fit	actin related protein 2/3 complex subunit 5 like
chr16_-_29899245 Show fit	8.62	ENST00000537485.5	SEZ6L2 Ensembl NCBI GeneCards UniProt Show fit	seizure related 6 homolog like 2
chr19_-_3061403 Show fit	8.44	ENST00000586839.1	TLE5 Ensembl NCBI GeneCards UniProt Show fit	TLE family member 5, transcriptional modulator
chr13_-_23433676 Show fit	8.01	ENST00000682547.1 ENST00000455470.6 ENST00000382292.9	SACS Ensembl NCBI GeneCards UniProt Show fit	sacsin molecular chaperone
chr6_+_44246166 Show fit	8.00	ENST00000620073.4	HSP90AB1 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein 90 alpha family class B member 1
chr12_-_120469571 Show fit	7.83	ENST00000550458.1	SRSF9 Ensembl NCBI GeneCards UniProt Show fit	serine and arginine rich splicing factor 9
chr13_+_42272134 Show fit	7.73	ENST00000025301.4	AKAP11 Ensembl NCBI GeneCards UniProt Show fit	A-kinase anchoring protein 11
chr19_+_35154914 Show fit	7.44	ENST00000423817.7	FXYD5 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 5
chr19_+_735026 Show fit	7.30	ENST00000592155.5 ENST00000590161.2	PALM Ensembl NCBI GeneCards UniProt Show fit	paralemmin
chr16_+_715092 Show fit	7.15	ENST00000568223.7	METRN Ensembl NCBI GeneCards UniProt Show fit	meteorin, glial cell differentiation regulator
chr5_-_1523900 Show fit	7.04	ENST00000283415.4	LPCAT1 Ensembl NCBI GeneCards UniProt Show fit	lysophosphatidylcholine acyltransferase 1
chr1_-_53945661 Show fit	7.04	ENST00000194214.10	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 11
chr19_+_35154715 Show fit	6.98	ENST00000392218.6 ENST00000543307.5 ENST00000392219.7 ENST00000541435.6 ENST00000590686.5 ENST00000342879.7 ENST00000588699.5	FXYD5 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 5
chr10_+_14838288 Show fit	6.91	ENST00000640019.3 ENST00000493178.1 ENST00000378372.8	ENSG00000284024.4 Ensembl NCBI GeneCards UniProt Show fit HSPA14 Ensembl NCBI GeneCards UniProt Show fit	novel protein heat shock protein family A (Hsp70) member 14
chr8_+_41490396 Show fit	6.89	ENST00000518270.5 ENST00000520817.5	GOLGA7 Ensembl NCBI GeneCards UniProt Show fit	golgin A7
chr2_-_55050376 Show fit	6.81	ENST00000402434.6	RTN4 Ensembl NCBI GeneCards UniProt Show fit	reticulon 4
chr20_+_46029165 Show fit	6.74	ENST00000616201.4 ENST00000616202.4 ENST00000616933.4 ENST00000626937.2	SLC12A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 5
chrX_+_103215072 Show fit	6.73	ENST00000372695.6 ENST00000372691.3	BEX4 Ensembl NCBI GeneCards UniProt Show fit	brain expressed X-linked 4
chr20_+_46029206 Show fit	6.41	ENST00000243964.7	SLC12A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 5
chrX_+_51893533 Show fit	6.33	ENST00000375722.5 ENST00000326587.12 ENST00000375695.2	MAGED1 Ensembl NCBI GeneCards UniProt Show fit	MAGE family member D1
chr4_-_169757873 Show fit	6.28	ENST00000393381.3	HPF1 Ensembl NCBI GeneCards UniProt Show fit	histone PARylation factor 1
chr2_-_55050442 Show fit	6.26	ENST00000337526.11	RTN4 Ensembl NCBI GeneCards UniProt Show fit	reticulon 4
chr10_-_133336862 Show fit	6.26	ENST00000368555.3 ENST00000252939.9 ENST00000368558.1	CALY Ensembl NCBI GeneCards UniProt Show fit	calcyon neuron specific vesicular protein
chr8_+_41490553 Show fit	6.23	ENST00000405786.2 ENST00000357743.9	GOLGA7 Ensembl NCBI GeneCards UniProt Show fit	golgin A7
chr5_-_177409535 Show fit	6.14	ENST00000253496.4	F12 Ensembl NCBI GeneCards UniProt Show fit	coagulation factor XII
chr2_-_55050556 Show fit	6.07	ENST00000394611.6	RTN4 Ensembl NCBI GeneCards UniProt Show fit	reticulon 4
chr8_-_102124253 Show fit	6.04	ENST00000524209.5 ENST00000517822.5 ENST00000523923.5 ENST00000521599.5 ENST00000521964.5 ENST00000311028.4 ENST00000518166.5	NCALD Ensembl NCBI GeneCards UniProt Show fit	neurocalcin delta
chr14_-_24146596 Show fit	6.01	ENST00000560410.5 ENST00000216802.10 ENST00000615264.4 ENST00000630027.1	PSME2 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 2
chr17_+_43006740 Show fit	5.97	ENST00000438323.2 ENST00000415816.7	IFI35 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein 35
chr15_+_42402375 Show fit	5.90	ENST00000397200.8 ENST00000569827.5	CAPN3 Ensembl NCBI GeneCards UniProt Show fit	calpain 3
chr12_+_121400102 Show fit	5.84	ENST00000392465.7 ENST00000554606.5 ENST00000392464.3 ENST00000555076.1	RNF34 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 34
chr12_+_121400041 Show fit	5.65	ENST00000361234.9 ENST00000613529.4	RNF34 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 34
chr2_-_55050518 Show fit	5.48	ENST00000317610.11 ENST00000357732.8	RTN4 Ensembl NCBI GeneCards UniProt Show fit	reticulon 4
chr16_+_30183595 Show fit	5.42	ENST00000219150.10 ENST00000570045.5 ENST00000565497.5 ENST00000570244.5	CORO1A Ensembl NCBI GeneCards UniProt Show fit	coronin 1A
chrX_+_119236274 Show fit	5.41	ENST00000217971.8	PGRMC1 Ensembl NCBI GeneCards UniProt Show fit	progesterone receptor membrane component 1
chr1_-_43172504 Show fit	5.34	ENST00000431635.6	EBNA1BP2 Ensembl NCBI GeneCards UniProt Show fit	EBNA1 binding protein 2
chr14_-_49852760 Show fit	5.33	ENST00000555970.5 ENST00000298310.10 ENST00000554626.5 ENST00000556672.1	NEMF Ensembl NCBI GeneCards UniProt Show fit	nuclear export mediator factor
chr5_-_132777866 Show fit	5.30	ENST00000448933.5	SEPTIN8 Ensembl NCBI GeneCards UniProt Show fit	septin 8
chrX_+_149540593 Show fit	5.24	ENST00000450602.6 ENST00000441248.5	EOLA1 Ensembl NCBI GeneCards UniProt Show fit	endothelium and lymphocyte associated ASCH domain 1
chrX_+_119236245 Show fit	5.22	ENST00000535419.2	PGRMC1 Ensembl NCBI GeneCards UniProt Show fit	progesterone receptor membrane component 1
chr1_-_21176836 Show fit	5.21	ENST00000634879.2 ENST00000400422.6 ENST00000602326.5 ENST00000411888.5 ENST00000438975.5 ENST00000374935.7	EIF4G3 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 4 gamma 3
chr5_-_132777404 Show fit	5.17	ENST00000296873.11	SEPTIN8 Ensembl NCBI GeneCards UniProt Show fit	septin 8
chr12_+_6536605 Show fit	5.16	ENST00000619601.1	GAPDH Ensembl NCBI GeneCards UniProt Show fit	glyceraldehyde-3-phosphate dehydrogenase
chr2_+_169799279 Show fit	5.07	ENST00000409333.1	SSB Ensembl NCBI GeneCards UniProt Show fit	small RNA binding exonuclease protection factor La
chr19_+_17747737 Show fit	5.04	ENST00000600676.5 ENST00000600209.5 ENST00000596309.5 ENST00000598539.5 ENST00000597474.5 ENST00000593385.5 ENST00000598067.5 ENST00000593833.5	FCHO1 Ensembl NCBI GeneCards UniProt Show fit	FCH and mu domain containing endocytic adaptor 1
chr20_+_54208072 Show fit	5.03	ENST00000371419.7	PFDN4 Ensembl NCBI GeneCards UniProt Show fit	prefoldin subunit 4
chr19_-_55280194 Show fit	4.94	ENST00000588971.1 ENST00000255631.9 ENST00000587551.1	HSPBP1 Ensembl NCBI GeneCards UniProt Show fit	HSPA (Hsp70) binding protein 1
chr6_-_43016856 Show fit	4.91	ENST00000645375.1 ENST00000645410.1	MEA1 Ensembl NCBI GeneCards UniProt Show fit	male-enhanced antigen 1
chr8_+_27325516 Show fit	4.82	ENST00000346049.10 ENST00000420218.3	PTK2B Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine kinase 2 beta
chr1_-_43172244 Show fit	4.80	ENST00000236051.3	EBNA1BP2 Ensembl NCBI GeneCards UniProt Show fit	EBNA1 binding protein 2
chr19_+_7348930 Show fit	4.80	ENST00000668164.2	ARHGEF18 Ensembl NCBI GeneCards UniProt Show fit	Rho/Rac guanine nucleotide exchange factor 18
chr8_-_54022441 Show fit	4.79	ENST00000396401.7 ENST00000521604.7 ENST00000640382.1 ENST00000640041.1	TCEA1 Ensembl NCBI GeneCards UniProt Show fit	transcription elongation factor A1
chr7_-_712940 Show fit	4.79	ENST00000544935.5 ENST00000430040.5 ENST00000456696.2 ENST00000406797.5	PRKAR1B Ensembl NCBI GeneCards UniProt Show fit	protein kinase cAMP-dependent type I regulatory subunit beta
chr11_-_796185 Show fit	4.77	ENST00000533385.5 ENST00000528936.5 ENST00000629634.2 ENST00000625752.2 ENST00000528606.5 ENST00000320230.9	SLC25A22 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 25 member 22
chr2_+_170929198 Show fit	4.76	ENST00000234160.5	GORASP2 Ensembl NCBI GeneCards UniProt Show fit	golgi reassembly stacking protein 2
chr6_+_68635273 Show fit	4.75	ENST00000370598.6	ADGRB3 Ensembl NCBI GeneCards UniProt Show fit	adhesion G protein-coupled receptor B3
chr8_-_103415085 Show fit	4.74	ENST00000297578.9	SLC25A32 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 25 member 32
chr1_+_2019324 Show fit	4.71	ENST00000638411.1 ENST00000378585.7 ENST00000640067.1	GABRD Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit delta
chr20_+_11890785 Show fit	4.71	ENST00000399006.6 ENST00000405977.5	BTBD3 Ensembl NCBI GeneCards UniProt Show fit	BTB domain containing 3
chr22_-_17773976 Show fit	4.67	ENST00000317361.11	BID Ensembl NCBI GeneCards UniProt Show fit	BH3 interacting domain death agonist
chr19_-_55280063 Show fit	4.64	ENST00000593263.5 ENST00000433386.7	HSPBP1 Ensembl NCBI GeneCards UniProt Show fit	HSPA (Hsp70) binding protein 1
chr17_-_42017142 Show fit	4.60	ENST00000589586.6 ENST00000674252.1 ENST00000426588.7 ENST00000589576.6 ENST00000590774.6 ENST00000674166.1	DNAJC7 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member C7
chr19_+_17747698 Show fit	4.58	ENST00000594202.5 ENST00000252771.11	FCHO1 Ensembl NCBI GeneCards UniProt Show fit	FCH and mu domain containing endocytic adaptor 1
chr6_+_44247087 Show fit	4.52	ENST00000353801.7 ENST00000371646.10	HSP90AB1 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein 90 alpha family class B member 1
chr19_+_48325323 Show fit	4.46	ENST00000596315.5	EMP3 Ensembl NCBI GeneCards UniProt Show fit	epithelial membrane protein 3
chr12_-_57547121 Show fit	4.42	ENST00000550954.5 ENST00000434715.7 ENST00000678505.1 ENST00000543672.6 ENST00000546670.5 ENST00000548249.6	DCTN2 Ensembl NCBI GeneCards UniProt Show fit	dynactin subunit 2
chr14_+_23306958 Show fit	4.36	ENST00000554635.1 ENST00000557008.2	BCL2L2 Ensembl NCBI GeneCards UniProt Show fit BCL2L2-PABPN1 Ensembl NCBI GeneCards UniProt Show fit	BCL2 like 2 BCL2L2-PABPN1 readthrough
chrX_+_71254781 Show fit	4.32	ENST00000677446.1	NONO Ensembl NCBI GeneCards UniProt Show fit	non-POU domain containing octamer binding
chr1_-_235128819 Show fit	4.26	ENST00000366607.5	TOMM20 Ensembl NCBI GeneCards UniProt Show fit	translocase of outer mitochondrial membrane 20
chr6_+_29656993 Show fit	4.25	ENST00000376888.6	MOG Ensembl NCBI GeneCards UniProt Show fit	myelin oligodendrocyte glycoprotein
chr12_-_57547224 Show fit	4.21	ENST00000678322.1	DCTN2 Ensembl NCBI GeneCards UniProt Show fit	dynactin subunit 2
chr2_-_33599269 Show fit	4.20	ENST00000431950.1 ENST00000403368.1 ENST00000238823.13	FAM98A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 98 member A
chr2_+_186486246 Show fit	4.19	ENST00000337859.11	ZC3H15 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing 15
chr1_-_53945584 Show fit	4.14	ENST00000371377.3	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 11
chr20_+_58651785 Show fit	4.08	ENST00000358029.8	STX16 Ensembl NCBI GeneCards UniProt Show fit	syntaxin 16
chr2_-_135876382 Show fit	4.07	ENST00000264156.3	MCM6 Ensembl NCBI GeneCards UniProt Show fit	minichromosome maintenance complex component 6
chr19_-_55279690 Show fit	4.07	ENST00000587959.1 ENST00000585927.1 ENST00000587922.5 ENST00000585698.1	HSPBP1 Ensembl NCBI GeneCards UniProt Show fit	HSPA (Hsp70) binding protein 1
chr1_-_53945567 Show fit	4.06	ENST00000371378.6	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 11
chr12_-_112418819 Show fit	4.04	ENST00000551291.6	RPL6 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L6
chr11_+_121576760 Show fit	4.02	ENST00000532694.5 ENST00000534286.5	SORL1 Ensembl NCBI GeneCards UniProt Show fit	sortilin related receptor 1
chr20_+_58651228 Show fit	3.96	ENST00000361830.7 ENST00000458280.5 ENST00000355957.9 ENST00000312283.12 ENST00000412911.5 ENST00000359617.8 ENST00000371141.8	STX16 Ensembl NCBI GeneCards UniProt Show fit	syntaxin 16
chr7_+_141551278 Show fit	3.90	ENST00000629555.2 ENST00000473247.5 ENST00000648690.1 ENST00000649286.2 ENST00000649914.1 ENST00000648395.1 ENST00000648068.1 ENST00000650547.1	AGK Ensembl NCBI GeneCards UniProt Show fit	acylglycerol kinase
chr22_-_17774412 Show fit	3.78	ENST00000342111.9 ENST00000622694.5	BID Ensembl NCBI GeneCards UniProt Show fit	BH3 interacting domain death agonist
chr5_-_892533 Show fit	3.77	ENST00000483173.5	BRD9 Ensembl NCBI GeneCards UniProt Show fit	bromodomain containing 9
chr19_+_9827886 Show fit	3.76	ENST00000358666.7 ENST00000590068.1 ENST00000593087.1 ENST00000586895.6	UBL5 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin like 5
chr19_-_18896081 Show fit	3.74	ENST00000429504.6 ENST00000623882.4 ENST00000247005.8	CERS1 Ensembl NCBI GeneCards UniProt Show fit GDF1 Ensembl NCBI GeneCards UniProt Show fit	ceramide synthase 1 growth differentiation factor 1
chr19_+_44914833 Show fit	3.74	ENST00000589078.1 ENST00000586638.5	APOC1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein C1
chr21_-_39183398 Show fit	3.67	ENST00000331573.8	PSMG1 Ensembl NCBI GeneCards UniProt Show fit	proteasome assembly chaperone 1
chr16_+_69424634 Show fit	3.66	ENST00000515314.6 ENST00000561792.6 ENST00000568237.1	CYB5B Ensembl NCBI GeneCards UniProt Show fit	cytochrome b5 type B
chr19_-_38617928 Show fit	3.66	ENST00000396857.7 ENST00000586296.5	MAP4K1 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase kinase 1
chr11_-_72642450 Show fit	3.64	ENST00000444035.6 ENST00000544570.5	PDE2A Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 2A
chr16_-_29923237 Show fit	3.61	ENST00000568995.1 ENST00000566413.1	KCTD13 Ensembl NCBI GeneCards UniProt Show fit	potassium channel tetramerization domain containing 13
chr6_+_29657120 Show fit	3.61	ENST00000396704.7 ENST00000416766.6 ENST00000483013.5 ENST00000490427.5 ENST00000376891.8 ENST00000376898.7 ENST00000396701.6 ENST00000494692.5 ENST00000431798.6	MOG Ensembl NCBI GeneCards UniProt Show fit	myelin oligodendrocyte glycoprotein
chr5_-_132777371 Show fit	3.60	ENST00000620483.4	SEPTIN8 Ensembl NCBI GeneCards UniProt Show fit	septin 8
chr6_-_99568611 Show fit	3.60	ENST00000369217.8 ENST00000369220.8 ENST00000482541.2 ENST00000520429.6 ENST00000523985.5 ENST00000518714.5	CCNC Ensembl NCBI GeneCards UniProt Show fit	cyclin C
chr20_-_54070520 Show fit	3.55	ENST00000371435.6 ENST00000395961.7	BCAS1 Ensembl NCBI GeneCards UniProt Show fit	brain enriched myelin associated protein 1
chr6_+_29657085 Show fit	3.50	ENST00000376917.8 ENST00000376894.8	MOG Ensembl NCBI GeneCards UniProt Show fit	myelin oligodendrocyte glycoprotein
chr11_-_72642407 Show fit	3.47	ENST00000376450.7	PDE2A Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 2A
chr14_-_24146314 Show fit	3.46	ENST00000559056.5	PSME2 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 2
chr16_-_21857418 Show fit	3.42	ENST00000415645.6	NPIPB4 Ensembl NCBI GeneCards UniProt Show fit	nuclear pore complex interacting protein family member B4
chr2_+_71130586 Show fit	3.40	ENST00000498451.2 ENST00000244230.7	MPHOSPH10 Ensembl NCBI GeneCards UniProt Show fit	M-phase phosphoprotein 10
chr1_+_2019379 Show fit	3.40	ENST00000638771.1 ENST00000640949.1 ENST00000640030.1	GABRD Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit delta
chr19_+_48321454 Show fit	3.34	ENST00000599704.5	EMP3 Ensembl NCBI GeneCards UniProt Show fit	epithelial membrane protein 3
chr19_+_10252206 Show fit	3.30	ENST00000253099.11 ENST00000393733.6 ENST00000588502.5	MRPL4 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L4
chr7_+_101154981 Show fit	3.30	ENST00000646560.1	AP1S1 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 1 subunit sigma 1
chr4_+_113292838 Show fit	3.26	ENST00000672411.1 ENST00000673231.1	ANK2 Ensembl NCBI GeneCards UniProt Show fit	ankyrin 2
chr1_-_23800402 Show fit	3.25	ENST00000374497.7 ENST00000425913.5	GALE Ensembl NCBI GeneCards UniProt Show fit	UDP-galactose-4-epimerase
chr19_-_38617912 Show fit	3.25	ENST00000591517.5	MAP4K1 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase kinase 1
chrX_+_12791353 Show fit	3.22	ENST00000380663.7 ENST00000398491.6 ENST00000380668.10 ENST00000489404.5	PRPS2 Ensembl NCBI GeneCards UniProt Show fit	phosphoribosyl pyrophosphate synthetase 2
chr6_+_43489579 Show fit	3.18	ENST00000438588.6	TJAP1 Ensembl NCBI GeneCards UniProt Show fit	tight junction associated protein 1
chr11_-_2992373 Show fit	3.16	ENST00000620138.4 ENST00000526115.5	NAP1L4 Ensembl NCBI GeneCards UniProt Show fit	nucleosome assembly protein 1 like 4
chr7_-_727242 Show fit	3.14	ENST00000537384.6 ENST00000417852.5	PRKAR1B Ensembl NCBI GeneCards UniProt Show fit	protein kinase cAMP-dependent type I regulatory subunit beta
chr4_+_113292925 Show fit	3.12	ENST00000673353.1 ENST00000505342.6 ENST00000672915.1 ENST00000509550.5	ANK2 Ensembl NCBI GeneCards UniProt Show fit	ankyrin 2
chr21_-_39183466 Show fit	3.12	ENST00000380900.2	PSMG1 Ensembl NCBI GeneCards UniProt Show fit	proteasome assembly chaperone 1
chrX_-_71255060 Show fit	3.11	ENST00000373988.5 ENST00000373998.5	ZMYM3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger MYM-type containing 3
chr3_-_177197210 Show fit	3.09	ENST00000431421.5 ENST00000422066.5 ENST00000413084.5 ENST00000673974.1 ENST00000422442.6	TBL1XR1 Ensembl NCBI GeneCards UniProt Show fit	TBL1X receptor 1
chr4_+_106316531 Show fit	3.08	ENST00000684504.1 ENST00000442366.6 ENST00000672337.1 ENST00000394701.6 ENST00000672341.1 ENST00000671868.1 ENST00000673123.1 ENST00000672328.1 ENST00000672911.1 ENST00000672285.1	AIMP1 Ensembl NCBI GeneCards UniProt Show fit	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
chr22_-_17774482 Show fit	3.06	ENST00000399765.5 ENST00000614949.4 ENST00000399767.6	BID Ensembl NCBI GeneCards UniProt Show fit	BH3 interacting domain death agonist
chr15_+_76931704 Show fit	2.99	ENST00000320963.9 ENST00000394885.8 ENST00000394883.3	RCN2 Ensembl NCBI GeneCards UniProt Show fit	reticulocalbin 2
chrX_-_63785149 Show fit	2.98	ENST00000671741.2 ENST00000625116.3 ENST00000624355.1	ARHGEF9 Ensembl NCBI GeneCards UniProt Show fit	Cdc42 guanine nucleotide exchange factor 9
chr3_+_54123452 Show fit	2.97	ENST00000620722.4 ENST00000490478.5	CACNA2D3 Ensembl NCBI GeneCards UniProt Show fit	calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr11_-_2992267 Show fit	2.90	ENST00000448187.5 ENST00000532325.6 ENST00000399614.6 ENST00000380542.9	NAP1L4 Ensembl NCBI GeneCards UniProt Show fit	nucleosome assembly protein 1 like 4
chr15_-_34343112 Show fit	2.83	ENST00000557912.1 ENST00000328848.6	NOP10 Ensembl NCBI GeneCards UniProt Show fit	NOP10 ribonucleoprotein
chr17_-_81514629 Show fit	2.79	ENST00000681052.1 ENST00000575659.6	ACTG1 Ensembl NCBI GeneCards UniProt Show fit	actin gamma 1
chr12_-_6606427 Show fit	2.76	ENST00000642879.1	CHD4 Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 4
chr11_+_87037820 Show fit	2.73	ENST00000340353.11	TMEM135 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 135
chr21_+_43741420 Show fit	2.70	ENST00000467908.1	PDXK Ensembl NCBI GeneCards UniProt Show fit	pyridoxal kinase
chr2_+_37344594 Show fit	2.69	ENST00000404976.5 ENST00000338415.8	QPCT Ensembl NCBI GeneCards UniProt Show fit	glutaminyl-peptide cyclotransferase
chr11_+_68684534 Show fit	2.69	ENST00000265643.4	GAL Ensembl NCBI GeneCards UniProt Show fit	galanin and GMAP prepropeptide
chr12_+_7155867 Show fit	2.66	ENST00000535313.2 ENST00000331148.5	CLSTN3 Ensembl NCBI GeneCards UniProt Show fit	calsyntenin 3
chr12_+_112418928 Show fit	2.62	ENST00000351677.7 ENST00000639857.1	PTPN11 Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase non-receptor type 11
chr6_-_152983031 Show fit	2.54	ENST00000229758.8	FBXO5 Ensembl NCBI GeneCards UniProt Show fit	F-box protein 5
chr3_+_180912656 Show fit	2.49	ENST00000357559.9 ENST00000491062.5 ENST00000468861.5 ENST00000445140.6 ENST00000484958.5	FXR1 Ensembl NCBI GeneCards UniProt Show fit	FMR1 autosomal homolog 1
chr3_+_158105819 Show fit	2.43	ENST00000480820.5	RSRC1 Ensembl NCBI GeneCards UniProt Show fit	arginine and serine rich coiled-coil 1
chr19_+_44905785 Show fit	2.43	ENST00000446996.5 ENST00000252486.9 ENST00000434152.5	APOE Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein E
chr3_+_173398438 Show fit	2.38	ENST00000457714.5	NLGN1 Ensembl NCBI GeneCards UniProt Show fit	neuroligin 1
chr19_-_42255119 Show fit	2.37	ENST00000222329.9 ENST00000594664.1	ERF Ensembl NCBI GeneCards UniProt Show fit ENSG00000268643.2 Ensembl NCBI GeneCards UniProt Show fit	ETS2 repressor factor novel protein
chr4_+_189940838 Show fit	2.33	ENST00000524583.5 ENST00000226798.9 ENST00000531991.6	FRG1 Ensembl NCBI GeneCards UniProt Show fit	FSHD region gene 1
chr18_+_11752041 Show fit	2.32	ENST00000423027.8	GNAL Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha L
chr17_+_6444441 Show fit	2.26	ENST00000250056.12 ENST00000571373.5 ENST00000570337.6 ENST00000572595.6 ENST00000572447.6 ENST00000576056.5	PIMREG Ensembl NCBI GeneCards UniProt Show fit	PICALM interacting mitotic regulator
chr1_-_42335869 Show fit	2.25	ENST00000372573.5	FOXJ3 Ensembl NCBI GeneCards UniProt Show fit	forkhead box J3
chr1_+_171557845 Show fit	2.25	ENST00000644916.1	PRRC2C Ensembl NCBI GeneCards UniProt Show fit	proline rich coiled-coil 2C
chr12_-_48957365 Show fit	2.24	ENST00000398092.4 ENST00000539611.1	ENSG00000272822.2 Ensembl NCBI GeneCards UniProt Show fit ARF3 Ensembl NCBI GeneCards UniProt Show fit	novel protein ADP ribosylation factor 3
chr3_+_38138478 Show fit	2.21	ENST00000396334.8 ENST00000417037.8 ENST00000652213.1 ENST00000650112.2 ENST00000651800.2 ENST00000421516.3 ENST00000650905.2	MYD88 Ensembl NCBI GeneCards UniProt Show fit	MYD88 innate immune signal transduction adaptor
chr22_-_31630805 Show fit	2.21	ENST00000266095.9	PISD Ensembl NCBI GeneCards UniProt Show fit	phosphatidylserine decarboxylase
chr19_+_44914247 Show fit	2.21	ENST00000588750.5 ENST00000588802.5	APOC1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein C1
chr19_+_44914588 Show fit	2.19	ENST00000592535.6	APOC1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein C1
chr11_-_414948 Show fit	2.19	ENST00000530494.1 ENST00000528209.5 ENST00000528058.1 ENST00000431843.7	SIGIRR Ensembl NCBI GeneCards UniProt Show fit	single Ig and TIR domain containing
chr1_-_31644866 Show fit	2.18	ENST00000373703.5	PEF1 Ensembl NCBI GeneCards UniProt Show fit	penta-EF-hand domain containing 1
chr3_-_18424533 Show fit	2.17	ENST00000417717.6	SATB1 Ensembl NCBI GeneCards UniProt Show fit	SATB homeobox 1
chr17_-_57988179 Show fit	2.14	ENST00000581208.2 ENST00000583932.1	VEZF1 Ensembl NCBI GeneCards UniProt Show fit	vascular endothelial zinc finger 1
chr15_-_42491105 Show fit	2.12	ENST00000565380.5 ENST00000564754.7	ZNF106 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 106
chr6_+_87590067 Show fit	2.10	ENST00000546266.5 ENST00000257789.4 ENST00000392844.8	ORC3 Ensembl NCBI GeneCards UniProt Show fit	origin recognition complex subunit 3
chr17_-_4967790 Show fit	2.09	ENST00000575142.5 ENST00000206020.8	SPAG7 Ensembl NCBI GeneCards UniProt Show fit	sperm associated antigen 7
chr1_-_160285120 Show fit	2.06	ENST00000368072.10	PEX19 Ensembl NCBI GeneCards UniProt Show fit	peroxisomal biogenesis factor 19
chr12_+_50057548 Show fit	2.03	ENST00000228468.8 ENST00000447966.7	ASIC1 Ensembl NCBI GeneCards UniProt Show fit	acid sensing ion channel subunit 1
chr12_-_6606320 Show fit	2.02	ENST00000642594.1 ENST00000644289.1 ENST00000645095.1	CHD4 Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 4
chr10_+_100987529 Show fit	2.00	ENST00000370228.2 ENST00000311916.8 ENST00000473656.5	TWNK Ensembl NCBI GeneCards UniProt Show fit	twinkle mtDNA helicase
chr7_+_120951116 Show fit	1.93	ENST00000431467.1	ING3 Ensembl NCBI GeneCards UniProt Show fit	inhibitor of growth family member 3
chr16_-_90008988 Show fit	1.90	ENST00000568662.2	DBNDD1 Ensembl NCBI GeneCards UniProt Show fit	dysbindin domain containing 1
chrX_+_71283577 Show fit	1.87	ENST00000420903.6 ENST00000373856.8 ENST00000678437.1 ENST00000678830.1 ENST00000677879.1 ENST00000373841.5 ENST00000276079.13 ENST00000676797.1 ENST00000678660.1 ENST00000678231.1 ENST00000677612.1 ENST00000413858.5 ENST00000450092.6	NONO Ensembl NCBI GeneCards UniProt Show fit	non-POU domain containing octamer binding
chr17_-_42979993 Show fit	1.84	ENST00000409103.5 ENST00000360221.8 ENST00000454303.1 ENST00000591916.7 ENST00000451885.3	PTGES3L-AARSD1 Ensembl NCBI GeneCards UniProt Show fit PTGES3L Ensembl NCBI GeneCards UniProt Show fit	PTGES3L-AARSD1 readthrough prostaglandin E synthase 3 like
chr3_+_4493340 Show fit	1.73	ENST00000357086.10 ENST00000354582.12 ENST00000649015.2 ENST00000467056.6	ITPR1 Ensembl NCBI GeneCards UniProt Show fit	inositol 1,4,5-trisphosphate receptor type 1
chr17_+_82056480 Show fit	1.73	ENST00000578168.1	GPS1 Ensembl NCBI GeneCards UniProt Show fit	G protein pathway suppressor 1
chr3_+_4493442 Show fit	1.65	ENST00000456211.8 ENST00000443694.5 ENST00000648266.1	ITPR1 Ensembl NCBI GeneCards UniProt Show fit	inositol 1,4,5-trisphosphate receptor type 1
chr16_+_85908988 Show fit	1.65	ENST00000566369.1	IRF8 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 8
chr1_-_64966488 Show fit	1.64	ENST00000342505.5 ENST00000673254.1	JAK1 Ensembl NCBI GeneCards UniProt Show fit	Janus kinase 1
chr10_-_102419934 Show fit	1.60	ENST00000406432.5	PSD Ensembl NCBI GeneCards UniProt Show fit	pleckstrin and Sec7 domain containing
chr11_-_64742937 Show fit	1.56	ENST00000394428.5 ENST00000394429.5	RASGRP2 Ensembl NCBI GeneCards UniProt Show fit	RAS guanyl releasing protein 2
chr1_-_155978144 Show fit	1.54	ENST00000313695.11 ENST00000497907.5	ARHGEF2 Ensembl NCBI GeneCards UniProt Show fit	Rho/Rac guanine nucleotide exchange factor 2
chr2_+_24049673 Show fit	1.49	ENST00000380991.8	FKBP1B Ensembl NCBI GeneCards UniProt Show fit	FKBP prolyl isomerase 1B
chr16_-_30122944 Show fit	1.49	ENST00000484663.5 ENST00000478356.5	MAPK3 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase 3
chr3_+_38165484 Show fit	1.47	ENST00000446845.5 ENST00000311806.8	OXSR1 Ensembl NCBI GeneCards UniProt Show fit	oxidative stress responsive kinase 1
chr19_-_41353904 Show fit	1.46	ENST00000221930.6	TGFB1 Ensembl NCBI GeneCards UniProt Show fit	transforming growth factor beta 1
chr10_+_110226805 Show fit	1.45	ENST00000651495.1 ENST00000652506.1 ENST00000651811.1 ENST00000651167.1 ENST00000651516.1 ENST00000651467.1 ENST00000651004.1 ENST00000650843.1 ENST00000650644.1 ENST00000650696.1 ENST00000652604.1 ENST00000652463.1 ENST00000650810.1 ENST00000650952.1 ENST00000652028.1 ENST00000651866.1 ENST00000651848.1 ENST00000442296.5 ENST00000369612.1	MXI1 Ensembl NCBI GeneCards UniProt Show fit	MAX interactor 1, dimerization protein
chr17_+_7307579 Show fit	1.44	ENST00000572815.5	EIF5A Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 5A
chr19_+_10655023 Show fit	1.44	ENST00000590009.5	ILF3 Ensembl NCBI GeneCards UniProt Show fit	interleukin enhancer binding factor 3
chr2_-_15561305 Show fit	1.43	ENST00000281513.10	NBAS Ensembl NCBI GeneCards UniProt Show fit	NBAS subunit of NRZ tethering complex
chr12_-_101407727 Show fit	1.38	ENST00000539055.5 ENST00000551688.1 ENST00000551671.5 ENST00000261636.13	ARL1 Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor like GTPase 1
chr5_+_169583636 Show fit	1.38	ENST00000506574.5 ENST00000515224.5 ENST00000629457.2 ENST00000508247.5 ENST00000265295.9 ENST00000513941.5	SPDL1 Ensembl NCBI GeneCards UniProt Show fit	spindle apparatus coiled-coil protein 1
chr20_-_64107546 Show fit	1.37	ENST00000684052.1	NPBWR2 Ensembl NCBI GeneCards UniProt Show fit	neuropeptides B and W receptor 2
chrX_-_154516183 Show fit	1.36	ENST00000442929.1 ENST00000426266.5 ENST00000447601.7 ENST00000359889.9 ENST00000369641.7 ENST00000322269.10 ENST00000419205.5	FAM3A Ensembl NCBI GeneCards UniProt Show fit	FAM3 metabolism regulating signaling molecule A
chr2_+_233195433 Show fit	1.35	ENST00000417661.1	INPP5D Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate-5-phosphatase D
chr6_-_113971120 Show fit	1.33	ENST00000520895.5 ENST00000521163.5 ENST00000524334.1 ENST00000519065.6 ENST00000368632.6	HDAC2 Ensembl NCBI GeneCards UniProt Show fit	histone deacetylase 2
chr17_+_77319465 Show fit	1.32	ENST00000329047.13	SEPTIN9 Ensembl NCBI GeneCards UniProt Show fit	septin 9
chr19_+_14529580 Show fit	1.30	ENST00000215567.10	TECR Ensembl NCBI GeneCards UniProt Show fit	trans-2,3-enoyl-CoA reductase
chr19_-_10502745 Show fit	1.30	ENST00000393623.6	KEAP1 Ensembl NCBI GeneCards UniProt Show fit	kelch like ECH associated protein 1
chr14_-_95516616 Show fit	1.28	ENST00000682763.1	SYNE3 Ensembl NCBI GeneCards UniProt Show fit	spectrin repeat containing nuclear envelope family member 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.9	20.7	GO:0014810	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014810)
4.8	14.4	GO:0046586	regulation of calcium-dependent cell-cell adhesion(GO:0046586)
4.2	12.5	GO:1901388	regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
3.8	11.5	GO:2000374	regulation of oxygen metabolic process(GO:2000374)
3.3	13.1	GO:0018231	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
2.5	24.6	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
2.2	13.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
2.1	6.3	GO:0018312	peptidyl-serine ADP-ribosylation(GO:0018312)
2.0	10.2	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
1.8	5.5	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
1.8	7.3	GO:0010900	negative regulation of phosphatidylcholine catabolic process(GO:0010900)
1.8	7.1	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
1.6	4.8	GO:2000538	regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
1.6	9.4	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
1.5	6.1	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
1.3	5.2	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.3	12.7	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.3	3.8	GO:0007057	spindle assembly involved in female meiosis I(GO:0007057)
1.2	3.7	GO:0036146	cellular response to mycotoxin(GO:0036146)
1.2	4.8	GO:0099558	maintenance of synapse structure(GO:0099558)
1.2	4.7	GO:0051182	coenzyme transport(GO:0051182)
1.1	4.3	GO:0035927	RNA import into mitochondrion(GO:0035927)
1.1	10.6	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
1.0	7.3	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
1.0	15.2	GO:0070986	left/right axis specification(GO:0070986)
1.0	10.7	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.9	2.8	GO:0000454	snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.9	2.7	GO:0042822	pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.9	2.7	GO:0051464	positive regulation of cortisol secretion(GO:0051464)
0.9	11.5	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.8	5.1	GO:0042780	tRNA 3'-end processing(GO:0042780)
0.8	7.2	GO:0072553	terminal button organization(GO:0072553)
0.7	1.5	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.7	2.1	GO:0061760	antifungal innate immune response(GO:0061760)
0.7	2.1	GO:1902299	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.7	2.7	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.7	5.9	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
0.6	3.2	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.6	6.4	GO:0036371	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.6	6.2	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.6	9.0	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5	1.1	GO:0043400	cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462)
0.5	3.7	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.5	8.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.5	4.2	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.5	15.9	GO:0048268	clathrin coat assembly(GO:0048268)
0.5	1.5	GO:2000681	negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.5	2.4	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.5	8.0	GO:0090161	Golgi ribbon formation(GO:0090161)
0.5	6.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.4	2.2	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.4	2.2	GO:1902527	positive regulation of protein monoubiquitination(GO:1902527)
0.4	1.3	GO:0002184	cytoplasmic translational termination(GO:0002184)
0.4	1.7	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.4	6.8	GO:0043248	proteasome assembly(GO:0043248)
0.4	2.0	GO:0050915	sensory perception of sour taste(GO:0050915)
0.4	1.2	GO:0044376	RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.4	1.5	GO:0071802	negative regulation of podosome assembly(GO:0071802)
0.4	7.8	GO:0032060	bleb assembly(GO:0032060)
0.4	4.6	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.3	1.4	GO:0045659	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.3	2.7	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.3	2.9	GO:0060613	fat pad development(GO:0060613)
0.3	2.2	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.3	2.6	GO:0048680	positive regulation of axon regeneration(GO:0048680)
0.3	2.7	GO:0038203	TORC2 signaling(GO:0038203)
0.3	6.9	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.3	1.3	GO:0072396	response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.3	8.6	GO:0071539	protein localization to centrosome(GO:0071539)
0.3	0.8	GO:0045082	positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.3	3.3	GO:0019388	galactose catabolic process(GO:0019388)
0.2	1.5	GO:0000189	MAPK import into nucleus(GO:0000189) regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.2	5.5	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.2	7.8	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2	9.3	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.2	0.6	GO:0006097	glyoxylate cycle(GO:0006097)
0.2	1.6	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.2	1.4	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.2	4.8	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.2	2.2	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2	2.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.2	14.2	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.2	1.4	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.2	0.8	GO:0015692	lead ion transport(GO:0015692)
0.1	9.9	GO:0006301	postreplication repair(GO:0006301)
0.1	1.7	GO:0000338	protein deneddylation(GO:0000338)
0.1	6.9	GO:0006458	'de novo' protein folding(GO:0006458)
0.1	0.2	GO:0010899	regulation of phosphatidylcholine catabolic process(GO:0010899)
0.1	1.1	GO:0044860	protein localization to plasma membrane raft(GO:0044860)
0.1	1.3	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1	9.5	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1	1.4	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1	1.7	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.1	0.6	GO:1990034	calcium ion export from cell(GO:1990034)
0.1	1.4	GO:0034501	protein localization to kinetochore(GO:0034501)
0.1	1.4	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.1	3.6	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.1	1.1	GO:0002191	cap-dependent translational initiation(GO:0002191)
0.1	0.8	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.1	9.7	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1	3.1	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.1	3.5	GO:0090140	regulation of mitochondrial fission(GO:0090140)
0.1	2.3	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1	0.4	GO:0060335	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1	3.6	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.1	2.5	GO:0060148	positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.1	1.3	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	3.3	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.1	1.6	GO:0044130	negative regulation of growth of symbiont in host(GO:0044130)
0.1	0.5	GO:0051012	microtubule sliding(GO:0051012)
0.1	0.2	GO:0003420	regulation of growth plate cartilage chondrocyte proliferation(GO:0003420)
0.1	1.3	GO:0030497	fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.1	1.9	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	4.8	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)
0.1	7.9	GO:0007030	Golgi organization(GO:0007030)
0.1	1.6	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.1	6.1	GO:0006334	nucleosome assembly(GO:0006334)
0.1	0.4	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1	0.8	GO:0007220	Notch receptor processing(GO:0007220)
0.1	0.8	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1	0.2	GO:0090273	positive regulation of pancreatic juice secretion(GO:0090187) regulation of somatostatin secretion(GO:0090273) positive regulation of somatostatin secretion(GO:0090274)
0.1	0.9	GO:0000042	protein targeting to Golgi(GO:0000042)
0.1	2.8	GO:0045214	sarcomere organization(GO:0045214)
0.0	3.6	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.4	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	1.4	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.4	GO:0006682	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0	3.3	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	5.8	GO:1902476	chloride transmembrane transport(GO:1902476)
0.0	1.0	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.3	GO:2000786	positive regulation of autophagosome assembly(GO:2000786)
0.0	2.4	GO:0046677	response to antibiotic(GO:0046677)
0.0	1.0	GO:0033081	regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0	3.8	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0	0.1	GO:1902255	embryonic nail plate morphogenesis(GO:0035880) activation of meiosis(GO:0090427) positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0	3.8	GO:0060337	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0	0.9	GO:0060292	long term synaptic depression(GO:0060292)
0.0	5.0	GO:0046718	viral entry into host cell(GO:0046718)
0.0	2.2	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	0.5	GO:0060965	negative regulation of gene silencing by miRNA(GO:0060965)
0.0	1.4	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	3.7	GO:0006805	xenobiotic metabolic process(GO:0006805)
0.0	5.3	GO:0051168	nuclear export(GO:0051168)
0.0	2.1	GO:0006968	cellular defense response(GO:0006968)
0.0	0.1	GO:1990564	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0	1.2	GO:0045739	positive regulation of DNA repair(GO:0045739)
0.0	5.1	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0	1.2	GO:0006400	tRNA modification(GO:0006400)
0.0	1.6	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	2.9	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0	4.2	GO:0006457	protein folding(GO:0006457)
0.0	0.6	GO:1901185	negative regulation of ERBB signaling pathway(GO:1901185)
0.0	1.1	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.0	0.3	GO:0006895	Golgi to endosome transport(GO:0006895)
0.0	2.7	GO:0019722	calcium-mediated signaling(GO:0019722)
0.0	1.8	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.6	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	2.6	GO:0006479	protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0	0.4	GO:0015012	heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0	2.0	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.0	1.2	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.1	GO:0034447	very-low-density lipoprotein particle clearance(GO:0034447)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	12.5	GO:1990917	sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
2.5	10.2	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
2.4	9.5	GO:0008537	proteasome activator complex(GO:0008537)
2.2	13.1	GO:0002178	palmitoyltransferase complex(GO:0002178)
1.3	10.7	GO:0061700	GATOR2 complex(GO:0061700)
1.0	3.1	GO:0017102	methionyl glutamyl tRNA synthetase complex(GO:0017102)
1.0	25.0	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.9	10.6	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.9	3.4	GO:0034457	Mpp10 complex(GO:0034457)
0.8	3.2	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.8	8.0	GO:0070852	cell body fiber(GO:0070852)
0.7	5.0	GO:0016272	prefoldin complex(GO:0016272)
0.7	2.1	GO:0005656	nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.7	4.2	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.7	6.2	GO:0042382	paraspeckles(GO:0042382)
0.6	8.6	GO:0005869	dynactin complex(GO:0005869)
0.6	2.4	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.6	13.9	GO:0030992	intraciliary transport particle B(GO:0030992)
0.6	9.3	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.6	5.2	GO:0097452	GAIT complex(GO:0097452)
0.5	4.3	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.5	7.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.5	1.9	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.5	1.4	GO:0070939	Dsl1p complex(GO:0070939)
0.5	9.3	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.4	9.0	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.4	1.3	GO:0018444	translation release factor complex(GO:0018444)
0.4	2.8	GO:0072588	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.4	4.2	GO:0005955	calcineurin complex(GO:0005955)
0.4	4.8	GO:0043083	synaptic cleft(GO:0043083)
0.4	6.3	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3	7.3	GO:0032591	dendritic spine membrane(GO:0032591)
0.3	4.3	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.3	7.4	GO:0042627	chylomicron(GO:0042627)
0.3	4.1	GO:0042555	MCM complex(GO:0042555)
0.3	10.1	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.2	5.4	GO:0001891	phagocytic cup(GO:0001891)
0.2	11.3	GO:0043198	dendritic shaft(GO:0043198)
0.2	8.1	GO:1902711	GABA-A receptor complex(GO:1902711)
0.2	2.2	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.2	0.8	GO:0033257	Bcl3/NF-kappaB2 complex(GO:0033257)
0.2	11.5	GO:0032592	integral component of mitochondrial membrane(GO:0032592)
0.2	1.3	GO:0030893	meiotic cohesin complex(GO:0030893)
0.2	2.8	GO:0097433	dense body(GO:0097433)
0.2	8.9	GO:0043034	costamere(GO:0043034)
0.2	0.8	GO:0070826	paraferritin complex(GO:0070826)
0.1	0.9	GO:0005594	collagen type IX trimer(GO:0005594)
0.1	2.7	GO:0031932	TORC2 complex(GO:0031932)
0.1	8.0	GO:0031201	SNARE complex(GO:0031201)
0.1	2.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.1	0.8	GO:0070765	gamma-secretase complex(GO:0070765)
0.1	1.4	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	1.3	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	9.6	GO:0005905	clathrin-coated pit(GO:0005905)
0.1	4.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	4.8	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.1	1.4	GO:0005642	annulate lamellae(GO:0005642)
0.1	8.8	GO:0005811	lipid particle(GO:0005811)
0.1	4.7	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	3.3	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	1.2	GO:0005883	neurofilament(GO:0005883)
0.1	10.6	GO:0035579	specific granule membrane(GO:0035579)
0.1	3.3	GO:0016592	mediator complex(GO:0016592)
0.1	2.8	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	0.4	GO:0033503	HULC complex(GO:0033503)
0.1	5.9	GO:0030315	T-tubule(GO:0030315)
0.1	1.1	GO:0016600	flotillin complex(GO:0016600)
0.1	7.1	GO:0042734	presynaptic membrane(GO:0042734)
0.1	2.6	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	1.5	GO:0031143	pseudopodium(GO:0031143)
0.1	8.7	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	2.2	GO:0005720	nuclear heterochromatin(GO:0005720)
0.1	1.5	GO:0000791	euchromatin(GO:0000791)
0.0	2.9	GO:0005876	spindle microtubule(GO:0005876)
0.0	3.5	GO:0035580	specific granule lumen(GO:0035580)
0.0	2.0	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	1.7	GO:0008180	COP9 signalosome(GO:0008180)
0.0	2.3	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.8	GO:0048786	presynaptic active zone(GO:0048786)
0.0	1.9	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	3.4	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.0	1.6	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	1.4	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	8.2	GO:0005667	transcription factor complex(GO:0005667)
0.0	1.5	GO:0005902	microvillus(GO:0005902)
0.0	0.8	GO:0031526	brush border membrane(GO:0031526)
0.0	1.7	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	2.2	GO:0005802	trans-Golgi network(GO:0005802)
0.0	0.3	GO:0031082	BLOC complex(GO:0031082)
0.0	1.4	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	16.0	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	1.0	GO:0005643	nuclear pore(GO:0005643)
0.0	4.8	GO:0016607	nuclear speck(GO:0016607)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	12.5	GO:0002135	CTP binding(GO:0002135)
4.1	20.7	GO:0045174	glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
2.6	10.6	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
1.8	7.0	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
1.7	5.2	GO:0035605	peptidyl-cysteine S-nitrosylase activity(GO:0035605)
1.6	4.8	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
1.4	9.5	GO:0061133	endopeptidase activator activity(GO:0061133)
1.1	9.8	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.1	3.3	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
1.0	10.2	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.9	13.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.9	2.7	GO:0031403	lithium ion binding(GO:0031403)
0.8	7.1	GO:0030911	TPR domain binding(GO:0030911)
0.7	13.1	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.7	2.0	GO:0043139	5'-3' DNA helicase activity(GO:0043139)
0.6	9.6	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.6	6.3	GO:0032051	clathrin light chain binding(GO:0032051)
0.6	14.8	GO:0070628	proteasome binding(GO:0070628)
0.6	2.2	GO:0004609	phosphatidylserine decarboxylase activity(GO:0004609)
0.5	2.7	GO:0004966	galanin receptor activity(GO:0004966)
0.5	3.2	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.5	4.3	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.5	4.2	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.5	2.0	GO:0044736	acid-sensing ion channel activity(GO:0044736)
0.5	4.8	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.4	9.0	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4	2.6	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.4	2.8	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.4	5.1	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.4	3.9	GO:0001727	lipid kinase activity(GO:0001727)
0.4	3.8	GO:0055104	ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.4	13.7	GO:0005123	death receptor binding(GO:0005123)
0.3	5.9	GO:0031432	titin binding(GO:0031432)
0.3	6.9	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.3	1.4	GO:0043515	kinetochore binding(GO:0043515)
0.3	1.3	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.3	4.7	GO:0008517	folic acid transporter activity(GO:0008517)
0.3	10.2	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.3	1.5	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.3	5.4	GO:0032036	myosin heavy chain binding(GO:0032036)
0.3	0.8	GO:0080101	phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.3	3.8	GO:0031386	protein tag(GO:0031386)
0.3	1.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.3	2.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.3	4.0	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.2	2.5	GO:0002151	G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592)
0.2	14.2	GO:0030507	spectrin binding(GO:0030507)
0.2	1.3	GO:0036033	mediator complex binding(GO:0036033)
0.2	5.2	GO:0000339	RNA cap binding(GO:0000339)
0.2	14.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.2	1.3	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2	7.7	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.2	8.1	GO:0004890	GABA-A receptor activity(GO:0004890)
0.2	0.6	GO:0004450	isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2	8.0	GO:0005484	SNAP receptor activity(GO:0005484)
0.2	1.6	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.2	1.2	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.2	3.6	GO:0017049	GTP-Rho binding(GO:0017049)
0.2	2.2	GO:0051400	BH domain binding(GO:0051400)
0.2	7.7	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.2	10.5	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.2	6.6	GO:0050780	dopamine receptor binding(GO:0050780)
0.2	0.8	GO:0015087	cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2	2.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.1	2.8	GO:0051787	misfolded protein binding(GO:0051787)
0.1	0.4	GO:0035241	protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.1	2.4	GO:0042043	neurexin family protein binding(GO:0042043)
0.1	4.6	GO:0001671	ATPase activator activity(GO:0001671)
0.1	1.5	GO:0016755	transferase activity, transferring amino-acyl groups(GO:0016755)
0.1	3.9	GO:0043014	alpha-tubulin binding(GO:0043014)
0.1	0.4	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.1	47.2	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.1	1.7	GO:0004985	opioid receptor activity(GO:0004985)
0.1	0.7	GO:0008420	CTD phosphatase activity(GO:0008420)
