Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for GLIS3

Z-value: 3.97

Motif logo

logo of

Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
GLIS3
ENSG00000107249.24 GLIS3

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_52949107 25.82 ENST00000388835.4
KRT18
keratin 18
chr1_-_45522870 16.76 ENST00000424390.2
PRDX1
peroxiredoxin 1
chr19_+_48325323 16.56 ENST00000596315.5
EMP3
epithelial membrane protein 3
chr1_-_45521854 14.68 ENST00000372079.1
ENST00000319248.13
PRDX1
peroxiredoxin 1
chr1_-_45521931 13.35 ENST00000447184.6
ENST00000262746.5
PRDX1
peroxiredoxin 1
chr17_-_75182536 12.64 ENST00000578238.2
SUMO2
small ubiquitin like modifier 2
chr18_+_3451585 11.00 ENST00000551541.5
TGIF1
TGFB induced factor homeobox 1
chr5_+_172959416 10.29 ENST00000265100.6
ENST00000519239.5
RPL26L1
ribosomal protein L26 like 1
chr18_+_3451647 8.51 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGIF1
TGFB induced factor homeobox 1
chrX_+_65667645 8.29 ENST00000360270.7
MSN
moesin
chr11_+_68684534 7.90 ENST00000265643.4
GAL
galanin and GMAP prepropeptide
chr19_-_3061403 6.76 ENST00000586839.1
TLE5
TLE family member 5, transcriptional modulator
chr19_-_10503186 6.57 ENST00000592055.2
ENST00000171111.10
KEAP1
kelch like ECH associated protein 1
chrX_+_119236245 5.89 ENST00000535419.2
PGRMC1
progesterone receptor membrane component 1
chr6_+_44223553 5.81 ENST00000371740.10
ENST00000371755.9
ENST00000643869.1
ENST00000371731.6
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chrX_+_119236274 5.75 ENST00000217971.8
PGRMC1
progesterone receptor membrane component 1
chr19_-_42255119 5.12 ENST00000222329.9
ENST00000594664.1
ERF
ENSG00000268643.2
ETS2 repressor factor
novel protein
chr5_+_172959511 5.08 ENST00000519522.1
RPL26L1
ribosomal protein L26 like 1
chr22_+_31093358 4.84 ENST00000404574.5
SMTN
smoothelin
chr19_+_46347063 4.83 ENST00000012443.9
ENST00000391919.1
PPP5C
protein phosphatase 5 catalytic subunit
chr5_-_132777866 4.82 ENST00000448933.5
SEPTIN8
septin 8
chr3_-_25783434 4.72 ENST00000396649.7
ENST00000280700.10
ENST00000428257.5
NGLY1
N-glycanase 1
chr6_+_44223770 4.66 ENST00000652453.1
ENST00000393841.6
ENST00000371724.6
ENST00000642777.1
ENST00000645692.1
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr10_+_22321056 4.58 ENST00000376663.8
BMI1
BMI1 proto-oncogene, polycomb ring finger
chr1_-_53945584 4.35 ENST00000371377.3
HSPB11
heat shock protein family B (small) member 11
chr1_-_53945567 4.24 ENST00000371378.6
HSPB11
heat shock protein family B (small) member 11
chr3_-_25783381 4.07 ENST00000308710.9
ENST00000676225.1
NGLY1
N-glycanase 1
chr1_-_42335869 4.06 ENST00000372573.5
FOXJ3
forkhead box J3
chr10_-_125161019 3.70 ENST00000411419.6
CTBP2
C-terminal binding protein 2
chr20_-_31722854 3.40 ENST00000307677.5
BCL2L1
BCL2 like 1
chr15_+_90935277 3.34 ENST00000418476.2
UNC45A
unc-45 myosin chaperone A
chr16_+_69187125 3.13 ENST00000336278.8
SNTB2
syntrophin beta 2
chr19_-_41353904 2.96 ENST00000221930.6
TGFB1
transforming growth factor beta 1
chr5_-_179623098 2.92 ENST00000630639.1
ENST00000329433.10
ENST00000510411.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr5_-_132777371 2.70 ENST00000620483.4
SEPTIN8
septin 8
chr17_-_75182949 2.66 ENST00000314523.7
ENST00000420826.7
SUMO2
small ubiquitin like modifier 2
chr5_-_132777404 2.62 ENST00000296873.11
SEPTIN8
septin 8
chr16_-_90008988 2.58 ENST00000568662.2
DBNDD1
dysbindin domain containing 1
chr1_-_52552994 2.35 ENST00000355809.4
ENST00000528642.5
ENST00000470626.1
ENST00000257177.9
ENST00000371544.7
TUT4
terminal uridylyl transferase 4
chr3_+_173398438 2.18 ENST00000457714.5
NLGN1
neuroligin 1
chr18_-_63158208 2.16 ENST00000678301.1
BCL2
BCL2 apoptosis regulator
chr1_-_42335189 2.12 ENST00000361776.5
ENST00000445886.5
ENST00000361346.6
FOXJ3
forkhead box J3
chr19_-_10502745 1.98 ENST00000393623.6
KEAP1
kelch like ECH associated protein 1
chr3_+_37987970 1.97 ENST00000283713.10
VILL
villin like
chr22_+_50190569 1.95 ENST00000395827.5
TRABD
TraB domain containing
chr17_+_7888783 1.84 ENST00000330494.12
ENST00000358181.8
CHD3
chromodomain helicase DNA binding protein 3
chr22_-_50526337 1.82 ENST00000651490.1
ENST00000543927.6
TYMP
SCO2
thymidine phosphorylase
synthesis of cytochrome C oxidase 2
chr6_+_24494939 1.73 ENST00000348925.2
ENST00000357578.8
ALDH5A1
aldehyde dehydrogenase 5 family member A1
chr6_+_33204645 1.67 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8
chr4_-_83334782 1.62 ENST00000681769.1
ENST00000513463.1
ENST00000311412.10
HPSE
heparanase
chr21_-_44910630 1.56 ENST00000320216.10
ENST00000397852.5
ITGB2
integrin subunit beta 2
chr5_-_132777344 1.50 ENST00000378706.5
SEPTIN8
septin 8
chr1_-_246931892 1.44 ENST00000648844.2
AHCTF1
AT-hook containing transcription factor 1
chr17_-_5111836 1.40 ENST00000575898.5
ZNF232
zinc finger protein 232
chr20_-_31723491 1.14 ENST00000676582.1
ENST00000422920.2
BCL2L1
BCL2 like 1
chr1_-_160285120 0.86 ENST00000368072.10
PEX19
peroxisomal biogenesis factor 19
chr8_-_29263063 0.63 ENST00000524189.6
KIF13B
kinesin family member 13B
chr19_+_40775154 0.60 ENST00000594436.5
ENST00000597784.5
MIA
MIA SH3 domain containing
chr14_+_22462932 0.58 ENST00000390477.2
TRDC
T cell receptor delta constant
chr18_-_48950960 0.55 ENST00000262158.8
SMAD7
SMAD family member 7
chr17_-_35119733 0.16 ENST00000460118.6
ENST00000335858.11
RAD51D
RAD51 paralog D
chr5_-_179623659 0.01 ENST00000519056.5
ENST00000506721.5
ENST00000503105.5
ENST00000504348.5
ENST00000508103.5
ENST00000510431.5
ENST00000515158.5
ENST00000393432.8
ENST00000442819.6
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
2.1 10.5 GO:0015862 uridine transport(GO:0015862)
1.4 8.3 GO:0022614 membrane to membrane docking(GO:0022614)
1.3 44.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.8 16.6 GO:0032060 bleb assembly(GO:0032060)
0.8 8.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.7 3.0 GO:0052255 ossification involved in bone remodeling(GO:0043932) induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.7 2.2 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.7 30.4 GO:0097284 hepatocyte apoptotic process(GO:0097284)
0.7 10.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.7 4.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.6 8.6 GO:0070986 left/right axis specification(GO:0070986)
0.5 2.2 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.4 4.6 GO:0007379 segment specification(GO:0007379)
0.4 3.7 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 1.7 GO:0009450 gamma-aminobutyric acid catabolic process(GO:0009450)
0.3 15.3 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 15.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 1.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.5 GO:2000317 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 1.8 GO:0008535 respiratory chain complex IV assembly(GO:0008535) pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.1 0.6 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.1 1.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 0.9 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.1 1.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 2.0 GO:0051693 actin filament capping(GO:0051693)
0.0 4.6 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 3.3 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 22.4 GO:0071363 cellular response to growth factor stimulus(GO:0071363)
0.0 11.6 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 1.8 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.8 GO:1990635 proximal dendrite(GO:1990635)
0.6 25.8 GO:0034451 centriolar satellite(GO:0034451)
0.4 8.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.4 4.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 1.6 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.3 4.6 GO:0035102 PRC1 complex(GO:0035102)
0.2 3.7 GO:0097470 ribbon synapse(GO:0097470)
0.2 44.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 8.6 GO:0097542 ciliary tip(GO:0097542)
0.1 15.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 8.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.2 GO:0032433 filopodium tip(GO:0032433)
0.1 2.2 GO:0046930 pore complex(GO:0046930)
0.1 15.3 GO:0016605 PML body(GO:0016605)
0.1 11.4 GO:0035579 specific granule membrane(GO:0035579)
0.1 1.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 3.1 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.5 GO:0016342 catenin complex(GO:0016342)
0.1 1.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.6 GO:0033270 paranode region of axon(GO:0033270)
0.0 2.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 10.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.6 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 44.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.6 7.9 GO:0004966 galanin receptor activity(GO:0004966)
1.1 15.3 GO:0031386 protein tag(GO:0031386)
0.9 25.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.7 4.6 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.7 19.5 GO:0070410 co-SMAD binding(GO:0070410)
0.6 1.8 GO:0009032 thymidine phosphorylase activity(GO:0009032) pyrimidine-nucleoside phosphorylase activity(GO:0016154)
0.6 3.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.6 6.7 GO:0051434 BH3 domain binding(GO:0051434)
0.5 1.6 GO:0004566 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.5 3.7 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.5 10.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.4 1.7 GO:0070404 NADH binding(GO:0070404)
0.2 1.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.2 4.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.9 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 2.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.5 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.1 10.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 11.3 GO:0005496 steroid binding(GO:0005496)
0.1 15.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 8.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 4.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.7 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 5.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.6 GO:0071889 14-3-3 protein binding(GO:0071889)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 44.2 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.3 6.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3 25.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 18.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 19.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 7.8 PID RHOA PATHWAY RhoA signaling pathway
0.1 3.0 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 10.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 19.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 10.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 6.7 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.2 8.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 3.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 15.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.6 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 8.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 3.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell