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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GRHL1

Z-value: 2.10

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.18 GRHL1

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_-_4338786 10.07 ENST00000601482.1
ENST00000600324.5
ENST00000594605.6
STAP2
signal transducing adaptor family member 2
chr1_-_112704921 9.81 ENST00000414971.1
ENST00000534717.5
RHOC
ras homolog family member C
chr19_-_291132 9.38 ENST00000327790.7
PLPP2
phospholipid phosphatase 2
chr2_-_208254232 9.21 ENST00000415913.5
ENST00000415282.5
ENST00000446179.5
IDH1
isocitrate dehydrogenase (NADP(+)) 1
chr11_+_706117 9.11 ENST00000533256.5
ENST00000614442.4
EPS8L2
EPS8 like 2
chr2_-_85414039 8.18 ENST00000447219.6
ENST00000409670.5
ENST00000409724.5
CAPG
capping actin protein, gelsolin like
chr1_+_156061142 7.65 ENST00000361084.10
RAB25
RAB25, member RAS oncogene family
chr5_+_126423176 7.38 ENST00000542322.5
ENST00000544396.5
GRAMD2B
GRAM domain containing 2B
chr5_+_126423122 7.01 ENST00000515200.5
GRAMD2B
GRAM domain containing 2B
chr5_+_126423363 6.91 ENST00000285689.8
GRAMD2B
GRAM domain containing 2B
chr3_+_52211442 6.81 ENST00000459884.1
ALAS1
5'-aminolevulinate synthase 1
chr19_+_44809053 6.62 ENST00000611077.5
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr13_+_48232609 5.98 ENST00000649266.1
ITM2B
integral membrane protein 2B
chr11_-_64166102 5.96 ENST00000255681.7
ENST00000675777.1
MACROD1
mono-ADP ribosylhydrolase 1
chr11_+_76782250 5.83 ENST00000533752.1
ENST00000612930.1
TSKU
tsukushi, small leucine rich proteoglycan
chr1_-_201399302 5.48 ENST00000633953.1
ENST00000391967.7
LAD1
ladinin 1
chr11_-_120138104 5.36 ENST00000341846.10
TRIM29
tripartite motif containing 29
chr1_+_43974902 5.20 ENST00000532642.5
ENST00000236067.8
ENST00000471859.6
ENST00000472174.7
ATP6V0B
ATPase H+ transporting V0 subunit b
chr19_+_44809089 5.03 ENST00000270233.12
ENST00000591520.6
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr19_-_17245889 4.97 ENST00000291442.4
NR2F6
nuclear receptor subfamily 2 group F member 6
chrX_-_120469282 4.46 ENST00000200639.9
ENST00000371335.4
LAMP2
lysosomal associated membrane protein 2
chr12_+_56104527 4.19 ENST00000552766.5
ENST00000303305.11
PA2G4
proliferation-associated 2G4
chr1_+_40258202 4.13 ENST00000372759.4
ZMPSTE24
zinc metallopeptidase STE24
chr11_-_11353241 4.01 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr13_+_48233171 3.90 ENST00000378549.5
ENST00000647800.2
ITM2B
integral membrane protein 2B
chr1_+_94418435 3.71 ENST00000647998.2
ABCD3
ATP binding cassette subfamily D member 3
chr3_-_49104745 3.67 ENST00000635194.1
ENST00000306125.12
ENST00000634602.1
ENST00000414533.5
ENST00000635443.1
ENST00000452739.5
ENST00000635231.1
QARS1
glutaminyl-tRNA synthetase 1
chr18_+_9475494 3.57 ENST00000383432.8
RALBP1
ralA binding protein 1
chr3_-_49104457 3.54 ENST00000635292.1
ENST00000635541.1
ENST00000464962.6
QARS1
glutaminyl-tRNA synthetase 1
chr6_-_43059367 3.35 ENST00000230413.9
ENST00000487429.1
ENST00000388752.8
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr4_-_128288791 3.01 ENST00000613358.4
ENST00000520121.6
PGRMC2
progesterone receptor membrane component 2
chr3_-_172523460 2.99 ENST00000420541.6
TNFSF10
TNF superfamily member 10
chr3_-_172523423 2.91 ENST00000241261.7
TNFSF10
TNF superfamily member 10
chrX_+_147911910 2.80 ENST00000370475.9
FMR1
FMRP translational regulator 1
chr18_+_9474994 2.65 ENST00000019317.8
RALBP1
ralA binding protein 1
chr4_+_109815503 2.47 ENST00000394631.7
GAR1
GAR1 ribonucleoprotein
chr7_-_139109337 2.43 ENST00000464606.5
ZC3HAV1
zinc finger CCCH-type containing, antiviral 1
chr14_-_23071617 2.28 ENST00000357481.6
ACIN1
apoptotic chromatin condensation inducer 1
chr1_+_34782259 2.24 ENST00000373362.3
GJB3
gap junction protein beta 3
chr7_-_102543849 2.00 ENST00000644544.1
UPK3BL2
uroplakin 3B like 2
chr14_-_23071538 1.93 ENST00000555566.1
ENST00000338631.10
ENST00000557515.5
ENST00000397341.7
ACIN1
apoptotic chromatin condensation inducer 1
chr17_+_7572818 1.87 ENST00000293831.13
ENST00000582169.5
ENST00000578754.5
ENST00000578495.5
ENST00000585024.5
ENST00000583802.5
ENST00000577269.5
ENST00000584784.5
ENST00000582746.5
ENST00000581621.1
EIF4A1
ENSG00000264772.6
eukaryotic translation initiation factor 4A1
novel transcript
chr4_+_109815734 1.72 ENST00000226796.7
GAR1
GAR1 ribonucleoprotein
chr7_-_102642791 1.60 ENST00000340457.8
UPK3BL1
uroplakin 3B like 1
chr16_+_2514253 1.48 ENST00000565223.1
ATP6V0C
ATPase H+ transporting V0 subunit c
chr20_-_18057841 1.46 ENST00000278780.7
OVOL2
ovo like zinc finger 2
chr7_+_76510528 1.40 ENST00000334348.8
UPK3B
uroplakin 3B
chr14_-_80211472 1.30 ENST00000557125.1
ENST00000438257.9
ENST00000422005.7
DIO2
iodothyronine deiodinase 2
chrX_+_147912039 1.29 ENST00000334557.10
ENST00000439526.6
FMR1
FMRP translational regulator 1
chr10_-_50885656 1.24 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr15_+_66386902 0.95 ENST00000307102.10
MAP2K1
mitogen-activated protein kinase kinase 1
chr2_+_113058637 0.89 ENST00000346807.7
IL36RN
interleukin 36 receptor antagonist
chr1_-_24143112 0.86 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chr9_-_75088198 0.80 ENST00000376808.8
NMRK1
nicotinamide riboside kinase 1
chr1_-_50960230 0.72 ENST00000396153.7
FAF1
Fas associated factor 1
chr7_+_76510516 0.68 ENST00000257632.9
UPK3B
uroplakin 3B
chr19_-_40090860 0.63 ENST00000599972.1
ENST00000450241.6
ENST00000595687.6
ENST00000340963.9
ZNF780A
zinc finger protein 780A
chr7_+_76510608 0.60 ENST00000394849.1
UPK3B
uroplakin 3B
chr12_-_10807286 0.57 ENST00000240615.3
TAS2R8
taste 2 receptor member 8
chr11_-_67674606 0.55 ENST00000674110.1
ENST00000349015.7
ALDH3B2
aldehyde dehydrogenase 3 family member B2
chr18_+_9475450 0.43 ENST00000585015.6
RALBP1
ralA binding protein 1
chr7_-_80922354 0.37 ENST00000419255.6
SEMA3C
semaphorin 3C
chr11_-_67674725 0.33 ENST00000525827.6
ENST00000673966.1
ENST00000673873.1
ALDH3B2
aldehyde dehydrogenase 3 family member B2
chr10_-_92243246 0.31 ENST00000412050.8
ENST00000614585.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr6_-_46921926 0.29 ENST00000283296.12
ADGRF5
adhesion G protein-coupled receptor F5
chr10_-_50885619 0.20 ENST00000373997.8
A1CF
APOBEC1 complementation factor
chr1_-_28058087 0.12 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3
chr14_-_80211268 0.10 ENST00000556811.5
DIO2
iodothyronine deiodinase 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0006097 glyoxylate cycle(GO:0006097)
2.0 9.8 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
1.5 5.8 GO:0061073 ciliary body morphogenesis(GO:0061073)
1.4 4.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
1.4 4.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
1.4 4.1 GO:1901254 modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
1.2 6.0 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.9 3.7 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.9 9.9 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.7 9.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.5 4.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.5 8.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.4 4.5 GO:1905146 lysosomal protein catabolic process(GO:1905146)
0.4 7.7 GO:0031268 pseudopodium organization(GO:0031268)
0.4 6.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.3 2.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.3 1.5 GO:0060214 endocardium formation(GO:0060214)
0.2 1.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 5.9 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.2 6.7 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.2 5.0 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.2 9.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.2 0.3 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.1 10.1 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 0.9 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.1 1.4 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.9 GO:0019732 antifungal humoral response(GO:0019732)
0.1 0.4 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 6.1 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.0 3.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.3 GO:0043129 surfactant homeostasis(GO:0043129)
0.0 11.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 1.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.8 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 4.0 GO:0030307 positive regulation of cell growth(GO:0030307)
0.0 0.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 6.7 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 4.2 GO:0007050 cell cycle arrest(GO:0007050)
0.0 3.0 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
1.4 4.1 GO:1902737 dendritic filopodium(GO:1902737)
0.7 8.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.7 6.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.6 4.2 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.4 4.2 GO:0061574 ASAP complex(GO:0061574)
0.4 1.4 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3 21.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 7.7 GO:0031143 pseudopodium(GO:0031143)
0.2 12.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 8.6 GO:0032420 stereocilium(GO:0032420)
0.2 9.9 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 2.2 GO:0005922 connexon complex(GO:0005922)
0.1 1.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 3.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 9.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 4.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 5.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.5 GO:0005604 basement membrane(GO:0005604)
0.0 4.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 11.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 GO:0005055 laminin receptor activity(GO:0005055)
3.1 9.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.6 9.4 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
1.4 6.8 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.7 4.1 GO:0034046 poly(G) binding(GO:0034046)
0.6 4.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.5 3.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 1.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 6.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.3 7.7 GO:0031489 myosin V binding(GO:0031489)
0.3 9.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 1.4 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 5.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 5.2 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 0.9 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 0.8 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.2 5.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 0.9 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 2.2 GO:0005243 gap junction channel activity(GO:0005243)
0.1 5.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 9.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 2.4 GO:0070403 NAD+ binding(GO:0070403)
0.1 1.9 GO:0000339 RNA cap binding(GO:0000339)
0.1 6.0 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.9 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 4.1 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.1 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 8.2 GO:0051015 actin filament binding(GO:0051015)
0.0 9.8 GO:0003924 GTPase activity(GO:0003924)
0.0 3.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 3.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 5.5 GO:0045296 cadherin binding(GO:0045296)
0.0 1.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 21.3 GO:0042802 identical protein binding(GO:0042802)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 6.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 5.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 6.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 4.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 5.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.9 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.2 6.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.2 9.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 6.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 9.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 5.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 3.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 0.9 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 1.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 4.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 5.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 6.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 4.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+