0.1	1.3	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1	4.0	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.1	0.3	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	11.1	GO:0051082	unfolded protein binding(GO:0051082)
0.1	1.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.1	1.4	GO:0017070	U6 snRNA binding(GO:0017070)
0.1	3.1	GO:0000049	tRNA binding(GO:0000049)
0.1	1.7	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	1.6	GO:0019992	diacylglycerol binding(GO:0019992)
0.1	8.8	GO:0020037	heme binding(GO:0020037)
0.1	0.7	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.1	2.3	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1	2.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1	1.0	GO:0008195	phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577)
0.1	11.3	GO:0042393	histone binding(GO:0042393)
0.1	7.4	GO:0001618	virus receptor activity(GO:0001618)
0.1	0.6	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1	1.5	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.1	0.4	GO:0050694	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	1.5	GO:0004707	MAP kinase activity(GO:0004707)
0.0	1.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	1.5	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	3.9	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.5	GO:0035198	miRNA binding(GO:0035198)
0.0	7.3	GO:0051015	actin filament binding(GO:0051015)
0.0	1.1	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	2.6	GO:0008276	protein methyltransferase activity(GO:0008276)
0.0	1.2	GO:0019239	deaminase activity(GO:0019239)
0.0	0.6	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	2.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	2.6	GO:0008565	protein transporter activity(GO:0008565)
0.0	0.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.4	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	2.1	GO:0005262	calcium channel activity(GO:0005262)
0.0	1.6	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	1.4	GO:0000149	SNARE binding(GO:0000149)
0.0	1.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	3.3	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	0.9	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0	4.3	GO:0003713	transcription coactivator activity(GO:0003713)
0.0	0.4	GO:0051879	Hsp90 protein binding(GO:0051879)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	9.4	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4	44.5	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.3	6.9	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.3	6.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	13.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	1.6	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	15.1	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.1	2.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	2.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1	3.4	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	3.0	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	4.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	1.5	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	2.2	PID PLK1 PATHWAY	PLK1 signaling events
0.0	4.7	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	1.3	PID ATM PATHWAY	ATM pathway
0.0	2.1	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	2.1	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.7	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	5.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	2.4	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	1.1	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	10.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.7	18.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.7	12.5	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.6	10.6	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.6	20.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.5	11.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.5	2.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.5	4.6	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.4	6.3	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.4	7.0	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.3	3.1	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.3	35.0	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.3	10.7	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.3	9.0	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.3	4.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.2	3.3	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2	7.8	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.2	1.5	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	13.2	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.2	2.1	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.2	6.0	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	5.1	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	4.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	4.8	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.1	3.1	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.1	5.0	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1	2.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	8.0	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	1.5	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	7.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	3.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	2.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.1	2.1	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	5.2	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	12.0	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	4.3	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	5.8	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	5.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	12.4	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	1.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	2.7	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	0.7	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	3.6	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	1.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	1.4	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0	0.6	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.8	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	1.3	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	5.5	REACTOME METABOLISM OF CARBOHYDRATES	Genes involved in Metabolism of carbohydrates
0.0	0.6	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.4	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	3.3	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
0.0	0.7	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)

Results for GLIS2

Z-value: 3.65

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Transcription factors associated with GLIS2

Activity profile of GLIS2 motif

Sorted Z-values of GLIS2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: